ID   M4A14_HUMAN             Reviewed;         679 AA.
AC   Q96JA4; E9PJE3; Q2TVT5; Q3B7W3; Q86XH8; Q9NTC2;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   24-JAN-2024, entry version 142.
DE   RecName: Full=Membrane-spanning 4-domains subfamily A member 14;
DE   AltName: Full=Testis development protein NYD-SP21;
GN   Name=MS4A14; Synonyms=MS4A13, MS4A16;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS TYR-177 AND ARG-584.
RC   TISSUE=Testis;
RA   Li J.M., Sha J.H., Zhou Z.M.;
RT   "A new testis development gene NYD-SP21 from human testes.";
RL   Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND VARIANTS TYR-177 AND
RP   ARG-584.
RC   TISSUE=Testis;
RA   Liang Y., Tedder T.F.;
RT   "MS4A genes.";
RL   Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 191-679 (ISOFORMS 1/2), AND
RP   VARIANT ARG-584.
RC   TISSUE=Testis;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
CC   -!- FUNCTION: May be involved in signal transduction as a component of a
CC       multimeric receptor complex. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q96JA4; O14735: CDIPT; NbExp=3; IntAct=EBI-12839612, EBI-358858;
CC       Q96JA4; Q8N6F1-2: CLDN19; NbExp=3; IntAct=EBI-12839612, EBI-12256978;
CC       Q96JA4; Q96F15: GIMAP5; NbExp=3; IntAct=EBI-12839612, EBI-6166686;
CC       Q96JA4; Q96IW7: SEC22A; NbExp=3; IntAct=EBI-12839612, EBI-8652744;
CC       Q96JA4; Q969K7: TMEM54; NbExp=3; IntAct=EBI-12839612, EBI-3922833;
CC       Q96JA4; Q8N661: TMEM86B; NbExp=3; IntAct=EBI-12839612, EBI-2548832;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1;
CC         IsoId=Q96JA4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q96JA4-2; Sequence=VSP_031780;
CC       Name=3;
CC         IsoId=Q96JA4-4; Sequence=VSP_031779, VSP_031781, VSP_031782;
CC       Name=4;
CC         IsoId=Q96JA4-5; Sequence=VSP_056734;
CC   -!- SIMILARITY: Belongs to the MS4A family. {ECO:0000305}.
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DR   EMBL; AF367473; AAK53409.2; -; mRNA.
DR   EMBL; AY094610; AAM48587.1; -; mRNA.
DR   EMBL; AY094611; AAM48588.1; -; mRNA.
DR   EMBL; AY584610; AAV91959.1; -; mRNA.
DR   EMBL; AP003127; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC107431; AAI07432.1; -; mRNA.
DR   EMBL; AL137391; CAB70719.1; -; mRNA.
DR   CCDS; CCDS31569.1; -. [Q96JA4-1]
DR   CCDS; CCDS41652.1; -. [Q96JA4-2]
DR   CCDS; CCDS58136.1; -. [Q96JA4-5]
DR   PIR; T46450; T46450.
DR   RefSeq; NP_001073160.1; NM_001079692.2. [Q96JA4-2]
DR   RefSeq; NP_001248757.1; NM_001261828.1. [Q96JA4-5]
DR   RefSeq; NP_115986.3; NM_032597.4. [Q96JA4-1]
DR   AlphaFoldDB; Q96JA4; -.
DR   BioGRID; 124204; 6.
DR   IntAct; Q96JA4; 6.
DR   STRING; 9606.ENSP00000433761; -.
DR   TCDB; 1.A.37.3.1; the cd20 ca(2+) channel (cd20) family.
DR   GlyGen; Q96JA4; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q96JA4; -.
DR   PhosphoSitePlus; Q96JA4; -.
DR   SwissPalm; Q96JA4; -.
DR   BioMuta; MS4A14; -.
DR   DMDM; 296434579; -.
DR   PaxDb; 9606-ENSP00000433761; -.
DR   PeptideAtlas; Q96JA4; -.
DR   ProteomicsDB; 21112; -.
DR   ProteomicsDB; 76921; -. [Q96JA4-1]
DR   ProteomicsDB; 76922; -. [Q96JA4-2]
DR   Pumba; Q96JA4; -.
DR   Antibodypedia; 43483; 111 antibodies from 17 providers.
DR   DNASU; 84689; -.
DR   Ensembl; ENST00000300187.11; ENSP00000300187.6; ENSG00000166928.11. [Q96JA4-1]
DR   Ensembl; ENST00000395005.6; ENSP00000378453.2; ENSG00000166928.11. [Q96JA4-2]
DR   Ensembl; ENST00000531783.5; ENSP00000433761.1; ENSG00000166928.11. [Q96JA4-5]
DR   GeneID; 84689; -.
DR   KEGG; hsa:84689; -.
DR   MANE-Select; ENST00000300187.11; ENSP00000300187.6; NM_032597.5; NP_115986.3.
