Q96JA4 (M4A14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Membrane-spanning 4-domains subfamily A member 14

Alternative name(s):
Testis development protein NYD-SP21

Gene names

Name:	MS4A14
Synonyms:	MS4A13, MS4A16

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	679 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in signal transduction as a component of a multimeric receptor complex By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the MS4A family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	Receptor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96JA4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96JA4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     90-106: Missing.

Isoform 3 (identifier: Q96JA4-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: Missing.
     157-170: VLFFLPSDVTQNSE → DFILLTPPHSSHFL
     171-679: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 679	679	Membrane-spanning 4-domains subfamily A member 14		PRO_0000320967
Regions
	Transmembrane	50 – 70	21	Helical; Potential
	Transmembrane	76 – 96	21	Helical; Potential
	Transmembrane	110 – 130	21	Helical; Potential
	Transmembrane	141 – 161	21	Helical; Potential
	Compositional bias	426 – 665	240	Gln-rich
Natural variations
	Alternative sequence	1 – 112	112	Missing in isoform 3.		VSP_031779
	Alternative sequence	90 – 106	17	Missing in isoform 2.		VSP_031780
	Alternative sequence	157 – 170	14	VLFFL…TQNSE → DFILLTPPHSSHFL in isoform 3.		VSP_031781
	Alternative sequence	171 – 679	509	Missing in isoform 3.		VSP_031782
	Natural variant	177	1	N → Y. Ref.1 Ref.2 Corresponds to variant rs7131283 [ dbSNP | Ensembl ].		VAR_039330
	Natural variant	584	1	G → R. Ref.1 Ref.2 Ref.5 Corresponds to variant rs3825020 [ dbSNP | Ensembl ].		VAR_039331

