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Q96JB1

- DYH8_HUMAN

UniProt

Q96JB1 - DYH8_HUMAN

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Protein

Dynein heavy chain 8, axonemal

Gene

DNAH8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1846 – 18538ATPSequence Analysis
Nucleotide bindingi2128 – 21358ATPSequence Analysis

GO - Molecular functioni

  1. ATPase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. microtubule motor activity Source: UniProtKB

GO - Biological processi

  1. cilium or flagellum-dependent cell motility Source: UniProtKB
  2. metabolic process Source: GOC
  3. microtubule-based movement Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein heavy chain 8, axonemal
Alternative name(s):
Axonemal beta dynein heavy chain 8
Ciliary dynein heavy chain 8
Gene namesi
Name:DNAH8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:2952. DNAH8.

Subcellular locationi

Cytoplasmcytoskeletoncilium axoneme By similarity

GO - Cellular componenti

  1. axonemal dynein complex Source: UniProtKB
  2. microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27405.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 44904490Dynein heavy chain 8, axonemalPRO_0000274044Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei674 – 6741Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96JB1.
PaxDbiQ96JB1.
PRIDEiQ96JB1.

PTM databases

PhosphoSiteiQ96JB1.

Expressioni

Gene expression databases

BgeeiQ96JB1.
CleanExiHS_DNAH8.
ExpressionAtlasiQ96JB1. baseline and differential.
GenevestigatoriQ96JB1.

Organism-specific databases

HPAiHPA028447.
HPA030108.

Interactioni

Subunit structurei

Consists of at least two heavy chains and a number of intermediate and light chains.

Protein-protein interaction databases

STRINGi9606.ENSP00000352312.

Structurei

3D structure databases

ProteinModelPortaliQ96JB1.
SMRiQ96JB1. Positions 1626-2270, 3144-3294, 3350-3766, 3919-4125.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1808 – 2030223AAA 1By similarityAdd
BLAST
Regioni2090 – 2309220AAA 2By similarityAdd
BLAST
Regioni2416 – 2669254AAA 3By similarityAdd
BLAST
Regioni2780 – 3034255AAA 4By similarityAdd
BLAST
Regioni3049 – 3346298StalkBy similarityAdd
BLAST
Regioni3432 – 3662231AAA 5By similarityAdd
BLAST
Regioni3877 – 4091215AAA 6By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili3072 – 316493Sequence AnalysisAdd
BLAST
Coiled coili3290 – 335465Sequence AnalysisAdd
BLAST
Coiled coili3594 – 363037Sequence AnalysisAdd
BLAST

Domaini

Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.

Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG5245.
GeneTreeiENSGT00760000118964.
HOVERGENiHBG005543.
InParanoidiQ96JB1.
PhylomeDBiQ96JB1.
TreeFamiTF316836.

