Q96JB1 (DYH8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dynein heavy chain 8, axonemal

Alternative name(s):
Axonemal beta dynein heavy chain 8
Ciliary dynein heavy chain 8

Gene names

Name:

DNAH8

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	4490 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly By similarity.
Subunit structure	Consists of at least two heavy chains and a number of intermediate and light chains.
Subcellular location	Cytoplasm › cytoskeleton › cilium axoneme By similarity.
Domain	Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.
Sequence similarities	Belongs to the dynein heavy chain family.
Sequence caution	The sequence CAI19770.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI19821.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI19822.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI20293.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI20294.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI21587.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI21588.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI42435.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI42436.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cell projection Cilium Cytoplasm Cytoskeleton Dynein Microtubule
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Motor protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC ciliary or flagellar motility Non-traceable author statement Ref.3. Source: UniProtKB microtubule-based movement Inferred from electronic annotation. Source: InterPro
Cellular_component	axonemal dynein complex Non-traceable author statement Ref.3. Source: UniProtKB cilium axoneme Inferred from electronic annotation. Source: UniProtKB-SubCell microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: InterPro microtubule motor activity Non-traceable author statement Ref.3. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96JB1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96JB1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1978-2013: Missing.

Isoform 3 (identifier: Q96JB1-3)

The sequence of this isoform is not available.

Isoform 4 (identifier: Q96JB1-4)