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: BD523CE5C28E1207	FASTA	679	76,580
	10 20 30 40 50 60 MESTSQDRRA THVITIKPNE TVLTAFPYRP HSSLLDFLKG EPRVLGATQI LLALIIVGFG 70 80 90 100 110 120 TIFALNYIGF SQRLPLVVLT GYPFWGALIF ILTGYLTVTD KKSKLLGQGV TGMNVISSLV 130 140 150 160 170 180 AITGITFTIL SYRHQDKYCQ MPSFEEICVF SRTLFIVLFF LPSDVTQNSE QPAPEENDQL 190 200 210 220 230 240 QFVLQEEFSS DDSTTNAQSV IFGGYAFFKL TLSRSPLVSQ PGNKGREFVP DEQKQSILPS 250 260 270 280 290 300 PKFSEEEIEP LPPTLEKKPS ENMSIQLDST FKQMKDEDLQ SAIVQPSQMQ TKLLQDQAAS 310 320 330 340 350 360 LQVFPSHSAL KLEDISPEDL PSQALPVEGL SEQTMPSKST SSHVKQSSNL TANDLPPQGI 370 380 390 400 410 420 LSQDTSSQDM LFHDMTSQDM QSLDMLSQDT PSHAMPPQDI PSQDMLSQAL SAHAILPEAS 430 440 450 460 470 480 TSHIVQFPEI QHLLQQPPDL QPENTEPQNQ QILQMSYQDI RSEVMEETKE WKSEEELHRR 490 500 510 520 530 540 KSSRRHSLNQ QTKALQYLRR HSLDVQAKGQ KSSKRHSLDQ QSKGWQSPKQ KSLDQQIKDW 550 560 570 580 590 600 LSPKRHSVDK QAQLNQTKEQ LPDQQAEDQQ AKGEQYPEGQ SKDGQVKDQQ TDKEQNSKKQ 610 620 630 640 650 660 TQDQQTEDQP AQEKKSPKGQ FQNVQAEGQQ AQVEKVPKLL CQDSESQIQQ YQFWQFHKGN 670 LQAGQPRTVN LLAKNPLTG
	Isoform 2 [UniParc]. Checksum: 92F73E6A55A1D08B	FASTA	662	74,658
	10 20 30 40 50 60 MESTSQDRRA THVITIKPNE TVLTAFPYRP HSSLLDFLKG EPRVLGATQI LLALIIVGFG 70 80 90 100 110 120 TIFALNYIGF SQRLPLVVLT GYPFWGALIG QGVTGMNVIS SLVAITGITF TILSYRHQDK 130 140 150 160 170 180 YCQMPSFEEI CVFSRTLFIV LFFLPSDVTQ NSEQPAPEEN DQLQFVLQEE FSSDDSTTNA 190 200 210 220 230 240 QSVIFGGYAF FKLTLSRSPL VSQPGNKGRE FVPDEQKQSI LPSPKFSEEE IEPLPPTLEK 250 260 270 280 290 300 KPSENMSIQL DSTFKQMKDE DLQSAIVQPS QMQTKLLQDQ AASLQVFPSH SALKLEDISP 310 320 330 340 350 360 EDLPSQALPV EGLSEQTMPS KSTSSHVKQS SNLTANDLPP QGILSQDTSS QDMLFHDMTS 370 380 390 400 410 420 QDMQSLDMLS QDTPSHAMPP QDIPSQDMLS QALSAHAILP EASTSHIVQF PEIQHLLQQP 430 440 450 460 470 480 PDLQPENTEP QNQQILQMSY QDIRSEVMEE TKEWKSEEEL HRRKSSRRHS LNQQTKALQY 490 500 510 520 530 540 LRRHSLDVQA KGQKSSKRHS LDQQSKGWQS PKQKSLDQQI KDWLSPKRHS VDKQAQLNQT 550 560 570 580 590 600 KEQLPDQQAE DQQAKGEQYP EGQSKDGQVK DQQTDKEQNS KKQTQDQQTE DQPAQEKKSP 610 620 630 640 650 660 KGQFQNVQAE GQQAQVEKVP KLLCQDSESQ IQQYQFWQFH KGNLQAGQPR TVNLLAKNPL TG
	Isoform 3 [UniParc]. Checksum: B33AEBC4EF01BFA0	FASTA	58	6,710
	10 20 30 40 50 MNVISSLVAI TGITFTILSY RHQDKYCQMP SFEEICVFSR TLFIDFILLT PPHSSHFL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A new testis development gene NYD-SP21 from human testes." Li J.M., Sha J.H., Zhou Z.M. Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS TYR-177 AND ARG-584. Tissue: Testis.
[2]	"MS4A genes." Liang Y., Tedder T.F. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS TYR-177 AND ARG-584. Tissue: Testis.
[3]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Testis.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 191-679 (ISOFORMS 1/2), VARIANT ARG-584. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF367473 mRNA. Translation: AAK53409.2. AY094610 mRNA. Translation: AAM48587.1. AY094611 mRNA. Translation: AAM48588.1. AY584610 mRNA. Translation: AAV91959.1. AP003127 Genomic DNA. No translation available. BC107431 mRNA. Translation: AAI07432.1. AL137391 mRNA. Translation: CAB70719.1.
IPI	IPI00064014. IPI00816529. IPI00976524.
PIR	T46450.
RefSeq	NP_001073160.1. NM_001079692.2. NP_115986.3. NM_032597.4.
UniGene	Hs.709736.
3D structure databases
ProteinModelPortal	Q96JA4.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000300187.
PTM databases
PhosphoSite	Q96JA4.
Polymorphism databases
DMDM	296434579.
Proteomic databases
PaxDb	Q96JA4.
PRIDE	Q96JA4.
Protocols and materials databases
DNASU	84689.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000300187; ENSP00000300187; ENSG00000166928. ENST00000395001; ENSP00000378449; ENSG00000166928. ENST00000395005; ENSP00000378453; ENSG00000166928.
GeneID	84689.
KEGG	hsa:84689.
UCSC	uc001npi.3. human. uc001npk.3. human.
Organism-specific databases
CTD	84689.
GeneCards	GC11P060163.
HGNC	HGNC:30706. MS4A14.
neXtProt	NX_Q96JA4.
PharmGKB	PA162396237.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG41161.
HOGENOM	HOG000168377.
HOVERGEN	HBG067611.
InParanoid	Q96JA4.
PhylomeDB	Q96JA4.
Gene expression databases
ArrayExpress	Q96JA4.
Bgee	Q96JA4.
CleanEx	HS_MS4A13. HS_MS4A14.
Genevestigator	Q96JA4.
Family and domain databases
InterPro	IPR007237. CD20-like. [Graphical view]
Pfam	PF04103. CD20. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	84689.
NextBio	74744.

Entry information

Entry name

M4A14_HUMAN

Accession

Primary (citable) accession number: Q96JA4
Secondary accession number(s): Q2TVT5 , Q3B7W3, Q86XH8, Q9NTC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	May 18, 2010
Last modified:	April 3, 2013
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.