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Protein

Lysyl oxidase homolog 4

Gene

LOXL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May modulate the formation of a collagenous extracellular matrix.

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi611CopperSequence analysis1
Metal bindingi613CopperSequence analysis1
Metal bindingi615CopperSequence analysis1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000138131-MONOMER.
ReactomeiR-HSA-1566948. Elastic fibre formation.
R-HSA-2243919. Crosslinking of collagen fibrils.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysyl oxidase homolog 4 (EC:1.4.3.-)
Alternative name(s):
Lysyl oxidase-like protein 4
Lysyl oxidase-related protein C
Gene namesi
Name:LOXL4
Synonyms:LOXC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:17171. LOXL4.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB-SubCell
  • membrane Source: InterPro
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi84171.
OpenTargetsiENSG00000138131.
PharmGKBiPA30431.

Polymorphism and mutation databases

BioMutaiLOXL4.
DMDMi20177960.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001853525 – 756Lysyl oxidase homolog 4Add BLAST732

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58 ↔ 122PROSITE-ProRule annotation
Disulfide bondi71 ↔ 132PROSITE-ProRule annotation
Disulfide bondi102 ↔ 112PROSITE-ProRule annotation
Disulfide bondi191 ↔ 276PROSITE-ProRule annotation
Glycosylationi198N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi204 ↔ 286PROSITE-ProRule annotation
Disulfide bondi251 ↔ 261PROSITE-ProRule annotation
Disulfide bondi336 ↔ 400PROSITE-ProRule annotation
Disulfide bondi349 ↔ 410PROSITE-ProRule annotation
Disulfide bondi380 ↔ 390PROSITE-ProRule annotation
Disulfide bondi450 ↔ 515PROSITE-ProRule annotation
Disulfide bondi463 ↔ 528PROSITE-ProRule annotation
Disulfide bondi497 ↔ 507PROSITE-ProRule annotation
Disulfide bondi558 ↔ 564PROSITE-ProRule annotation
Disulfide bondi610 ↔ 658PROSITE-ProRule annotation
Glycosylationi629N-linked (GlcNAc...)Sequence analysis1
Cross-linki638 ↔ 674Lysine tyrosylquinone (Lys-Tyr)By similarity
Disulfide bondi642 ↔ 648PROSITE-ProRule annotation
Disulfide bondi670 ↔ 680PROSITE-ProRule annotation
Modified residuei6742',4',5'-topaquinoneBy similarity1
Disulfide bondi717 ↔ 731PROSITE-ProRule annotation

Post-translational modificationi

The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.

Keywords - PTMi

Disulfide bond, Glycoprotein, LTQ, TPQ

Proteomic databases

EPDiQ96JB6.
MaxQBiQ96JB6.
PaxDbiQ96JB6.
PeptideAtlasiQ96JB6.
PRIDEiQ96JB6.

PTM databases

iPTMnetiQ96JB6.
PhosphoSitePlusiQ96JB6.

Expressioni

Tissue specificityi

Expressed in many tissues, the highest levels among the tissues studied being in the skeletal muscle, testis and pancreas. Expressed in cartilage.

Gene expression databases

BgeeiENSG00000138131.
CleanExiHS_LOXL4.
GenevisibleiQ96JB6. HS.

Organism-specific databases

HPAiCAB033876.
HPA037609.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KDM1AO603412EBI-749562,EBI-710124
PRMT6Q96LA82EBI-749562,EBI-912440
TRIP13Q156456EBI-749562,EBI-358993

Protein-protein interaction databases

BioGridi123925. 16 interactors.
IntActiQ96JB6. 11 interactors.
MINTiMINT-1448374.
STRINGi9606.ENSP00000260702.

Structurei

3D structure databases

ProteinModelPortaliQ96JB6.
SMRiQ96JB6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 133SRCR 1PROSITE-ProRule annotationAdd BLAST102
Domaini159 – 287SRCR 2PROSITE-ProRule annotationAdd BLAST129
Domaini311 – 411SRCR 3PROSITE-ProRule annotationAdd BLAST101
Domaini421 – 529SRCR 4PROSITE-ProRule annotationAdd BLAST109

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni533 – 736Lysyl-oxidase likeAdd BLAST204

Sequence similaritiesi

Belongs to the lysyl oxidase family.Curated
Contains 4 SRCR domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IE2X. Eukaryota.
ENOG410XSN1. LUCA.
GeneTreeiENSGT00840000129699.
HOGENOMiHOG000220841.
HOVERGENiHBG052336.
InParanoidiQ96JB6.
KOiK00280.
OMAiQCRCKYD.
OrthoDBiEOG091G02XD.
PhylomeDBiQ96JB6.
TreeFamiTF326061.