The sequence of this isoform is not available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 4490	4490	Dynein heavy chain 8, axonemal		PRO_0000274044
Regions
	Nucleotide binding	1846 – 1853	8	ATP Potential
	Nucleotide binding	2128 – 2135	8	ATP Potential
	Region	1808 – 2030	223	AAA 1 By similarity
	Region	2090 – 2309	220	AAA 2 By similarity
	Region	2416 – 2669	254	AAA 3 By similarity
	Region	2780 – 3034	255	AAA 4 By similarity
	Region	3049 – 3346	298	Stalk By similarity
	Region	3432 – 3662	231	AAA 5 By similarity
	Region	3877 – 4091	215	AAA 6 By similarity
	Coiled coil	3072 – 3164	93	Potential
	Coiled coil	3290 – 3354	65	Potential
	Coiled coil	3594 – 3630	37	Potential
Amino acid modifications
	Modified residue	674	1	Phosphoserine Ref.5
Natural variations
	Alternative sequence	1978 – 2013	36	Missing in isoform 2.		VSP_022614
	Natural variant	71	1	N → S. Corresponds to variant rs6935293 [ dbSNP | Ensembl ].		VAR_030171
	Natural variant	473	1	G → R. Corresponds to variant rs1738254 [ dbSNP | Ensembl ].		VAR_030172
	Natural variant	573	1	I → V. Ref.1 Corresponds to variant rs3823430 [ dbSNP | Ensembl ].		VAR_030173
	Natural variant	727	1	A → T. Corresponds to variant rs1678674 [ dbSNP | Ensembl ].		VAR_030174
	Natural variant	807	1	G → E. Ref.1 Corresponds to variant rs874808 [ dbSNP | Ensembl ].		VAR_030175
	Natural variant	1202	1	E → K. Ref.1 Corresponds to variant rs9357283 [ dbSNP | Ensembl ].		VAR_030176
	Natural variant	2226	1	T → M in a colorectal cancer sample; somatic mutation. Ref.6		VAR_036213
	Natural variant	2444	1	T → N. Corresponds to variant rs862432 [ dbSNP | Ensembl ].		VAR_030177
	Natural variant	4106	1	T → M. Corresponds to variant rs1537232 [ dbSNP | Ensembl ].		VAR_030178
	Natural variant	4271	1	I → V. Ref.1 Corresponds to variant rs10484847 [ dbSNP | Ensembl ].		VAR_030179
Experimental info
	Sequence conflict	1622	1	A → T in AAK60620. Ref.1
	Sequence conflict	1945 – 1947	3	IFL → VFI in CAB06060. Ref.3
	Sequence conflict	3495	1	H → R in AAK60620. Ref.1
	Sequence conflict	4118	1	G → D in AAK60620. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: E5809E32FF08199B	FASTA	4,490	514,664
	10 20 30 40 50 60 MMKLYIDNAA PDKLKGLCIF FVRCRNDVAI NVKTIQEEAL FTVLDASKGL LNGIRDMLAN 70 80 90 100 110 120 IFLPAVLATN NWGALNQSKQ GESEKHIFTE TINRYLSFLD GARISIEGTV KLKTIDNVNF 130 140 150 160 170 180 SKLHTFEEVT AAASNSETVH QLEEVLMVWY KQIEQVLIES EQMRKEAGDS GPLTELEHWK 190 200 210 220 230 240 RMSAKFNYII EQIKGPSCKA VINVLNVAHS KLLKNWRDLD ARITDTANES KDNVRYLYTL 250 260 270 280 290 300 EKVCQPLYNH DLVSMAHGIQ NLINAIRMIH GVSRYYNTSE RMTSLFIKVT NQMVTACKAY 310 320 330 340 350 360 ITDGGLNHVW DQETPVVLKK IQDCIFLFKE YQASFHKTRK LISESSGEKS FEVSEMYIFG 370 380 390 400 410 420 KFEAFCKRLE KITEMITVVQ TYSTLSNSTI