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Q96JB3

- HIC2_HUMAN

UniProt

Q96JB3 - HIC2_HUMAN

Protein

Hypermethylated in cancer 2 protein

Gene

HIC2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 2 (02 May 2002)
      Previous versions | rss
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    Functioni

    Transcriptional repressor.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri442 – 46928C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri505 – 53228C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri533 – 56028C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri561 – 58828C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri589 – 61527C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW
    3. protein C-terminus binding Source: UniProtKB

    GO - Biological processi

    1. negative regulation of transcription, DNA-templated Source: UniProtKB
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hypermethylated in cancer 2 protein
    Short name:
    Hic-2
    Alternative name(s):
    HIC1-related gene on chromosome 22 protein
    Hic-3
    Zinc finger and BTB domain-containing protein 30
    Gene namesi
    Name:HIC2
    Synonyms:HRG22, KIAA1020, ZBTB30
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:18595. HIC2.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB
    2. plasma membrane Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38357.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 615615Hypermethylated in cancer 2 proteinPRO_0000046945Add
    BLAST

    Proteomic databases

    MaxQBiQ96JB3.
    PaxDbiQ96JB3.
    PRIDEiQ96JB3.

    PTM databases

    PhosphoSiteiQ96JB3.

    Expressioni

    Tissue specificityi

    Highest levels in cerebellum.

    Gene expression databases

    BgeeiQ96JB3.
    CleanExiHS_HIC2.
    GenevestigatoriQ96JB3.

    Organism-specific databases

    HPAiHPA031884.

    Interactioni

    Subunit structurei

    Self-associates. Interacts with HIC1.1 Publication

    Protein-protein interaction databases

    BioGridi116741. 5 interactions.
    IntActiQ96JB3. 4 interactions.
    MINTiMINT-1397107.
    STRINGi9606.ENSP00000302994.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96JB3.
    SMRiQ96JB3. Positions 23-135, 389-613.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 10964BTBPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni246 – 2505Binding to CtBP

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
    Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri442 – 46928C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri505 – 53228C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri533 – 56028C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri561 – 58828C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri589 – 61527C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000026793.
    HOVERGENiHBG079492.
    InParanoidiQ96JB3.
    OMAiIMVENSI.
    OrthoDBiEOG7T1R9Z.
    PhylomeDBiQ96JB3.
    TreeFamiTF333488.

    Family and domain databases

    Gene3Di3.30.160.60. 5 hits.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00651. BTB. 1 hit.
    PF00096. zf-C2H2. 2 hits.
    [Graphical view]
    SMARTiSM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 5 hits.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96JB3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVSGPLALRW CAWAGRGDMG PDMELPSHSK QLLLQLNQQR TKGFLCDVII    50
    MVENSIFRAH KNVLAASSIY FKSLVLHDNL INLDTDMVSS TVFQQILDFI 100
    YTGKLLPSDQ PAEPNFSTLL TAASYLQLPE LAALCRRKLK RAGKPFGSGR 150
    AGSTGMGRPP RSQRLSTASV IQARYQGLVD GRKGAHAPQE LPQAKGSDDE 200
    LFLGGSNQDS VQGLGRAVCP AGGEAGLGGC SSSTNGSSGG CEQELGLDLS 250
    KKSPPLPPAT PGPHLTPDDA AQLSDSQHGS PPAASAPPVA NSASYSELGG 300
    TPDEPMDLEG AEDNHLSLLE APGGQPRKSL RHSTRKKEWG KKEPVAGSPF 350
    ERREAGPKGP CPGEEGEGVG DRVPNGILAS GAGPSGPYGE PPYPCKEEEE 400
    NGKDASEDSA QSGSEGGSGH ASAHYMYRQE GYETVSYGDN LYVCIPCAKG 450
    FPSSEQLNAH VETHTEEELF IKEEGAYETG SGGAEEEAED LSAPSAAYTA 500
    EPRPFKCSVC EKTYKDPATL RQHEKTHWLT RPFPCNICGK MFTQRGTMTR 550
    HMRSHLGLKP FACDECGMRF TRQYRLTEHM RVHSGEKPYE CQLCGGKFTQ 600
    QRNLISHLRM HTSPS 615
    Length:615
    Mass (Da):66,156
    Last modified:May 2, 2002 - v2
    Checksum:iB0368C631B198C95
    GO
    Isoform 2 (identifier: Q96JB3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-18: Missing.

