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Q96JB5

- CK5P3_HUMAN

UniProt

Q96JB5 - CK5P3_HUMAN

Protein

CDK5 regulatory subunit-associated protein 3

Gene

CDK5RAP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (16 Jun 2003)
      Previous versions | rss
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    Functioni

    Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via its interaction with CDK5R1 By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. protein kinase binding Source: UniProtKB

    GO - Biological processi

    1. brain development Source: UniProtKB
    2. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    3. protein ufmylation Source: MGI
    4. regulation of cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB
    5. regulation of neuron differentiation Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CDK5 regulatory subunit-associated protein 3
    Alternative name(s):
    CDK5 activator-binding protein C53
    Protein HSF-27
    Gene namesi
    Name:CDK5RAP3
    Synonyms:IC53
    ORF Names:MSTP016, OK/SW-cl.114, PP1553
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:18673. CDK5RAP3.

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38633.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 506506CDK5 regulatory subunit-associated protein 3PRO_0000220516Add
    BLAST

    Post-translational modificationi

    Phosphorylated in vitro by CDK5.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ96JB5.
    PaxDbiQ96JB5.
    PRIDEiQ96JB5.

    PTM databases

    PhosphoSiteiQ96JB5.

    Expressioni

    Tissue specificityi

    Ubiquitous. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform 3 is expressed in kidney, liver, skeletal muscle and placenta.3 Publications

    Gene expression databases

    ArrayExpressiQ96JB5.
    BgeeiQ96JB5.
    CleanExiHS_CDK5RAP3.
    GenevestigatoriQ96JB5.

    Organism-specific databases

    HPAiHPA022141.
    HPA022882.
    HPA027883.

    Interactioni

    Subunit structurei

    Interacts with CDK5R1. This interaction is prevented by the association between CDK5R1 and CDK5RAP3 By similarity. Interacts with the enteric adenovirus serotype 41 fiber protein. Interacts with UFL1.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    RELAQ042064EBI-718818,EBI-73886

    Protein-protein interaction databases

    BioGridi123213. 31 interactions.
    IntActiQ96JB5. 16 interactions.
    MINTiMINT-1410069.
    STRINGi9606.ENSP00000344683.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96JB5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CDK5RAP3 family.Curated

    Phylogenomic databases

    eggNOGiNOG237881.
    HOGENOMiHOG000231047.
    HOVERGENiHBG050978.
    InParanoidiQ96JB5.
    OMAiRRHCSLK.
    PhylomeDBiQ96JB5.

    Family and domain databases

    InterProiIPR008491. DUF773.
    [Graphical view]
    PANTHERiPTHR14894. PTHR14894. 1 hit.
    PfamiPF05600. DUF773. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96JB5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEDHQHVPID IQTSKLLDWL VDRRHCSLKW QSLVLTIREK INAAIQDMPE    50
    SEEIAQLLSG SYIHYFHCLR ILDLLKGTEA STKNIFGRYS SQRMKDWQEI 100
    IALYEKDNTY LVELSSLLVR NVNYEIPSLK KQIAKCQQLQ QEYSRKEEEC 150
    QAGAAEMREQ FYHSCKQYGI TGENVRGELL ALVKDLPSQL AEIGAAAQQS 200
    LGEAIDVYQA SVGFVCESPT EQVLPMLRFV QKRGNSTVYE WRTGTEPSVV 250
    ERPHLEELPE QVAEDAIDWG DFGVEAVSEG TDSGISAEAA GIDWGIFPES 300
    DSKDPGGDGI DWGDDAVALQ ITVLEAGTQA PEGVARGPDA LTLLEYTETR 350
    NQFLDELMEL EIFLAQRAVE LSEEADVLSV SQFQLAPAIL QGQTKEKMVT 400
    MVSVLEDLIG KLTSLQLQHL FMILASPRYV DRVTEFLQQK LKQSQLLALK 450
    KELMVQKQQE ALEEQAALEP KLDLLLEKTK ELQKLIEADI SKRYSGRPVN 500
    LMGTSL 506
    Length:506
    Mass (Da):56,921
    Last modified:June 16, 2003 - v2
    Checksum:iA21E59A79E1F87E0
    GO
    Isoform 2 (identifier: Q96JB5-2) [UniParc]FASTAAdd to Basket

    Also known as: IC53

    The sequence of this isoform differs from the canonical sequence as follows:
         1-87: Missing.
         88-111: RYSSQRMKDWQEIIALYEKDNTYL → MCVHPGACLPHVGVSWAEFPGHFS

    Note: Due to an intron retention.