Family and domain databases

Gene3Di3.10.250.10. 4 hits.
InterProiIPR001695. Lysyl_oxidase.
IPR019828. Lysyl_oxidase_CS.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF01186. Lysyl_oxidase. 1 hit.
PF00530. SRCR. 4 hits.
[Graphical view]
PRINTSiPR00074. LYSYLOXIDASE.
PR00258. SPERACTRCPTR.
SMARTiSM00202. SR. 4 hits.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 4 hits.
PROSITEiPS00926. LYSYL_OXIDASE. 1 hit.
PS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96JB6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWSPPATLF LFLLLLGQPP PSRPQSLGTT KLRLVGPESK PEEGRLEVLH
60 70 80 90 100
QGQWGTVCDD NFAIQEATVA CRQLGFEAAL TWAHSAKYGQ GEGPIWLDNV
110 120 130 140 150
RCVGTESSLD QCGSNGWGVS DCSHSEDVGV ICHPRRHRGY LSETVSNALG
160 170 180 190 200
PQGRRLEEVR LKPILASAKQ HSPVTEGAVE VKYEGHWRQV CDQGWTMNNS
210 220 230 240 250
RVVCGMLGFP SEVPVDSHYY RKVWDLKMRD PKSRLKSLTN KNSFWIHQVT
260 270 280 290 300
CLGTEPHMAN CQVQVAPARG KLRPACPGGM HAVVSCVAGP HFRPPKTKPQ
310 320 330 340 350
RKGSWAEEPR VRLRSGAQVG EGRVEVLMNR QWGTVCDHRW NLISASVVCR
360 370 380 390 400
QLGFGSAREA LFGARLGQGL GPIHLSEVRC RGYERTLSDC PALEGSQNGC
410 420 430 440 450
QHENDAAVRC NVPNMGFQNQ VRLAGGRIPE EGLLEVQVEV NGVPRWGSVC
460 470 480 490 500
SENWGLTEAM VACRQLGLGF AIHAYKETWF WSGTPRAQEV VMSGVRCSGT
510 520 530 540 550
ELALQQCQRH GPVHCSHGGG RFLAGVSCMD SAPDLVMNAQ LVQETAYLED
560 570 580 590 600
RPLSQLYCAH EENCLSKSAD HMDWPYGYRR LLRFSTQIYN LGRTDFRPKT
610 620 630 640 650
GRDSWVWHQC HRHYHSIEVF THYDLLTLNG SKVAEGHKAS FCLEDTNCPT
660 670 680 690 700
GLQRRYACAN FGEQGVTVGC WDTYRHDIDC QWVDITDVGP GNYIFQVIVN
710 720 730 740 750
PHYEVAESDF SNNMLQCRCK YDGHRVWLHN CHTGNSYPAN AELSLEQEQR

LRNNLI
Length:756
Mass (Da):84,483
Last modified:December 1, 2001 - v1
Checksum:i13051ACADB922BBC
GO

Sequence cautioni

The sequence AAH07522 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3W → R in AAH13153 (PubMed:15489334).Curated1
Sequence conflicti101R → Q in AAH13153 (PubMed:15489334).Curated1
Sequence conflicti493S → G in AAL27543 (PubMed:11691588).Curated1
Sequence conflicti539A → T in AAL27543 (PubMed:11691588).Curated1
Sequence conflicti542V → A in AAL27543 (PubMed:11691588).Curated1
Sequence conflicti703Y → H in AAL27543 (PubMed:11691588).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050012154R → Q.Corresponds to variant rs33995374dbSNPEnsembl.1
Natural variantiVAR_059431372P → T.Corresponds to variant rs11189525dbSNPEnsembl.1
Natural variantiVAR_050013405D → A.1 PublicationCorresponds to variant rs1983864dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF338441 mRNA. Translation: AAK71934.1.
AY036093 mRNA. Translation: AAK64186.1.
AF395336 mRNA. Translation: AAL27543.1.
AK025542 mRNA. Translation: BAB15167.1.
AK172781 mRNA. Translation: BAD18762.1.
AL139241 Genomic DNA. Translation: CAH72819.1.
CH471066 Genomic DNA. Translation: EAW49886.1.
BC007522 mRNA. Translation: AAH07522.1. Different initiation.
BC013153 mRNA. Translation: AAH13153.1.
CCDSiCCDS7473.1.
RefSeqiNP_115587.6. NM_032211.6.
UniGeneiHs.306814.
Hs.671890.

