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Protein

Zinc finger protein 479

Gene

ZNF479

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri185 – 21228C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri213 – 23523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri241 – 26323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri269 – 29123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri297 – 31923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri325 – 34723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri353 – 37523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri381 – 40323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri409 – 43123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri437 – 45923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri465 – 48723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri493 – 51523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 479
Alternative name(s):
Zinc finger protein Kr19
Short name:
HKr19
Gene namesi
Name:ZNF479
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:23258. ZNF479.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134903704.

Polymorphism and mutation databases

BioMutaiZNF479.
DMDMi38258829.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 524524Zinc finger protein 479PRO_0000047606Add
BLAST

Proteomic databases

EPDiQ96JC4.
PaxDbiQ96JC4.
PRIDEiQ96JC4.

PTM databases

iPTMnetiQ96JC4.
PhosphoSiteiQ96JC4.

Expressioni

Tissue specificityi

Expressed primarily in testis and fetal tissues.1 Publication

Gene expression databases

BgeeiQ96JC4.
CleanExiHS_ZNF479.
ExpressionAtlasiQ96JC4. baseline and differential.
GenevisibleiQ96JC4. HS.

Interactioni

Protein-protein interaction databases

BioGridi124767. 1 interaction.
IntActiQ96JC4. 1 interaction.
STRINGi9606.ENSP00000333776.

Structurei

3D structure databases

ProteinModelPortaliQ96JC4.
SMRiQ96JC4. Positions 9-56, 152-523.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 8772KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri185 – 21228C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri213 – 23523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri241 – 26323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri269 – 29123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri297 – 31923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri325 – 34723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri353 – 37523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri381 – 40323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri409 – 43123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri437 – 45923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri465 – 48723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri493 – 51523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOVERGENiHBG018163.
InParanoidiQ96JC4.
KOiK09228.
OMAiGYSEVNQ.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ96JC4.
TreeFamiTF342117.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96JC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKRPGPPGS REMGLLTFRD IAIEFSLEEW QCLDCAQRNL YRDVMLENYR
60 70 80 90 100
NLVSLGIAVS KPDLITCLEQ NKESQNIKRN EMVAKHPVTR SHFTQDLQPE
110 120 130 140 150
QGIKDSLQKV IPRTYGKCGH EKLQFKKCCK SVGEYEVHKG GYSEVNQCLS
160 170 180 190 200
TTQNKIFQTH KYVKVFGKFS NSNRDKTRYT GNKHFKCNKY GKSFCMLSHL
210 220 230 240 250
NQHQVIHTRE KSYKCKECGK SFNCSSNHTT HKIIHTGEKP YRCEECGKAF
260 270 280 290 300
SWSANLTRHK RTHTGEKPYT CEECGQAFRR SSALTNHKRI HTGERPYKCE
310 320 330 340 350
ECGKAFSVSS TLTDHKRIHT GEKPCRCEEC GKAFSWSSNL TRHKRIHTRE
360 370 380 390 400
KPYACEECGQ AFSLSSNLMR HRRIHTGEKP YTCEECGQDF RRSSALTIHK
410 420 430 440 450
RIHTGERPYK CEECGKVFSL SSTLTDHKRI HTGERPYKCE ECGKAFSLSS
460 470 480 490 500
TLTDHKRIHT GERPYTCEEC GKAFNCSSTL MQHKRIHTGE KPYKCEECEQ
510 520
AFKWHSSLAK HKIIHTGEKP YKCE
Length:524
Mass (Da):60,598
Last modified:December 1, 2001 - v1
Checksum:iF1AD4929DC67D105
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF277624 mRNA. Translation: AAK61307.1.
CCDSiCCDS43590.1.
RefSeqiNP_150376.1. NM_033273.2.
XP_005271848.1. XM_005271791.3.
XP_011513905.1. XM_011515603.1.
XP_011513906.1. XM_011515604.1.
XP_011513907.1. XM_011515605.1.
XP_011513908.1. XM_011515606.1.
XP_011513909.1. XM_011515607.1.
XP_011513910.1. XM_011515608.1.
UniGeneiHs.616660.

Genome annotation databases

EnsembliENST00000319636; ENSP00000324518; ENSG00000185177.
ENST00000331162; ENSP00000333776; ENSG00000185177.
GeneIDi90827.
KEGGihsa:90827.
UCSCiuc010kzo.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF277624 mRNA. Translation: AAK61307.1.
CCDSiCCDS43590.1.
RefSeqiNP_150376.1. NM_033273.2.
XP_005271848.1. XM_005271791.3.
XP_011513905.1. XM_011515603.1.
XP_011513906.1. XM_011515604.1.
XP_011513907.1. XM_011515605.1.
XP_011513908.1. XM_011515606.1.
XP_011513909.1. XM_011515607.1.
XP_011513910.1. XM_011515608.1.
UniGeneiHs.616660.

3D structure databases

ProteinModelPortaliQ96JC4.
SMRiQ96JC4. Positions 9-56, 152-523.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124767. 1 interaction.
IntActiQ96JC4. 1 interaction.
STRINGi9606.ENSP00000333776.

PTM databases

iPTMnetiQ96JC4.
PhosphoSiteiQ96JC4.

Polymorphism and mutation databases

BioMutaiZNF479.
DMDMi38258829.

Proteomic databases

EPDiQ96JC4.
PaxDbiQ96JC4.
PRIDEiQ96JC4.

Protocols and materials databases

DNASUi90827.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319636; ENSP00000324518; ENSG00000185177.
ENST00000331162; ENSP00000333776; ENSG00000185177.
GeneIDi90827.
KEGGihsa:90827.
UCSCiuc010kzo.4. human.

Organism-specific databases

CTDi90827.
GeneCardsiZNF479.
HGNCiHGNC:23258. ZNF479.
neXtProtiNX_Q96JC4.
PharmGKBiPA134903704.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOVERGENiHBG018163.
InParanoidiQ96JC4.
KOiK09228.
OMAiGYSEVNQ.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ96JC4.
TreeFamiTF342117.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF479. human.
GenomeRNAii90827.
NextBioi76978.
PROiQ96JC4.

Gene expression databases

BgeeiQ96JC4.
CleanExiHS_ZNF479.
ExpressionAtlasiQ96JC4. baseline and differential.
GenevisibleiQ96JC4. HS.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and preliminary functional analysis of two novel human KRAB zinc finger proteins, HKr18 and HKr19."
    Mark C., Looman C., Abrink M., Hellman L.
    DNA Cell Biol. 20:275-286(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Testis.

Entry informationi

Entry nameiZN479_HUMAN
AccessioniPrimary (citable) accession number: Q96JC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.