Q96JB8 (MPP4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
MAGUK p55 subfamily member 4

Alternative name(s):
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein
Discs large homolog 6

Gene names

Name:	MPP4
Synonyms:	ALS2CR5, DLG6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	637 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in retinal photoreceptors development By similarity.
Subunit structure	Interacts with MPDZ. May interact with GRIA2 By similarity. Forms a complex with CRB1 and MPP5. Interacts with FASLG. Ref.6 Ref.8
Subcellular location	Cytoplasm. Note: Detected at the outer limiting membrane (OLM) and in the outer plexiform layer (OPL) of the retina. At the OLM, detected apical to the adherens junction (AJ). Ref.6
Tissue specificity	Expressed in the retina (at protein level). Highly expressed in the retina. Lower amounts are detected in brain, testis, ARPE-19, RPE/choroid and fetal eye. Isoform 5 is retina-specific. Ref.1 Ref.5 Ref.6 Ref.7
Sequence similarities	Belongs to the MAGUK family. Contains 1 guanylate kinase-like domain. Contains 2 L27 domains. Contains 1 PDZ (DHR) domain. Contains 1 SH3 domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat SH3 domain
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein localization to synapse Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell presynaptic membrane Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96JB8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96JB8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     245-257: Missing.
     332-363: SISMEEEDDMKIDEKCVEADEETFESEELSED → Y

Isoform 3 (identifier: Q96JB8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     121-164: Missing.
     311-637: Missing.

Isoform 4 (identifier: Q96JB8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     121-164: Missing.
     311-337: KQREFWWSQPYQPHTCLKSTLSISMEE → WSFALVAQAGVQWHYLDSLQPLPPGFKRFSCLSLPRSWDYI
     358-362: Missing.

Isoform 5 (identifier: Q96JB8-5)