EGIDIMAIKF RNIYQGVKKK QYDILDPRRT 430 440 450 460 470 480 EFDTDFLDFM TKINGLEVQI QAFMNSSFGK ILSSQQALQL LQRFQKLNIP CLGLEINHTI 490 500 510 520 530 540 ERILQYYVAE LDATKKLYHS QKDDPPLARN MPPIAGKILW VRQLYRRISE PINYFFKNSD 550 560 570 580 590 600 ILSSPDGKAV IRQYNKISYV LVEFEVVYHT AWIREISQLH YALQATLFVR HPETGKLLVN 610 620 630 640 650 660 FDPKILEVVR ETKCMIKMKL DVPEQAKRLL KLESKLKADK LYLQGLLQYY DELCQEVPSV 670 680 690 700 710 720 FVNLMTPKMK KVESVLRQGL TVLTWSSLTL ESFFQEVELV LDMFNQLLKK ISDLCEMHID 730 740 750 760 770 780 TVLKEIAKTV LISLPESGAT KVEDMLTLNE TYTKEWADIL NHKSKHVEEA VRELISIFEQ 790 800 810 820 830 840 IYEVKYTGKV GKQSEQRKHV VFGSETGEGE NNDYEANIVN EFDTHDKEDE FKKECKEVFA 850 860 870 880 890 900 FFSHQLLDSL QKATRLSLDT MKRRIFVASL YGRKQSEDII SFIKSEVHLA IPNVVMIPSL 910 920 930 940 950 960 DDIQQAINRM IQLTLEVSRG VAHWGQQQIR PIKSVIPSPT TTDVTHQNTG KLLKKEERSF 970 980 990 1000 1010 1020 EEAIPARKLK NFYPGVAEHK DISKLVLLLS SSVNSLRKAA HEALQDFQKY KTLWTEDRDV 1030 1040 1050 1060 1070 1080 KVKEFLANNP SLTEIRSEIL HYATFEQEID ELKPIIVVGA LELHTEPMKL ALSIEAKAWK 1090 1100 1110 1120 1130 1140 MLLCRYLNEE YKKKMSYMIA FINEYLKKLS RPIRDLDDVR FAMEALSCIR DNEIQMDMTL 1150 1160 1170 1180 1190 1200 GPIEEAYAIL NRFEVEVTKE ESEAVDTLRY SFNKLQSKAV SVQEDLVQVQ PKFKSNLLES 1210 1220 1230 1240 1250 1260 VEVFREDVIN FAEAYELEGP MVPNIPPQEA SNRLQIFQAS FDDLWRKFVT YSSGEQLFGL 1270 1280 1290 1300 1310 1320 PVTDYEVLHK TRKELNLLQK LYGLYDTVMS SISGYYEILW GDVDIEKINA ELLEFQNRCR 1330 1340 1350 1360 1370 1380 KLPKGLKDWQ AFLDLKKRID DFSESCPLLE MMTNKAMKQR HWDRISELTG TPFDVESDSF 1390 1400 1410 1420 1430 1440 CLRNIMEAPL LKHKDDIEDI CISAIKEKDI EAKLTQVIEN WTNQNLSFAA FKGKGELLLK 1450 1460 1470 1480 1490 1500 GTESGEIITL MEDSLMVLGS LLSNRYNAPF KKNIQNWVYK LSTSSDIIEE WLVVQNLWVY 1510 1520 1530 1540 1550 1560 LEAVFVGGDI AKQLPQEAKR FQNIDKSWIK IMQRAHENPN VINCCVGDET MGQLLPHLHE 1570 1580 1590 1600 1610 1620 QLEVCQKSLT GYLEKKRLLF PRFFFVSDPV LLEILGQASD SHTIQPHLPA VSDNINEVTF 1630 1640 1650 1660 1670 1680 HAKDYDRIMA VISREGEKIV LDNSVMAKGP VEIWLLDLLK MQMSSLHNII RSAFYQISDS 1690 1700 1710 1720 1730 1740 GFQLLPFLSH FPAQVGLLGI QMLWTHDSEE ALRNAKDDRK IMQVTNQKFL DILNTLISQT 1750 1760 1770 1780 1790 1800 THDLSKFDRV KFETLITIHV HQRDIFDDLV KMHIKSPTDF EWLKQSRFYF KEDLDQTVVS 1810 1820 1830 1840 1850 1860 ITDVDFIYQN EFLGCTDRLV ITPLTDRCYI TLAQALGMNM GGAPAGPAGT GKTETTKDMG 1870 1880 1890 1900 1910 1920 RCLGKYVVVF NCSDQMDFRG LGRIFKGLAQ SGSWGCFDEF NRIELPVLSV AAQQIYIVLT 1930 1940 1950 1960 1970 1980 ARKERKKQFI FSDGDCVDLN PEFGIFLTMN PGYAGRQELP ENLKIQFRTV AMMVPDRQII 1990 2000 2010 2020 2030 2040 MRVKLASCGF LENVILAQKF YVLYKLCEEQ LTKQVHYDFG LRNILSVLRT LGSQKRARPE 2050 2060 2070 2080 2090 2100 DSELSIVMRG LRDMNLSKLV DEDEPLFLSL INDLFPGLQL DSNTYAELQN AVAHQVQIEG 2110 2120 2130 2140 2150 2160 LINHPPWNLK LVQLYETSLV RHGLMTLGPS GSGKTTVITI LMKAQTECGR PHREMRMNPK 2170 2180 2190 2200 2210 2220 AITAPQMFGR LDTATNDWTD GIFSTLWRKT LKAKKGENIF LILDGPVDAI WIENLNSVLD 2230 2240 2250 2260 2270 2280 DNKTLTLANG DRIPMAPSCK LLFEVHNIEN ASPATVSRMG MVYISSSALS WRPILQAWLK 2290 2300 2310 2320 2330 2340 KRTAQEAAVF LTLYEKVFED TYTYMKLNLN PKMQLLECNY IVQSLNLLEG LIPSKEEGGV 2350 2360 2370 2380 2390 2400 SCVEHLHKLF VFGLMWSLGA LLELESREKL EAFLRQHESK LDLPEIPKGS NQTMYEFYVT 2410 2420 2430 2440 2450 2460 DYGDWEHWNK KLQPYYYPTD SIPEYSSILV PNVDNIRTNF LIDTIAKQHK AVLLTGEQGT 2470 2480 2490 2500 2510 2520 AKTVMVKAYL KKYDPEVQLS KSLNFSSATE PMMFQRTIES YVDKRIGSTY GPPGGRKMTV 2530 2540 2550 2560 2570 2580 FIDDINMPVI NEWGDQITNE IVRQMMEMEG MYSLDKPGDF TTIVDVQLIA AMIHPGGGRN 2590 2600 2610 2620 2630 2640 DIPQRLKRQF TVFNCTLPSN ASIDKIFGII GCGYFDPCRS FKPQICEMIV NLVSVGRVLW 2650 2660 2670 2680 2690 2700 QWTKVKMLPT PSKFHYIFNL RDLSRIWQGM LTIKAEECAS IPTLLSLFKH ECSRVIADRF 2710 2720 2730 2740 2750 2760 ITPEDEQWFN AHLTRAVEEN IGSDAASCIL PEPYFVDFLR EMPEPTGDEP EDSVFEVPKI 2770 2780 2790 2800 2810 2820 YELMPSFDFL AEKLQFYQRQ FNEIIRGTSL DLVFFKDAMT HLIKISRIIR TSCGNALLVG 2830 2840 2850 2860 2870 2880 VGGSGKQSLS RLASFIAGYQ IFQITLTRSY NVTNLTDDLK ALYKVAGADG KGITFIFTDS 2890 2900 2910 2920 2930 2940 EIKDEAFLEY LNNLLSSGEI SNLFARDEMD EITQGLISVM KRELPRHPPT FDNLYEYFIS 2950 2960 2970 2980 2990 3000 RSRKNLHVVL CFSPVGEKFR ARSLKFPGLI SGCTMDWFSR WPREALIAVA SYFLSDYNIV 3010 3020 3030 3040 3050 3060 CSSEIKRQVV ETMGLFHDMV SESCESYFQR YRRRAHVTPK SYLSFINGYK NIYAEKVKFI 3070 3080 3090 3100 3110 3120 NEQAERMNIG LDKLMEASES VAKLSQDLAV KEKELAVASI KADEVLAEVT VSAQASAKIK 3130 3140 3150 3160 3170 3180 NEVQEVKDKA QKIVDEIDSE KVKAESKLEA AKPALEEAEA ALNTIKPNDI ATVRKLAKPP 3190 3200 3210 3220 3230 3240 HLIMRIMDCV LLLFQKKIDP VTMDPEKSCC KPSWGESLKL MSATGFLWSL QQFPKDTINE 3250 3260 3270 3280 3290 3300 ETVELLQPYF NMDDYTFESA KKVCGNVAGL LSWTLAMAIF YGINREVLPL KANLAKQEGR 3310 3320 3330 3340 3350 3360 LAVANAELGK AQALLDEKQA ELDKVQAKFD AAMNEKMDLL NDADTCRKKM QAASTLIDGL 3370 3380 3390 3400 3410 3420 SGEKIRWTQQ SKEFKAQINR LVGDILLCTG FLSYLGPFNQ IFRNYLLKDQ WEMELRARKI 3430 3440 3450 3460 3470 3480 PFTENLNLIS MLVDPPTIGE WGLQGLPGDD LSIQNGIIVT KATRYPLLID PQTQGKTWIK 3490 3500 3510 3520 3530 3540 SKEKENDLQV TSLNHKYFRT HLEDSLSLGR PLLIEDIHEE LDPALDNVLE KNFIKSGTTF 3550 3560 3570 3580 3590 3600 KVKVGDKECD IMDTFKLYIT TKLPNPAFTP EINAKTSVID FTVTMKGLEN QLLRRVILTE 3610 3620 3630 3640 3650 3660 KQELEAERVK LLEDVTFNKR KMKELEDNLL YKLSATKGSL VDDESLIGVL RTTKQTAAEV 3670 3680 3690 3700 3710 3720 SEKLHVAAET EIKINAAQEE FRPAATRGSI LYFLITEMSM VNIMYQTSLA QFLKLFDQSM 3730 3740 3750 3760 3770 3780 ARSEKSPLPQ KRITNIIEYL TYEVFTYSVR GLYENHKFLF VLLMTLKIDL QRGTVKHREF 3790 3800 3810 3820 3830 3840 QALIKGGAAL DLKACPPKPY RWILDMTWLN LVELSKLPQF AEIMNQISRN EKGWKSWFDK 3850 3860 3870 