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Q96JB1

- DYH8_HUMAN

UniProt

Q96JB1 - DYH8_HUMAN

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Protein
Dynein heavy chain 8, axonemal
Gene
DNAH8
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1846 – 18538ATP Reviewed prediction
Nucleotide bindingi2128 – 21358ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATPase activity Source: InterPro
  3. microtubule motor activity Source: UniProtKB

GO - Biological processi

  1. cilium or flagellum-dependent cell motility Source: UniProtKB
  2. metabolic process Source: GOC
  3. microtubule-based movement Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein heavy chain 8, axonemal
Alternative name(s):
Axonemal beta dynein heavy chain 8
Ciliary dynein heavy chain 8
Gene namesi
Name:DNAH8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:2952. DNAH8.

Subcellular locationi

Cytoplasmcytoskeletoncilium axoneme By similarity

GO - Cellular componenti

  1. axonemal dynein complex Source: UniProtKB
  2. microtubule Source: UniProtKB-KW
  3. motile cilium Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27405.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 44904490Dynein heavy chain 8, axonemal
PRO_0000274044Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei674 – 6741Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96JB1.
PaxDbiQ96JB1.
PRIDEiQ96JB1.

PTM databases

PhosphoSiteiQ96JB1.

Expressioni

Gene expression databases

ArrayExpressiQ96JB1.
BgeeiQ96JB1.
CleanExiHS_DNAH8.
GenevestigatoriQ96JB1.

Organism-specific databases

HPAiHPA028447.
HPA030108.

Interactioni

Subunit structurei

Consists of at least two heavy chains and a number of intermediate and light chains.

Protein-protein interaction databases

STRINGi9606.ENSP00000352312.

Structurei

3D structure databases

ProteinModelPortaliQ96JB1.
SMRiQ96JB1. Positions 1838-1903, 2124-2156, 2449-2611, 3144-3294, 3350-3766, 3919-4125.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1808 – 2030223AAA 1 By similarity
Add
BLAST
Regioni2090 – 2309220AAA 2 By similarity
Add
BLAST
Regioni2416 – 2669254AAA 3 By similarity
Add
BLAST
Regioni2780 – 3034255AAA 4 By similarity
Add
BLAST
Regioni3049 – 3346298Stalk By similarity
Add
BLAST
Regioni3432 – 3662231AAA 5 By similarity
Add
BLAST
Regioni3877 – 4091215AAA 6 By similarity
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili3072 – 316493 Reviewed prediction
Add
BLAST
Coiled coili3290 – 335465 Reviewed prediction
Add
BLAST
Coiled coili3594 – 363037 Reviewed prediction
Add
BLAST

Domaini

Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG5245.
HOVERGENiHBG005543.
InParanoidiQ96JB1.
PhylomeDBiQ96JB1.
TreeFamiTF316836.