    Show »
    Length:597
    Mass (Da):64,228
    Checksum:iC536567FC3A1AAC8
    GO

    Sequence cautioni

    The sequence BAA82972.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti49 – 513IIM → TIR in CAC70715. (PubMed:11554746)Curated
    Sequence conflicti176 – 1761Q → R in BAA82972. (PubMed:10470851)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1818Missing in isoform 2. 1 PublicationVSP_006829Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ313204 mRNA. Translation: CAC70715.1.
    AF349035 mRNA. Translation: AAK72951.1.
    AB028943 mRNA. Translation: BAA82972.2. Different initiation.
    CR456377 mRNA. Translation: CAG30263.1.
    AP000557 Genomic DNA. No translation available.
    BC094787 mRNA. Translation: AAH94787.1.
    AL162003 mRNA. Translation: CAB82344.1.
    CCDSiCCDS13789.1. [Q96JB3-1]
    PIRiT47181.
    RefSeqiNP_055909.2. NM_015094.2. [Q96JB3-1]
    XP_005261452.1. XM_005261395.1. [Q96JB3-1]
    UniGeneiHs.632767.

    Genome annotation databases

    EnsembliENST00000407464; ENSP00000385319; ENSG00000169635. [Q96JB3-1]
    ENST00000407598; ENSP00000384889; ENSG00000169635. [Q96JB3-1]
    ENST00000443632; ENSP00000387757; ENSG00000169635. [Q96JB3-1]
    GeneIDi23119.
    KEGGihsa:23119.
    UCSCiuc002zur.4. human. [Q96JB3-1]

    Polymorphism databases

    DMDMi20454983.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ313204 mRNA. Translation: CAC70715.1 .
    AF349035 mRNA. Translation: AAK72951.1 .
    AB028943 mRNA. Translation: BAA82972.2 . Different initiation.
    CR456377 mRNA. Translation: CAG30263.1 .
    AP000557 Genomic DNA. No translation available.
    BC094787 mRNA. Translation: AAH94787.1 .
    AL162003 mRNA. Translation: CAB82344.1 .
    CCDSi CCDS13789.1. [Q96JB3-1 ]
    PIRi T47181.
    RefSeqi NP_055909.2. NM_015094.2. [Q96JB3-1 ]
    XP_005261452.1. XM_005261395.1. [Q96JB3-1 ]
    UniGenei Hs.632767.

    3D structure databases

    ProteinModelPortali Q96JB3.
    SMRi Q96JB3. Positions 23-135, 389-613.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116741. 5 interactions.
    IntActi Q96JB3. 4 interactions.
    MINTi MINT-1397107.
    STRINGi 9606.ENSP00000302994.

    PTM databases

    PhosphoSitei Q96JB3.

    Polymorphism databases

    DMDMi 20454983.

    Proteomic databases

    MaxQBi Q96JB3.
    PaxDbi Q96JB3.
    PRIDEi Q96JB3.

    Protocols and materials databases

    DNASUi 23119.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000407464 ; ENSP00000385319 ; ENSG00000169635 . [Q96JB3-1 ]
    ENST00000407598 ; ENSP00000384889 ; ENSG00000169635 . [Q96JB3-1 ]
    ENST00000443632 ; ENSP00000387757 ; ENSG00000169635 . [Q96JB3-1 ]
    GeneIDi 23119.
    KEGGi hsa:23119.
    UCSCi uc002zur.4. human. [Q96JB3-1 ]

    Organism-specific databases

    CTDi 23119.
    GeneCardsi GC22P021771.
    HGNCi HGNC:18595. HIC2.
    HPAi HPA031884.
    MIMi 607712. gene.
    neXtProti NX_Q96JB3.
    PharmGKBi PA38357.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000026793.
    HOVERGENi HBG079492.
    InParanoidi Q96JB3.
    OMAi IMVENSI.
    OrthoDBi EOG7T1R9Z.
    PhylomeDBi Q96JB3.
    TreeFami TF333488.

    Miscellaneous databases

    GeneWikii HIC2.
    GenomeRNAii 23119.
    NextBioi 44339.
    PROi Q96JB3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96JB3.
    CleanExi HS_HIC2.
    Genevestigatori Q96JB3.

    Family and domain databases

    Gene3Di 3.30.160.60. 5 hits.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00651. BTB. 1 hit.
    PF00096. zf-C2H2. 2 hits.
    [Graphical view ]
    SMARTi SM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 5 hits.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1."
      Deltour S., Pinte S., Guerardel C., Leprince D.
      Biochem. Biophys. Res. Commun. 287:427-434(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-85 (ISOFORM 1), ALTERNATIVE SPLICING, SELF-ASSOCIATION, INTERACTION WITH HIC1.
    2. "Complete deduced structure of HIC-3, a novel human btb/poz and ZF factor of the HIC family."
      Alliel P.M., Goudou D., Bitoun M., Seddiqi N., Rieger F., Perin J.-P.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Brain.
    3. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 301-615.
      Tissue: Testis.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiHIC2_HUMAN
    AccessioniPrimary (citable) accession number: Q96JB3
    Secondary accession number(s): Q504T6
    , Q96KR3, Q9NSM9, Q9UPX9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2002
    Last sequence update: May 2, 2002
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3