3880 3890 3900 DAPEEEIIPD GYNDSLDTCH KLLLIRSWCP DRTVFQARKY IADSLEEKYT EPVILNLEKT 3910 3920 3930 3940 3950 3960 WEESDTRTPL ICFLSMGSDP TNQIDALAKK LKLECRTISM GQGQEVHARK LIQMSMQQGG 3970 3980 3990 4000 4010 4020 WVLLQNCHLG LEFMEELLET LITTEASDDS FRVWITTEPH DRFPITLLQT SLKFTNEPPQ 4030 4040 4050 4060 4070 4080 GVRAGLKRTF AGINQDLLDI SNLPMWKPML YTVAFLHSTV QERRKFGPLG WNIPYEFNSA 4090 4100 4110 4120 4130 4140 DFSASVQFIQ NHLDECDIKK GVSWNTVRYM IGEVQYGGRV TDDFDKRLLN CFARVWFSEK 4150 4160 4170 4180 4190 4200 MFEPSFCFYT GYKIPLCKTL DQYFEYIQSL PSLDNPEVFG LHPNADITYQ SNTASAVLET 4210 4220 4230 4240 4250 4260 ITNIQPKESG GGVGETREAI VYRLSEDMLS KLPPDYIPHE VKSRLIKMGH LNSMNIFLRQ 4270 4280 4290 4300 4310 4320 EIDRMQRVIS ILRSSLSDLK LAIEGTIIMS ENLRDALDNM YDARIPQLWK RVSWDSSTLG 4330 4340 4350 4360 4370 4380 FWFTELLERN AQFSTWIFEG RPNVFWMTGF FNPQGFLTAM RQEVTRAHKG WALDTVTIHN 4390 4400 4410 4420 4430 4440 EVLRQTKEEI TSPPGEGVYI YGLYMDGAAW DRRNGKLMES TPKVLFTQLP VLHIFAINST 4450 4460 4470 4480 4490 APKDPKLYVC PIYKKPRRTD LTFITVVYLR TVLSPDHWIL RGVALLCDIK
	Isoform 2 [UniParc]. Checksum: 99F3877237ACCF7A	FASTA	4,454	510,448
	10 20 30 40 50 60 MMKLYIDNAA PDKLKGLCIF FVRCRNDVAI NVKTIQEEAL FTVLDASKGL LNGIRDMLAN 70 80 90 100 110 120 IFLPAVLATN NWGALNQSKQ GESEKHIFTE TINRYLSFLD GARISIEGTV KLKTIDNVNF 130 140 150 160 170 180 SKLHTFEEVT AAASNSETVH QLEEVLMVWY KQIEQVLIES EQMRKEAGDS GPLTELEHWK 190 200 210 220 230 240 RMSAKFNYII EQIKGPSCKA VINVLNVAHS KLLKNWRDLD ARITDTANES KDNVRYLYTL 250 260 270 280 290 300 EKVCQPLYNH DLVSMAHGIQ NLINAIRMIH GVSRYYNTSE RMTSLFIKVT NQMVTACKAY 310 320 330 340 350 360 ITDGGLNHVW DQETPVVLKK IQDCIFLFKE YQASFHKTRK LISESSGEKS FEVSEMYIFG 370 380 390 400 410 420 KFEAFCKRLE KITEMITVVQ TYSTLSNSTI EGIDIMAIKF RNIYQGVKKK QYDILDPRRT 430 440 450 460 470 480 EFDTDFLDFM TKINGLEVQI QAFMNSSFGK ILSSQQALQL LQRFQKLNIP CLGLEINHTI 490 500 510 520 530 540 ERILQYYVAE LDATKKLYHS QKDDPPLARN MPPIAGKILW VRQLYRRISE PINYFFKNSD 550 560 570 580 590 600 ILSSPDGKAV IRQYNKISYV LVEFEVVYHT AWIREISQLH YALQATLFVR HPETGKLLVN 610 620 630 640 650 660 FDPKILEVVR ETKCMIKMKL DVPEQAKRLL KLESKLKADK LYLQGLLQYY DELCQEVPSV 670 680 690 700 710 720 FVNLMTPKMK KVESVLRQGL TVLTWSSLTL ESFFQEVELV LDMFNQLLKK ISDLCEMHID 730 740 750 760 770 780 TVLKEIAKTV LISLPESGAT KVEDMLTLNE TYTKEWADIL NHKSKHVEEA VRELISIFEQ 790 800 810 820 830 840 IYEVKYTGKV GKQSEQRKHV VFGSETGEGE NNDYEANIVN EFDTHDKEDE FKKECKEVFA 850 860 870 880 890 900 FFSHQLLDSL QKATRLSLDT MKRRIFVASL YGRKQSEDII SFIKSEVHLA IPNVVMIPSL 910 920 930 940 950 960 DDIQQAINRM IQLTLEVSRG VAHWGQQQIR PIKSVIPSPT TTDVTHQNTG KLLKKEERSF 970 980 990 1000 1010 1020 EEAIPARKLK NFYPGVAEHK DISKLVLLLS SSVNSLRKAA HEALQDFQKY KTLWTEDRDV 1030 1040 1050 1060 1070 1080 KVKEFLANNP SLTEIRSEIL HYATFEQEID ELKPIIVVGA LELHTEPMKL ALSIEAKAWK 1090 1100 1110 