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Protein
Submitted name:

Amyloid lambda 6 light chain variable region PIP

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Amyloid lambda 6 light chain variable region PIPImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi22 ↔ 91Combined sources

Proteomic databases

PRIDEiQ96JD1.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PW3X-ray1.90A/B1-112[»]
5C9KX-ray1.92A/B/C/D/E/F/G/H1-111[»]
ProteinModelPortaliQ96JD1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96JD1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 102102Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST

Phylogenomic databases

HOVERGENiHBG018013.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q96JD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
NFMLTQPHSV SESPGKTITI SCTRSSGSIA SNYVQWYQQR PGSAPTTVIY
60 70 80 90 100
EDNQRPSGVP DRFSGSIDSS SNSASLTISG LKTEDEADYY CQSYDSNNYA
110
LFGGGTQLTV LG
Length:112
Mass (Da):12,047
Last modified:December 1, 2001 - v1
Checksum:i0D3885AC23567B9F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei112 – 1121Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF267874 mRNA. Translation: AAK58586.1.
PIRiA30323.
UniGeneiHs.535668.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF267874 mRNA. Translation: AAK58586.1.
PIRiA30323.
UniGeneiHs.535668.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PW3X-ray1.90A/B1-112[»]
5C9KX-ray1.92A/B/C/D/E/F/G/H1-111[»]
ProteinModelPortaliQ96JD1.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ96JD1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG018013.

Miscellaneous databases

EvolutionaryTraceiQ96JD1.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Amyloid lambda 6 light chain variable region PIP."
    Perfetti V., Casarini S., Colli Vignarelli M., Merlini G.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Bone marrowImported.
  2. "Structural basis of light chain amyloidogenicity: comparison of the thermodynamic properties, fibrillogenic potential and tertiary structural features of four Vlambda6 proteins."
    Wall J.S., Gupta V., Wilkerson M., Schell M., Loris R., Adams P., Solomon A., Stevens F., Dealwis C.
    J. Mol. Recognit. 17:323-331(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS), DISULFIDE BONDS.
  3. "Mutating amyloidogenic lambda6 light chain AR back to germline 6aJL2."
    Luna-Martinez O.D., Villalba-Velazquez M.I., Sanchez-Alcala R., Hernandez-Santoyo A., Fernandez-Velasco D.A., Rodriguez-Romero A., Becerril-Lujan B.
    Submitted (JUN-2015) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.92 ANGSTROMS) OF 1-111, DISULFIDE BONDS.

Entry informationi

Entry nameiQ96JD1_HUMAN
AccessioniPrimary (citable) accession number: Q96JD1
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.