Family and domain databases

Gene3Di3.40.50.300. 6 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011704. ATPase_dyneun-rel_AAA.
IPR026983. DHC_fam.
IPR024743. Dynein_HC_stalk.
IPR024317. Dynein_heavy_chain_D4_dom.
IPR004273. Dynein_heavy_dom.
IPR013594. Dynein_heavy_dom-1.
IPR013602. Dynein_heavy_dom-2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10676. PTHR10676. 1 hit.
PfamiPF07728. AAA_5. 1 hit.
PF12780. AAA_8. 1 hit.
PF08385. DHC_N1. 1 hit.
PF08393. DHC_N2. 1 hit.
PF03028. Dynein_heavy. 1 hit.
PF12777. MT. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 3 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 5 hits.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96JB1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMKLYIDNAA PDKLKGLCIF FVRCRNDVAI NVKTIQEEAL FTVLDASKGL
60 70 80 90 100
LNGIRDMLAN IFLPAVLATN NWGALNQSKQ GESEKHIFTE TINRYLSFLD
110 120 130 140 150
GARISIEGTV KLKTIDNVNF SKLHTFEEVT AAASNSETVH QLEEVLMVWY
160 170 180 190 200
KQIEQVLIES EQMRKEAGDS GPLTELEHWK RMSAKFNYII EQIKGPSCKA
210 220 230 240 250
VINVLNVAHS KLLKNWRDLD ARITDTANES KDNVRYLYTL EKVCQPLYNH
260 270 280 290 300
DLVSMAHGIQ NLINAIRMIH GVSRYYNTSE RMTSLFIKVT NQMVTACKAY
310 320 330 340 350
ITDGGLNHVW DQETPVVLKK IQDCIFLFKE YQASFHKTRK LISESSGEKS
360 370 380 390 400
FEVSEMYIFG KFEAFCKRLE KITEMITVVQ TYSTLSNSTI EGIDIMAIKF
410 420 430 440 450
RNIYQGVKKK QYDILDPRRT EFDTDFLDFM TKINGLEVQI QAFMNSSFGK
460 470 480 490 500
ILSSQQALQL LQRFQKLNIP CLGLEINHTI ERILQYYVAE LDATKKLYHS
510 520 530 540 550
QKDDPPLARN MPPIAGKILW VRQLYRRISE PINYFFKNSD ILSSPDGKAV
560 570 580 590 600
IRQYNKISYV LVEFEVVYHT AWIREISQLH YALQATLFVR HPETGKLLVN
610 620 630 640 650
FDPKILEVVR ETKCMIKMKL DVPEQAKRLL KLESKLKADK LYLQGLLQYY
660 670 680 690 700
DELCQEVPSV FVNLMTPKMK KVESVLRQGL TVLTWSSLTL ESFFQEVELV
710 720 730 740 750
LDMFNQLLKK ISDLCEMHID TVLKEIAKTV LISLPESGAT KVEDMLTLNE
760 770 780 790 800
TYTKEWADIL NHKSKHVEEA VRELISIFEQ IYEVKYTGKV GKQSEQRKHV
810 820 830 840 850
VFGSETGEGE NNDYEANIVN EFDTHDKEDE FKKECKEVFA FFSHQLLDSL
860 870 880 890 900
QKATRLSLDT MKRRIFVASL YGRKQSEDII SFIKSEVHLA IPNVVMIPSL
910 920 930 940 950
DDIQQAINRM IQLTLEVSRG VAHWGQQQIR PIKSVIPSPT TTDVTHQNTG
960 970 980 990 1000
KLLKKEERSF EEAIPARKLK NFYPGVAEHK DISKLVLLLS SSVNSLRKAA
1010 1020 1030 1040 1050
HEALQDFQKY KTLWTEDRDV KVKEFLANNP SLTEIRSEIL HYATFEQEID
1060 1070 1080 1090 1100
ELKPIIVVGA LELHTEPMKL ALSIEAKAWK MLLCRYLNEE YKKKMSYMIA
1110 1120 1130 1140 1150
FINEYLKKLS RPIRDLDDVR FAMEALSCIR DNEIQMDMTL GPIEEAYAIL
1160 1170 1180 1190 1200
NRFEVEVTKE ESEAVDTLRY SFNKLQSKAV SVQEDLVQVQ PKFKSNLLES
1210 1220 1230 1240 1250
VEVFREDVIN FAEAYELEGP MVPNIPPQEA SNRLQIFQAS FDDLWRKFVT
1260 1270 1280 1290 1300
