Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q96JB2

- COG3_HUMAN

UniProt

Q96JB2 - COG3_HUMAN

Protein

Conserved oligomeric Golgi complex subunit 3

Gene

COG3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in ER-Golgi transport.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. protein transporter activity Source: UniProtKB

    GO - Biological processi

    1. ER to Golgi vesicle-mediated transport Source: UniProtKB
    2. intracellular protein transport Source: InterPro
    3. intra-Golgi vesicle-mediated transport Source: UniProtKB
    4. protein glycosylation Source: UniProtKB
    5. protein localization to organelle Source: UniProtKB
    6. protein stabilization Source: UniProtKB
    7. retrograde vesicle-mediated transport, Golgi to ER Source: UniProtKB

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Conserved oligomeric Golgi complex subunit 3
    Short name:
    COG complex subunit 3
    Alternative name(s):
    Component of oligomeric Golgi complex 3
    Vesicle-docking protein SEC34 homolog
    p94
    Gene namesi
    Name:COG3
    Synonyms:SEC34
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:18619. COG3.

    Subcellular locationi

    Golgi apparatusGolgi stack membrane 1 Publication; Peripheral membrane protein 1 Publication
    Note: Associated with the peripheral membrane of cis/medial cisternae.

    GO - Cellular componenti

    1. cis-Golgi network Source: InterPro
    2. cytoplasm Source: HPA
    3. Golgi apparatus Source: UniProtKB
    4. Golgi cisterna membrane Source: UniProtKB-SubCell
    5. Golgi transport complex Source: UniProtKB
    6. nucleus Source: HPA
    7. plasma membrane Source: HPA

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38602.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed3 Publications
    Chaini2 – 828827Conserved oligomeric Golgi complex subunit 3PRO_0000213500Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine3 Publications
    Modified residuei663 – 6631Phosphoserine3 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ96JB2.
    PaxDbiQ96JB2.
    PRIDEiQ96JB2.

    PTM databases

    PhosphoSiteiQ96JB2.

    Expressioni

    Tissue specificityi

    Widely expressed with highest levels in pancreas and testis and lowest levels in lung.1 Publication

    Gene expression databases

    BgeeiQ96JB2.
    CleanExiHS_COG3.
    GenevestigatoriQ96JB2.

    Organism-specific databases

    HPAiHPA040353.

    Interactioni

    Subunit structurei

    Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.By similarity

    Protein-protein interaction databases

    BioGridi123680. 18 interactions.
    IntActiQ96JB2. 10 interactions.
    MINTiMINT-3054332.
    STRINGi9606.ENSP00000258654.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96JB2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the COG3 family.Curated

    Phylogenomic databases

    eggNOGiNOG300871.
    HOGENOMiHOG000264596.
    HOVERGENiHBG051062.
    InParanoidiQ96JB2.
    OMAiKIPEYQQ.
    OrthoDBiEOG7NGQ9R.
    PhylomeDBiQ96JB2.
    TreeFamiTF314200.

    Family and domain databases

    InterProiIPR007265. COG_su3.
    [Graphical view]
    PANTHERiPTHR13302. PTHR13302. 1 hit.
    PfamiPF04136. Sec34. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96JB2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAEAALLLLP EAAAERDARE KLALWDRRPD TTAPLTDRQT DSVLELKAAA    50
    ENLPVPAELP IEDLCSLTSQ SLPIELTSVV PESTEDILLK GFTSLGMEEE 100
    RIETAQQFFS WFAKLQTQMD QDEGTKYRQM RDYLSGFQEQ CDAILNDVNS 150
    ALQHLESLQK QYLFVSNKTG TLHEACEQLL KEQSELVDLA ENIQQKLSYF 200
    NELETINTKL NSPTLSVNSD GFIPMLAKLD DCITYISSHP NFKDYPIYLL 250
    KFKQCLSKAL HLMKTYTVNT LQTLTSQLLK RDPSSVPNAD NAFTLFYVKF 300
    RAAAPKVRTL IEQIELRSEK IPEYQQLLND IHQCYLDQRE LLLGPSIACT 350
    VAELTSQNNR DHCALVRSGC AFMVHVCQDE HQLYNEFFTK PTSKLDELLE 400
    KLCVSLYDVF RPLIIHVIHL ETLSELCGIL KNEVLEDHVQ NNAEQLGAFA 450
    AGVKQMLEDV QERLVYRTHI YIQTDITGYK PAPGDLAYPD KLVMMEQIAQ 500
    SLKDEQKKVP SEASFSDVHL EEGESNSLTK SGSTESLNPR PQTTISPADL 550
    HGMWYPTVRR TLVCLSKLYR CIDRAVFQGL SQEALSACIQ SLLGASESIS 600
    KNKTQIDGQL FLIKHLLILR EQIAPFHTEF TIKEISLDLK KTRDAAFKIL 650
    NPMTVPRFFR LNSNNALIEF LLEGTPEIRE HYLDSKKDVD RHLKSACEQF 700
    IQQQTKLFVE QLEEFMTKVS ALKTMASQGG PKYTLSQQPW AQPAKVNDLA 750
    ATAYKTIKTK LPVTLRSMSL YLSNKDTEFI LFKPVRNNIQ QVFQKFHALL 800
    KEEFSPEDIQ IIACPSMEQL SLLLLVSK 828
    Length:828
    Mass (Da):94,096
    Last modified:January 23, 2007 - v3
    Checksum:iB3DCF03FD4DC6A60
    GO
    Isoform 2 (identifier: Q96JB2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         443-444: AE → GK
         445-828: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:444
    Mass (Da):50,540
    Checksum:i55874C370679512F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti106 – 1072QQ → HE in AAK66974. (PubMed:11292827)Curated
    Sequence conflicti825 – 8251L → S in AAK66974. (PubMed:11292827)Curated
    Sequence conflicti825 – 8251L → S in AAK06848. (PubMed:11929878)Curated
    Sequence conflicti825 – 8251L → S in BAG37012. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti620 – 6201R → C in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036454
    Natural varianti747 – 7471N → S.1 Publication
    Corresponds to variant rs2274285 [ dbSNP | Ensembl ].
    VAR_055663

