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Q96JB5

- CK5P3_HUMAN

UniProt

Q96JB5 - CK5P3_HUMAN

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Protein

CDK5 regulatory subunit-associated protein 3

Gene

CDK5RAP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via its interaction with CDK5R1 (By similarity).By similarity

GO - Molecular functioni

  1. protein kinase binding Source: UniProtKB

GO - Biological processi

  1. brain development Source: UniProtKB
  2. protein ufmylation Source: MGI
  3. regulation of cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB
  4. regulation of neuron differentiation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
CDK5 regulatory subunit-associated protein 3
Alternative name(s):
CDK5 activator-binding protein C53
Protein HSF-27
Gene namesi
Name:CDK5RAP3
Synonyms:IC53
ORF Names:MSTP016, OK/SW-cl.114, PP1553
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:18673. CDK5RAP3.

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38633.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506CDK5 regulatory subunit-associated protein 3PRO_0000220516Add
BLAST

Post-translational modificationi

Phosphorylated in vitro by CDK5.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96JB5.
PaxDbiQ96JB5.
PRIDEiQ96JB5.

PTM databases

PhosphoSiteiQ96JB5.

Expressioni

Tissue specificityi

Ubiquitous. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform 3 is expressed in kidney, liver, skeletal muscle and placenta.3 Publications

Gene expression databases

BgeeiQ96JB5.
CleanExiHS_CDK5RAP3.
ExpressionAtlasiQ96JB5. baseline and differential.
GenevestigatoriQ96JB5.

Organism-specific databases

HPAiHPA022141.
HPA022882.
HPA027883.

Interactioni

Subunit structurei

Interacts with CDK5R1. This interaction is prevented by the association between CDK5R1 and CDK5RAP3 (By similarity). Interacts with the enteric adenovirus serotype 41 fiber protein. Interacts with UFL1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RELAQ042064EBI-718818,EBI-73886

Protein-protein interaction databases

BioGridi123213. 33 interactions.
IntActiQ96JB5. 17 interactions.
MINTiMINT-1410069.
STRINGi9606.ENSP00000344683.

Structurei

3D structure databases

ProteinModelPortaliQ96JB5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CDK5RAP3 family.Curated

Phylogenomic databases

eggNOGiNOG237881.
GeneTreeiENSGT00390000000713.
HOGENOMiHOG000231047.
HOVERGENiHBG050978.
InParanoidiQ96JB5.
OMAiRRHCSLK.
PhylomeDBiQ96JB5.

Family and domain databases

InterProiIPR008491. DUF773.
[Graphical view]
PANTHERiPTHR14894. PTHR14894. 1 hit.
PfamiPF05600. DUF773. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96JB5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDHQHVPID IQTSKLLDWL VDRRHCSLKW QSLVLTIREK INAAIQDMPE
60 70 80 90 100
SEEIAQLLSG SYIHYFHCLR ILDLLKGTEA STKNIFGRYS SQRMKDWQEI
110 120 130 140 150
IALYEKDNTY LVELSSLLVR NVNYEIPSLK KQIAKCQQLQ QEYSRKEEEC
160 170 180 190 200
QAGAAEMREQ FYHSCKQYGI TGENVRGELL ALVKDLPSQL AEIGAAAQQS
210 220 230 240 250
LGEAIDVYQA SVGFVCESPT EQVLPMLRFV QKRGNSTVYE WRTGTEPSVV
260 270 280 290 300
ERPHLEELPE QVAEDAIDWG DFGVEAVSEG TDSGISAEAA GIDWGIFPES
310 320 330 340 350
DSKDPGGDGI DWGDDAVALQ ITVLEAGTQA PEGVARGPDA LTLLEYTETR
360 370 380 390 400
NQFLDELMEL EIFLAQRAVE LSEEADVLSV SQFQLAPAIL QGQTKEKMVT
410 420 430 440 450
MVSVLEDLIG KLTSLQLQHL FMILASPRYV DRVTEFLQQK LKQSQLLALK
460 470 480 490 500
KELMVQKQQE ALEEQAALEP KLDLLLEKTK ELQKLIEADI SKRYSGRPVN

LMGTSL
Length:506
Mass (Da):56,921
Last modified:June 16, 2003 - v2
Checksum:iA21E59A79E1F87E0
GO
Isoform 2 (identifier: Q96JB5-2) [UniParc]FASTAAdd to Basket

Also known as: IC53

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.
     88-111: RYSSQRMKDWQEIIALYEKDNTYL → MCVHPGACLPHVGVSWAEFPGHFS

Note: Due to an intron retention.

Show »
Length:419
Mass (Da):46,351
Checksum:iDA15DED087A5A795
GO
Isoform 3 (identifier: Q96JB5-3) [UniParc]FASTAAdd to Basket

Also known as: IC53-2

The sequence of this isoform differs from the canonical sequence as follows:
     1-225: Missing.

Note: Due to intron retention. No experimental confirmation available.

Show »
Length:281
Mass (Da):31,200
Checksum:iBDC6C94A65DF078C
GO
Isoform 4 (identifier: Q96JB5-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: ME → MRRQSMTSATRDLHTALDGKATQGGKK

Note: No experimental confirmation available.

Show »
Length:531
Mass (Da):59,589
Checksum:iAE71C7A39A36A358
GO

Sequence cautioni

The sequence AAK69655.1 differs from that shown. Reason: Frameshift at position 410. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti98 – 981Q → R in BAH13320. (PubMed:14702039)Curated
Sequence conflicti113 – 1131E → V in BAD97107. 1 PublicationCurated
Sequence conflicti406 – 4061E → K in AAK69655. 1 PublicationCurated
Sequence conflicti443 – 4431Q → E in BAD97107. 1 PublicationCurated
Sequence conflicti479 – 4791T → A in BAH13320. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti324 – 3241L → V.
Corresponds to variant rs35054799 [ dbSNP | Ensembl ].
VAR_048688

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 225225Missing in isoform 3. 1 PublicationVSP_007568Add
BLAST
Alternative sequencei1 – 8787Missing in isoform 2. 1 PublicationVSP_007566Add
BLAST
Alternative sequencei1 – 22ME → MRRQSMTSATRDLHTALDGK ATQGGKK in isoform 4. 1 PublicationVSP_055646
Alternative sequencei88 – 11124RYSSQ…DNTYL → MCVHPGACLPHVGVSWAEFP GHFS in isoform 2. 1 PublicationVSP_007567Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110322 mRNA. Translation: AAG39277.1.
AF217982 mRNA. Translation: AAG17225.1.
AF343090 mRNA. Translation: AAK69655.1. Frameshift.
AB062433 mRNA. Translation: BAB93496.1.
AK023722 mRNA. Translation: BAB14657.1.
AK300643 mRNA. Translation: BAH13320.1.
AK223387 mRNA. Translation: BAD97107.1.
AC018521 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94772.1.
CH471109 Genomic DNA. Translation: EAW94774.1.
CH471109 Genomic DNA. Translation: EAW94775.1.
CH471109 Genomic DNA. Translation: EAW94778.1.
BC009957 mRNA. Translation: AAH09957.1.
BC072435 mRNA. Translation: AAH72435.1.
CCDSiCCDS42356.1. [Q96JB5-1]
CCDS62232.1. [Q96JB5-4]
PIRiJC7863.
RefSeqiNP_001265126.1. NM_001278197.1. [Q96JB5-4]
NP_001265127.1. NM_001278198.1.
NP_001265145.1. NM_001278216.1. [Q96JB5-3]
NP_001265146.1. NM_001278217.1. [Q96JB5-2]
NP_788276.1. NM_176096.2. [Q96JB5-1]
XP_006722176.1. XM_006722113.1. [Q96JB5-2]
UniGeneiHs.20157.

Genome annotation databases

EnsembliENST00000338399; ENSP00000344683; ENSG00000108465. [Q96JB5-1]
ENST00000536708; ENSP00000438886; ENSG00000108465. [Q96JB5-4]
GeneIDi80279.
KEGGihsa:80279.
UCSCiuc002imr.4. human. [Q96JB5-1]
uc002ims.4. human. [Q96JB5-2]

Polymorphism databases

DMDMi32129444.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110322 mRNA. Translation: AAG39277.1 .
AF217982 mRNA. Translation: AAG17225.1 .
AF343090 mRNA. Translation: AAK69655.1 . Frameshift.
AB062433 mRNA. Translation: BAB93496.1 .
AK023722 mRNA. Translation: BAB14657.1 .
AK300643 mRNA. Translation: BAH13320.1 .
AK223387 mRNA. Translation: BAD97107.1 .
AC018521 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94772.1 .
CH471109 Genomic DNA. Translation: EAW94774.1 .
CH471109 Genomic DNA. Translation: EAW94775.1 .
CH471109 Genomic DNA. Translation: EAW94778.1 .
BC009957 mRNA. Translation: AAH09957.1 .
BC072435 mRNA. Translation: AAH72435.1 .
CCDSi CCDS42356.1. [Q96JB5-1 ]
CCDS62232.1. [Q96JB5-4 ]
PIRi JC7863.
RefSeqi NP_001265126.1. NM_001278197.1. [Q96JB5-4 ]
NP_001265127.1. NM_001278198.1.
NP_001265145.1. NM_001278216.1. [Q96JB5-3 ]
NP_001265146.1. NM_001278217.1. [Q96JB5-2 ]
NP_788276.1. NM_176096.2. [Q96JB5-1 ]
XP_006722176.1. XM_006722113.1. [Q96JB5-2 ]
UniGenei Hs.20157.

