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Q96JB1 (DYH8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dynein heavy chain 8, axonemal
Alternative name(s):
Axonemal beta dynein heavy chain 8
Ciliary dynein heavy chain 8
Gene names
Name:DNAH8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length4490 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly By similarity.

Subunit structure

Consists of at least two heavy chains and a number of intermediate and light chains.

Subcellular location

Cytoplasmcytoskeletoncilium axoneme By similarity.

Domain

Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.

Sequence similarities

Belongs to the dynein heavy chain family.

Sequence caution

The sequence CAI19770.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI19821.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI19822.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI20293.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI20294.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI21587.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI21588.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI42435.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI42436.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96JB1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96JB1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1978-2013: Missing.
Isoform 3 (identifier: Q96JB1-3)

The sequence of this isoform is not available.
Isoform 4 (identifier: Q96JB1-4)

The sequence of this isoform is not available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 44904490Dynein heavy chain 8, axonemal
PRO_0000274044

Regions

Nucleotide binding1846 – 18538ATP Potential
Nucleotide binding2128 – 21358ATP Potential
Region1808 – 2030223AAA 1 By similarity
Region2090 – 2309220AAA 2 By similarity
Region2416 – 2669254AAA 3 By similarity
Region2780 – 3034255AAA 4 By similarity
Region3049 – 3346298Stalk By similarity
Region3432 – 3662231AAA 5 By similarity
Region3877 – 4091215AAA 6 By similarity
Coiled coil3072 – 316493 Potential
Coiled coil3290 – 335465 Potential
Coiled coil3594 – 363037 Potential

Amino acid modifications

Modified residue6741Phosphoserine Ref.5

Natural variations

Alternative sequence1978 – 201336Missing in isoform 2.
VSP_022614
Natural variant711N → S.
Corresponds to variant rs6935293 [ dbSNP | Ensembl ].
VAR_030171
Natural variant4731G → R.
Corresponds to variant rs1738254 [ dbSNP | Ensembl ].
VAR_030172
Natural variant5731I → V. Ref.1
Corresponds to variant rs3823430 [ dbSNP | Ensembl ].
VAR_030173
Natural variant7271A → T.
Corresponds to variant rs1678674 [ dbSNP | Ensembl ].
VAR_030174
Natural variant8071G → E. Ref.1
Corresponds to variant rs874808 [ dbSNP | Ensembl ].
VAR_030175
Natural variant12021E → K. Ref.1
Corresponds to variant rs9357283 [ dbSNP | Ensembl ].
VAR_030176
Natural variant22261T → M in a colorectal cancer sample; somatic mutation. Ref.6
VAR_036213
Natural variant24441T → N.
Corresponds to variant rs862432 [ dbSNP | Ensembl ].
VAR_030177
Natural variant41061T → M.
Corresponds to variant rs1537232 [ dbSNP | Ensembl ].
VAR_030178
Natural variant42711I → V. Ref.1
Corresponds to variant rs10484847 [ dbSNP | Ensembl ].
VAR_030179

Experimental info

Sequence conflict16221A → T in AAK60620. Ref.1
Sequence conflict1945 – 19473IFL → VFI in CAB06060. Ref.3
Sequence conflict34951H → R in AAK60620. Ref.1
Sequence conflict41181G → D in AAK60620. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: E5809E32FF08199B

FASTA4,490514,664
        10         20         30         40         50         60 
MMKLYIDNAA PDKLKGLCIF FVRCRNDVAI NVKTIQEEAL FTVLDASKGL LNGIRDMLAN 

        70         80         90        100        110        120 
IFLPAVLATN NWGALNQSKQ GESEKHIFTE TINRYLSFLD GARISIEGTV KLKTIDNVNF 

       130        140        150        160        170        180 
SKLHTFEEVT AAASNSETVH QLEEVLMVWY KQIEQVLIES EQMRKEAGDS GPLTELEHWK 

       190        200        210        220        230        240 
RMSAKFNYII EQIKGPSCKA VINVLNVAHS KLLKNWRDLD ARITDTANES KDNVRYLYTL 

