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Q96JB5 (CK5P3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CDK5 regulatory subunit-associated protein 3
Alternative name(s):
CDK5 activator-binding protein C53
Protein HSF-27
Gene names
Name:CDK5RAP3
Synonyms:IC53
ORF Names:MSTP016, OK/SW-cl.114, PP1553
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length506 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via its interaction with CDK5R1 By similarity. Ref.2

Subunit structure

Interacts with CDK5R1. This interaction is prevented by the association between CDK5R1 and CDK5RAP3 By similarity. Interacts with the enteric adenovirus serotype 41 fiber protein. Interacts with UFL1. Ref.10

Tissue specificity

Ubiquitous. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform 3 is expressed in kidney, liver, skeletal muscle and placenta. Ref.1 Ref.2 Ref.9

Post-translational modification

Phosphorylated in vitro by CDK5 By similarity.

Sequence similarities

Belongs to the CDK5RAP3 family.

Sequence caution

The sequence AAK69655.1 differs from that shown. Reason: Frameshift at position 410.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

RELAQ042064EBI-718818,EBI-73886

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96JB5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96JB5-2)

Also known as: IC53;

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.
     88-111: RYSSQRMKDWQEIIALYEKDNTYL → MCVHPGACLPHVGVSWAEFPGHFS
Note: Due to an intron retention.
Isoform 3 (identifier: Q96JB5-3)

Also known as: IC53-2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-225: Missing.
Note: Due to intron retention. No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 506506CDK5 regulatory subunit-associated protein 3
PRO_0000220516

Natural variations

Alternative sequence1 – 225225Missing in isoform 3.
VSP_007568
Alternative sequence1 – 8787Missing in isoform 2.
VSP_007566
Alternative sequence88 – 11124RYSSQ…DNTYL → MCVHPGACLPHVGVSWAEFP GHFS in isoform 2.
VSP_007567
Natural variant3241L → V.
Corresponds to variant rs35054799 [ dbSNP | Ensembl ].
VAR_048688

Experimental info

Sequence conflict1131E → V in BAD97107. Ref.6
Sequence conflict4061E → K in AAK69655. Ref.3
Sequence conflict4431Q → E in BAD97107. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 16, 2003. Version 2.
Checksum: A21E59A79E1F87E0

FASTA50656,921
        10         20         30         40         50         60 
MEDHQHVPID IQTSKLLDWL VDRRHCSLKW QSLVLTIREK INAAIQDMPE SEEIAQLLSG 

        70         80         90        100        110        120 
SYIHYFHCLR ILDLLKGTEA STKNIFGRYS SQRMKDWQEI IALYEKDNTY LVELSSLLVR 

       130        140        150        160        170        180 
NVNYEIPSLK KQIAKCQQLQ QEYSRKEEEC QAGAAEMREQ FYHSCKQYGI TGENVRGELL 

       190        200        210        220        230        240 
ALVKDLPSQL AEIGAAAQQS LGEAIDVYQA SVGFVCESPT EQVLPMLRFV QKRGNSTVYE 

       250        260        270        280        290        300 
WRTGTEPSVV ERPHLEELPE QVAEDAIDWG DFGVEAVSEG TDSGISAEAA GIDWGIFPES 

       310        320        330        340        350        360 
DSKDPGGDGI DWGDDAVALQ ITVLEAGTQA PEGVARGPDA LTLLEYTETR NQFLDELMEL 

       370        380        390        400        410        420 
EIFLAQRAVE LSEEADVLSV SQFQLAPAIL QGQTKEKMVT MVSVLEDLIG KLTSLQLQHL 

       430        440        450        460        470        480 
FMILASPRYV DRVTEFLQQK LKQSQLLALK KELMVQKQQE ALEEQAALEP KLDLLLEKTK 

       490        500 
ELQKLIEADI SKRYSGRPVN LMGTSL 

« Hide

Isoform 2 (IC53) [UniParc].

Checksum: DA15DED087A5A795
Show »

FASTA41946,351
Isoform 3 (IC53-2) [UniParc].