1120 1130 1140 MLLCRYLNEE YKKKMSYMIA FINEYLKKLS RPIRDLDDVR FAMEALSCIR DNEIQMDMTL 1150 1160 1170 1180 1190 1200 GPIEEAYAIL NRFEVEVTKE ESEAVDTLRY SFNKLQSKAV SVQEDLVQVQ PKFKSNLLES 1210 1220 1230 1240 1250 1260 VEVFREDVIN FAEAYELEGP MVPNIPPQEA SNRLQIFQAS FDDLWRKFVT YSSGEQLFGL 1270 1280 1290 1300 1310 1320 PVTDYEVLHK TRKELNLLQK LYGLYDTVMS SISGYYEILW GDVDIEKINA ELLEFQNRCR 1330 1340 1350 1360 1370 1380 KLPKGLKDWQ AFLDLKKRID DFSESCPLLE MMTNKAMKQR HWDRISELTG TPFDVESDSF 1390 1400 1410 1420 1430 1440 CLRNIMEAPL LKHKDDIEDI CISAIKEKDI EAKLTQVIEN WTNQNLSFAA FKGKGELLLK 1450 1460 1470 1480 1490 1500 GTESGEIITL MEDSLMVLGS LLSNRYNAPF KKNIQNWVYK LSTSSDIIEE WLVVQNLWVY 1510 1520 1530 1540 1550 1560 LEAVFVGGDI AKQLPQEAKR FQNIDKSWIK IMQRAHENPN VINCCVGDET MGQLLPHLHE 1570 1580 1590 1600 1610 1620 QLEVCQKSLT GYLEKKRLLF PRFFFVSDPV LLEILGQASD SHTIQPHLPA VSDNINEVTF 1630 1640 1650 1660 1670 1680 HAKDYDRIMA VISREGEKIV LDNSVMAKGP VEIWLLDLLK MQMSSLHNII RSAFYQISDS 1690 1700 1710 1720 1730 1740 GFQLLPFLSH FPAQVGLLGI QMLWTHDSEE ALRNAKDDRK IMQVTNQKFL DILNTLISQT 1750 1760 1770 1780 1790 1800 THDLSKFDRV KFETLITIHV HQRDIFDDLV KMHIKSPTDF EWLKQSRFYF KEDLDQTVVS 1810 1820 1830 1840 1850 1860 ITDVDFIYQN EFLGCTDRLV ITPLTDRCYI TLAQALGMNM GGAPAGPAGT GKTETTKDMG 1870 1880 1890 1900 1910 1920 RCLGKYVVVF NCSDQMDFRG LGRIFKGLAQ SGSWGCFDEF NRIELPVLSV AAQQIYIVLT 1930 1940 1950 1960 1970 1980 ARKERKKQFI FSDGDCVDLN PEFGIFLTMN PGYAGRQELP ENLKIQFRTV AMMVPDRQVH 1990 2000 2010 2020 2030 2040 YDFGLRNILS VLRTLGSQKR ARPEDSELSI VMRGLRDMNL SKLVDEDEPL FLSLINDLFP 2050 2060 2070 2080 2090 2100 GLQLDSNTYA ELQNAVAHQV QIEGLINHPP WNLKLVQLYE TSLVRHGLMT LGPSGSGKTT 2110 2120 2130 2140 2150 2160 VITILMKAQT ECGRPHREMR MNPKAITAPQ MFGRLDTATN DWTDGIFSTL WRKTLKAKKG 2170 2180 2190 2200 2210 2220 ENIFLILDGP VDAIWIENLN SVLDDNKTLT LANGDRIPMA PSCKLLFEVH NIENASPATV 2230 2240 2250 2260 2270 2280 SRMGMVYISS SALSWRPILQ AWLKKRTAQE AAVFLTLYEK VFEDTYTYMK LNLNPKMQLL 2290 2300 2310 2320 2330 2340 ECNYIVQSLN LLEGLIPSKE EGGVSCVEHL HKLFVFGLMW SLGALLELES REKLEAFLRQ 2350 2360 2370 2380 2390 2400 HESKLDLPEI PKGSNQTMYE FYVTDYGDWE HWNKKLQPYY YPTDSIPEYS SILVPNVDNI 2410 2420 2430 2440 2450 2460 RTNFLIDTIA KQHKAVLLTG EQGTAKTVMV KAYLKKYDPE VQLSKSLNFS SATEPMMFQR 2470 2480 2490 2500 2510 2520 TIESYVDKRI GSTYGPPGGR KMTVFIDDIN MPVINEWGDQ ITNEIVRQMM EMEGMYSLDK 2530 2540 2550 2560 2570 2580 PGDFTTIVDV QLIAAMIHPG GGRNDIPQRL KRQFTVFNCT LPSNASIDKI FGIIGCGYFD 2590 2600 2610 2620 2630 2640 PCRSFKPQIC EMIVNLVSVG RVLWQWTKVK MLPTPSKFHY IFNLRDLSRI WQGMLTIKAE 2650 2660 2670 2680 2690 2700 ECASIPTLLS LFKHECSRVI ADRFITPEDE QWFNAHLTRA VEENIGSDAA SCILPEPYFV 2710 2720 2730 2740 2750 2760 DFLREMPEPT GDEPEDSVFE VPKIYELMPS FDFLAEKLQF YQRQFNEIIR GTSLDLVFFK 2770 2780 2790 2800 2810 2820 DAMTHLIKIS RIIRTSCGNA LLVGVGGSGK