Reviewed,
UniProtKB/Swiss-Prot Q96JB3 (HIC2_HUMAN)
Last modified
June 16, 2009.
Version 77.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Hypermethylated in cancer 2 protein Short name=Hic-2 Alternative name(s): Hic-3 HIC1-related gene on chromosome 22 Zinc finger and BTB domain-containing protein 30 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 615 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Transcriptional repressor. |
| Subunit structure | Interacts with CtBP. |
| Subcellular location | |
| Tissue specificity | Highest levels in cerebellum. |
| Sequence similarities | Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily. Contains 1 BTB (POZ) domain. Contains 5 C2H2-type zinc fingers. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Nucleus |
| Coding sequence diversity | Alternative splicing |
| Domain | Repeat Zinc-finger |
| Ligand | DNA-binding Metal-binding Zinc |
| Molecular function | Repressor |
| Gene Ontology (GO) | |
| Biological process | negative regulation of transcription, DNA-dependent Ref.1 Non-traceable author statement. Source: UniProtKB transcriptionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | nucleus Ref.1 Inferred from direct assay. Source: UniProtKB |
| Molecular function | DNA binding Ref.1 Non-traceable author statement. Source: UniProtKB protein C-terminus bindingInferred from physical interaction. Source: UniProtKB zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q96JB3-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q96JB3-2) The sequence of this isoform differs from the canonical sequence as follows: 1-18: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 615 | 615 | Hypermethylated in cancer 2 protein | PRO_0000046945 | |||||
Regions | |||||||||
| Domain | 46 – 109 | 64 | BTB | ||||||
| Zinc finger | 442 – 469 | 28 | C2H2-type 1 | ||||||
| Zinc finger | 505 – 532 | 28 | C2H2-type 2 | ||||||
| Zinc finger | 533 – 560 | 28 | C2H2-type 3 | ||||||
| Zinc finger | 561 – 588 | 28 | C2H2-type 4 | ||||||
| Zinc finger | 589 – 615 | 27 | C2H2-type 5 | ||||||
| Region | 246 – 250 | 5 | Binding to CtBP | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 18 | 18 | Missing in isoform 2. | VSP_006829 | |||||
Experimental info | |||||||||
| Sequence conflict | 49 – 51 | 3 | IIM → TIR in CAC70715. Ref.1 | ||||||
| Sequence conflict | 176 | 1 | Q → R in BAA82972. Ref.3 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1." Deltour S., Pinte S., Guerardel C., Leprince D. Biochem. Biophys. Res. Commun. 287:427-434(2001) [PubMed: 11554746] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-85 (ISOFORM 1), ALTERNATIVE SPLICING. |
| [2] | "Complete deduced structure of HIC-3, a novel human btb/poz and ZF factor of the HIC family." Alliel P.M., Goudou D., Bitoun M., Seddiqi N., Rieger F., Perin J.-P. Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Brain. |
| [3] | "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:197-205(1999) [PubMed: 10470851] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain. |
| [4] | "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract] Cited for: SEQUENCE REVISION. |
| [5] | "A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004) [PubMed: 15461802] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). |
| [6] | "The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. Wright H.Nature 402:489-495(1999) [PubMed: 10591208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [7] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Placenta. |
| [8] | "The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 301-615. Tissue: Testis. |
| [9] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| AJ313204 mRNA. Translation: CAC70715.1. AF349035 mRNA. Translation: AAK72951.1. AB028943 mRNA. Translation: BAA82972.2. Different initiation. CR456377 mRNA. Translation: CAG30263.1. AP000557 Genomic DNA. No translation available. BC094787 mRNA. Translation: AAH94787.1. AL162003 mRNA. Translation: CAB82344.1. | |
| IPI | IPI00219839. IPI00376570. |
| PIR | T47181. |
| RefSeq | NP_055909.2. |
| UniGene | Hs.632767 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1A1H based on UniProtKB P08046. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q96JB3. 2 interactions. |
PTM databases | |
| PhosphoSite | Q96JB3. |
Proteomic databases | |
| PRIDE | Q96JB3. |
Genome annotation databases | |
| Ensembl | ENSG00000169635. Homo sapiens. [Contig view] |
| GeneID | 23119. |
| KEGG | hsa:23119. |
Organism-specific databases | |
| GeneCards | GC22P020096. |
| H-InvDB | HIX0016273. |
| HGNC | HGNC:18595. HIC2. |
| MIM | 607712. gene. |
| PharmGKB | PA26466. |
| HUGE | Search... |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q96JB3. |
| HOVERGEN | Q96JB3. |
| OMA | Q96JB3. GDRVPNG. |
Gene expression databases | |
| ArrayExpress | Q96JB3. |
| Bgee | Q96JB3. |
| CleanEx | HS_HIC2. |
| GermOnline | ENSG00000169635. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view] |
| Gene3D | G3DSA:3.30.710.10. BTB/POZ_fold. 1 hit. G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 2 hits. |
| Pfam | PF00651. BTB. 1 hit. PF00096. zf-C2H2. 4 hits. [Graphical view] |
| ProDom | PD000003. Znf_C2H2. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00225. BTB. 1 hit. SM00355. ZnF_C2H2. 5 hits. [Graphical view] |
| PROSITE | PS50097. BTB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 5 hits. PS50157. ZINC_FINGER_C2H2_2. 5 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 44339. |
| SOURCE | Search... |
Entry information
| Entry name | HIC2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q96JB3 Secondary accession number(s): Q504T6 Q9UPX9 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 22 Human chromosome 22: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


