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Q96JB2

- COG3_HUMAN

UniProt

Q96JB2 - COG3_HUMAN

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Protein

Conserved oligomeric Golgi complex subunit 3

Gene

COG3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in ER-Golgi transport.1 Publication

GO - Molecular functioni

  1. protein transporter activity Source: UniProtKB

GO - Biological processi

  1. ER to Golgi vesicle-mediated transport Source: UniProtKB
  2. intracellular protein transport Source: InterPro
  3. intra-Golgi vesicle-mediated transport Source: UniProtKB
  4. protein glycosylation Source: UniProtKB
  5. protein localization to organelle Source: UniProtKB
  6. protein stabilization Source: UniProtKB
  7. retrograde vesicle-mediated transport, Golgi to ER Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 3
Short name:
COG complex subunit 3
Alternative name(s):
Component of oligomeric Golgi complex 3
Vesicle-docking protein SEC34 homolog
p94
Gene namesi
Name:COG3
Synonyms:SEC34
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:18619. COG3.

Subcellular locationi

Golgi apparatusGolgi stack membrane 1 Publication; Peripheral membrane protein 1 Publication
Note: Associated with the peripheral membrane of cis/medial cisternae.

GO - Cellular componenti

  1. cis-Golgi network Source: InterPro
  2. cytoplasm Source: HPA
  3. Golgi apparatus Source: UniProtKB
  4. Golgi transport complex Source: UniProtKB
  5. nucleus Source: HPA
  6. plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38602.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed3 Publications
Chaini2 – 828827Conserved oligomeric Golgi complex subunit 3PRO_0000213500Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine3 Publications
Modified residuei663 – 6631Phosphoserine3 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ96JB2.
PaxDbiQ96JB2.
PRIDEiQ96JB2.

PTM databases

PhosphoSiteiQ96JB2.

Expressioni

Tissue specificityi

Widely expressed with highest levels in pancreas and testis and lowest levels in lung.1 Publication

Gene expression databases

BgeeiQ96JB2.
CleanExiHS_COG3.
GenevestigatoriQ96JB2.

Organism-specific databases

HPAiHPA040353.

Interactioni

Subunit structurei

Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.By similarity

Protein-protein interaction databases

BioGridi123680. 29 interactions.
IntActiQ96JB2. 10 interactions.
MINTiMINT-3054332.
STRINGi9606.ENSP00000258654.

Structurei

3D structure databases

ProteinModelPortaliQ96JB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COG3 family.Curated

Phylogenomic databases

eggNOGiNOG300871.
GeneTreeiENSGT00390000015682.
HOGENOMiHOG000264596.
HOVERGENiHBG051062.
InParanoidiQ96JB2.
OMAiKIPEYQQ.
OrthoDBiEOG7NGQ9R.
PhylomeDBiQ96JB2.
TreeFamiTF314200.

Family and domain databases

InterProiIPR007265. COG_su3.
[Graphical view]
PANTHERiPTHR13302. PTHR13302. 1 hit.
PfamiPF04136. Sec34. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96JB2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEAALLLLP EAAAERDARE KLALWDRRPD TTAPLTDRQT DSVLELKAAA
60 70 80 90 100
ENLPVPAELP IEDLCSLTSQ SLPIELTSVV PESTEDILLK GFTSLGMEEE
110 120 130 140 150
RIETAQQFFS WFAKLQTQMD QDEGTKYRQM RDYLSGFQEQ CDAILNDVNS
160 170 180 190 200
ALQHLESLQK QYLFVSNKTG TLHEACEQLL KEQSELVDLA ENIQQKLSYF
210 220 230 240 250
NELETINTKL NSPTLSVNSD GFIPMLAKLD DCITYISSHP NFKDYPIYLL
260 270 280 290 300
KFKQCLSKAL HLMKTYTVNT LQTLTSQLLK RDPSSVPNAD NAFTLFYVKF
310 320 330 340 350
RAAAPKVRTL IEQIELRSEK IPEYQQLLND IHQCYLDQRE LLLGPSIACT
360 370 380 390 400
VAELTSQNNR DHCALVRSGC AFMVHVCQDE HQLYNEFFTK PTSKLDELLE
410 420 430 440 450
KLCVSLYDVF RPLIIHVIHL ETLSELCGIL KNEVLEDHVQ NNAEQLGAFA
460 470 480 490 500
AGVKQMLEDV QERLVYRTHI YIQTDITGYK PAPGDLAYPD KLVMMEQIAQ
510 520 530 540 550
SLKDEQKKVP SEASFSDVHL EEGESNSLTK SGSTESLNPR PQTTISPADL
560 570 580 590 600
HGMWYPTVRR TLVCLSKLYR CIDRAVFQGL SQEALSACIQ SLLGASESIS
610 620 630 640 650
KNKTQIDGQL FLIKHLLILR EQIAPFHTEF TIKEISLDLK KTRDAAFKIL
660 670 680 690 700
NPMTVPRFFR LNSNNALIEF LLEGTPEIRE HYLDSKKDVD RHLKSACEQF
710 720 730 740 750
IQQQTKLFVE QLEEFMTKVS ALKTMASQGG PKYTLSQQPW AQPAKVNDLA
760 770 780 790 800
ATAYKTIKTK LPVTLRSMSL YLSNKDTEFI LFKPVRNNIQ QVFQKFHALL
810 820
KEEFSPEDIQ IIACPSMEQL SLLLLVSK
Length:828
Mass (Da):94,096
Last modified:January 23, 2007 - v3
Checksum:iB3DCF03FD4DC6A60
GO
Isoform 2 (identifier: Q96JB2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     443-444: AE → GK
     445-828: Missing.

Note: No experimental confirmation available.

Show »
Length:444
Mass (Da):50,540
Checksum:i55874C370679512F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti106 – 1072QQ → HE in AAK66974. (PubMed:11292827)Curated
Sequence conflicti825 – 8251L → S in AAK66974. (PubMed:11292827)Curated
Sequence conflicti825 – 8251L → S in AAK06848. (PubMed:11929878)Curated
Sequence conflicti825 – 8251L → S in BAG37012. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti620 – 6201R → C in a breast cancer sample; somatic mutation. 1 Publication
VAR_036454
Natural varianti747 – 7471N → S.1 Publication
Corresponds to variant rs2274285 [ dbSNP | Ensembl ].
VAR_055663

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei443 – 4442AE → GK in isoform 2. 1 PublicationVSP_013652
Alternative sequencei445 – 828384Missing in isoform 2. 1 PublicationVSP_013653Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF349676 mRNA. Translation: AAK66974.1.
AF332595 mRNA. Translation: AAK06848.1.
AK314387 mRNA. Translation: BAG37012.1.
AL139326, AL606514 Genomic DNA. Translation: CAH72888.1.
BC038953 mRNA. Translation: AAH38953.1.
CCDSiCCDS9398.1. [Q96JB2-1]
RefSeqiNP_113619.2. NM_031431.3.
UniGeneiHs.507948.

Genome annotation databases

EnsembliENST00000349995; ENSP00000258654; ENSG00000136152. [Q96JB2-1]
ENST00000617493; ENSP00000481332; ENSG00000136152. [Q96JB2-2]
GeneIDi83548.
KEGGihsa:83548.
UCSCiuc001vai.3. human. [Q96JB2-2]
uc001vak.3. human. [Q96JB2-1]

Polymorphism databases

DMDMi85701302.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF349676 mRNA. Translation: AAK66974.1 .
AF332595 mRNA. Translation: AAK06848.1 .
AK314387 mRNA. Translation: BAG37012.1 .
AL139326 , AL606514 Genomic DNA. Translation: CAH72888.1 .
BC038953 mRNA. Translation: AAH38953.1 .
CCDSi CCDS9398.1. [Q96JB2-1 ]
RefSeqi NP_113619.2. NM_031431.3.
UniGenei Hs.507948.

3D structure databases

ProteinModelPortali Q96JB2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123680. 29 interactions.
IntActi Q96JB2. 10 interactions.
MINTi MINT-3054332.
STRINGi 9606.ENSP00000258654.

PTM databases

PhosphoSitei Q96JB2.

Polymorphism databases

DMDMi 85701302.

Proteomic databases

MaxQBi Q96JB2.
PaxDbi Q96JB2.
PRIDEi Q96JB2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000349995 ; ENSP00000258654 ; ENSG00000136152 . [Q96JB2-1 ]
ENST00000617493 ; ENSP00000481332 ; ENSG00000136152 . [Q96JB2-2 ]
GeneIDi 83548.
KEGGi hsa:83548.
UCSCi uc001vai.3. human. [Q96JB2-2 ]
uc001vak.3. human. [Q96JB2-1 ]

Organism-specific databases

CTDi 83548.
GeneCardsi GC13P046039.
H-InvDB HIX0011290.
HGNCi HGNC:18619. COG3.
HPAi HPA040353.
MIMi 606975. gene.
neXtProti NX_Q96JB2.
PharmGKBi PA38602.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG300871.
GeneTreei ENSGT00390000015682.
HOGENOMi HOG000264596.
HOVERGENi HBG051062.
InParanoidi Q96JB2.
OMAi KIPEYQQ.
OrthoDBi EOG7NGQ9R.
PhylomeDBi Q96JB2.
TreeFami TF314200.

Miscellaneous databases

ChiTaRSi COG3. human.
GeneWikii COG3.
GenomeRNAii 83548.
NextBioi 72485.
PROi Q96JB2.
SOURCEi Search...

Gene expression databases

Bgeei Q96JB2.
CleanExi HS_COG3.
Genevestigatori Q96JB2.

Family and domain databases

InterProi IPR007265. COG_su3.
[Graphical view ]
PANTHERi PTHR13302. PTHR13302. 1 hit.
Pfami PF04136. Sec34. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a human ortholog of Sec34p as a component of the cis-Golgi vesicle tethering machinery."
    Suvorova E.S., Kurten R.C., Lupashin V.V.
    J. Biol. Chem. 276:22810-22818(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Fetal brain.
  2. "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp."
    Loh E., Hong W.
    J. Biol. Chem. 277:21955-21961(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, VARIANT SER-747.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  4. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Leukocyte.
  6. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
    Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
    Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-16, ACETYLATION AT ALA-2.
    Tissue: Platelet.
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-663, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-663, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-663, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-620.

Entry informationi

Entry nameiCOG3_HUMAN
AccessioniPrimary (citable) accession number: Q96JB2
Secondary accession number(s): B2RAW5
, Q5VT70, Q8IXX4, Q9BZ92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3