QSLSRLASFI AGYQIFQITL TRSYNVTNLT 2830 2840 2850 2860 2870 2880 DDLKALYKVA GADGKGITFI FTDSEIKDEA FLEYLNNLLS SGEISNLFAR DEMDEITQGL 2890 2900 2910 2920 2930 2940 ISVMKRELPR HPPTFDNLYE YFISRSRKNL HVVLCFSPVG EKFRARSLKF PGLISGCTMD 2950 2960 2970 2980 2990 3000 WFSRWPREAL IAVASYFLSD YNIVCSSEIK RQVVETMGLF HDMVSESCES YFQRYRRRAH 3010 3020 3030 3040 3050 3060 VTPKSYLSFI NGYKNIYAEK VKFINEQAER MNIGLDKLME ASESVAKLSQ DLAVKEKELA 3070 3080 3090 3100 3110 3120 VASIKADEVL AEVTVSAQAS AKIKNEVQEV KDKAQKIVDE IDSEKVKAES KLEAAKPALE 3130 3140 3150 3160 3170 3180 EAEAALNTIK PNDIATVRKL AKPPHLIMRI MDCVLLLFQK KIDPVTMDPE KSCCKPSWGE 3190 3200 3210 3220 3230 3240 SLKLMSATGF LWSLQQFPKD TINEETVELL QPYFNMDDYT FESAKKVCGN VAGLLSWTLA 3250 3260 3270 3280 3290 3300 MAIFYGINRE VLPLKANLAK QEGRLAVANA ELGKAQALLD EKQAELDKVQ AKFDAAMNEK 3310 3320 3330 3340 3350 3360 MDLLNDADTC RKKMQAASTL IDGLSGEKIR WTQQSKEFKA QINRLVGDIL LCTGFLSYLG 3370 3380 3390 3400 3410 3420 PFNQIFRNYL LKDQWEMELR ARKIPFTENL NLISMLVDPP TIGEWGLQGL PGDDLSIQNG 3430 3440 3450 3460 3470 3480 IIVTKATRYP LLIDPQTQGK TWIKSKEKEN DLQVTSLNHK YFRTHLEDSL SLGRPLLIED 3490 3500 3510 3520 3530 3540 IHEELDPALD NVLEKNFIKS GTTFKVKVGD KECDIMDTFK LYITTKLPNP AFTPEINAKT 3550 3560 3570 3580 3590 3600 SVIDFTVTMK GLENQLLRRV ILTEKQELEA ERVKLLEDVT FNKRKMKELE DNLLYKLSAT 3610 3620 3630 3640 3650 3660 KGSLVDDESL IGVLRTTKQT AAEVSEKLHV AAETEIKINA AQEEFRPAAT RGSILYFLIT 3670 3680 3690 3700 3710 3720 EMSMVNIMYQ TSLAQFLKLF DQSMARSEKS PLPQKRITNI IEYLTYEVFT YSVRGLYENH 3730 3740 3750 3760 3770 3780 KFLFVLLMTL KIDLQRGTVK HREFQALIKG GAALDLKACP PKPYRWILDM TWLNLVELSK 3790 3800 3810 3820 3830 3840 LPQFAEIMNQ ISRNEKGWKS WFDKDAPEEE IIPDGYNDSL DTCHKLLLIR SWCPDRTVFQ 3850 3860 3870 3880 3890 3900 ARKYIADSLE EKYTEPVILN LEKTWEESDT RTPLICFLSM GSDPTNQIDA LAKKLKLECR 3910 3920 3930 3940 3950 3960 TISMGQGQEV HARKLIQMSM QQGGWVLLQN CHLGLEFMEE LLETLITTEA SDDSFRVWIT 3970 3980 3990 4000 4010 4020 TEPHDRFPIT LLQTSLKFTN EPPQGVRAGL KRTFAGINQD LLDISNLPMW KPMLYTVAFL 4030 4040 4050 4060 4070 4080 HSTVQERRKF GPLGWNIPYE FNSADFSASV QFIQNHLDEC DIKKGVSWNT VRYMIGEVQY 4090 4100 4110 4120 4130 4140 GGRVTDDFDK RLLNCFARVW FSEKMFEPSF CFYTGYKIPL CKTLDQYFEY IQSLPSLDNP 4150 4160 4170 4180 4190 4200 EVFGLHPNAD ITYQSNTASA VLETITNIQP KESGGGVGET REAIVYRLSE DMLSKLPPDY 4210 4220 4230 4240 4250 4260 IPHEVKSRLI KMGHLNSMNI FLRQEIDRMQ RVISILRSSL SDLKLAIEGT IIMSENLRDA 4270 4280 4290 4300 4310 4320 LDNMYDARIP QLWKRVSWDS STLGFWFTEL LERNAQFSTW IFEGRPNVFW MTGFFNPQGF 4330 4340 4350 4360 4370 4380 LTAMRQEVTR AHKGWALDTV TIHNEVLRQT KEEITSPPGE GVYIYGLYMD GAAWDRRNGK 4390 4400 4410 4420 4430 4440 LMESTPKVLF TQLPVLHIFA INSTAPKDPK LYVCPIYKKP RRTDLTFITV VYLRTVLSPD 4450 HWILRGVALL CDIK
	Isoform 3 (Sequence not available).		–	–
	Isoform 4 (Sequence not available).		–	–