       250        260        270        280        290        300 
EKVCQPLYNH DLVSMAHGIQ NLINAIRMIH GVSRYYNTSE RMTSLFIKVT NQMVTACKAY 

       310        320        330        340        350        360 
ITDGGLNHVW DQETPVVLKK IQDCIFLFKE YQASFHKTRK LISESSGEKS FEVSEMYIFG 

       370        380        390        400        410        420 
KFEAFCKRLE KITEMITVVQ TYSTLSNSTI EGIDIMAIKF RNIYQGVKKK QYDILDPRRT 

       430        440        450        460        470        480 
EFDTDFLDFM TKINGLEVQI QAFMNSSFGK ILSSQQALQL LQRFQKLNIP CLGLEINHTI 

       490        500        510        520        530        540 
ERILQYYVAE LDATKKLYHS QKDDPPLARN MPPIAGKILW VRQLYRRISE PINYFFKNSD 

       550        560        570        580        590        600 
ILSSPDGKAV IRQYNKISYV LVEFEVVYHT AWIREISQLH YALQATLFVR HPETGKLLVN 

       610        620        630        640        650        660 
FDPKILEVVR ETKCMIKMKL DVPEQAKRLL KLESKLKADK LYLQGLLQYY DELCQEVPSV 

       670        680        690        700        710        720 
FVNLMTPKMK KVESVLRQGL TVLTWSSLTL ESFFQEVELV LDMFNQLLKK ISDLCEMHID 

       730        740        750        760        770        780 
TVLKEIAKTV LISLPESGAT KVEDMLTLNE TYTKEWADIL NHKSKHVEEA VRELISIFEQ 

       790        800        810        820        830        840 
IYEVKYTGKV GKQSEQRKHV VFGSETGEGE NNDYEANIVN EFDTHDKEDE FKKECKEVFA 

       850        860        870        880        890        900 
FFSHQLLDSL QKATRLSLDT MKRRIFVASL YGRKQSEDII SFIKSEVHLA IPNVVMIPSL 

       910        920        930        940        950        960 
DDIQQAINRM IQLTLEVSRG VAHWGQQQIR PIKSVIPSPT TTDVTHQNTG KLLKKEERSF 

       970        980        990       1000       1010       1020 
EEAIPARKLK NFYPGVAEHK DISKLVLLLS SSVNSLRKAA HEALQDFQKY KTLWTEDRDV 

      1030       1040       1050       1060       1070       1080 
KVKEFLANNP SLTEIRSEIL HYATFEQEID ELKPIIVVGA LELHTEPMKL ALSIEAKAWK 

      1090       1100       1110       1120       1130       1140 
MLLCRYLNEE YKKKMSYMIA FINEYLKKLS RPIRDLDDVR FAMEALSCIR DNEIQMDMTL 

      1150       1160       1170       1180       1190       1200 
GPIEEAYAIL NRFEVEVTKE ESEAVDTLRY SFNKLQSKAV SVQEDLVQVQ PKFKSNLLES 

      1210       1220       1230       1240       1250       1260 
VEVFREDVIN FAEAYELEGP MVPNIPPQEA SNRLQIFQAS FDDLWRKFVT YSSGEQLFGL 

      1270       1280       1290       1300       1310       1320 
PVTDYEVLHK TRKELNLLQK LYGLYDTVMS SISGYYEILW GDVDIEKINA ELLEFQNRCR 

      1330       1340       1350       1360       1370       1380 
KLPKGLKDWQ AFLDLKKRID DFSESCPLLE MMTNKAMKQR HWDRISELTG TPFDVESDSF 

      1390       1400       1410       1420       1430       1440 
CLRNIMEAPL LKHKDDIEDI CISAIKEKDI EAKLTQVIEN WTNQNLSFAA FKGKGELLLK 

      1450       1460       1470       1480       1490       1500 
GTESGEIITL MEDSLMVLGS LLSNRYNAPF KKNIQNWVYK LSTSSDIIEE WLVVQNLWVY 