Genome annotation databases

EnsembliENST00000260702; ENSP00000260702; ENSG00000138131.
GeneIDi84171.
KEGGihsa:84171.
UCSCiuc001kpa.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF338441 mRNA. Translation: AAK71934.1.
AY036093 mRNA. Translation: AAK64186.1.
AF395336 mRNA. Translation: AAL27543.1.
AK025542 mRNA. Translation: BAB15167.1.
AK172781 mRNA. Translation: BAD18762.1.
AL139241 Genomic DNA. Translation: CAH72819.1.
CH471066 Genomic DNA. Translation: EAW49886.1.
BC007522 mRNA. Translation: AAH07522.1. Different initiation.
BC013153 mRNA. Translation: AAH13153.1.
CCDSiCCDS7473.1.
RefSeqiNP_115587.6. NM_032211.6.
UniGeneiHs.306814.
Hs.671890.

3D structure databases

ProteinModelPortaliQ96JB6.
SMRiQ96JB6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123925. 16 interactors.
IntActiQ96JB6. 11 interactors.
MINTiMINT-1448374.
STRINGi9606.ENSP00000260702.

PTM databases

iPTMnetiQ96JB6.
PhosphoSitePlusiQ96JB6.

Polymorphism and mutation databases

BioMutaiLOXL4.
DMDMi20177960.

Proteomic databases

EPDiQ96JB6.
MaxQBiQ96JB6.
PaxDbiQ96JB6.
PeptideAtlasiQ96JB6.
PRIDEiQ96JB6.

Protocols and materials databases

DNASUi84171.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260702; ENSP00000260702; ENSG00000138131.
GeneIDi84171.
KEGGihsa:84171.
UCSCiuc001kpa.2. human.

Organism-specific databases

CTDi84171.
DisGeNETi84171.
GeneCardsiLOXL4.
HGNCiHGNC:17171. LOXL4.
HPAiCAB033876.
HPA037609.
MIMi607318. gene.
neXtProtiNX_Q96JB6.
OpenTargetsiENSG00000138131.
PharmGKBiPA30431.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE2X. Eukaryota.
ENOG410XSN1. LUCA.
GeneTreeiENSGT00840000129699.
HOGENOMiHOG000220841.
HOVERGENiHBG052336.
InParanoidiQ96JB6.
KOiK00280.
OMAiQCRCKYD.
OrthoDBiEOG091G02XD.
PhylomeDBiQ96JB6.
TreeFamiTF326061.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000138131-MONOMER.
ReactomeiR-HSA-1566948. Elastic fibre formation.
R-HSA-2243919. Crosslinking of collagen fibrils.

Miscellaneous databases

ChiTaRSiLOXL4. human.
GeneWikiiLOXL4.
GenomeRNAii84171.
PROiQ96JB6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138131.
CleanExiHS_LOXL4.
GenevisibleiQ96JB6. HS.

Family and domain databases

Gene3Di3.10.250.10. 4 hits.
InterProiIPR001695. Lysyl_oxidase.
IPR019828. Lysyl_oxidase_CS.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF01186. Lysyl_oxidase. 1 hit.
PF00530. SRCR. 4 hits.
[Graphical view]
PRINTSiPR00074. LYSYLOXIDASE.
PR00258. SPERACTRCPTR.
SMARTiSM00202. SR. 4 hits.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 4 hits.
PROSITEiPS00926. LYSYL_OXIDASE. 1 hit.
PS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLOXL4_HUMAN
AccessioniPrimary (citable) accession number: Q96JB6
Secondary accession number(s): Q5W0B3
, Q96DY1, Q96PC0, Q9H6T5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.