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The T complex distorter 2 candidate gene, Dnahc8, encodes at least two testis-specific axonemal dynein heavy chains that differ extensively at their amino and carboxyl termini." Samant S.A., Ogunkua O., Hui L., Fossella J., Pilder S.H. Dev. Biol. 250:24-43(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, VARIANTS VAL-573; GLU-807; LYS-1202 AND VAL-4271. Tissue: Testis.
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene." Neesen J., Koehler M.R., Kirschner R., Steinlein C., Kreutzberger J., Engel W., Schmid M. Gene 200:193-202(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1846-1952 (ISOFORM 1). Tissue: Testis.
[4]	"Chromosomal localization of human dynein heavy chain genes." Maiti A.K., Mattei M.-G., Jorissen M., Volz A., Ziegler A., Bouvagnet P. Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1856-1912 (ISOFORM 1). Tissue: Nasal polyp.
[5]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-674, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-2226.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF356519 mRNA. Translation: AAK60620.1. AL035690 , AL034345, AL035555, AL353700 Genomic DNA. Translation: CAI19769.1. AL035690 , AL034345, AL035555, AL353700, AL391415 Genomic DNA. Translation: CAI19770.1. Sequence problems. AL035555 , AL034345, AL035690, AL353700 Genomic DNA. Translation: CAI19819.1. AL035555 , AL034345, AL353700, AL391415 Genomic DNA. Translation: CAI19821.1. Sequence problems. AL035555 , AL034345, AL035690, AL353700, AL391415 Genomic DNA. Translation: CAI19822.1. Sequence problems. AL353700 , AL034345, AL035555, AL035690 Genomic DNA. Translation: CAI20292.1. AL353700 , AL034345, AL035555, AL391415 Genomic DNA. Translation: CAI20293.1. Sequence problems. AL353700 , AL034345, AL035555, AL035690, AL391415 Genomic DNA. Translation: CAI20294.1. Sequence problems. AL391415 , AL034345, AL035555, AL353700 Genomic DNA. Translation: CAI21587.1. Sequence problems. AL391415 , AL034345, AL035555, AL035690, AL353700 Genomic DNA. Translation: CAI21588.1. Sequence problems. AL034345 , AL035555, AL035690, AL353700 Genomic DNA. Translation: CAI42433.1. AL034345 Genomic DNA. Translation: CAI42434.1. AL034345 , AL035555, AL353700, AL391415 Genomic DNA. Translation: CAI42435.1. Sequence problems. AL034345 , AL035555, AL035690, AL353700, AL391415 Genomic DNA. Translation: CAI42436.1. Sequence problems. Z83806 mRNA. Translation: CAB06060.1. AJ132091 mRNA. Translation: CAA10564.1.
IPI	IPI00014845. IPI00478021.
RefSeq	NP_001193856.1. NM_001206927.1.
UniGene	Hs.520106. Hs.686107.
3D structure databases
ProteinModelPortal	Q96JB1.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000352312.
PTM databases
PhosphoSite	Q96JB1.
Polymorphism databases
DMDM	124007137.
Proteomic databases
PaxDb	Q96JB1.
PRIDE	Q96JB1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000327475; ENSP00000333363; ENSG00000124721. ENST00000359357; ENSP00000352312; ENSG00000124721. ENST00000441566; ENSP00000402294; ENSG00000124721.
GeneID	1769.
KEGG	hsa:1769.
UCSC	uc003ooe.2. human.
Organism-specific databases
CTD	1769.
GeneCards	GC06P038685.
H-InvDB	HIX0033271.
HGNC	HGNC:2952. DNAH8.
HPA	HPA028447. HPA030108.
MIM	603337. gene.
neXtProt	NX_Q96JB1.
PharmGKB	PA27405.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5245.
HOVERGEN	HBG005543.
InParanoid	Q96JB1.
OrthoDB	EOG4JDH5V.
Gene expression databases
ArrayExpress	Q96JB1.
Bgee	Q96JB1.
CleanEx	HS_DNAH8.
Genevestigator	Q96JB1.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR011704. ATPase_dyneun-rel_AAA. IPR026983. DHC_fam. IPR024743. Dynein_HC_stalk. IPR024317. Dynein_heavy_chain_D4_dom. IPR004273. Dynein_heavy_dom. IPR013594. Dynein_heavy_dom-1. IPR013602. Dynein_heavy_dom-2. [Graphical view]
PANTHER	PTHR10676. PTHR10676. 1 hit.
Pfam	PF07728. AAA_5. 1 hit. PF12780. AAA_8. 1 hit. PF08385. DHC_N1. 1 hit. PF08393. DHC_N2. 1 hit. PF03028. Dynein_heavy. 1 hit. PF12777. MT. 1 hit. [Graphical view]
SMART	SM00382. AAA. 3 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	1769.
NextBio	7201.
SOURCE	Search...

Entry information

Entry name

DYH8_HUMAN

Accession

Primary (citable) accession number: Q96JB1
Secondary accession number(s): O00438 , Q5JYI2, Q5T2M3, Q5T2M4, Q5TG00, Q9UEM4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.