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Protein

CDK5 regulatory subunit-associated protein 3

Gene

CDK5RAP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via its interaction with CDK5R1 (By similarity).By similarity

GO - Molecular functioni

  • cyclin binding Source: UniProtKB
  • MDM2/MDM4 family protein binding Source: UniProtKB
  • NF-kappaB binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • ubiquitin-like protein ligase binding Source: MGI

GO - Biological processi

  • brain development Source: UniProtKB
  • cell proliferation Source: UniProtKB
  • mitotic G2/M transition checkpoint Source: UniProtKB
  • mitotic G2 DNA damage checkpoint Source: UniProtKB
  • negative regulation of cellular protein catabolic process Source: UniProtKB
  • negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
  • negative regulation of protein phosphorylation Source: UniProtKB
  • negative regulation of protein serine/threonine kinase activity Source: UniProtKB
  • positive regulation of protein localization to nucleus Source: UniProtKB
  • positive regulation of protein ubiquitination Source: UniProtKB
  • positive regulation of signal transduction by p53 class mediator Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  • protein ufmylation Source: MGI
  • regulation of cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB
  • regulation of neuron differentiation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
CDK5 regulatory subunit-associated protein 3
Alternative name(s):
CDK5 activator-binding protein C53
LXXLL/leucine-zipper-containing ARF-binding protein1 Publication
Protein HSF-27
Gene namesi
Name:CDK5RAP3
Synonyms:IC53, LZAP1 Publication
ORF Names:MSTP016, OK/SW-cl.114, PP1553
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:18673. CDK5RAP3.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • endomembrane system Source: GO_Central
  • membrane Source: UniProtKB
  • nucleus Source: UniProtKB
  • protein complex Source: MGI
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38633.

Polymorphism and mutation databases

DMDMi32129444.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506CDK5 regulatory subunit-associated protein 3PRO_0000220516Add
BLAST

Post-translational modificationi

Phosphorylated in vitro by CDK5.By similarity
Ubiquitinated. Probably triggers proteasomal degradation and is negatively regulated by UFL1.1 Publication
May be ufmylated.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ96JB5.
PaxDbiQ96JB5.
PRIDEiQ96JB5.

PTM databases

PhosphoSiteiQ96JB5.

Expressioni

Tissue specificityi

Ubiquitous. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform 3 is expressed in kidney, liver, skeletal muscle and placenta.3 Publications

Gene expression databases

BgeeiQ96JB5.
CleanExiHS_CDK5RAP3.
ExpressionAtlasiQ96JB5. baseline and differential.
GenevisibleiQ96JB5. HS.

Organism-specific databases

HPAiHPA022141.
HPA022882.
HPA027883.

Interactioni

Subunit structurei

Interacts with CDK5R1. CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1 (By similarity). Interacts with UFL1; the interaction is direct (PubMed:20164180, PubMed:20228063). Interacts with DDRGK1 (PubMed:20228063).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FKBP6O753443EBI-718818,EBI-744771
RELAQ042064EBI-718818,EBI-73886
TSPYL4Q9UJ043EBI-718818,EBI-308511

Protein-protein interaction databases

BioGridi123213. 35 interactions.
IntActiQ96JB5. 19 interactions.
MINTiMINT-1410069.
STRINGi9606.ENSP00000344683.

Structurei

3D structure databases

ProteinModelPortaliQ96JB5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni269 – 506238Required for interaction with UFL11 PublicationAdd
BLAST

Sequence similaritiesi

Belongs to the CDK5RAP3 family.Curated

Phylogenomic databases

eggNOGiNOG237881.
GeneTreeiENSGT00390000000713.
HOGENOMiHOG000231047.
HOVERGENiHBG050978.
InParanoidiQ96JB5.
OMAiFVQKRGN.
PhylomeDBiQ96JB5.

Family and domain databases

InterProiIPR008491. DUF773.
[Graphical view]
PANTHERiPTHR14894. PTHR14894. 1 hit.
PfamiPF05600. DUF773. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96JB5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDHQHVPID IQTSKLLDWL VDRRHCSLKW QSLVLTIREK INAAIQDMPE
60 70 80 90 100
SEEIAQLLSG SYIHYFHCLR ILDLLKGTEA STKNIFGRYS SQRMKDWQEI
110 120 130 140 150
IALYEKDNTY LVELSSLLVR NVNYEIPSLK KQIAKCQQLQ QEYSRKEEEC
160 170 180 190 200
QAGAAEMREQ FYHSCKQYGI TGENVRGELL ALVKDLPSQL AEIGAAAQQS
210 220 230 240 250
LGEAIDVYQA SVGFVCESPT EQVLPMLRFV QKRGNSTVYE WRTGTEPSVV
260 270 280 290 300
ERPHLEELPE QVAEDAIDWG DFGVEAVSEG TDSGISAEAA GIDWGIFPES
310 320 330 340 350
DSKDPGGDGI DWGDDAVALQ ITVLEAGTQA PEGVARGPDA LTLLEYTETR
360 370 380 390 400
NQFLDELMEL EIFLAQRAVE LSEEADVLSV SQFQLAPAIL QGQTKEKMVT
410 420 430 440 450
MVSVLEDLIG KLTSLQLQHL FMILASPRYV DRVTEFLQQK LKQSQLLALK
460 470 480 490 500
KELMVQKQQE ALEEQAALEP KLDLLLEKTK ELQKLIEADI SKRYSGRPVN