DR   UCSC; uc001npj.4; human. [Q96JA4-1]
DR   AGR; HGNC:30706; -.
DR   CTD; 84689; -.
DR   DisGeNET; 84689; -.
DR   GeneCards; MS4A14; -.
DR   HGNC; HGNC:30706; MS4A14.
DR   HPA; ENSG00000166928; Tissue enriched (testis).
DR   neXtProt; NX_Q96JA4; -.
DR   OpenTargets; ENSG00000166928; -.
DR   PharmGKB; PA162396237; -.
DR   VEuPathDB; HostDB:ENSG00000166928; -.
DR   eggNOG; ENOG502S7I2; Eukaryota.
DR   GeneTree; ENSGT00940000163132; -.
DR   InParanoid; Q96JA4; -.
DR   OMA; EWQFEMQ; -.
DR   OrthoDB; 4630942at2759; -.
DR   PhylomeDB; Q96JA4; -.
DR   TreeFam; TF337098; -.
DR   PathwayCommons; Q96JA4; -.
DR   SignaLink; Q96JA4; -.
DR   BioGRID-ORCS; 84689; 10 hits in 1140 CRISPR screens.
DR   GenomeRNAi; 84689; -.
DR   Pharos; Q96JA4; Tdark.
DR   PRO; PR:Q96JA4; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q96JA4; Protein.
DR   Bgee; ENSG00000166928; Expressed in sperm and 108 other cell types or tissues.
DR   ExpressionAtlas; Q96JA4; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR   InterPro; IPR007237; CD20-like.
DR   InterPro; IPR030417; MS4A.
DR   PANTHER; PTHR23320:SF10; MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 14; 1.
DR   PANTHER; PTHR23320; MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED; 1.
DR   Pfam; PF04103; CD20; 1.
DR   Genevisible; Q96JA4; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Membrane; Receptor; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..679
FT                   /note="Membrane-spanning 4-domains subfamily A member 14"
FT                   /id="PRO_0000320967"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          218..259
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          331..363
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          469..491
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          505..633
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        519..537
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        548..576
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        585..601
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        615..630
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..112
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_031779"
FT   VAR_SEQ         90..106
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_031780"
FT   VAR_SEQ         156
FT                   /note="I -> IGILLILLIISIAELSISVTIASFRSKCWTQSDE (in isoform
FT                   4)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_056734"
FT   VAR_SEQ         157..170
FT                   /note="VLFFLPSDVTQNSE -> DFILLTPPHSSHFL (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_031781"
FT   VAR_SEQ         171..679
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_031782"
FT   VARIANT         177
FT                   /note="N -> Y (in dbSNP:rs7131283)"
FT                   /evidence="ECO:0000269|Ref.1, ECO:0000269|Ref.2"
FT                   /id="VAR_039330"
FT   VARIANT         584
FT                   /note="G -> R (in dbSNP:rs3825020)"
FT                   /evidence="ECO:0000269|PubMed:17974005, ECO:0000269|Ref.1,
FT                   ECO:0000269|Ref.2"
FT                   /id="VAR_039331"
SQ   SEQUENCE   679 AA;  76580 MW;  BD523CE5C28E1207 CRC64;
     MESTSQDRRA THVITIKPNE TVLTAFPYRP HSSLLDFLKG EPRVLGATQI LLALIIVGFG
     TIFALNYIGF SQRLPLVVLT GYPFWGALIF ILTGYLTVTD KKSKLLGQGV TGMNVISSLV
     AITGITFTIL SYRHQDKYCQ MPSFEEICVF SRTLFIVLFF LPSDVTQNSE QPAPEENDQL
     QFVLQEEFSS DDSTTNAQSV IFGGYAFFKL TLSRSPLVSQ PGNKGREFVP DEQKQSILPS
     PKFSEEEIEP LPPTLEKKPS ENMSIQLDST FKQMKDEDLQ SAIVQPSQMQ TKLLQDQAAS
     LQVFPSHSAL KLEDISPEDL PSQALPVEGL SEQTMPSKST SSHVKQSSNL TANDLPPQGI
     LSQDTSSQDM LFHDMTSQDM QSLDMLSQDT PSHAMPPQDI PSQDMLSQAL SAHAILPEAS
     TSHIVQFPEI QHLLQQPPDL QPENTEPQNQ QILQMSYQDI RSEVMEETKE WKSEEELHRR
     KSSRRHSLNQ QTKALQYLRR HSLDVQAKGQ KSSKRHSLDQ QSKGWQSPKQ KSLDQQIKDW
     LSPKRHSVDK QAQLNQTKEQ LPDQQAEDQQ AKGEQYPEGQ SKDGQVKDQQ TDKEQNSKKQ
     TQDQQTEDQP AQEKKSPKGQ FQNVQAEGQQ AQVEKVPKLL CQDSESQIQQ YQFWQFHKGN
     LQAGQPRTVN LLAKNPLTG
//