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei443 – 4442AE → GK in isoform 2. 1 PublicationVSP_013652
    Alternative sequencei445 – 828384Missing in isoform 2. 1 PublicationVSP_013653Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF349676 mRNA. Translation: AAK66974.1.
    AF332595 mRNA. Translation: AAK06848.1.
    AK314387 mRNA. Translation: BAG37012.1.
    AL139326, AL606514 Genomic DNA. Translation: CAH72888.1.
    BC038953 mRNA. Translation: AAH38953.1.
    CCDSiCCDS9398.1. [Q96JB2-1]
    RefSeqiNP_113619.2. NM_031431.3.
    UniGeneiHs.507948.

    Genome annotation databases

    EnsembliENST00000349995; ENSP00000258654; ENSG00000136152. [Q96JB2-1]
    GeneIDi83548.
    KEGGihsa:83548.
    UCSCiuc001vai.3. human. [Q96JB2-2]
    uc001vak.3. human. [Q96JB2-1]

    Polymorphism databases

    DMDMi85701302.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF349676 mRNA. Translation: AAK66974.1 .
    AF332595 mRNA. Translation: AAK06848.1 .
    AK314387 mRNA. Translation: BAG37012.1 .
    AL139326 , AL606514 Genomic DNA. Translation: CAH72888.1 .
    BC038953 mRNA. Translation: AAH38953.1 .
    CCDSi CCDS9398.1. [Q96JB2-1 ]
    RefSeqi NP_113619.2. NM_031431.3.
    UniGenei Hs.507948.

    3D structure databases

    ProteinModelPortali Q96JB2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123680. 18 interactions.
    IntActi Q96JB2. 10 interactions.
    MINTi MINT-3054332.
    STRINGi 9606.ENSP00000258654.

    PTM databases

    PhosphoSitei Q96JB2.

    Polymorphism databases

    DMDMi 85701302.

    Proteomic databases

    MaxQBi Q96JB2.
    PaxDbi Q96JB2.
    PRIDEi Q96JB2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000349995 ; ENSP00000258654 ; ENSG00000136152 . [Q96JB2-1 ]
    GeneIDi 83548.
    KEGGi hsa:83548.
    UCSCi uc001vai.3. human. [Q96JB2-2 ]
    uc001vak.3. human. [Q96JB2-1 ]

    Organism-specific databases

    CTDi 83548.
    GeneCardsi GC13P046039.
    H-InvDB HIX0011290.
    HGNCi HGNC:18619. COG3.
    HPAi HPA040353.
    MIMi 606975. gene.
    neXtProti NX_Q96JB2.
    PharmGKBi PA38602.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG300871.
    HOGENOMi HOG000264596.
    HOVERGENi HBG051062.
    InParanoidi Q96JB2.
    OMAi KIPEYQQ.
    OrthoDBi EOG7NGQ9R.
    PhylomeDBi Q96JB2.
    TreeFami TF314200.

    Miscellaneous databases

    GeneWikii COG3.
    GenomeRNAii 83548.
    NextBioi 72485.
    PROi Q96JB2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96JB2.
    CleanExi HS_COG3.
    Genevestigatori Q96JB2.

    Family and domain databases

    InterProi IPR007265. COG_su3.
    [Graphical view ]
    PANTHERi PTHR13302. PTHR13302. 1 hit.
    Pfami PF04136. Sec34. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a human ortholog of Sec34p as a component of the cis-Golgi vesicle tethering machinery."
      Suvorova E.S., Kurten R.C., Lupashin V.V.
      J. Biol. Chem. 276:22810-22818(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Fetal brain.
    2. "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp."
      Loh E., Hong W.
      J. Biol. Chem. 277:21955-21961(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, VARIANT SER-747.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    4. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Leukocyte.
    6. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
      Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-16, ACETYLATION AT ALA-2.
      Tissue: Platelet.
    7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-663, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-663, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-663, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-620.

    Entry informationi

    Entry nameiCOG3_HUMAN
    AccessioniPrimary (citable) accession number: Q96JB2
    Secondary accession number(s): B2RAW5
    , Q5VT70, Q8IXX4, Q9BZ92
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2002
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 108 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3