The sequence of this isoform differs from the canonical sequence as follows:
     93-164: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 637	637	MAGUK p55 subfamily member 4		PRO_0000094577
Regions
	Domain	24 – 80	57	L27 1
	Domain	87 – 137	51	L27 2
	Domain	154 – 235	82	PDZ
	Domain	242 – 312	71	SH3
	Domain	427 – 616	190	Guanylate kinase-like
	Coiled coil	568 – 621	54	Potential
Natural variations
	Alternative sequence	93 – 164	72	Missing in isoform 5.		VSP_013991
	Alternative sequence	121 – 164	44	Missing in isoform 3 and isoform 4.		VSP_003157
	Alternative sequence	245 – 257	13	Missing in isoform 2.		VSP_003159
	Alternative sequence	311 – 637	327	Missing in isoform 3.		VSP_003158
	Alternative sequence	311 – 337	27	KQREF…ISMEE → WSFALVAQAGVQWHYLDSLQ PLPPGFKRFSCLSLPRSWDY I in isoform 4.		VSP_013992
	Alternative sequence	332 – 363	32	SISME…ELSED → Y in isoform 2.		VSP_003160
	Alternative sequence	358 – 362	5	Missing in isoform 4.		VSP_013993
	Natural variant	44	1	G → S. Ref.1 Ref.2 Ref.3 Corresponds to variant rs6725443 [ dbSNP | Ensembl ].		VAR_022643
	Natural variant	562	1	V → I. Corresponds to variant rs11894115 [ dbSNP | Ensembl ].		VAR_050015
Experimental info
	Sequence conflict	5	1	D → G in BAD18399. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: B180AE8635E32CDD	FASTA	637	72,779
	10 20 30 40 50 60 MIQSDKGADP PDKKDMKLST ATNPQNGLSQ ILRLVLQELS LFYGRDVNGV CLLYDLLHSP 70 80 90 100 110 120 WLQALLKIYD CLQEFKEKKL VPATPHAQVL SYEVVELLRE TPTSPEIQEL RQMLQAPHFK 130 140 150 160 170 180 ALLSAHDTIA QKDFEPLLPP LPDNIPESEE AMRIVCLVKN QQPLGATIKR HEMTGDILVA 190 200 210 220 230 240 RIIHGGLAER SGLLYAGDKL VEVNGVSVEG LDPEQVIHIL AMSRGTIMFK VVPVSDPPVN 250 260 270 280 290 300 SQQMVYVRAM TEYWPQEDPD IPCMDAGLPF QKGDILQIVD QNDALWWQAR KISDPATCAG 310 320 330 340 350 360 LVPSNHLLKR KQREFWWSQP YQPHTCLKST LSISMEEEDD MKIDEKCVEA DEETFESEEL 370 380 390 400 410 420 SEDKEEFVGY GQKFFIAGFR RSMRLCRRKS HLSPLHASVC CTGSCYSAVG APYEEVVRYQ 430 440 450 460 470 480 RRPSDKYRLI VLMGPSGVGV NELRRQLIEF NPSHFQSAVP HTTRTKKSYE MNGREYHYVS 490 500 510 520 530 540 KETFENLIYS HRMLEYGEYK GHLYGTSVDA VQTVLVEGKI CVMDLEPQDI QGVRTHELKP 550 560 570 580 590 600 YVIFIKPSNM RCMKQSRKNA KVITDYYVDM KFKDEDLQEM ENLAQRMETQ FGQFFDHVIV 610 620 630 NDSLHDACAQ LLSAIQKAQE EPQWVPATWI SSDTESQ
	Isoform 2 [UniParc]. Checksum: 2AE3ACCFDCAB8236	FASTA	593	67,565
	10 20 30 40 50 60 MIQSDKGADP PDKKDMKLST ATNPQNGLSQ ILRLVLQELS LFYGRDVNGV CLLYDLLHSP 70 80 90 100 110 120 WLQALLKIYD CLQEFKEKKL VPATPHAQVL SYEVVELLRE TPTSPEIQEL RQMLQAPHFK 130 140 150 160 170 180 ALLSAHDTIA QKDFEPLLPP LPDNIPESEE AMRIVCLVKN QQPLGATIKR HEMTGDILVA 190 200 210 220 230 240 RIIHGGLAER SGLLYAGDKL VEVNGVSVEG LDPEQVIHIL AMSRGTIMFK VVPVSDPPVN 250 260 270 280 290 300 SQQMDPDIPC MDAGLPFQKG DILQIVDQND ALWWQARKIS DPATCAGLVP SNHLLKRKQR 310 320 330 340 350 360 EFWWSQPYQP HTCLKSTLYK EEFVGYGQKF FIAGFRRSMR LCRRKSHLSP LHASVCCTGS 370 380 390 400 410 420 CYSAVGAPYE EVVRYQRRPS DKYRLIVLMG PSGVGVNELR RQLIEFNPSH FQSAVPHTTR 430 440 450 460 470 480 TKKSYEMNGR EYHYVSKETF ENLIYSHRML EYGEYKGHLY GTSVDAVQTV LVEGKICVMD 490 500 510 520 530 540 LEPQDIQGVR THELKPYVIF IKPSNMRCMK QSRKNAKVIT DYYVDMKFKD EDLQEMENLA 550 560 570 580 590 QRMETQFGQF FDHVIVNDSL HDACAQLLSA IQKAQEEPQW VPATWISSDT ESQ
	Isoform 3 [UniParc]. Checksum: 4B29F97B2268AB26	FASTA	266	29,771