      1510       1520       1530       1540       1550       1560 
LEAVFVGGDI AKQLPQEAKR FQNIDKSWIK IMQRAHENPN VINCCVGDET MGQLLPHLHE 

      1570       1580       1590       1600       1610       1620 
QLEVCQKSLT GYLEKKRLLF PRFFFVSDPV LLEILGQASD SHTIQPHLPA VSDNINEVTF 

      1630       1640       1650       1660       1670       1680 
HAKDYDRIMA VISREGEKIV LDNSVMAKGP VEIWLLDLLK MQMSSLHNII RSAFYQISDS 

      1690       1700       1710       1720       1730       1740 
GFQLLPFLSH FPAQVGLLGI QMLWTHDSEE ALRNAKDDRK IMQVTNQKFL DILNTLISQT 

      1750       1760       1770       1780       1790       1800 
THDLSKFDRV KFETLITIHV HQRDIFDDLV KMHIKSPTDF EWLKQSRFYF KEDLDQTVVS 

      1810       1820       1830       1840       1850       1860 
ITDVDFIYQN EFLGCTDRLV ITPLTDRCYI TLAQALGMNM GGAPAGPAGT GKTETTKDMG 

      1870       1880       1890       1900       1910       1920 
RCLGKYVVVF NCSDQMDFRG LGRIFKGLAQ SGSWGCFDEF NRIELPVLSV AAQQIYIVLT 

      1930       1940       1950       1960       1970       1980 
ARKERKKQFI FSDGDCVDLN PEFGIFLTMN PGYAGRQELP ENLKIQFRTV AMMVPDRQII 

      1990       2000       2010       2020       2030       2040 
MRVKLASCGF LENVILAQKF YVLYKLCEEQ LTKQVHYDFG LRNILSVLRT LGSQKRARPE 

      2050       2060       2070       2080       2090       2100 
DSELSIVMRG LRDMNLSKLV DEDEPLFLSL INDLFPGLQL DSNTYAELQN AVAHQVQIEG 

      2110       2120       2130       2140       2150       2160 
LINHPPWNLK LVQLYETSLV RHGLMTLGPS GSGKTTVITI LMKAQTECGR PHREMRMNPK 

      2170       2180       2190       2200       2210       2220 
AITAPQMFGR LDTATNDWTD GIFSTLWRKT LKAKKGENIF LILDGPVDAI WIENLNSVLD 

      2230       2240       2250       2260       2270       2280 
DNKTLTLANG DRIPMAPSCK LLFEVHNIEN ASPATVSRMG MVYISSSALS WRPILQAWLK 

      2290       2300       2310       2320       2330       2340 
KRTAQEAAVF LTLYEKVFED TYTYMKLNLN PKMQLLECNY IVQSLNLLEG LIPSKEEGGV 

      2350       2360       2370       2380       2390       2400 
SCVEHLHKLF VFGLMWSLGA LLELESREKL EAFLRQHESK LDLPEIPKGS NQTMYEFYVT 

      2410       2420       2430       2440       2450       2460 
DYGDWEHWNK KLQPYYYPTD SIPEYSSILV PNVDNIRTNF LIDTIAKQHK AVLLTGEQGT 

      2470       2480       2490       2500       2510       2520 
AKTVMVKAYL KKYDPEVQLS KSLNFSSATE PMMFQRTIES YVDKRIGSTY GPPGGRKMTV 

      2530       2540       2550       2560       2570       2580 
FIDDINMPVI NEWGDQITNE IVRQMMEMEG MYSLDKPGDF TTIVDVQLIA AMIHPGGGRN 

      2590       2600       2610       2620       2630       2640 
DIPQRLKRQF TVFNCTLPSN ASIDKIFGII GCGYFDPCRS FKPQICEMIV NLVSVGRVLW 

      2650       2660       2670       2680       2690       2700 
QWTKVKMLPT PSKFHYIFNL RDLSRIWQGM LTIKAEECAS IPTLLSLFKH ECSRVIADRF 