YSSGEQLFGL PVTDYEVLHK TRKELNLLQK LYGLYDTVMS SISGYYEILW
1310 1320 1330 1340 1350
GDVDIEKINA ELLEFQNRCR KLPKGLKDWQ AFLDLKKRID DFSESCPLLE
1360 1370 1380 1390 1400
MMTNKAMKQR HWDRISELTG TPFDVESDSF CLRNIMEAPL LKHKDDIEDI
1410 1420 1430 1440 1450
CISAIKEKDI EAKLTQVIEN WTNQNLSFAA FKGKGELLLK GTESGEIITL
1460 1470 1480 1490 1500
MEDSLMVLGS LLSNRYNAPF KKNIQNWVYK LSTSSDIIEE WLVVQNLWVY
1510 1520 1530 1540 1550
LEAVFVGGDI AKQLPQEAKR FQNIDKSWIK IMQRAHENPN VINCCVGDET
1560 1570 1580 1590 1600
MGQLLPHLHE QLEVCQKSLT GYLEKKRLLF PRFFFVSDPV LLEILGQASD
1610 1620 1630 1640 1650
SHTIQPHLPA VSDNINEVTF HAKDYDRIMA VISREGEKIV LDNSVMAKGP
1660 1670 1680 1690 1700
VEIWLLDLLK MQMSSLHNII RSAFYQISDS GFQLLPFLSH FPAQVGLLGI
1710 1720 1730 1740 1750
QMLWTHDSEE ALRNAKDDRK IMQVTNQKFL DILNTLISQT THDLSKFDRV
1760 1770 1780 1790 1800
KFETLITIHV HQRDIFDDLV KMHIKSPTDF EWLKQSRFYF KEDLDQTVVS
1810 1820 1830 1840 1850
ITDVDFIYQN EFLGCTDRLV ITPLTDRCYI TLAQALGMNM GGAPAGPAGT
1860 1870 1880 1890 1900
GKTETTKDMG RCLGKYVVVF NCSDQMDFRG LGRIFKGLAQ SGSWGCFDEF
1910 1920 1930 1940 1950
NRIELPVLSV AAQQIYIVLT ARKERKKQFI FSDGDCVDLN PEFGIFLTMN
1960 1970 1980 1990 2000
PGYAGRQELP ENLKIQFRTV AMMVPDRQII MRVKLASCGF LENVILAQKF
2010 2020 2030 2040 2050
YVLYKLCEEQ LTKQVHYDFG LRNILSVLRT LGSQKRARPE DSELSIVMRG
2060 2070 2080 2090 2100
LRDMNLSKLV DEDEPLFLSL INDLFPGLQL DSNTYAELQN AVAHQVQIEG
2110 2120 2130 2140 2150
LINHPPWNLK LVQLYETSLV RHGLMTLGPS GSGKTTVITI LMKAQTECGR
2160 2170 2180 2190 2200
PHREMRMNPK AITAPQMFGR LDTATNDWTD GIFSTLWRKT LKAKKGENIF
2210 2220 2230 2240 2250
LILDGPVDAI WIENLNSVLD DNKTLTLANG DRIPMAPSCK LLFEVHNIEN
2260 2270 2280 2290 2300
ASPATVSRMG MVYISSSALS WRPILQAWLK KRTAQEAAVF LTLYEKVFED
2310 2320 2330 2340 2350
TYTYMKLNLN PKMQLLECNY IVQSLNLLEG LIPSKEEGGV SCVEHLHKLF
2360 2370 2380 2390 2400
VFGLMWSLGA LLELESREKL EAFLRQHESK LDLPEIPKGS NQTMYEFYVT
2410 2420 2430 2440 2450
DYGDWEHWNK KLQPYYYPTD SIPEYSSILV PNVDNIRTNF LIDTIAKQHK
2460 2470 2480 2490 2500
AVLLTGEQGT AKTVMVKAYL KKYDPEVQLS KSLNFSSATE PMMFQRTIES
2510 2520 2530 2540 2550
YVDKRIGSTY GPPGGRKMTV FIDDINMPVI NEWGDQITNE IVRQMMEMEG
2560 2570 2580 2590 2600
MYSLDKPGDF TTIVDVQLIA AMIHPGGGRN DIPQRLKRQF TVFNCTLPSN
2610 2620 2630 2640 2650
ASIDKIFGII GCGYFDPCRS FKPQICEMIV NLVSVGRVLW QWTKVKMLPT
2660 2670 2680 2690 2700
PSKFHYIFNL RDLSRIWQGM LTIKAEECAS IPTLLSLFKH ECSRVIADRF
2710 2720 2730 2740 2750
ITPEDEQWFN AHLTRAVEEN IGSDAASCIL PEPYFVDFLR EMPEPTGDEP
2760 2770 2780 2790 2800
EDSVFEVPKI YELMPSFDFL AEKLQFYQRQ FNEIIRGTSL DLVFFKDAMT
2810 2820 2830 2840 2850
HLIKISRIIR TSCGNALLVG VGGSGKQSLS RLASFIAGYQ IFQITLTRSY
2860 2870 2880 2890 2900
NVTNLTDDLK ALYKVAGADG KGITFIFTDS EIKDEAFLEY LNNLLSSGEI
2910 2920 2930 2940 2950
SNLFARDEMD EITQGLISVM KRELPRHPPT FDNLYEYFIS RSRKNLHVVL
2960 2970 2980 2990 3000
CFSPVGEKFR ARSLKFPGLI SGCTMDWFSR WPREALIAVA SYFLSDYNIV
3010 3020 3030 3040 3050
CSSEIKRQVV ETMGLFHDMV SESCESYFQR YRRRAHVTPK SYLSFINGYK
3060 3070 3080 3090 3100
NIYAEKVKFI NEQAERMNIG LDKLMEASES VAKLSQDLAV KEKELAVASI
3110 3120 3130 3140 3150
KADEVLAEVT VSAQASAKIK NEVQEVKDKA QKIVDEIDSE KVKAESKLEA
3160 3170 3180 3190 3200
AKPALEEAEA ALNTIKPNDI ATVRKLAKPP HLIMRIMDCV LLLFQKKIDP
3210 3220 3230 3240 3250
VTMDPEKSCC KPSWGESLKL MSATGFLWSL QQFPKDTINE ETVELLQPYF
3260 3270 3280 3290 3300
NMDDYTFESA KKVCGNVAGL LSWTLAMAIF YGINREVLPL KANLAKQEGR
3310 3320 3330 3340 3350
LAVANAELGK AQALLDEKQA ELDKVQAKFD AAMNEKMDLL NDADTCRKKM
3360 3370 3380 3390 3400
QAASTLIDGL SGEKIRWTQQ SKEFKAQINR LVGDILLCTG FLSYLGPFNQ
3410 3420 3430 3440 3450
IFRNYLLKDQ WEMELRARKI PFTENLNLIS MLVDPPTIGE WGLQGLPGDD
3460 3470 3480 3490 3500
LSIQNGIIVT KATRYPLLID PQTQGKTWIK SKEKENDLQV TSLNHKYFRT
3510 3520 3530 3540 3550
HLEDSLSLGR PLLIEDIHEE LDPALDNVLE KNFIKSGTTF KVKVGDKECD
3560 3570 3580 3590 3600
IMDTFKLYIT TKLPNPAFTP EINAKTSVID FTVTMKGLEN QLLRRVILTE
3610 3620 3630 3640 3650
KQELEAERVK LLEDVTFNKR KMKELEDNLL YKLSATKGSL VDDESLIGVL
3660 3670 3680 3690 3700
RTTKQTAAEV SEKLHVAAET EIKINAAQEE FRPAATRGSI LYFLITEMSM
3710 3720 3730 3740 3750
VNIMYQTSLA QFLKLFDQSM ARSEKSPLPQ KRITNIIEYL TYEVFTYSVR
3760 3770 3780 3790 3800
GLYENHKFLF VLLMTLKIDL QRGTVKHREF QALIKGGAAL DLKACPPKPY
3810 3820 3830 3840 3850
RWILDMTWLN LVELSKLPQF AEIMNQISRN EKGWKSWFDK DAPEEEIIPD
3860 3870 3880 3890 3900
GYNDSLDTCH KLLLIRSWCP DRTVFQARKY IADSLEEKYT EPVILNLEKT
3910 3920 3930 3940 3950
WEESDTRTPL ICFLSMGSDP TNQIDALAKK LKLECRTISM GQGQEVHARK
3960 3970 3980 3990 4000
LIQMSMQQGG WVLLQNCHLG LEFMEELLET LITTEASDDS FRVWITTEPH
4010 4020 4030 4040 4050
DRFPITLLQT SLKFTNEPPQ GVRAGLKRTF AGINQDLLDI SNLPMWKPML
4060 4070 4080 4090 4100
YTVAFLHSTV QERRKFGPLG WNIPYEFNSA DFSASVQFIQ NHLDECDIKK
4110 4120 4130 4140 4150
GVSWNTVRYM IGEVQYGGRV TDDFDKRLLN CFARVWFSEK MFEPSFCFYT
4160 4170 4180 4190 4200
GYKIPLCKTL DQYFEYIQSL PSLDNPEVFG LHPNADITYQ SNTASAVLET
4210 4220 4230 4240 4250
ITNIQPKESG GGVGETREAI VYRLSEDMLS KLPPDYIPHE VKSRLIKMGH
4260 4270 4280 4290 4300
LNSMNIFLRQ EIDRMQRVIS ILRSSLSDLK LAIEGTIIMS ENLRDALDNM
4310 4320 4330 4340 4350
YDARIPQLWK RVSWDSSTLG FWFTELLERN AQFSTWIFEG RPNVFWMTGF
4360 4370 4380 4390 4400
FNPQGFLTAM RQEVTRAHKG WALDTVTIHN EVLRQTKEEI TSPPGEGVYI
4410 4420 4430 4440 4450
YGLYMDGAAW DRRNGKLMES TPKVLFTQLP VLHIFAINST APKDPKLYVC
4460 4470 4480 4490
PIYKKPRRTD LTFITVVYLR TVLSPDHWIL RGVALLCDIK
Length:4,490
Mass (Da):514,664
Last modified:January 23, 2007 - v2
Checksum:iE5809E32FF08199B
GO
Isoform 2 (identifier: Q96JB1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1978-2013: Missing.