Family and domain databases

Gene3Di3.40.50.300. 6 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011704. ATPase_dyneun-rel_AAA.
IPR026983. DHC_fam.
IPR024743. Dynein_HC_stalk.
IPR024317. Dynein_heavy_chain_D4_dom.
IPR004273. Dynein_heavy_dom.
IPR013594. Dynein_heavy_dom-1.
IPR013602. Dynein_heavy_dom-2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10676. PTHR10676. 1 hit.
PfamiPF07728. AAA_5. 1 hit.
PF12780. AAA_8. 1 hit.
PF08385. DHC_N1. 1 hit.
PF08393. DHC_N2. 1 hit.
PF03028. Dynein_heavy. 1 hit.
PF12777. MT. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 3 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 5 hits.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96JB1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MMKLYIDNAA PDKLKGLCIF FVRCRNDVAI NVKTIQEEAL FTVLDASKGL     50
LNGIRDMLAN IFLPAVLATN NWGALNQSKQ GESEKHIFTE TINRYLSFLD 100
GARISIEGTV KLKTIDNVNF SKLHTFEEVT AAASNSETVH QLEEVLMVWY 150
KQIEQVLIES EQMRKEAGDS GPLTELEHWK RMSAKFNYII EQIKGPSCKA 200
VINVLNVAHS KLLKNWRDLD ARITDTANES KDNVRYLYTL EKVCQPLYNH 250
DLVSMAHGIQ NLINAIRMIH GVSRYYNTSE RMTSLFIKVT NQMVTACKAY 300
ITDGGLNHVW DQETPVVLKK IQDCIFLFKE YQASFHKTRK LISESSGEKS 350
FEVSEMYIFG KFEAFCKRLE KITEMITVVQ TYSTLSNSTI EGIDIMAIKF 400
RNIYQGVKKK QYDILDPRRT EFDTDFLDFM TKINGLEVQI QAFMNSSFGK 450
ILSSQQALQL LQRFQKLNIP CLGLEINHTI ERILQYYVAE LDATKKLYHS 500
QKDDPPLARN MPPIAGKILW VRQLYRRISE PINYFFKNSD ILSSPDGKAV 550
IRQYNKISYV LVEFEVVYHT AWIREISQLH YALQATLFVR HPETGKLLVN 600
FDPKILEVVR ETKCMIKMKL DVPEQAKRLL KLESKLKADK LYLQGLLQYY 650
DELCQEVPSV FVNLMTPKMK KVESVLRQGL TVLTWSSLTL ESFFQEVELV 700
LDMFNQLLKK ISDLCEMHID TVLKEIAKTV LISLPESGAT KVEDMLTLNE 750
TYTKEWADIL NHKSKHVEEA VRELISIFEQ IYEVKYTGKV GKQSEQRKHV 800
VFGSETGEGE NNDYEANIVN EFDTHDKEDE FKKECKEVFA FFSHQLLDSL 850
QKATRLSLDT MKRRIFVASL YGRKQSEDII SFIKSEVHLA IPNVVMIPSL 900
DDIQQAINRM IQLTLEVSRG VAHWGQQQIR PIKSVIPSPT TTDVTHQNTG 950
KLLKKEERSF EEAIPARKLK NFYPGVAEHK DISKLVLLLS SSVNSLRKAA 1000
HEALQDFQKY KTLWTEDRDV KVKEFLANNP SLTEIRSEIL HYATFEQEID 1050
ELKPIIVVGA LELHTEPMKL ALSIEAKAWK MLLCRYLNEE YKKKMSYMIA 1100
FINEYLKKLS RPIRDLDDVR FAMEALSCIR DNEIQMDMTL GPIEEAYAIL 1150
NRFEVEVTKE ESEAVDTLRY SFNKLQSKAV SVQEDLVQVQ PKFKSNLLES 1200
VEVFREDVIN FAEAYELEGP MVPNIPPQEA SNRLQIFQAS FDDLWRKFVT 1250
YSSGEQLFGL PVTDYEVLHK TRKELNLLQK LYGLYDTVMS SISGYYEILW 1300
GDVDIEKINA ELLEFQNRCR KLPKGLKDWQ AFLDLKKRID DFSESCPLLE 1350
MMTNKAMKQR HWDRISELTG TPFDVESDSF CLRNIMEAPL LKHKDDIEDI 1400
CISAIKEKDI EAKLTQVIEN WTNQNLSFAA FKGKGELLLK GTESGEIITL 1450
MEDSLMVLGS LLSNRYNAPF KKNIQNWVYK LSTSSDIIEE WLVVQNLWVY 1500
LEAVFVGGDI AKQLPQEAKR FQNIDKSWIK IMQRAHENPN VINCCVGDET 1550
MGQLLPHLHE QLEVCQKSLT GYLEKKRLLF PRFFFVSDPV LLEILGQASD 1600
SHTIQPHLPA VSDNINEVTF HAKDYDRIMA VISREGEKIV LDNSVMAKGP 1650
VEIWLLDLLK MQMSSLHNII RSAFYQISDS GFQLLPFLSH FPAQVGLLGI 1700
QMLWTHDSEE ALRNAKDDRK IMQVTNQKFL DILNTLISQT THDLSKFDRV 1750
KFETLITIHV HQRDIFDDLV KMHIKSPTDF EWLKQSRFYF KEDLDQTVVS 1800
ITDVDFIYQN EFLGCTDRLV ITPLTDRCYI TLAQALGMNM GGAPAGPAGT 1850
GKTETTKDMG RCLGKYVVVF NCSDQMDFRG LGRIFKGLAQ SGSWGCFDEF 1900
NRIELPVLSV AAQQIYIVLT ARKERKKQFI FSDGDCVDLN PEFGIFLTMN 1950
PGYAGRQELP ENLKIQFRTV AMMVPDRQII MRVKLASCGF LENVILAQKF 2000