      2710       2720       2730       2740       2750       2760 
ITPEDEQWFN AHLTRAVEEN IGSDAASCIL PEPYFVDFLR EMPEPTGDEP EDSVFEVPKI 

      2770       2780       2790       2800       2810       2820 
YELMPSFDFL AEKLQFYQRQ FNEIIRGTSL DLVFFKDAMT HLIKISRIIR TSCGNALLVG 

      2830       2840       2850       2860       2870       2880 
VGGSGKQSLS RLASFIAGYQ IFQITLTRSY NVTNLTDDLK ALYKVAGADG KGITFIFTDS 

      2890       2900       2910       2920       2930       2940 
EIKDEAFLEY LNNLLSSGEI SNLFARDEMD EITQGLISVM KRELPRHPPT FDNLYEYFIS 

      2950       2960       2970       2980       2990       3000 
RSRKNLHVVL CFSPVGEKFR ARSLKFPGLI SGCTMDWFSR WPREALIAVA SYFLSDYNIV 

      3010       3020       3030       3040       3050       3060 
CSSEIKRQVV ETMGLFHDMV SESCESYFQR YRRRAHVTPK SYLSFINGYK NIYAEKVKFI 

      3070       3080       3090       3100       3110       3120 
NEQAERMNIG LDKLMEASES VAKLSQDLAV KEKELAVASI KADEVLAEVT VSAQASAKIK 

      3130       3140       3150       3160       3170       3180 
NEVQEVKDKA QKIVDEIDSE KVKAESKLEA AKPALEEAEA ALNTIKPNDI ATVRKLAKPP 

      3190       3200       3210       3220       3230       3240 
HLIMRIMDCV LLLFQKKIDP VTMDPEKSCC KPSWGESLKL MSATGFLWSL QQFPKDTINE 

      3250       3260       3270       3280       3290       3300 
ETVELLQPYF NMDDYTFESA KKVCGNVAGL LSWTLAMAIF YGINREVLPL KANLAKQEGR 

      3310       3320       3330       3340       3350       3360 
LAVANAELGK AQALLDEKQA ELDKVQAKFD AAMNEKMDLL NDADTCRKKM QAASTLIDGL 

      3370       3380       3390       3400       3410       3420 
SGEKIRWTQQ SKEFKAQINR LVGDILLCTG FLSYLGPFNQ IFRNYLLKDQ WEMELRARKI 

      3430       3440       3450       3460       3470       3480 
PFTENLNLIS MLVDPPTIGE WGLQGLPGDD LSIQNGIIVT KATRYPLLID PQTQGKTWIK 

      3490       3500       3510       3520       3530       3540 
SKEKENDLQV TSLNHKYFRT HLEDSLSLGR PLLIEDIHEE LDPALDNVLE KNFIKSGTTF 

      3550       3560       3570       3580       3590       3600 
KVKVGDKECD IMDTFKLYIT TKLPNPAFTP EINAKTSVID FTVTMKGLEN QLLRRVILTE 

      3610       3620       3630       3640       3650       3660 
KQELEAERVK LLEDVTFNKR KMKELEDNLL YKLSATKGSL VDDESLIGVL RTTKQTAAEV 

      3670       3680       3690       3700       3710       3720 
SEKLHVAAET EIKINAAQEE FRPAATRGSI LYFLITEMSM VNIMYQTSLA QFLKLFDQSM 

      3730       3740       3750       3760       3770       3780 
ARSEKSPLPQ KRITNIIEYL TYEVFTYSVR GLYENHKFLF VLLMTLKIDL QRGTVKHREF 

      3790       3800       3810       3820       3830       3840 
QALIKGGAAL DLKACPPKPY RWILDMTWLN LVELSKLPQF AEIMNQISRN EKGWKSWFDK 

      3850       3860       3870       3880       3890       3900 
DAPEEEIIPD GYNDSLDTCH KLLLIRSWCP DRTVFQARKY IADSLEEKYT EPVILNLEKT 

      3910       3920       3930       3940       3950       3960 
WEESDTRTPL ICFLSMGSDP TNQIDALAKK LKLECRTISM GQGQEVHARK LIQMSMQQGG 