Show »
Length:4,454
Mass (Da):510,448
Checksum:i99F3877237ACCF7A
GO
Isoform 3 (identifier: Q96JB1-3)

Sequence is not available
Length:
Mass (Da):
Isoform 4 (identifier: Q96JB1-4)

Sequence is not available
Length:
Mass (Da):

Sequence cautioni

The sequence CAI19770.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI19821.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI19822.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI20293.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI20294.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI21587.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI21588.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI42435.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI42436.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1622 – 16221A → T in AAK60620. (PubMed:12297094)Curated
Sequence conflicti1945 – 19473IFL → VFI in CAB06060. (PubMed:9373155)Curated
Sequence conflicti3495 – 34951H → R in AAK60620. (PubMed:12297094)Curated
Sequence conflicti4118 – 41181G → D in AAK60620. (PubMed:12297094)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti71 – 711N → S.
Corresponds to variant rs6935293 [ dbSNP | Ensembl ].
VAR_030171
Natural varianti473 – 4731G → R.
Corresponds to variant rs1738254 [ dbSNP | Ensembl ].
VAR_030172
Natural varianti573 – 5731I → V.1 Publication
Corresponds to variant rs3823430 [ dbSNP | Ensembl ].
VAR_030173
Natural varianti727 – 7271A → T.
Corresponds to variant rs1678674 [ dbSNP | Ensembl ].
VAR_030174
Natural varianti807 – 8071G → E.1 Publication
Corresponds to variant rs874808 [ dbSNP | Ensembl ].
VAR_030175
Natural varianti1202 – 12021E → K.1 Publication
Corresponds to variant rs9357283 [ dbSNP | Ensembl ].
VAR_030176
Natural varianti2226 – 22261T → M in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036213
Natural varianti2444 – 24441T → N.
Corresponds to variant rs862432 [ dbSNP | Ensembl ].
VAR_030177
Natural varianti4106 – 41061T → M.
Corresponds to variant rs1537232 [ dbSNP | Ensembl ].
VAR_030178
Natural varianti4271 – 42711I → V.1 Publication
Corresponds to variant rs10484847 [ dbSNP | Ensembl ].
VAR_030179