YVLYKLCEEQ LTKQVHYDFG LRNILSVLRT LGSQKRARPE DSELSIVMRG 2050
LRDMNLSKLV DEDEPLFLSL INDLFPGLQL DSNTYAELQN AVAHQVQIEG 2100
LINHPPWNLK LVQLYETSLV RHGLMTLGPS GSGKTTVITI LMKAQTECGR 2150
PHREMRMNPK AITAPQMFGR LDTATNDWTD GIFSTLWRKT LKAKKGENIF 2200
LILDGPVDAI WIENLNSVLD DNKTLTLANG DRIPMAPSCK LLFEVHNIEN 2250
ASPATVSRMG MVYISSSALS WRPILQAWLK KRTAQEAAVF LTLYEKVFED 2300
TYTYMKLNLN PKMQLLECNY IVQSLNLLEG LIPSKEEGGV SCVEHLHKLF 2350
VFGLMWSLGA LLELESREKL EAFLRQHESK LDLPEIPKGS NQTMYEFYVT 2400
DYGDWEHWNK KLQPYYYPTD SIPEYSSILV PNVDNIRTNF LIDTIAKQHK 2450
AVLLTGEQGT AKTVMVKAYL KKYDPEVQLS KSLNFSSATE PMMFQRTIES 2500
YVDKRIGSTY GPPGGRKMTV FIDDINMPVI NEWGDQITNE IVRQMMEMEG 2550
MYSLDKPGDF TTIVDVQLIA AMIHPGGGRN DIPQRLKRQF TVFNCTLPSN 2600
ASIDKIFGII GCGYFDPCRS FKPQICEMIV NLVSVGRVLW QWTKVKMLPT 2650
PSKFHYIFNL RDLSRIWQGM LTIKAEECAS IPTLLSLFKH ECSRVIADRF 2700
ITPEDEQWFN AHLTRAVEEN IGSDAASCIL PEPYFVDFLR EMPEPTGDEP 2750
EDSVFEVPKI YELMPSFDFL AEKLQFYQRQ FNEIIRGTSL DLVFFKDAMT 2800
HLIKISRIIR TSCGNALLVG VGGSGKQSLS RLASFIAGYQ IFQITLTRSY 2850
NVTNLTDDLK ALYKVAGADG KGITFIFTDS EIKDEAFLEY LNNLLSSGEI 2900
SNLFARDEMD EITQGLISVM KRELPRHPPT FDNLYEYFIS RSRKNLHVVL 2950
CFSPVGEKFR ARSLKFPGLI SGCTMDWFSR WPREALIAVA SYFLSDYNIV 3000
CSSEIKRQVV ETMGLFHDMV SESCESYFQR YRRRAHVTPK SYLSFINGYK 3050
NIYAEKVKFI NEQAERMNIG LDKLMEASES VAKLSQDLAV KEKELAVASI 3100
KADEVLAEVT VSAQASAKIK NEVQEVKDKA QKIVDEIDSE KVKAESKLEA 3150
AKPALEEAEA ALNTIKPNDI ATVRKLAKPP HLIMRIMDCV LLLFQKKIDP 3200
VTMDPEKSCC KPSWGESLKL MSATGFLWSL QQFPKDTINE ETVELLQPYF 3250
NMDDYTFESA KKVCGNVAGL LSWTLAMAIF YGINREVLPL KANLAKQEGR 3300
LAVANAELGK AQALLDEKQA ELDKVQAKFD AAMNEKMDLL NDADTCRKKM 3350
QAASTLIDGL SGEKIRWTQQ SKEFKAQINR LVGDILLCTG FLSYLGPFNQ 3400
IFRNYLLKDQ WEMELRARKI PFTENLNLIS MLVDPPTIGE WGLQGLPGDD 3450
LSIQNGIIVT KATRYPLLID PQTQGKTWIK SKEKENDLQV TSLNHKYFRT 3500
HLEDSLSLGR PLLIEDIHEE LDPALDNVLE KNFIKSGTTF KVKVGDKECD 3550
IMDTFKLYIT TKLPNPAFTP EINAKTSVID FTVTMKGLEN QLLRRVILTE 3600
KQELEAERVK LLEDVTFNKR KMKELEDNLL YKLSATKGSL VDDESLIGVL 3650
RTTKQTAAEV SEKLHVAAET EIKINAAQEE FRPAATRGSI LYFLITEMSM 3700
VNIMYQTSLA QFLKLFDQSM ARSEKSPLPQ KRITNIIEYL TYEVFTYSVR 3750
GLYENHKFLF VLLMTLKIDL QRGTVKHREF QALIKGGAAL DLKACPPKPY 3800
RWILDMTWLN LVELSKLPQF AEIMNQISRN EKGWKSWFDK DAPEEEIIPD 3850
GYNDSLDTCH KLLLIRSWCP DRTVFQARKY IADSLEEKYT EPVILNLEKT 3900
WEESDTRTPL ICFLSMGSDP TNQIDALAKK LKLECRTISM GQGQEVHARK 3950
LIQMSMQQGG WVLLQNCHLG LEFMEELLET LITTEASDDS FRVWITTEPH 4000
DRFPITLLQT SLKFTNEPPQ GVRAGLKRTF AGINQDLLDI SNLPMWKPML 4050
YTVAFLHSTV QERRKFGPLG WNIPYEFNSA DFSASVQFIQ NHLDECDIKK 4100
GVSWNTVRYM IGEVQYGGRV TDDFDKRLLN CFARVWFSEK MFEPSFCFYT 4150
GYKIPLCKTL DQYFEYIQSL PSLDNPEVFG LHPNADITYQ SNTASAVLET 4200
ITNIQPKESG GGVGETREAI VYRLSEDMLS KLPPDYIPHE VKSRLIKMGH 4250
LNSMNIFLRQ EIDRMQRVIS ILRSSLSDLK LAIEGTIIMS ENLRDALDNM 4300
YDARIPQLWK RVSWDSSTLG FWFTELLERN AQFSTWIFEG RPNVFWMTGF 4350
FNPQGFLTAM RQEVTRAHKG WALDTVTIHN EVLRQTKEEI TSPPGEGVYI 4400
YGLYMDGAAW DRRNGKLMES TPKVLFTQLP VLHIFAINST APKDPKLYVC 4450
PIYKKPRRTD LTFITVVYLR TVLSPDHWIL RGVALLCDIK 4490
Length:4,490
Mass (Da):514,664
Last modified:January 23, 2007 - v2
Checksum:iE5809E32FF08199B
GO
Isoform 2 (identifier: Q96JB1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1978-2013: Missing.

Show »
Length:4,454
Mass (Da):510,448
Checksum:i99F3877237ACCF7A
GO
Isoform 3 (identifier: Q96JB1-3)

Sequence is not available
Length:
Mass (Da):
Isoform 4 (identifier: Q96JB1-4)

Sequence is not available
Length:
Mass (Da):

Sequence cautioni

The sequence CAI19770.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI19821.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI19822.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI20293.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI20294.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI21587.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI21588.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI42435.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI42436.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti71 – 711N → S.
Corresponds to variant rs6935293 [ dbSNP | Ensembl ].
VAR_030171
Natural varianti473 – 4731G → R.
Corresponds to variant rs1738254 [ dbSNP | Ensembl ].
VAR_030172
Natural varianti573 – 5731I → V.1 Publication
Corresponds to variant rs3823430 [ dbSNP | Ensembl ].
VAR_030173
Natural varianti727 – 7271A → T.
Corresponds to variant rs1678674 [ dbSNP | Ensembl ].
VAR_030174
Natural varianti807 – 8071G → E.1 Publication
Corresponds to variant rs874808 [ dbSNP | Ensembl ].
VAR_030175
Natural varianti1202 – 12021E → K.1 Publication
Corresponds to variant rs9357283 [ dbSNP | Ensembl ].
VAR_030176
Natural varianti2226 – 22261T → M in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036213
Natural varianti2444 – 24441T → N.
Corresponds to variant rs862432 [ dbSNP | Ensembl ].
VAR_030177
Natural varianti4106 – 41061T → M.
Corresponds to variant rs1537232 [ dbSNP | Ensembl ].
VAR_030178
Natural varianti4271 – 42711I → V.1 Publication
Corresponds to variant rs10484847 [ dbSNP | Ensembl ].
VAR_030179

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1978 – 201336Missing in isoform 2.
VSP_022614Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1622 – 16221A → T in AAK60620. 1 Publication
Sequence conflicti1945 – 19473IFL → VFI in CAB06060. 1 Publication
Sequence conflicti3495 – 34951H → R in AAK60620. 1 Publication
Sequence conflicti4118 – 41181G → D in AAK60620. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF356519 mRNA. Translation: AAK60620.1.
AL035690
, AL034345, AL035555, AL353700 Genomic DNA. Translation: CAI19769.1.
AL035690
, AL034345, AL035555, AL353700, AL391415 Genomic DNA. Translation: CAI19770.1. Sequence problems.
AL035555
, AL034345, AL035690, AL353700 Genomic DNA. Translation: CAI19819.1.
AL035555
, AL034345, AL353700, AL391415 Genomic DNA. Translation: CAI19821.1. Sequence problems.
AL035555
, AL034345, AL035690, AL353700, AL391415 Genomic DNA. Translation: CAI19822.1. Sequence problems.
AL353700
, AL034345, AL035555, AL035690 Genomic DNA. Translation: CAI20292.1.
AL353700
, AL034345, AL035555, AL391415 Genomic DNA. Translation: CAI20293.1. Sequence problems.
AL353700
, AL034345, AL035555, AL035690, AL391415 Genomic DNA. Translation: CAI20294.1. Sequence problems.
AL391415
, AL034345, AL035555, AL353700 Genomic DNA. Translation: CAI21587.1. Sequence problems.
AL391415
, AL034345, AL035555, AL035690, AL353700 Genomic DNA. Translation: CAI21588.1. Sequence problems.
AL034345
, AL035555, AL035690, AL353700 Genomic DNA. Translation: CAI42433.1.
AL034345 Genomic DNA. Translation: CAI42434.1.
AL034345
, AL035555, AL353700, AL391415 Genomic DNA. Translation: CAI42435.1. Sequence problems.
AL034345
, AL035555, AL035690, AL353700, AL391415 Genomic DNA. Translation: CAI42436.1. Sequence problems.
Z83806 mRNA. Translation: CAB06060.1.
AJ132091 mRNA. Translation: CAA10564.1.
RefSeqiNP_001193856.1. NM_001206927.1.
UniGeneiHs.520106.
Hs.686107.

Genome annotation databases

EnsembliENST00000359357; ENSP00000352312; ENSG00000124721. [Q96JB1-1]
ENST00000441566; ENSP00000402294; ENSG00000124721. [Q96JB1-2]
GeneIDi1769.
KEGGihsa:1769.
UCSCiuc003ooe.2. human. [Q96JB1-1]

Polymorphism databases

DMDMi124007137.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF356519 mRNA. Translation: AAK60620.1 .
AL035690
, AL034345 , AL035555 , AL353700 Genomic DNA. Translation: CAI19769.1 .
AL035690
, AL034345 , AL035555 , AL353700 , AL391415 Genomic DNA. Translation: CAI19770.1 . Sequence problems.
AL035555
, AL034345 , AL035690 , AL353700 Genomic DNA. Translation: CAI19819.1 .
AL035555
, AL034345 , AL353700 , AL391415 Genomic DNA. Translation: CAI19821.1 . Sequence problems.
AL035555
, AL034345 , AL035690 , AL353700 , AL391415 Genomic DNA. Translation: CAI19822.1 . Sequence problems.
AL353700
, AL034345 , AL035555 , AL035690 Genomic DNA. Translation: CAI20292.1 .
AL353700
, AL034345 , AL035555 , AL391415 Genomic DNA. Translation: CAI20293.1 . Sequence problems.
AL353700
, AL034345 , AL035555 , AL035690 , AL391415 Genomic DNA. Translation: CAI20294.1 . Sequence problems.
AL391415
, AL034345 , AL035555 , AL353700 Genomic DNA. Translation: CAI21587.1 . Sequence problems.
AL391415
, AL034345 , AL035555 , AL035690 , AL353700 Genomic DNA. Translation: CAI21588.1 . Sequence problems.
AL034345
, AL035555 , AL035690 , AL353700 Genomic DNA. Translation: CAI42433.1 .
AL034345 Genomic DNA. Translation: CAI42434.1 .
AL034345
, AL035555 , AL353700 , AL391415 Genomic DNA. Translation: CAI42435.1 . Sequence problems.
AL034345
, AL035555 , AL035690 , AL353700 , AL391415 Genomic DNA. Translation: CAI42436.1 . Sequence problems.
Z83806 mRNA. Translation: CAB06060.1 .
AJ132091 mRNA. Translation: CAA10564.1 .
RefSeqi NP_001193856.1. NM_001206927.1.
UniGenei Hs.520106.
Hs.686107.