    Show »
    Length:419
    Mass (Da):46,351
    Checksum:iDA15DED087A5A795
    GO
    Isoform 3 (identifier: Q96JB5-3) [UniParc]FASTAAdd to Basket

    Also known as: IC53-2

    The sequence of this isoform differs from the canonical sequence as follows:
         1-225: Missing.

    Note: Due to intron retention. No experimental confirmation available.

    Show »
    Length:281
    Mass (Da):31,200
    Checksum:iBDC6C94A65DF078C
    GO
    Isoform 4 (identifier: Q96JB5-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-2: ME → MRRQSMTSATRDLHTALDGKATQGGKK

    Note: No experimental confirmation available.

    Show »
    Length:531
    Mass (Da):59,589
    Checksum:iAE71C7A39A36A358
    GO

    Sequence cautioni

    The sequence AAK69655.1 differs from that shown. Reason: Frameshift at position 410.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti98 – 981Q → R in BAH13320. (PubMed:14702039)Curated
    Sequence conflicti113 – 1131E → V in BAD97107. 1 PublicationCurated
    Sequence conflicti406 – 4061E → K in AAK69655. 1 PublicationCurated
    Sequence conflicti443 – 4431Q → E in BAD97107. 1 PublicationCurated
    Sequence conflicti479 – 4791T → A in BAH13320. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti324 – 3241L → V.
    Corresponds to variant rs35054799 [ dbSNP | Ensembl ].
    VAR_048688

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 225225Missing in isoform 3. 1 PublicationVSP_007568Add
    BLAST
    Alternative sequencei1 – 8787Missing in isoform 2. 1 PublicationVSP_007566Add
    BLAST
    Alternative sequencei1 – 22ME → MRRQSMTSATRDLHTALDGK ATQGGKK in isoform 4. 1 PublicationVSP_055646
    Alternative sequencei88 – 11124RYSSQ…DNTYL → MCVHPGACLPHVGVSWAEFP GHFS in isoform 2. 1 PublicationVSP_007567Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF110322 mRNA. Translation: AAG39277.1.
    AF217982 mRNA. Translation: AAG17225.1.
    AF343090 mRNA. Translation: AAK69655.1. Frameshift.
    AB062433 mRNA. Translation: BAB93496.1.
    AK023722 mRNA. Translation: BAB14657.1.
    AK300643 mRNA. Translation: BAH13320.1.
    AK223387 mRNA. Translation: BAD97107.1.
    AC018521 Genomic DNA. No translation available.
    CH471109 Genomic DNA. Translation: EAW94772.1.
    CH471109 Genomic DNA. Translation: EAW94774.1.
    CH471109 Genomic DNA. Translation: EAW94775.1.
    CH471109 Genomic DNA. Translation: EAW94778.1.
    BC009957 mRNA. Translation: AAH09957.1.
    BC072435 mRNA. Translation: AAH72435.1.
    CCDSiCCDS42356.1. [Q96JB5-1]
    PIRiJC7863.
    RefSeqiNP_001265127.1. NM_001278198.1.
    NP_001265145.1. NM_001278216.1. [Q96JB5-3]
    NP_001265146.1. NM_001278217.1. [Q96JB5-2]
    NP_788276.1. NM_176096.2. [Q96JB5-1]
    XP_006722176.1. XM_006722113.1. [Q96JB5-2]
    UniGeneiHs.20157.

    Genome annotation databases

    EnsembliENST00000338399; ENSP00000344683; ENSG00000108465. [Q96JB5-1]
    ENST00000536708; ENSP00000438886; ENSG00000108465. [Q96JB5-4]
    GeneIDi80279.
    KEGGihsa:80279.
    UCSCiuc002imr.4. human. [Q96JB5-1]
    uc002ims.4. human. [Q96JB5-2]

    Polymorphism databases

    DMDMi32129444.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF110322 mRNA. Translation: AAG39277.1 .
    AF217982 mRNA. Translation: AAG17225.1 .
    AF343090 mRNA. Translation: AAK69655.1 . Frameshift.
    AB062433 mRNA. Translation: BAB93496.1 .
    AK023722 mRNA. Translation: BAB14657.1 .
    AK300643 mRNA. Translation: BAH13320.1 .
    AK223387 mRNA. Translation: BAD97107.1 .
    AC018521 Genomic DNA. No translation available.
    CH471109 Genomic DNA. Translation: EAW94772.1 .
    CH471109 Genomic DNA. Translation: EAW94774.1 .
    CH471109 Genomic DNA. Translation: EAW94775.1 .
    CH471109 Genomic DNA. Translation: EAW94778.1 .
    BC009957 mRNA. Translation: AAH09957.1 .
    BC072435 mRNA. Translation: AAH72435.1 .
    CCDSi CCDS42356.1. [Q96JB5-1 ]
    PIRi JC7863.
    RefSeqi NP_001265127.1. NM_001278198.1.
    NP_001265145.1. NM_001278216.1. [Q96JB5-3 ]
    NP_001265146.1. NM_001278217.1. [Q96JB5-2 ]
    NP_788276.1. NM_176096.2. [Q96JB5-1 ]
    XP_006722176.1. XM_006722113.1. [Q96JB5-2 ]
    UniGenei Hs.20157.

    3D structure databases

    ProteinModelPortali Q96JB5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123213. 31 interactions.
    IntActi Q96JB5. 16 interactions.
    MINTi MINT-1410069.
    STRINGi 9606.ENSP00000344683.

    PTM databases

    PhosphoSitei Q96JB5.

    Polymorphism databases

    DMDMi 32129444.

    Proteomic databases

    MaxQBi Q96JB5.
    PaxDbi Q96JB5.
    PRIDEi Q96JB5.

    Protocols and materials databases

    DNASUi 80279.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000338399 ; ENSP00000344683 ; ENSG00000108465 . [Q96JB5-1 ]
    ENST00000536708 ; ENSP00000438886 ; ENSG00000108465 . [Q96JB5-4 ]
    GeneIDi 80279.
    KEGGi hsa:80279.
    UCSCi uc002imr.4. human. [Q96JB5-1 ]
    uc002ims.4. human. [Q96JB5-2 ]

    Organism-specific databases

    CTDi 80279.
    GeneCardsi GC17P046048.
    H-InvDB HIX0013932.
    HGNCi HGNC:18673. CDK5RAP3.
    HPAi HPA022141.
    HPA022882.
    HPA027883.
    MIMi 608202. gene.
    neXtProti NX_Q96JB5.
    PharmGKBi PA38633.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG237881.
    HOGENOMi HOG000231047.
    HOVERGENi HBG050978.
    InParanoidi Q96JB5.
    OMAi RRHCSLK.
    PhylomeDBi Q96JB5.

    Miscellaneous databases

    ChiTaRSi CDK5RAP3. human.
    GeneWikii CDK5RAP3.
    GenomeRNAii 80279.
    NextBioi 70750.
    PROi Q96JB5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96JB5.
    Bgeei Q96JB5.
    CleanExi HS_CDK5RAP3.
    Genevestigatori Q96JB5.

    Family and domain databases

    InterProi IPR008491. DUF773.
    [Graphical view ]
    PANTHERi PTHR14894. PTHR14894. 1 hit.
    Pfami PF05600. DUF773. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel gene IC53 stimulates ECV304 cell proliferation and is upregulated in failing heart."
      Chen J., Liu B., Liu Y.Q., Han Y., Yu H., Zhang Y., Lu L., Zhen Y., Hui R.T.
      Biochem. Biophys. Res. Commun. 294:161-166(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
      Tissue: Aorta.
    2. "Cloning and characterization of human IC53-2, a novel CDK5 activator binding protein."
      Xie Y.H., He X.H., Tang Y.T., Li J.J., Pan Z.M., Qin W.X., Wan da F., Gu J.R.
      Cell Res. 13:83-91(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, TISSUE SPECIFICITY.
      Tissue: Placenta.
    3. "Protein interacting with the receptor binding domain of enteric adenovirus serotype 41 fiber protein."
      Favier A.-L., Harsi C., Chrobozcek J.
      Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Kidney.
    4. "Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients."
      Shichijo S., Itoh K.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Colon adenocarcinoma.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
      Tissue: Placenta and Rectum.
    6. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Synovial cell.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    10. "Cloning of three novel neuronal Cdk5 activator binding proteins."
      Ching Y.-P., Qi Z., Wang J.H.
      Gene 242:285-294(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    11. "A novel LZAP-binding protein, NLBP, inhibits cell invasion."
      Kwon J., Cho H.J., Han S.H., No J.G., Kwon J.Y., Kim H.
      J. Biol. Chem. 285:12232-12240(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH UFL1.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCK5P3_HUMAN
    AccessioniPrimary (citable) accession number: Q96JB5
    Secondary accession number(s): B7Z6N4
    , D3DTU1, D3DTU2, F5H3I5, Q53FA2, Q9H3F8, Q9H8G0, Q9HBR9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2003
    Last sequence update: June 16, 2003
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3