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1978 – 201336Missing in isoform 2. CuratedVSP_022614Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF356519 mRNA. Translation: AAK60620.1.
AL035690
, AL034345, AL035555, AL353700 Genomic DNA. Translation: CAI19769.1.
AL035690
, AL034345, AL035555, AL353700, AL391415 Genomic DNA. Translation: CAI19770.1. Sequence problems.
AL035555
, AL034345, AL035690, AL353700 Genomic DNA. Translation: CAI19819.1.
AL035555
, AL034345, AL353700, AL391415 Genomic DNA. Translation: CAI19821.1. Sequence problems.
AL035555
, AL034345, AL035690, AL353700, AL391415 Genomic DNA. Translation: CAI19822.1. Sequence problems.
AL353700
, AL034345, AL035555, AL035690 Genomic DNA. Translation: CAI20292.1.
AL353700
, AL034345, AL035555, AL391415 Genomic DNA. Translation: CAI20293.1. Sequence problems.
AL353700
, AL034345, AL035555, AL035690, AL391415 Genomic DNA. Translation: CAI20294.1. Sequence problems.
AL391415
, AL034345, AL035555, AL353700 Genomic DNA. Translation: CAI21587.1. Sequence problems.
AL391415
, AL034345, AL035555, AL035690, AL353700 Genomic DNA. Translation: CAI21588.1. Sequence problems.
AL034345
, AL035555, AL035690, AL353700 Genomic DNA. Translation: CAI42433.1.
AL034345 Genomic DNA. Translation: CAI42434.1.
AL034345
, AL035555, AL353700, AL391415 Genomic DNA. Translation: CAI42435.1. Sequence problems.
AL034345
, AL035555, AL035690, AL353700, AL391415 Genomic DNA. Translation: CAI42436.1. Sequence problems.
Z83806 mRNA. Translation: CAB06060.1.
AJ132091 mRNA. Translation: CAA10564.1.
RefSeqiNP_001193856.1. NM_001206927.1.
UniGeneiHs.520106.
Hs.686107.

Genome annotation databases

EnsembliENST00000359357; ENSP00000352312; ENSG00000124721. [Q96JB1-1]
GeneIDi1769.
KEGGihsa:1769.
UCSCiuc003ooe.2. human. [Q96JB1-1]

Polymorphism databases

DMDMi124007137.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF356519 mRNA. Translation: AAK60620.1 .
AL035690
, AL034345 , AL035555 , AL353700 Genomic DNA. Translation: CAI19769.1 .
AL035690
, AL034345 , AL035555 , AL353700 , AL391415 Genomic DNA. Translation: CAI19770.1 . Sequence problems.
AL035555
, AL034345 , AL035690 , AL353700 Genomic DNA. Translation: CAI19819.1 .
AL035555
, AL034345 , AL353700 , AL391415 Genomic DNA. Translation: CAI19821.1 . Sequence problems.
AL035555
, AL034345 , AL035690 , AL353700 , AL391415 Genomic DNA. Translation: CAI19822.1 . Sequence problems.
AL353700
, AL034345 , AL035555 , AL035690 Genomic DNA. Translation: CAI20292.1 .
AL353700
, AL034345 , AL035555 , AL391415 Genomic DNA. Translation: CAI20293.1 . Sequence problems.
AL353700
, AL034345 , AL035555 , AL035690 , AL391415 Genomic DNA. Translation: CAI20294.1 . Sequence problems.
AL391415
, AL034345 , AL035555 , AL353700 Genomic DNA. Translation: CAI21587.1 . Sequence problems.
AL391415
, AL034345 , AL035555 , AL035690 , AL353700 Genomic DNA. Translation: CAI21588.1 . Sequence problems.
AL034345
, AL035555 , AL035690 , AL353700 Genomic DNA. Translation: CAI42433.1 .
AL034345 Genomic DNA. Translation: CAI42434.1 .
AL034345
, AL035555 , AL353700 , AL391415 Genomic DNA. Translation: CAI42435.1 . Sequence problems.
AL034345
, AL035555 , AL035690 , AL353700 , AL391415 Genomic DNA. Translation: CAI42436.1 . Sequence problems.
Z83806 mRNA. Translation: CAB06060.1 .
AJ132091 mRNA. Translation: CAA10564.1 .
RefSeqi NP_001193856.1. NM_001206927.1.
UniGenei Hs.520106.
Hs.686107.