	10 20 30 40 50 60 MIQSDKGADP PDKKDMKLST ATNPQNGLSQ ILRLVLQELS LFYGRDVNGV CLLYDLLHSP 70 80 90 100 110 120 WLQALLKIYD CLQEFKEKKL VPATPHAQVL SYEVVELLRE TPTSPEIQEL RQMLQAPHFK 130 140 150 160 170 180 GATIKRHEMT GDILVARIIH GGLAERSGLL YAGDKLVEVN GVSVEGLDPE QVIHILAMSR 190 200 210 220 230 240 GTIMFKVVPV SDPPVNSQQM VYVRAMTEYW PQEDPDIPCM DAGLPFQKGD ILQIVDQNDA 250 260 LWWQARKISD PATCAGLVPS NHLLKR
	Isoform 4 [UniParc]. Checksum: 45A4EC99FA4BB75B	FASTA	602	68,755
	10 20 30 40 50 60 MIQSDKGADP PDKKDMKLST ATNPQNGLSQ ILRLVLQELS LFYGRDVNGV CLLYDLLHSP 70 80 90 100 110 120 WLQALLKIYD CLQEFKEKKL VPATPHAQVL SYEVVELLRE TPTSPEIQEL RQMLQAPHFK 130 140 150 160 170 180 GATIKRHEMT GDILVARIIH GGLAERSGLL YAGDKLVEVN GVSVEGLDPE QVIHILAMSR 190 200 210 220 230 240 GTIMFKVVPV SDPPVNSQQM VYVRAMTEYW PQEDPDIPCM DAGLPFQKGD ILQIVDQNDA 250 260 270 280 290 300 LWWQARKISD PATCAGLVPS NHLLKRWSFA LVAQAGVQWH YLDSLQPLPP GFKRFSCLSL 310 320 330 340 350 360 PRSWDYIEDD MKIDEKCVEA DEETFESDKE EFVGYGQKFF IAGFRRSMRL CRRKSHLSPL 370 380 390 400 410 420 HASVCCTGSC YSAVGAPYEE VVRYQRRPSD KYRLIVLMGP SGVGVNELRR QLIEFNPSHF 430 440 450 460 470 480 QSAVPHTTRT KKSYEMNGRE YHYVSKETFE NLIYSHRMLE YGEYKGHLYG TSVDAVQTVL 490 500 510 520 530 540 VEGKICVMDL EPQDIQGVRT HELKPYVIFI KPSNMRCMKQ SRKNAKVITD YYVDMKFKDE 550 560 570 580 590 600 DLQEMENLAQ RMETQFGQFF DHVIVNDSLH DACAQLLSAI QKAQEEPQWV PATWISSDTE SQ
	Isoform 5 [UniParc]. Checksum: 4A18FB861772DBA3	FASTA	565	64,600
	10 20 30 40 50 60 MIQSDKGADP PDKKDMKLST ATNPQNGLSQ ILRLVLQELS LFYGRDVNGV CLLYDLLHSP 70 80 90 100 110 120 WLQALLKIYD CLQEFKEKKL VPATPHAQVL SYGATIKRHE MTGDILVARI IHGGLAERSG 130 140 150 160 170 180 LLYAGDKLVE VNGVSVEGLD PEQVIHILAM SRGTIMFKVV PVSDPPVNSQ QMVYVRAMTE 190 200 210 220 230 240 YWPQEDPDIP CMDAGLPFQK GDILQIVDQN DALWWQARKI SDPATCAGLV PSNHLLKRKQ 250 260 270 280 290 300 REFWWSQPYQ PHTCLKSTLS ISMEEEDDMK IDEKCVEADE ETFESEELSE DKEEFVGYGQ 310 320 330 340 350 360 KFFIAGFRRS MRLCRRKSHL SPLHASVCCT GSCYSAVGAP YEEVVRYQRR PSDKYRLIVL 370 380 390 400 410 420 MGPSGVGVNE LRRQLIEFNP SHFQSAVPHT TRTKKSYEMN GREYHYVSKE TFENLIYSHR 430 440 450 460 470 480 MLEYGEYKGH LYGTSVDAVQ TVLVEGKICV MDLEPQDIQG VRTHELKPYV IFIKPSNMRC 490 500 510 520 530 540 MKQSRKNAKV ITDYYVDMKF KDEDLQEMEN LAQRMETQFG QFFDHVIVND SLHDACAQLL 550 560 SAIQKAQEEP QWVPATWISS DTESQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of the human retina-specific gene MPP4, a novel member of the p55 subfamily of MAGUK proteins." Stoehr H., Weber B.H.F. Genomics 74:377-384(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT SER-44. Tissue: Retina.
[2]	"A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2." Hadano S., Hand C.K., Osuga H., Yanagisawa Y., Otomo A., Devon R.S., Miyamoto N., Showguchi-Miyata J., Okada Y., Singaraja R., Figlewicz D.A., Kwiatkowski T., Hosler B.A., Sagie T., Skaug J., Nasir J., Brown R.H. Jr., Scherer S.W. , Rouleau G.A., Hayden M.R., Ikeda J.-E. Nat. Genet. 29:166-173(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), VARIANT SER-44. Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANT SER-44. Tissue: Teratocarcinoma.
[4]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Characterization of MPP4, a gene highly expressed in photoreceptor cells, and mutation analysis in retinitis pigmentosa." Conte I., Lestingi M., den Hollander A., Miano M.G., Alfano G., Circolo D., Pugliese M., Testa F., Simonelli F., Rinaldi E., Baiget M., Banfi S., Ciccodicola A. Gene 297:33-38(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION (ISOFORM 5), TISSUE SPECIFICITY.
[6]	"MPP5 recruits MPP4 to the CRB1 complex in photoreceptors." Kantardzhieva A., Gosens I., Alexeeva S., Punte I.M., Versteeg I., Krieger E., Neefjes-Mol C.A., den Hollander A.I., Letteboer S.J.F., Klooster J., Cremers F.P.M., Roepman R., Wijnholds J. Invest. Ophthalmol. Vis. Sci. 46:2192-2201(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CRB1 AND MPP5, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[7]	"Membrane-associated guanylate kinase proteins MPP4 and MPP5 associate with Veli3 at distinct intercellular junctions of the neurosensory retina." Stoehr H., Molday L.L., Molday R.S., Weber B.H.F., Biedermann B., Reichenbach A., Kraemer F. J. Comp. Neurol. 481:31-41(2005) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[8]	"Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening." Voss M., Lettau M., Janssen O. BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FASLG.
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF316032 mRNA. Translation: AAK71862.1. AB053302 mRNA. Translation: BAB69012.1. AB053303 mRNA. Translation: BAB69013.1. AK131208 mRNA. Translation: BAD18399.1. AC007279 Genomic DNA. Translation: AAY15057.1.
IPI	IPI00157237. IPI00220204. IPI00220205. IPI00604511. IPI01013504.
RefSeq	NP_149055.1. NM_033066.2.
UniGene	Hs.63085.
3D structure databases
ProteinModelPortal	Q96JB8.
SMR	Q96JB8. Positions 62-135, 151-233, 245-313, 428-627.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96JB8. 1 interaction.
STRING	9606.ENSP00000387278.
PTM databases
PhosphoSite	Q96JB8.
Polymorphism databases
DMDM	296438297.
Proteomic databases
PaxDb	Q96JB8.
PRIDE	Q96JB8.
Protocols and materials databases
DNASU	58538.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000315506; ENSP00000319363; ENSG00000082126. ENST00000409474; ENSP00000387278; ENSG00000082126.
GeneID	58538.
KEGG	hsa:58538.
UCSC	uc002uyj.4. human. uc002uyk.4. human. uc002uym.1. human. uc010ftk.3. human.
Organism-specific databases
CTD	58538.
GeneCards	GC02M202509.
HGNC	HGNC:13680. MPP4.
HPA	HPA036387.
MIM	606575. gene.
neXtProt	NX_Q96JB8.
PharmGKB	PA30927.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0194.
HOGENOM	HOG000233034.
HOVERGEN	HBG001858.
InParanoid	Q96JB8.
OMA	FYSRDVN.
OrthoDB	EOG4F7NK0.
Gene expression databases
ArrayExpress	Q96JB8.
Bgee	Q96JB8.
CleanEx	HS_MPP4.
Genevestigator	Q96JB8.
GermOnline	ENSG00000082126. Homo sapiens.
Family and domain databases
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR020590. Guanylate_kinase_CS. IPR004172. L27. IPR014775. L27_C. IPR001478. PDZ. IPR001452. SH3_domain. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. PF02828. L27. 1 hit. PF00595. PDZ. 1 hit. PF00018. SH3_1. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. SM00569. L27. 2 hits. SM00228. PDZ. 1 hit. SM00326. SH3. 1 hit. [Graphical view]
SUPFAM	SSF50156. PDZ. 1 hit. SSF50044. SH3. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. PS51022. L27. 2 hits. PS50106. PDZ. 1 hit. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	58538.
NextBio	65122.
SOURCE	Search...

Entry information

Entry name

MPP4_HUMAN

Accession

Primary (citable) accession number: Q96JB8
Secondary accession number(s): C9IZK4 , Q53TT3, Q6ZNH6, Q96Q43, Q96Q44

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2003
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 105 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.