      3970       3980       3990       4000       4010       4020 
WVLLQNCHLG LEFMEELLET LITTEASDDS FRVWITTEPH DRFPITLLQT SLKFTNEPPQ 

      4030       4040       4050       4060       4070       4080 
GVRAGLKRTF AGINQDLLDI SNLPMWKPML YTVAFLHSTV QERRKFGPLG WNIPYEFNSA 

      4090       4100       4110       4120       4130       4140 
DFSASVQFIQ NHLDECDIKK GVSWNTVRYM IGEVQYGGRV TDDFDKRLLN CFARVWFSEK 

      4150       4160       4170       4180       4190       4200 
MFEPSFCFYT GYKIPLCKTL DQYFEYIQSL PSLDNPEVFG LHPNADITYQ SNTASAVLET 

      4210       4220       4230       4240       4250       4260 
ITNIQPKESG GGVGETREAI VYRLSEDMLS KLPPDYIPHE VKSRLIKMGH LNSMNIFLRQ 

      4270       4280       4290       4300       4310       4320 
EIDRMQRVIS ILRSSLSDLK LAIEGTIIMS ENLRDALDNM YDARIPQLWK RVSWDSSTLG 

      4330       4340       4350       4360       4370       4380 
FWFTELLERN AQFSTWIFEG RPNVFWMTGF FNPQGFLTAM RQEVTRAHKG WALDTVTIHN 

      4390       4400       4410       4420       4430       4440 
EVLRQTKEEI TSPPGEGVYI YGLYMDGAAW DRRNGKLMES TPKVLFTQLP VLHIFAINST 

      4450       4460       4470       4480       4490 
APKDPKLYVC PIYKKPRRTD LTFITVVYLR TVLSPDHWIL RGVALLCDIK 

« Hide

Isoform 2 [UniParc].

Checksum: 99F3877237ACCF7A
Show »

FASTA4,454510,448
Isoform 3 (Sequence not available).
Isoform 4 (Sequence not available).

References

« Hide 'large scale' references
[1]"The T complex distorter 2 candidate gene, Dnahc8, encodes at least two testis-specific axonemal dynein heavy chains that differ extensively at their amino and carboxyl termini."
Samant S.A., Ogunkua O., Hui L., Fossella J., Pilder S.H.
Dev. Biol. 250:24-43(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, VARIANTS VAL-573; GLU-807; LYS-1202 AND VAL-4271.
Tissue: Testis.
[2]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene."
Neesen J., Koehler M.R., Kirschner R., Steinlein C., Kreutzberger J., Engel W., Schmid M.
Gene 200:193-202(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1846-1952 (ISOFORM 1).
Tissue: Testis.
[4]"Chromosomal localization of human dynein heavy chain genes."
Maiti A.K., Mattei M.-G., Jorissen M., Volz A., Ziegler A., Bouvagnet P.
Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1856-1912 (ISOFORM 1).
Tissue: Nasal polyp.
[5]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-674, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-2226.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF356519 mRNA. Translation: AAK60620.1.
AL035690 expand/collapse EMBL AC list , AL034345, AL035555, AL353700 Genomic DNA. Translation: CAI19769.1.
AL035690 expand/collapse EMBL AC list , AL034345, AL035555, AL353700, AL391415 Genomic DNA. Translation: CAI19770.1. Sequence problems.
AL035555 expand/collapse EMBL AC list , AL034345, AL035690, AL353700 Genomic DNA. Translation: CAI19819.1.
AL035555 expand/collapse EMBL AC list , AL034345, AL353700, AL391415 Genomic DNA. Translation: CAI19821.1. Sequence problems.
AL035555 expand/collapse EMBL AC list , AL034345, AL035690, AL353700, AL391415 Genomic DNA. Translation: CAI19822.1. Sequence problems.
AL353700 expand/collapse EMBL AC list , AL034345, AL035555, AL035690 Genomic DNA. Translation: CAI20292.1.
AL353700 expand/collapse EMBL AC list , AL034345, AL035555, AL391415 Genomic DNA. Translation: CAI20293.1. Sequence problems.
AL353700 expand/collapse EMBL AC list , AL034345, AL035555, AL035690, AL391415 Genomic DNA. Translation: CAI20294.1. Sequence problems.
AL391415 expand/collapse EMBL AC list , AL034345, AL035555, AL353700 Genomic DNA. Translation: CAI21587.1. Sequence problems.
AL391415 expand/collapse EMBL AC list , AL034345, AL035555, AL035690, AL353700 Genomic DNA. Translation: CAI21588.1. Sequence problems.
AL034345 expand/collapse EMBL AC list , AL035555, AL035690, AL353700 Genomic DNA. Translation: CAI42433.1.
AL034345 Genomic DNA. Translation: CAI42434.1.
AL034345 expand/collapse EMBL AC list , AL035555, AL353700, AL391415 Genomic DNA. Translation: CAI42435.1. Sequence problems.
AL034345 expand/collapse EMBL AC list , AL035555, AL035690, AL353700, AL391415 Genomic DNA. Translation: CAI42436.1. Sequence problems.
Z83806 mRNA. Translation: CAB06060.1.
AJ132091 mRNA. Translation: CAA10564.1.
RefSeqNP_001193856.1. NM_001206927.1.
UniGeneHs.520106.
Hs.686107.

3D structure databases

ProteinModelPortalQ96JB1.
SMRQ96JB1. Positions 1838-1903, 2124-2156, 2449-2611, 3144-3294, 3350-3766, 3919-4125.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000352312.

PTM databases

PhosphoSiteQ96JB1.

Polymorphism databases

DMDM124007137.

Proteomic databases

MaxQBQ96JB1.
PaxDbQ96JB1.
PRIDEQ96JB1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000359357; ENSP00000352312; ENSG00000124721. [Q96JB1-1]
ENST00000441566; ENSP00000402294; ENSG00000124721. [Q96JB1-2]
GeneID1769.
KEGGhsa:1769.
UCSCuc003ooe.2. human. [Q96JB1-1]

Organism-specific databases

CTD1769.
GeneCardsGC06P038685.
H-InvDBHIX0033271.
HGNCHGNC:2952. DNAH8.
HPAHPA028447.
HPA030108.
MIM603337. gene.
neXtProtNX_Q96JB1.
PharmGKBPA27405.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5245.
HOVERGENHBG005543.
InParanoidQ96JB1.
PhylomeDBQ96JB1.
TreeFamTF316836.

Gene expression databases

ArrayExpressQ96JB1.
BgeeQ96JB1.
CleanExHS_DNAH8.
GenevestigatorQ96JB1.

Family and domain databases

Gene3D3.40.50.300. 6 hits.
InterProIPR003593. AAA+_ATPase.
IPR011704. ATPase_dyneun-rel_AAA.
IPR026983. DHC_fam.
IPR024743. Dynein_HC_stalk.
IPR024317. Dynein_heavy_chain_D4_dom.
IPR004273. Dynein_heavy_dom.
IPR013594. Dynein_heavy_dom-1.
IPR013602. Dynein_heavy_dom-2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR10676. PTHR10676. 1 hit.
PfamPF07728. AAA_5. 1 hit.
PF12780. AAA_8. 1 hit.
PF08385. DHC_N1. 1 hit.
PF08393. DHC_N2. 1 hit.
PF03028. Dynein_heavy. 1 hit.
PF12777. MT. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 3 hits.
[Graphical view]
SUPFAMSSF52540. SSF52540. 5 hits.
ProtoNetSearch...

Other

GenomeRNAi1769.
NextBio7201.
PROQ96JB1.
SOURCESearch...

Entry information

Entry nameDYH8_HUMAN
AccessionPrimary (citable) accession number: Q96JB1
Secondary accession number(s): O00438 expand/collapse secondary AC list , Q5JYI2, Q5T2M3, Q5T2M4, Q5TG00, Q9UEM4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM