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Q96JA4 (M4A14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Membrane-spanning 4-domains subfamily A member 14
Alternative name(s):
Testis development protein NYD-SP21
Gene names
Name:MS4A14
Synonyms:MS4A13, MS4A16
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length679 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in signal transduction as a component of a multimeric receptor complex By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the MS4A family.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionReceptor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96JA4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96JA4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     90-106: Missing.
Isoform 3 (identifier: Q96JA4-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: Missing.
     157-170: VLFFLPSDVTQNSE → DFILLTPPHSSHFL
     171-679: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 679679Membrane-spanning 4-domains subfamily A member 14
PRO_0000320967

Regions

Transmembrane50 – 7021Helical; Potential
Transmembrane76 – 9621Helical; Potential
Transmembrane110 – 13021Helical; Potential
Transmembrane141 – 16121Helical; Potential
Compositional bias426 – 665240Gln-rich

Natural variations

Alternative sequence1 – 112112Missing in isoform 3.
VSP_031779
Alternative sequence90 – 10617Missing in isoform 2.
VSP_031780
Alternative sequence157 – 17014VLFFL…TQNSE → DFILLTPPHSSHFL in isoform 3.
VSP_031781
Alternative sequence171 – 679509Missing in isoform 3.
VSP_031782
Natural variant1771N → Y. Ref.1 Ref.2
Corresponds to variant rs7131283 [ dbSNP | Ensembl ].
VAR_039330
Natural variant5841G → R. Ref.1 Ref.2 Ref.5
Corresponds to variant rs3825020 [ dbSNP | Ensembl ].
VAR_039331

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: BD523CE5C28E1207

FASTA67976,580
        10         20         30         40         50         60 
MESTSQDRRA THVITIKPNE TVLTAFPYRP HSSLLDFLKG EPRVLGATQI LLALIIVGFG 

        70         80         90        100        110        120 
TIFALNYIGF SQRLPLVVLT GYPFWGALIF ILTGYLTVTD KKSKLLGQGV TGMNVISSLV 

       130        140        150        160        170        180 
AITGITFTIL SYRHQDKYCQ MPSFEEICVF SRTLFIVLFF LPSDVTQNSE QPAPEENDQL 

       190        200        210        220        230        240 
QFVLQEEFSS DDSTTNAQSV IFGGYAFFKL TLSRSPLVSQ PGNKGREFVP DEQKQSILPS 

       250        260        270        280        290        300 
PKFSEEEIEP LPPTLEKKPS ENMSIQLDST FKQMKDEDLQ SAIVQPSQMQ TKLLQDQAAS 

       310        320        330        340        350        360 
LQVFPSHSAL KLEDISPEDL PSQALPVEGL SEQTMPSKST SSHVKQSSNL TANDLPPQGI 

       370        380        390        400        410        420 
LSQDTSSQDM LFHDMTSQDM QSLDMLSQDT PSHAMPPQDI PSQDMLSQAL SAHAILPEAS 

       430        440        450        460        470        480 
TSHIVQFPEI QHLLQQPPDL QPENTEPQNQ QILQMSYQDI RSEVMEETKE WKSEEELHRR 

       490        500        510        520        530        540 
KSSRRHSLNQ QTKALQYLRR HSLDVQAKGQ KSSKRHSLDQ QSKGWQSPKQ KSLDQQIKDW 

       550        560        570        580        590        600 
LSPKRHSVDK QAQLNQTKEQ LPDQQAEDQQ AKGEQYPEGQ SKDGQVKDQQ TDKEQNSKKQ 

       610        620        630        640        650        660 
TQDQQTEDQP AQEKKSPKGQ FQNVQAEGQQ AQVEKVPKLL CQDSESQIQQ YQFWQFHKGN 

       670 
LQAGQPRTVN LLAKNPLTG 

« Hide

Isoform 2 [UniParc].

Checksum: 92F73E6A55A1D08B
Show »

FASTA66274,658
Isoform 3 [UniParc].

Checksum: B33AEBC4EF01BFA0
Show »

FASTA586,710

References

« Hide 'large scale' references
[1]"A new testis development gene NYD-SP21 from human testes."
Li J.M., Sha J.H., Zhou Z.M.
Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS TYR-177 AND ARG-584.
Tissue: Testis.
[2]"MS4A genes."
Liang Y., Tedder T.F.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS TYR-177 AND ARG-584.
Tissue: Testis.
[3]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Testis.
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 191-679 (ISOFORMS 1/2), VARIANT ARG-584.
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF367473 mRNA. Translation: AAK53409.2.
AY094610 mRNA. Translation: AAM48587.1.
AY094611 mRNA. Translation: AAM48588.1.
AY584610 mRNA. Translation: AAV91959.1.
AP003127 Genomic DNA. No translation available.
BC107431 mRNA. Translation: AAI07432.1.
AL137391 mRNA. Translation: CAB70719.1.
PIRT46450.
RefSeqNP_001073160.1. NM_001079692.2.
NP_115986.3. NM_032597.4.
UniGeneHs.709736.

3D structure databases

ProteinModelPortalQ96JA4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000300187.

Protein family/group databases

TCDB1.A.37.3.1. the cd20 ca(2+) channel (cd20) family.

PTM databases

PhosphoSiteQ96JA4.

Polymorphism databases

DMDM296434579.

Proteomic databases

PaxDbQ96JA4.
PRIDEQ96JA4.

Protocols and materials databases

DNASU84689.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000300187; ENSP00000300187; ENSG00000166928. [Q96JA4-1]
ENST00000395001; ENSP00000378449; ENSG00000166928. [Q96JA4-4]
ENST00000395005; ENSP00000378453; ENSG00000166928. [Q96JA4-2]
GeneID84689.
KEGGhsa:84689.
UCSCuc001npi.3. human. [Q96JA4-1]
uc001npk.3. human. [Q96JA4-2]

Organism-specific databases

CTD84689.
GeneCardsGC11P060163.
HGNCHGNC:30706. MS4A14.
neXtProtNX_Q96JA4.
PharmGKBPA162396237.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG41161.
HOGENOMHOG000168377.
HOVERGENHBG067611.
InParanoidQ96JA4.
PhylomeDBQ96JA4.
TreeFamTF337098.

Gene expression databases

ArrayExpressQ96JA4.
BgeeQ96JA4.
CleanExHS_MS4A13.
HS_MS4A14.
GenevestigatorQ96JA4.

Family and domain databases

InterProIPR007237. CD20-like.
[Graphical view]
PfamPF04103. CD20. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi84689.
NextBio74744.
PROQ96JA4.

Entry information

Entry nameM4A14_HUMAN
AccessionPrimary (citable) accession number: Q96JA4
Secondary accession number(s): Q2TVT5 expand/collapse secondary AC list , Q3B7W3, Q86XH8, Q9NTC2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 18, 2010
Last modified: March 19, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM