Reviewed,
UniProtKB/Swiss-Prot Q96JB5 (CK5P3_HUMAN)
Last modified
July 7, 2009.
Version 67.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: CDK5 regulatory subunit-associated protein 3 Alternative name(s): CDK5 activator-binding protein C53 Protein HSF-27 | ||||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||||
| Taxonomic identifier | 9606 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 506 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via its interaction with CDK5R1 By similarity. |
| Subunit structure | Interacts with CDK5R1. This interaction is prevented by the association between CDK5R1 and CDK5RAP3 By similarity. Interacts with the enteric adenovirus serotype 41 fiber protein. |
| Tissue specificity | Ubiquitous. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform 3 is expressed in kidney, liver, skeletal muscle and placenta. Ref.1 Ref.2 Ref.8 |
| Post-translational modification | Phosphorylated in vitro by CDK5 By similarity. |
| Sequence similarities | Belongs to the CDK5RAP3 family. |
| Sequence caution | The sequence AAK69655.1 differs from that shown. Reason: Frameshift at position 410. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing Polymorphism |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | brain development Non-traceable author statement. Source: UniProtKB regulation of cyclin-dependent protein kinase activityInferred from sequence or structural similarity. Source: UniProtKB regulation of neuron differentiation Ref.8Non-traceable author statement. Source: UniProtKB |
| Molecular function | neuronal Cdc2-like kinase binding Ref.8 Non-traceable author statement. Source: UniProtKB |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| ARL1 | P40616 | 1 | EBI-718818,EBI-1052746 | |
| DDRGK1 | Q96HY6 | 1 | EBI-718818,EBI-1054024 | |
| DISC1 | Q9NRI5 | 2 | EBI-718818,EBI-529989 | |
| IGHA1 | P01876 | 1 | EBI-718818,EBI-727651 | |
| IGKC | P01834 | 1 | EBI-718818,EBI-1054530 | |
| KHK | P50053 | 1 | EBI-718818,EBI-1053974 | |
| KIAA0776 | O94874 | 1 | EBI-718818,EBI-1048088 | |
| RELA | Q04206 | 3 | EBI-718818,EBI-73886 | |
| SMNDC1 | O75940 | 1 | EBI-718818,EBI-1052641 | |
| UFC1 | Q9Y3C8 | 1 | EBI-718818,EBI-1045733 | |
| UFM1 | P61960 | 1 | EBI-718818,EBI-1045061 |
Alternative products
| This entry describes 3 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q96JB5-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q96JB5-2) Also known as: IC53; The sequence of this isoform differs from the canonical sequence as follows: 1-87: Missing. 88-111: RYSSQRMKDWQEIIALYEKDNTYL → MCVHPGACLPHVGVSWAEFPGHFS | ||||||
| Note: Due to an intron retention. | ||||||
| Isoform 3 (identifier: Q96JB5-3) Also known as: IC53-2; The sequence of this isoform differs from the canonical sequence as follows: 1-225: Missing. | ||||||
| Note: Due to intron retention. No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 506 | 506 | CDK5 regulatory subunit-associated protein 3 | PRO_0000220516 | |||||
Natural variations | |||||||||
| Alternative sequence | 1 – 225 | 225 | Missing in isoform 3. | VSP_007568 | |||||
| Alternative sequence | 1 – 87 | 87 | Missing in isoform 2. | VSP_007566 | |||||
| Alternative sequence | 88 – 111 | 24 | RYSSQ…DNTYL → MCVHPGACLPHVGVSWAEFP GHFS in isoform 2. | VSP_007567 | |||||
| Natural variant | 324 | 1 | L → V: dbSNP rs35054799. | VAR_048688 | |||||
Experimental info | |||||||||
| Sequence conflict | 113 | 1 | E → V in BAD97107. Ref.6 | ||||||
| Sequence conflict | 406 | 1 | E → K in AAK69655. Ref.3 | ||||||
| Sequence conflict | 443 | 1 | Q → E in BAD97107. Ref.6 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A novel gene IC53 stimulates ECV304 cell proliferation and is upregulated in failing heart." Chen J., Liu B., Liu Y.Q., Han Y., Yu H., Zhang Y., Lu L., Zhen Y., Hui R.T. Biochem. Biophys. Res. Commun. 294:161-166(2002) [PubMed: 12054757] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY. Tissue: Aorta. |
| [2] | "Cloning and characterization of human IC53-2, a novel CDK5 activator binding protein." Xie Y.H., He X.H., Tang Y.T., Li J.J., Pan Z.M., Qin W.X., Wan da F., Gu J.R. Cell Res. 13:83-91(2003) [PubMed: 12737517] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, TISSUE SPECIFICITY. Tissue: Placenta. |
| [3] | "Protein interacting with the receptor binding domain of enteric adenovirus serotype 41 fiber protein." Favier A.-L., Harsi C., Chrobozcek J. Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Kidney. |
| [4] | "Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients." Shichijo S., Itoh K. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Colon adenocarcinoma. |
| [5] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Placenta. |
| [6] | Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Synovial cell. |
| [7] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain. |
| [8] | "Cloning of three novel neuronal Cdk5 activator binding proteins." Ching Y.-P., Qi Z., Wang J.H. Gene 242:285-294(2000) [PubMed: 10721722] [Abstract] Cited for: TISSUE SPECIFICITY. |
| [9] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF110322 mRNA. Translation: AAG39277.1. AF217982 mRNA. Translation: AAG17225.1. AF343090 mRNA. Translation: AAK69655.1. Frameshift. AB062433 mRNA. Translation: BAB93496.1. AK023722 mRNA. Translation: BAB14657.1. AK223387 mRNA. Translation: BAD97107.1. BC009957 mRNA. Translation: AAH09957.1. BC072435 mRNA. Translation: AAH72435.1. | |
| IPI | IPI00018780. IPI00187145. IPI00414442. |
| PIR | JC7863. |
| RefSeq | NP_788276.1. |
| UniGene | Hs.20157 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q96JB5. 26 interactions. |
PTM databases | |
| PhosphoSite | Q96JB5. |
Proteomic databases | |
| PRIDE | Q96JB5. |
Genome annotation databases | |
| Ensembl | ENSG00000108465. Homo sapiens. [Contig view] |
| GeneID | 80279. |
| KEGG | hsa:80279. |
| UCSC | uc002imq.1. human. uc002imr.1. human. |
Organism-specific databases | |
| GeneCards | GC17P043403. |
| H-InvDB | HIX0013932. |
| HGNC | HGNC:18673. CDK5RAP3. |
| MIM | 608202. gene. |
| PharmGKB | PA38633. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q96JB5. |
| HOVERGEN | Q96JB5. |
| OMA | Q96JB5. SCKQYGI. |
Gene expression databases | |
| ArrayExpress | Q96JB5. |
| Bgee | Q96JB5. |
| CleanEx | HS_CDK5RAP3. |
| GermOnline | ENSG00000108465. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR008491. DUF773. [Graphical view] |
| PANTHER | PTHR14894. DUF773. 1 hit. |
| Pfam | PF05600. DUF773. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 70750. |
| SOURCE | Search... |
Entry information
| Entry name | CK5P3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q96JB5 Secondary accession number(s): Q53FA2 Q9HBR9 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 17 Human chromosome 17: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