3D structure databases

ProteinModelPortali Q96JB5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123213. 33 interactions.
IntActi Q96JB5. 17 interactions.
MINTi MINT-1410069.
STRINGi 9606.ENSP00000344683.

PTM databases

PhosphoSitei Q96JB5.

Polymorphism databases

DMDMi 32129444.

Proteomic databases

MaxQBi Q96JB5.
PaxDbi Q96JB5.
PRIDEi Q96JB5.

Protocols and materials databases

DNASUi 80279.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000338399 ; ENSP00000344683 ; ENSG00000108465 . [Q96JB5-1 ]
ENST00000536708 ; ENSP00000438886 ; ENSG00000108465 . [Q96JB5-4 ]
GeneIDi 80279.
KEGGi hsa:80279.
UCSCi uc002imr.4. human. [Q96JB5-1 ]
uc002ims.4. human. [Q96JB5-2 ]

Organism-specific databases

CTDi 80279.
GeneCardsi GC17P046048.
H-InvDB HIX0013932.
HGNCi HGNC:18673. CDK5RAP3.
HPAi HPA022141.
HPA022882.
HPA027883.
MIMi 608202. gene.
neXtProti NX_Q96JB5.
PharmGKBi PA38633.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG237881.
GeneTreei ENSGT00390000000713.
HOGENOMi HOG000231047.
HOVERGENi HBG050978.
InParanoidi Q96JB5.
OMAi RRHCSLK.
PhylomeDBi Q96JB5.

Miscellaneous databases

ChiTaRSi CDK5RAP3. human.
GeneWikii CDK5RAP3.
GenomeRNAii 80279.
NextBioi 35480018.
PROi Q96JB5.
SOURCEi Search...

Gene expression databases

Bgeei Q96JB5.
CleanExi HS_CDK5RAP3.
ExpressionAtlasi Q96JB5. baseline and differential.
Genevestigatori Q96JB5.

Family and domain databases

InterProi IPR008491. DUF773.
[Graphical view ]
PANTHERi PTHR14894. PTHR14894. 1 hit.
Pfami PF05600. DUF773. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel gene IC53 stimulates ECV304 cell proliferation and is upregulated in failing heart."
    Chen J., Liu B., Liu Y.Q., Han Y., Yu H., Zhang Y., Lu L., Zhen Y., Hui R.T.
    Biochem. Biophys. Res. Commun. 294:161-166(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    Tissue: Aorta.
  2. "Cloning and characterization of human IC53-2, a novel CDK5 activator binding protein."
    Xie Y.H., He X.H., Tang Y.T., Li J.J., Pan Z.M., Qin W.X., Wan da F., Gu J.R.
    Cell Res. 13:83-91(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, TISSUE SPECIFICITY.
    Tissue: Placenta.
  3. "Protein interacting with the receptor binding domain of enteric adenovirus serotype 41 fiber protein."
    Favier A.-L., Harsi C., Chrobozcek J.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Kidney.
  4. "Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients."
    Shichijo S., Itoh K.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon adenocarcinoma.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
    Tissue: Placenta and Rectum.
  6. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Synovial cell.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  10. "Cloning of three novel neuronal Cdk5 activator binding proteins."
    Ching Y.-P., Qi Z., Wang J.H.
    Gene 242:285-294(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  11. "A novel LZAP-binding protein, NLBP, inhibits cell invasion."
    Kwon J., Cho H.J., Han S.H., No J.G., Kwon J.Y., Kim H.
    J. Biol. Chem. 285:12232-12240(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UFL1.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCK5P3_HUMAN
AccessioniPrimary (citable) accession number: Q96JB5
Secondary accession number(s): B7Z6N4
, D3DTU1, D3DTU2, F5H3I5, Q53FA2, Q9H3F8, Q9H8G0, Q9HBR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 16, 2003
Last modified: November 26, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3