3D structure databases

ProteinModelPortali Q96JB1.
SMRi Q96JB1. Positions 1626-2270, 3144-3294, 3350-3766, 3919-4125.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000352312.

PTM databases

PhosphoSitei Q96JB1.

Polymorphism databases

DMDMi 124007137.

Proteomic databases

MaxQBi Q96JB1.
PaxDbi Q96JB1.
PRIDEi Q96JB1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000359357 ; ENSP00000352312 ; ENSG00000124721 . [Q96JB1-1 ]
GeneIDi 1769.
KEGGi hsa:1769.
UCSCi uc003ooe.2. human. [Q96JB1-1 ]

Organism-specific databases

CTDi 1769.
GeneCardsi GC06P038685.
H-InvDB HIX0033271.
HGNCi HGNC:2952. DNAH8.
HPAi HPA028447.
HPA030108.
MIMi 603337. gene.
neXtProti NX_Q96JB1.
PharmGKBi PA27405.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5245.
GeneTreei ENSGT00760000118964.
HOVERGENi HBG005543.
InParanoidi Q96JB1.
PhylomeDBi Q96JB1.
TreeFami TF316836.

Miscellaneous databases

GenomeRNAii 1769.
NextBioi 7201.
PROi Q96JB1.
SOURCEi Search...

Gene expression databases

Bgeei Q96JB1.
CleanExi HS_DNAH8.
ExpressionAtlasi Q96JB1. baseline and differential.
Genevestigatori Q96JB1.

Family and domain databases

Gene3Di 3.40.50.300. 6 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011704. ATPase_dyneun-rel_AAA.
IPR026983. DHC_fam.
IPR024743. Dynein_HC_stalk.
IPR024317. Dynein_heavy_chain_D4_dom.
IPR004273. Dynein_heavy_dom.
IPR013594. Dynein_heavy_dom-1.
IPR013602. Dynein_heavy_dom-2.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR10676. PTHR10676. 1 hit.
Pfami PF07728. AAA_5. 1 hit.
PF12780. AAA_8. 1 hit.
PF08385. DHC_N1. 1 hit.
PF08393. DHC_N2. 1 hit.
PF03028. Dynein_heavy. 1 hit.
PF12777. MT. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 3 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 5 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The T complex distorter 2 candidate gene, Dnahc8, encodes at least two testis-specific axonemal dynein heavy chains that differ extensively at their amino and carboxyl termini."
    Samant S.A., Ogunkua O., Hui L., Fossella J., Pilder S.H.
    Dev. Biol. 250:24-43(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, VARIANTS VAL-573; GLU-807; LYS-1202 AND VAL-4271.
    Tissue: Testis.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene."
    Neesen J., Koehler M.R., Kirschner R., Steinlein C., Kreutzberger J., Engel W., Schmid M.
    Gene 200:193-202(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1846-1952 (ISOFORM 1).
    Tissue: Testis.
  4. "Chromosomal localization of human dynein heavy chain genes."
    Maiti A.K., Mattei M.-G., Jorissen M., Volz A., Ziegler A., Bouvagnet P.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1856-1912 (ISOFORM 1).
    Tissue: Nasal polyp.
  5. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-674, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-2226.

Entry informationi

Entry nameiDYH8_HUMAN
AccessioniPrimary (citable) accession number: Q96JB1
Secondary accession number(s): O00438
, Q5JYI2, Q5T2M3, Q5T2M4, Q5TG00, Q9UEM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3