3D structure databases

ProteinModelPortali Q96JB1.
SMRi Q96JB1. Positions 1838-1903, 2124-2156, 2449-2611, 3144-3294, 3350-3766, 3919-4125.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000352312.

PTM databases

PhosphoSitei Q96JB1.

Polymorphism databases

DMDMi 124007137.

Proteomic databases

MaxQBi Q96JB1.
PaxDbi Q96JB1.
PRIDEi Q96JB1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000359357 ; ENSP00000352312 ; ENSG00000124721 . [Q96JB1-1 ]
ENST00000441566 ; ENSP00000402294 ; ENSG00000124721 . [Q96JB1-2 ]
GeneIDi 1769.
KEGGi hsa:1769.
UCSCi uc003ooe.2. human. [Q96JB1-1 ]

Organism-specific databases

CTDi 1769.
GeneCardsi GC06P038685.
H-InvDB HIX0033271.
HGNCi HGNC:2952. DNAH8.
HPAi HPA028447.
HPA030108.
MIMi 603337. gene.
neXtProti NX_Q96JB1.
PharmGKBi PA27405.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5245.
HOVERGENi HBG005543.
InParanoidi Q96JB1.
PhylomeDBi Q96JB1.
TreeFami TF316836.

Miscellaneous databases

GenomeRNAii 1769.
NextBioi 7201.
PROi Q96JB1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96JB1.
Bgeei Q96JB1.
CleanExi HS_DNAH8.
Genevestigatori Q96JB1.

Family and domain databases

Gene3Di 3.40.50.300. 6 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011704. ATPase_dyneun-rel_AAA.
IPR026983. DHC_fam.
IPR024743. Dynein_HC_stalk.
IPR024317. Dynein_heavy_chain_D4_dom.
IPR004273. Dynein_heavy_dom.
IPR013594. Dynein_heavy_dom-1.
IPR013602. Dynein_heavy_dom-2.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR10676. PTHR10676. 1 hit.
Pfami PF07728. AAA_5. 1 hit.
PF12780. AAA_8. 1 hit.
PF08385. DHC_N1. 1 hit.
PF08393. DHC_N2. 1 hit.
PF03028. Dynein_heavy. 1 hit.
PF12777. MT. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 3 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 5 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The T complex distorter 2 candidate gene, Dnahc8, encodes at least two testis-specific axonemal dynein heavy chains that differ extensively at their amino and carboxyl termini."
    Samant S.A., Ogunkua O., Hui L., Fossella J., Pilder S.H.
    Dev. Biol. 250:24-43(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, VARIANTS VAL-573; GLU-807; LYS-1202 AND VAL-4271.
    Tissue: Testis.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene."
    Neesen J., Koehler M.R., Kirschner R., Steinlein C., Kreutzberger J., Engel W., Schmid M.
    Gene 200:193-202(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1846-1952 (ISOFORM 1).
    Tissue: Testis.
  4. "Chromosomal localization of human dynein heavy chain genes."
    Maiti A.K., Mattei M.-G., Jorissen M., Volz A., Ziegler A., Bouvagnet P.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1856-1912 (ISOFORM 1).
    Tissue: Nasal polyp.
  5. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-674, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-2226.

Entry informationi

Entry nameiDYH8_HUMAN
AccessioniPrimary (citable) accession number: Q96JB1
Secondary accession number(s): O00438
, Q5JYI2, Q5T2M3, Q5T2M4, Q5TG00, Q9UEM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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