LMGTSL
Length:506
Mass (Da):56,921
Last modified:June 16, 2003 - v2
Checksum:iA21E59A79E1F87E0
GO
Isoform 2 (identifier: Q96JB5-2) [UniParc]FASTAAdd to basket

Also known as: IC53

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.
     88-111: RYSSQRMKDWQEIIALYEKDNTYL → MCVHPGACLPHVGVSWAEFPGHFS

Note: Due to an intron retention.
Show »
Length:419
Mass (Da):46,351
Checksum:iDA15DED087A5A795
GO
Isoform 3 (identifier: Q96JB5-3) [UniParc]FASTAAdd to basket

Also known as: IC53-2

The sequence of this isoform differs from the canonical sequence as follows:
     1-225: Missing.

Note: Due to intron retention. No experimental confirmation available.
Show »
Length:281
Mass (Da):31,200
Checksum:iBDC6C94A65DF078C
GO
Isoform 4 (identifier: Q96JB5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: ME → MRRQSMTSATRDLHTALDGKATQGGKK

Note: No experimental confirmation available.
Show »
Length:531
Mass (Da):59,589
Checksum:iAE71C7A39A36A358
GO

Sequence cautioni

The sequence AAK69655.1 differs from that shown. Reason: Frameshift at position 410. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti98 – 981Q → R in BAH13320 (PubMed:14702039).Curated
Sequence conflicti113 – 1131E → V in BAD97107 (Ref. 6) Curated
Sequence conflicti406 – 4061E → K in AAK69655 (Ref. 3) Curated
Sequence conflicti443 – 4431Q → E in BAD97107 (Ref. 6) Curated
Sequence conflicti479 – 4791T → A in BAH13320 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti324 – 3241L → V.
Corresponds to variant rs35054799 [ dbSNP | Ensembl ].
VAR_048688

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 225225Missing in isoform 3. 1 PublicationVSP_007568Add
BLAST
Alternative sequencei1 – 8787Missing in isoform 2. 1 PublicationVSP_007566Add
BLAST
Alternative sequencei1 – 22ME → MRRQSMTSATRDLHTALDGK ATQGGKK in isoform 4. 1 PublicationVSP_055646
Alternative sequencei88 – 11124RYSSQ…DNTYL → MCVHPGACLPHVGVSWAEFP GHFS in isoform 2. 1 PublicationVSP_007567Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110322 mRNA. Translation: AAG39277.1.
AF217982 mRNA. Translation: AAG17225.1.
AF343090 mRNA. Translation: AAK69655.1. Frameshift.
AB062433 mRNA. Translation: BAB93496.1.
AK023722 mRNA. Translation: BAB14657.1.
AK300643 mRNA. Translation: BAH13320.1.
AK223387 mRNA. Translation: BAD97107.1.
AC018521 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94772.1.
CH471109 Genomic DNA. Translation: EAW94774.1.
CH471109 Genomic DNA. Translation: EAW94775.1.
CH471109 Genomic DNA. Translation: EAW94778.1.
BC009957 mRNA. Translation: AAH09957.1.
BC072435 mRNA. Translation: AAH72435.1.
CCDSiCCDS42356.1. [Q96JB5-1]
CCDS62232.1. [Q96JB5-4]
PIRiJC7863.
RefSeqiNP_001265126.1. NM_001278197.1. [Q96JB5-4]
NP_001265127.1. NM_001278198.1.
NP_001265145.1. NM_001278216.1. [Q96JB5-3]
NP_001265146.1. NM_001278217.1. [Q96JB5-2]
NP_788276.1. NM_176096.2. [Q96JB5-1]
XP_011523599.1. XM_011525297.1. [Q96JB5-4]
UniGeneiHs.20157.

Genome annotation databases

EnsembliENST00000338399; ENSP00000344683; ENSG00000108465.
ENST00000536708; ENSP00000438886; ENSG00000108465. [Q96JB5-4]
GeneIDi80279.
KEGGihsa:80279.
UCSCiuc002imr.4. human. [Q96JB5-1]
uc002ims.4. human. [Q96JB5-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110322 mRNA. Translation: AAG39277.1.
AF217982 mRNA. Translation: AAG17225.1.
AF343090 mRNA. Translation: AAK69655.1. Frameshift.
AB062433 mRNA. Translation: BAB93496.1.
AK023722 mRNA. Translation: BAB14657.1.
AK300643 mRNA. Translation: BAH13320.1.
AK223387 mRNA. Translation: BAD97107.1.
AC018521 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94772.1.
CH471109 Genomic DNA. Translation: EAW94774.1.
CH471109 Genomic DNA. Translation: EAW94775.1.
CH471109 Genomic DNA. Translation: EAW94778.1.
BC009957 mRNA. Translation: AAH09957.1.
BC072435 mRNA. Translation: AAH72435.1.
CCDSiCCDS42356.1. [Q96JB5-1]
CCDS62232.1. [Q96JB5-4]
PIRiJC7863.
RefSeqiNP_001265126.1. NM_001278197.1. [Q96JB5-4]
NP_001265127.1. NM_001278198.1.
NP_001265145.1. NM_001278216.1. [Q96JB5-3]
NP_001265146.1. NM_001278217.1. [Q96JB5-2]
NP_788276.1. NM_176096.2. [Q96JB5-1]
XP_011523599.1. XM_011525297.1. [Q96JB5-4]
UniGeneiHs.20157.

3D structure databases

ProteinModelPortaliQ96JB5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123213. 35 interactions.
IntActiQ96JB5. 19 interactions.
MINTiMINT-1410069.
STRINGi9606.ENSP00000344683.

PTM databases

PhosphoSiteiQ96JB5.

Polymorphism and mutation databases

DMDMi32129444.

Proteomic databases

MaxQBiQ96JB5.
PaxDbiQ96JB5.
PRIDEiQ96JB5.

Protocols and materials databases

DNASUi80279.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338399; ENSP00000344683; ENSG00000108465.
ENST00000536708; ENSP00000438886; ENSG00000108465. [Q96JB5-4]
GeneIDi80279.
KEGGihsa:80279.
UCSCiuc002imr.4. human. [Q96JB5-1]
uc002ims.4. human. [Q96JB5-2]

Organism-specific databases

CTDi80279.
GeneCardsiGC17P046048.
H-InvDBHIX0013932.
HGNCiHGNC:18673. CDK5RAP3.
HPAiHPA022141.
HPA022882.
HPA027883.
MIMi608202. gene.
neXtProtiNX_Q96JB5.
PharmGKBiPA38633.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG237881.
GeneTreeiENSGT00390000000713.
HOGENOMiHOG000231047.
HOVERGENiHBG050978.
InParanoidiQ96JB5.
OMAiFVQKRGN.
PhylomeDBiQ96JB5.

Miscellaneous databases

ChiTaRSiCDK5RAP3. human.
GeneWikiiCDK5RAP3.
GenomeRNAii80279.
NextBioi35480018.
PROiQ96JB5.
SOURCEiSearch...

Gene expression databases

BgeeiQ96JB5.
CleanExiHS_CDK5RAP3.
ExpressionAtlasiQ96JB5. baseline and differential.
GenevisibleiQ96JB5. HS.

Family and domain databases

InterProiIPR008491. DUF773.
[Graphical view]
PANTHERiPTHR14894. PTHR14894. 1 hit.
PfamiPF05600. DUF773. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel gene IC53 stimulates ECV304 cell proliferation and is upregulated in failing heart."
    Chen J., Liu B., Liu Y.Q., Han Y., Yu H., Zhang Y., Lu L., Zhen Y., Hui R.T.
    Biochem. Biophys. Res. Commun. 294:161-166(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    Tissue: Aorta.
  2. "Cloning and characterization of human IC53-2, a novel CDK5 activator binding protein."
    Xie Y.H., He X.H., Tang Y.T., Li J.J., Pan Z.M., Qin W.X., Wan da F., Gu J.R.
    Cell Res. 13:83-91(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, TISSUE SPECIFICITY.
    Tissue: Placenta.
  3. "Protein interacting with the receptor binding domain of enteric adenovirus serotype 41 fiber protein."
    Favier A.-L., Harsi C., Chrobozcek J.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Kidney.
  4. "Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients."
    Shichijo S., Itoh K.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon adenocarcinoma.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
    Tissue: Placenta and Rectum.
  6. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Synovial cell.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  10. "Cloning of three novel neuronal Cdk5 activator binding proteins."
    Ching Y.-P., Qi Z., Wang J.H.
    Gene 242:285-294(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  11. "A novel LZAP-binding protein, NLBP, inhibits cell invasion."
    Kwon J., Cho H.J., Han S.H., No J.G., Kwon J.Y., Kim H.
    J. Biol. Chem. 285:12232-12240(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UFL1.
  12. "A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling."
    Wu J., Lei G., Mei M., Tang Y., Li H.
    J. Biol. Chem. 285:15126-15136(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DDRGK1 AND UFL1, REGION, UBIQUITINATION.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCK5P3_HUMAN
AccessioniPrimary (citable) accession number: Q96JB5
Secondary accession number(s): B7Z6N4
, D3DTU1, D3DTU2, F5H3I5, Q53FA2, Q9H3F8, Q9H8G0, Q9HBR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 16, 2003
Last modified: July 22, 2015
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.