Checksum: BDC6C94A65DF078C
Show »

FASTA28131,200

References

« Hide 'large scale' references
[1]"A novel gene IC53 stimulates ECV304 cell proliferation and is upregulated in failing heart."
Chen J., Liu B., Liu Y.Q., Han Y., Yu H., Zhang Y., Lu L., Zhen Y., Hui R.T.
Biochem. Biophys. Res. Commun. 294:161-166(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
Tissue: Aorta.
[2]"Cloning and characterization of human IC53-2, a novel CDK5 activator binding protein."
Xie Y.H., He X.H., Tang Y.T., Li J.J., Pan Z.M., Qin W.X., Wan da F., Gu J.R.
Cell Res. 13:83-91(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, TISSUE SPECIFICITY.
Tissue: Placenta.
[3]"Protein interacting with the receptor binding domain of enteric adenovirus serotype 41 fiber protein."
Favier A.-L., Harsi C., Chrobozcek J.
Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Kidney.
[4]"Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients."
Shichijo S., Itoh K.
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Colon adenocarcinoma.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Placenta.
[6]Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Synovial cell.
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[9]"Cloning of three novel neuronal Cdk5 activator binding proteins."
Ching Y.-P., Qi Z., Wang J.H.
Gene 242:285-294(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[10]"A novel LZAP-binding protein, NLBP, inhibits cell invasion."
Kwon J., Cho H.J., Han S.H., No J.G., Kwon J.Y., Kim H.
J. Biol. Chem. 285:12232-12240(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH UFL1.
[11]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF110322 mRNA. Translation: AAG39277.1.
AF217982 mRNA. Translation: AAG17225.1.
AF343090 mRNA. Translation: AAK69655.1. Frameshift.
AB062433 mRNA. Translation: BAB93496.1.
AK023722 mRNA. Translation: BAB14657.1.
AK223387 mRNA. Translation: BAD97107.1.
CH471109 Genomic DNA. Translation: EAW94772.1.
CH471109 Genomic DNA. Translation: EAW94774.1.
CH471109 Genomic DNA. Translation: EAW94775.1.
CH471109 Genomic DNA. Translation: EAW94778.1.
BC009957 mRNA. Translation: AAH09957.1.
BC072435 mRNA. Translation: AAH72435.1.
PIRJC7863.
RefSeqNP_001265127.1. NM_001278198.1.
NP_001265145.1. NM_001278216.1.
NP_001265146.1. NM_001278217.1.
NP_788276.1. NM_176096.2.
UniGeneHs.20157.

3D structure databases

ProteinModelPortalQ96JB5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123213. 31 interactions.
IntActQ96JB5. 16 interactions.
MINTMINT-1410069.
STRING9606.ENSP00000344683.

PTM databases

PhosphoSiteQ96JB5.

Polymorphism databases

DMDM32129444.

Proteomic databases

PaxDbQ96JB5.
PRIDEQ96JB5.

Protocols and materials databases

DNASU80279.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000338399; ENSP00000344683; ENSG00000108465. [Q96JB5-1]
GeneID80279.
KEGGhsa:80279.
UCSCuc002imr.4. human. [Q96JB5-1]
uc002ims.4. human. [Q96JB5-2]

Organism-specific databases

CTD80279.
GeneCardsGC17P046048.
H-InvDBHIX0013932.
HGNCHGNC:18673. CDK5RAP3.
HPAHPA022141.
HPA022882.
HPA027883.
MIM608202. gene.
neXtProtNX_Q96JB5.
PharmGKBPA38633.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG237881.
HOVERGENHBG050978.
InParanoidQ96JB5.
PhylomeDBQ96JB5.

Gene expression databases

ArrayExpressQ96JB5.
BgeeQ96JB5.
CleanExHS_CDK5RAP3.
GenevestigatorQ96JB5.

Family and domain databases

InterProIPR008491. DUF773.
[Graphical view]
PANTHERPTHR14894. PTHR14894. 1 hit.
PfamPF05600. DUF773. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCDK5RAP3. human.
GeneWikiCDK5RAP3.
GenomeRNAi80279.
NextBio70750.
PROQ96JB5.
SOURCESearch...

Entry information

Entry nameCK5P3_HUMAN
AccessionPrimary (citable) accession number: Q96JB5
Secondary accession number(s): D3DTU1 expand/collapse secondary AC list , D3DTU2, Q53FA2, Q9H3F8, Q9H8G0, Q9HBR9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 16, 2003
Last modified: April 16, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM