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Q96JB6 (LOXL4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysyl oxidase homolog 4

EC=1.4.3.-
Alternative name(s):
Lysyl oxidase-like protein 4
Lysyl oxidase-related protein C
Gene names
Name:LOXL4
Synonyms:LOXC
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length756 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May modulate the formation of a collagenous extracellular matrix.

Cofactor

Copper By similarity.

Contains 1 lysine tyrosylquinone By similarity.

Subcellular location

Secretedextracellular space Potential.

Tissue specificity

Expressed in many tissues, the highest levels among the tissues studied being in the skeletal muscle, testis and pancreas. Expressed in cartilage.

Post-translational modification

The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.

Sequence similarities

Belongs to the lysyl oxidase family.

Contains 4 SRCR domains.

Sequence caution

The sequence AAH07522.1 differs from that shown. Reason: Erroneous initiation.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 756732Lysyl oxidase homolog 4
PRO_0000018535

Regions

Domain32 – 133102SRCR 1
Domain159 – 287129SRCR 2
Domain311 – 411101SRCR 3
Domain421 – 529109SRCR 4
Region533 – 736204Lysyl-oxidase like

Sites

Metal binding6111Copper Potential
Metal binding6131Copper Potential
Metal binding6151Copper Potential

Amino acid modifications

Modified residue67412',4',5'-topaquinone By similarity
Glycosylation1981N-linked (GlcNAc...) Potential
Glycosylation6291N-linked (GlcNAc...) Potential
Disulfide bond58 ↔ 122 By similarity
Disulfide bond71 ↔ 132 By similarity
Disulfide bond102 ↔ 112 By similarity
Disulfide bond191 ↔ 276 By similarity
Disulfide bond204 ↔ 286 By similarity
Disulfide bond251 ↔ 261 By similarity
Disulfide bond336 ↔ 400 By similarity
Disulfide bond349 ↔ 410 By similarity
Disulfide bond380 ↔ 390 By similarity
Disulfide bond450 ↔ 515 By similarity
Disulfide bond463 ↔ 528 By similarity
Disulfide bond497 ↔ 507 By similarity
Disulfide bond558 ↔ 564 By similarity
Disulfide bond610 ↔ 658 By similarity
Disulfide bond642 ↔ 648 By similarity
Disulfide bond670 ↔ 680 By similarity
Disulfide bond717 ↔ 731 By similarity
Cross-link638 ↔ 674Lysine tyrosylquinone (Lys-Tyr) By similarity

Natural variations

Natural variant1541R → Q.
Corresponds to variant rs33995374 [ dbSNP | Ensembl ].
VAR_050012
Natural variant3721P → T.
Corresponds to variant rs11189525 [ dbSNP | Ensembl ].
VAR_059431
Natural variant4051D → A. Ref.7
Corresponds to variant rs1983864 [ dbSNP | Ensembl ].
VAR_050013

Experimental info

Sequence conflict31W → R in AAH13153. Ref.7
Sequence conflict1011R → Q in AAH13153. Ref.7
Sequence conflict4931S → G in AAL27543. Ref.3
Sequence conflict5391A → T in AAL27543. Ref.3
Sequence conflict5421V → A in AAL27543. Ref.3
Sequence conflict7031Y → H in AAL27543. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q96JB6 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 13051ACADB922BBC

FASTA75684,483
        10         20         30         40         50         60 
MAWSPPATLF LFLLLLGQPP PSRPQSLGTT KLRLVGPESK PEEGRLEVLH QGQWGTVCDD 

        70         80         90        100        110        120 
NFAIQEATVA CRQLGFEAAL TWAHSAKYGQ GEGPIWLDNV RCVGTESSLD QCGSNGWGVS 

       130        140        150        160        170        180 
DCSHSEDVGV ICHPRRHRGY LSETVSNALG PQGRRLEEVR LKPILASAKQ HSPVTEGAVE 

       190        200        210        220        230        240 
VKYEGHWRQV CDQGWTMNNS RVVCGMLGFP SEVPVDSHYY RKVWDLKMRD PKSRLKSLTN 

       250        260        270        280        290        300 
KNSFWIHQVT CLGTEPHMAN CQVQVAPARG KLRPACPGGM HAVVSCVAGP HFRPPKTKPQ 

       310        320        330        340        350        360 
RKGSWAEEPR VRLRSGAQVG EGRVEVLMNR QWGTVCDHRW NLISASVVCR QLGFGSAREA 

       370        380        390        400        410        420 
LFGARLGQGL GPIHLSEVRC RGYERTLSDC PALEGSQNGC QHENDAAVRC NVPNMGFQNQ 

       430        440        450        460        470        480 
VRLAGGRIPE EGLLEVQVEV NGVPRWGSVC SENWGLTEAM VACRQLGLGF AIHAYKETWF 

       490        500        510        520        530        540 
WSGTPRAQEV VMSGVRCSGT ELALQQCQRH GPVHCSHGGG RFLAGVSCMD SAPDLVMNAQ 

       550        560        570        580        590        600 
LVQETAYLED RPLSQLYCAH EENCLSKSAD HMDWPYGYRR LLRFSTQIYN LGRTDFRPKT 

       610        620        630        640        650        660 
GRDSWVWHQC HRHYHSIEVF THYDLLTLNG SKVAEGHKAS FCLEDTNCPT GLQRRYACAN 

       670        680        690        700        710        720 
FGEQGVTVGC WDTYRHDIDC QWVDITDVGP GNYIFQVIVN PHYEVAESDF SNNMLQCRCK 

       730        740        750 
YDGHRVWLHN CHTGNSYPAN AELSLEQEQR LRNNLI 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and biological activity of a novel lysyl oxidase-related gene expressed in cartilage."
Ito H., Akiyama H., Iguchi H., Iyama K., Miyamoto M., Ohsawa K., Nakamura T.
J. Biol. Chem. 276:24023-24029(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[2]"Cloning and characterization of a fifth human lysyl oxidase isoenzyme: the third member of the lysyl oxidase-related subfamily with four scavenger receptor cysteine-rich domains."
Maeki J.M., Tikkanen H., Kivirikko K.I.
Matrix Biol. 20:493-496(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"A novel human lysyl oxidase-like gene (LOXL4) on chromosome 10q24 has an altered scavenger receptor cysteine rich domain."
Asuncion L., Fogelgren B., Fong K.S.K., Fong S.F.T., Kim Y., Csiszar K.
Matrix Biol. 20:487-491(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-405.
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF338441 mRNA. Translation: AAK71934.1.
AY036093 mRNA. Translation: AAK64186.1.
AF395336 mRNA. Translation: AAL27543.1.
AK025542 mRNA. Translation: BAB15167.1.
AK172781 mRNA. Translation: BAD18762.1.
AL139241 Genomic DNA. Translation: CAH72819.1.
CH471066 Genomic DNA. Translation: EAW49886.1.
BC007522 mRNA. Translation: AAH07522.1. Different initiation.
BC013153 mRNA. Translation: AAH13153.1.
RefSeqNP_115587.6. NM_032211.6.
UniGeneHs.306814.
Hs.671890.

3D structure databases

ProteinModelPortalQ96JB6.
SMRQ96JB6. Positions 28-136, 173-265, 311-410, 419-529.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123925. 14 interactions.
IntActQ96JB6. 11 interactions.
MINTMINT-1448374.
STRING9606.ENSP00000260702.

PTM databases

PhosphoSiteQ96JB6.

Polymorphism databases

DMDM20177960.

Proteomic databases

PaxDbQ96JB6.
PRIDEQ96JB6.

Protocols and materials databases

DNASU84171.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000260702; ENSP00000260702; ENSG00000138131.
GeneID84171.
KEGGhsa:84171.
UCSCuc001kpa.1. human.

Organism-specific databases

CTD84171.
GeneCardsGC10M099997.
HGNCHGNC:17171. LOXL4.
HPACAB033876.
HPA037609.
MIM607318. gene.
neXtProtNX_Q96JB6.
PharmGKBPA30431.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40770.
HOGENOMHOG000220841.
HOVERGENHBG052336.
InParanoidQ96JB6.
KOK00280.
OMANCLSKSA.
OrthoDBEOG7SN8C6.
PhylomeDBQ96JB6.
TreeFamTF326061.

Enzyme and pathway databases

ReactomeREACT_118779. Extracellular matrix organization.

Gene expression databases

BgeeQ96JB6.
CleanExHS_LOXL4.
GenevestigatorQ96JB6.

Family and domain databases

Gene3D3.10.250.10. 4 hits.
InterProIPR001695. Lysyl_oxidase.
IPR019828. Lysyl_oxidase_CS.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamPF01186. Lysyl_oxidase. 1 hit.
PF00530. SRCR. 4 hits.
[Graphical view]
PRINTSPR00074. LYSYLOXIDASE.
PR00258. SPERACTRCPTR.
SMARTSM00202. SR. 4 hits.
[Graphical view]
SUPFAMSSF56487. SSF56487. 4 hits.
PROSITEPS00926. LYSYL_OXIDASE. 1 hit.
PS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSLOXL4. human.
GeneWikiLOXL4.
GenomeRNAi84171.
NextBio73532.
PROQ96JB6.
SOURCESearch...

Entry information

Entry nameLOXL4_HUMAN
AccessionPrimary (citable) accession number: Q96JB6
Secondary accession number(s): Q5W0B3 expand/collapse secondary AC list , Q96DY1, Q96PC0, Q9H6T5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM