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Q96J94

- PIWL1_HUMAN

UniProt

Q96J94 - PIWL1_HUMAN

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Protein
Piwi-like protein 1
Gene
PIWIL1, HIWI
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability By similarity. Isoform 3 may be a negative developmental regulator.3 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei381 – 3811Required for binding 2'-O-methylated 3'-end of piRNAs

GO - Molecular functioni

  1. mRNA binding Source: UniProtKB
  2. piRNA binding Source: UniProtKB
  3. protein binding Source: IntAct
  4. single-stranded RNA binding Source: Ensembl

GO - Biological processi

  1. gene silencing by RNA Source: UniProtKB
  2. meiotic nuclear division Source: UniProtKB-KW
  3. multicellular organismal development Source: UniProtKB-KW
  4. piRNA metabolic process Source: Ensembl
  5. regulation of translation Source: UniProtKB-KW
  6. spermatid development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Meiosis, RNA-mediated gene silencing, Spermatogenesis, Translation regulation

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Piwi-like protein 1
Gene namesi
Name:PIWIL1
Synonyms:HIWI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:9007. PIWIL1.

Subcellular locationi

Cytoplasm By similarity
Note: Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Also present in chromatoid body By similarity.

GO - Cellular componenti

  1. P granule Source: UniProtKB
  2. chromatoid body Source: UniProtKB
  3. cytoplasm Source: UniProtKB
  4. mRNA cap binding complex Source: Ensembl
  5. polysome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi379 – 3791P → H: Impairs binding to 2'-O-methylated 3'-end of piRNAs; when associated with Y-381. 1 Publication
Mutagenesisi381 – 3811M → Y: Impairs binding to 2'-O-methylated 3'-end of piRNAs; when associated with H-379. 1 Publication

Organism-specific databases

PharmGKBiPA33341.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 861861Piwi-like protein 1
PRO_0000234567Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141Omega-N-methylarginine; by PRMT5; alternate By similarity
Modified residuei14 – 141Symmetric dimethylarginine; by PRMT5; alternate By similarity
Modified residuei49 – 491Omega-N-methylarginine; by PRMT5 By similarity
Modified residuei53 – 531Omega-N-methylarginine By similarity
Modified residuei370 – 3701Omega-N-methylarginine; by PRMT5 By similarity

Post-translational modificationi

Arginine methylation by PRMT5 is required for the interaction with Tudor domain-containing protein (TDRD1, TDRKH/TDRD2, RNF17/TDRD4, TDRD6, TDRD7 and TDRD9) and subsequent localization to the meiotic nuage, also named P granule By similarity.

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ96J94.
PRIDEiQ96J94.

PTM databases

PhosphoSiteiQ96J94.

Expressioni

Tissue specificityi

Expressed in spermatocytes and spermatids. Also detected in prostate cancer (at protein level). Detected in most fetal and adult tissues. Expressed in testes, specifically in germline cells; detected in spermatocytes and spermatids during spermatogenesis. Increased expression in testicular tumors originating from embryonic germ cells with retention of germ cells phenotype. No expression in testicular tumors of somatic origin, such as Sertoli cell and Leydig cell tumors. Overexpressed in gastric cancer cells. Isoform 3 is ubiquitously expressed, and specifically in CD34+ hematopoietic progenitor cells but not in more differentiated cells.4 Publications

Inductioni

Isoform 3 is down-regulated in CD34+ hematopoietic cells during differentiation.1 Publication

Gene expression databases

ArrayExpressiQ96J94.
BgeeiQ96J94.
CleanExiHS_PIWIL1.
GenevestigatoriQ96J94.

Organism-specific databases

HPAiCAB012217.
HPA018798.

Interactioni

Subunit structurei

Interacts (via Piwi domain) with DICER1, suggesting that it forms ribonucleoprotein RISC complexes. This interaction is regulated by HSP90AB1 activity. Interacts with MAEL, KIF17, PABPC1, PRMT5 and WDR77. Interacts (when methylated on arginine residues) with TDRD1, TDRKH/TDRD2, RNF17/TDRD4, TDRD6, TDRD7 and TDRD9. Interacts with CLOCK By similarity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
DICER1Q9UPY32EBI-527417,EBI-395506

Protein-protein interaction databases

BioGridi114690. 5 interactions.
DIPiDIP-33534N.
IntActiQ96J94. 1 interaction.
STRINGi9606.ENSP00000245255.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi279 – 2857
Helixi286 – 2883
Helixi292 – 30312
Beta strandi307 – 3104
Turni311 – 3144
Beta strandi316 – 3183
Beta strandi321 – 3233
Beta strandi331 – 3333
Beta strandi335 – 3373
Beta strandi339 – 3413
Helixi342 – 3509
Beta strandi361 – 3644
Beta strandi370 – 3756
Beta strandi380 – 3823
Helixi384 – 3863
Beta strandi387 – 3893

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2L5CNMR-A266-399[»]
2L5DNMR-A266-399[»]
3O3IX-ray2.80X277-399[»]
3O6EX-ray2.90X277-399[»]
3O7VX-ray2.10X276-399[»]
ProteinModelPortaliQ96J94.
SMRiQ96J94. Positions 106-840.

Miscellaneous databases

EvolutionaryTraceiQ96J94.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini277 – 391115PAZ
Add
BLAST
Domaini555 – 847293Piwi
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni316 – 3183Required for binding 2'-O-methylated 3'-end of piRNAs
Regioni540 – 677138RNA-binding By similarity
Add
BLAST

Domaini

The PAZ domain specifically recognizes binds the 2'-O-methylated 3'-end of piRNAs.1 Publication

Sequence similaritiesi

Contains 1 PAZ domain.
Contains 1 Piwi domain.

Phylogenomic databases

eggNOGiNOG286051.
HOGENOMiHOG000254789.
HOVERGENiHBG049411.
InParanoidiQ96J94.
KOiK02156.
OMAiPGYIQPR.
OrthoDBiEOG712TVQ.
PhylomeDBiQ96J94.
TreeFamiTF354206.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR008625. GAGE.
IPR003100. PAZ_dom.
IPR003165. Piwi.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF05831. GAGE. 1 hit.
PF02170. PAZ. 1 hit.
PF02171. Piwi. 1 hit.
[Graphical view]
SMARTiSM00949. PAZ. 1 hit.
SM00950. Piwi. 1 hit.
[Graphical view]
SUPFAMiSSF101690. SSF101690. 1 hit.
SSF53098. SSF53098. 1 hit.
PROSITEiPS50821. PAZ. 1 hit.
PS50822. PIWI. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96J94-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTGRARARAR GRARGQETAQ LVGSTASQQP GYIQPRPQPP PAEGELFGRG    50
RQRGTAGGTA KSQGLQISAG FQELSLAERG GRRRDFHDLG VNTRQNLDHV 100
KESKTGSSGI IVRLSTNHFR LTSRPQWALY QYHIDYNPLM EARRLRSALL 150
FQHEDLIGKC HAFDGTILFL PKRLQQKVTE VFSKTRNGED VRITITLTNE 200
LPPTSPTCLQ FYNIIFRRLL KIMNLQQIGR NYYNPNDPID IPSHRLVIWP 250
GFTTSILQYE NSIMLCTDVS HKVLRSETVL DFMFNFYHQT EEHKFQEQVS 300
KELIGLVVLT KYNNKTYRVD DIDWDQNPKS TFKKADGSEV SFLEYYRKQY 350
NQEITDLKQP VLVSQPKRRR GPGGTLPGPA MLIPELCYLT GLTDKMRNDF 400
NVMKDLAVHT RLTPEQRQRE VGRLIDYIHK NDNVQRELRD WGLSFDSNLL 450
SFSGRILQTE KIHQGGKTFD YNPQFADWSK ETRGAPLISV KPLDNWLLIY 500
TRRNYEAANS LIQNLFKVTP AMGMQMRKAI MIEVDDRTEA YLRVLQQKVT 550
ADTQIVVCLL SSNRKDKYDA IKKYLCTDCP TPSQCVVART LGKQQTVMAI 600
ATKIALQMNC KMGGELWRVD IPLKLVMIVG IDCYHDMTAG RRSIAGFVAS 650
INEGMTRWFS RCIFQDRGQE LVDGLKVCLQ AALRAWNSCN EYMPSRIIVY 700
RDGVGDGQLK TLVNYEVPQF LDCLKSIGRG YNPRLTVIVV KKRVNTRFFA 750
QSGGRLQNPL PGTVIDVEVT RPEWYDFFIV SQAVRSGSVS PTHYNVIYDN 800
SGLKPDHIQR LTYKLCHIYY NWPGVIRVPA PCQYAHKLAF LVGQSIHREP 850
NLSLSNRLYY L 861
Length:861
Mass (Da):98,603
Last modified:December 1, 2001 - v1
Checksum:i58D7F6C7321DEFA4
GO
Isoform 2 (identifier: Q96J94-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     824-829: GVIRVP → VSASTC
     830-861: Missing.

Show »
Length:829
Mass (Da):94,845
Checksum:i03ADA415D1C159C3
GO
Isoform 3 (identifier: Q96J94-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-86: Missing.
     87-89: HDL → MIF

Show »
Length:775
Mass (Da):89,484
Checksum:iDF169A2E9EAFD916
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti491 – 4911K → N.1 Publication
Corresponds to variant rs17856812 [ dbSNP | Ensembl ].
VAR_026288
Natural varianti527 – 5271R → K.1 Publication
Corresponds to variant rs1106042 [ dbSNP | Ensembl ].
VAR_026289
Natural varianti575 – 5751L → P.1 Publication
Corresponds to variant rs17852568 [ dbSNP | Ensembl ].
VAR_026290

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8686Missing in isoform 3.
VSP_018366Add
BLAST
Alternative sequencei87 – 893HDL → MIF in isoform 3.
VSP_018367
Alternative sequencei824 – 8296GVIRVP → VSASTC in isoform 2.
VSP_018368
Alternative sequencei830 – 86132Missing in isoform 2.
VSP_018369Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti178 – 1781V → A in BAC04068. 1 Publication
Sequence conflicti314 – 3141N → I in AAC97371. 1 Publication
Sequence conflicti339 – 3391E → G in AAC97371. 1 Publication
Sequence conflicti353 – 3531E → K in BAF49084. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF264004 mRNA. Translation: AAK92281.1.
AF104260 mRNA. Translation: AAC97371.2.
AF387507 mRNA. Translation: AAK69348.1.
AK093133 mRNA. Translation: BAC04068.1.
BC028581 mRNA. Translation: AAH28581.1.
AB274731 mRNA. Translation: BAF49084.1.
CCDSiCCDS9268.1. [Q96J94-1]
RefSeqiNP_001177900.1. NM_001190971.1. [Q96J94-2]
NP_004755.2. NM_004764.4. [Q96J94-1]
XP_005253689.1. XM_005253632.2. [Q96J94-1]
XP_006719761.1. XM_006719698.1. [Q96J94-1]
UniGeneiHs.405659.

Genome annotation databases

EnsembliENST00000245255; ENSP00000245255; ENSG00000125207. [Q96J94-1]
GeneIDi9271.
KEGGihsa:9271.
UCSCiuc001uij.2. human. [Q96J94-2]
uc001uik.3. human. [Q96J94-1]

Polymorphism databases

DMDMi74716803.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF264004 mRNA. Translation: AAK92281.1 .
AF104260 mRNA. Translation: AAC97371.2 .
AF387507 mRNA. Translation: AAK69348.1 .
AK093133 mRNA. Translation: BAC04068.1 .
BC028581 mRNA. Translation: AAH28581.1 .
AB274731 mRNA. Translation: BAF49084.1 .
CCDSi CCDS9268.1. [Q96J94-1 ]
RefSeqi NP_001177900.1. NM_001190971.1. [Q96J94-2 ]
NP_004755.2. NM_004764.4. [Q96J94-1 ]
XP_005253689.1. XM_005253632.2. [Q96J94-1 ]
XP_006719761.1. XM_006719698.1. [Q96J94-1 ]
UniGenei Hs.405659.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2L5C NMR - A 266-399 [» ]
2L5D NMR - A 266-399 [» ]
3O3I X-ray 2.80 X 277-399 [» ]
3O6E X-ray 2.90 X 277-399 [» ]
3O7V X-ray 2.10 X 276-399 [» ]
ProteinModelPortali Q96J94.
SMRi Q96J94. Positions 106-840.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114690. 5 interactions.
DIPi DIP-33534N.
IntActi Q96J94. 1 interaction.
STRINGi 9606.ENSP00000245255.

PTM databases

PhosphoSitei Q96J94.

Polymorphism databases

DMDMi 74716803.

Proteomic databases

PaxDbi Q96J94.
PRIDEi Q96J94.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000245255 ; ENSP00000245255 ; ENSG00000125207 . [Q96J94-1 ]
GeneIDi 9271.
KEGGi hsa:9271.
UCSCi uc001uij.2. human. [Q96J94-2 ]
uc001uik.3. human. [Q96J94-1 ]

Organism-specific databases

CTDi 9271.
GeneCardsi GC12P130822.
HGNCi HGNC:9007. PIWIL1.
HPAi CAB012217.
HPA018798.
MIMi 605571. gene.
neXtProti NX_Q96J94.
PharmGKBi PA33341.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG286051.
HOGENOMi HOG000254789.
HOVERGENi HBG049411.
InParanoidi Q96J94.
KOi K02156.
OMAi PGYIQPR.
OrthoDBi EOG712TVQ.
PhylomeDBi Q96J94.
TreeFami TF354206.

Miscellaneous databases

EvolutionaryTracei Q96J94.
GeneWikii PIWIL1.
GenomeRNAii 9271.
NextBioi 34751.
PROi Q96J94.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96J94.
Bgeei Q96J94.
CleanExi HS_PIWIL1.
Genevestigatori Q96J94.

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
InterProi IPR008625. GAGE.
IPR003100. PAZ_dom.
IPR003165. Piwi.
IPR012337. RNaseH-like_dom.
[Graphical view ]
Pfami PF05831. GAGE. 1 hit.
PF02170. PAZ. 1 hit.
PF02171. Piwi. 1 hit.
[Graphical view ]
SMARTi SM00949. PAZ. 1 hit.
SM00950. Piwi. 1 hit.
[Graphical view ]
SUPFAMi SSF101690. SSF101690. 1 hit.
SSF53098. SSF53098. 1 hit.
PROSITEi PS50821. PAZ. 1 hit.
PS50822. PIWI. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human CD34+ stem cells express the hiwi gene, a human homologue of the Drosophila gene piwi."
    Sharma A.K., Nelson M.C., Brandt J.E., Wessman M., Mahmud N., Weller K.P., Hoffman R.
    Blood 97:426-434(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, INDUCTION.
    Tissue: Testis.
  2. "Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas."
    Qiao D., Zeeman A.-M., Deng W., Looijenga L.H.J., Lin H.
    Oncogene 21:3988-3999(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    Tissue: Testis.
  3. "Cloning and identification of human piwi protein related to testis development."
    Sha J.H.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Testis.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ASN-491; LYS-527 AND PRO-575.
    Tissue: Testis.
  6. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-530.
  7. "Identification of eight members of the Argonaute family in the human genome."
    Sasaki T., Shiohama A., Minoshima S., Shimizu N.
    Genomics 82:323-330(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. "Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer."
    Tahbaz N., Kolb F.A., Zhang H., Jaronczyk K., Filipowicz W., Hobman T.C.
    EMBO Rep. 5:189-194(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DICER1, FUNCTION.
  9. "Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells."
    Liu X., Sun Y., Guo J., Ma H., Li J., Dong B., Jin G., Zhang J., Wu J., Meng L., Shou C.
    Int. J. Cancer 118:1922-1929(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "Scanning of novel cancer/testis proteins by human testis proteomic analysis."
    Liu M., Hu Z., Qi L., Wang J., Zhou T., Guo Y., Zeng Y., Zheng B., Wu Y., Zhang P., Chen X., Tu W., Zhang T., Zhou Q., Jiang M., Guo X., Zhou Z., Sha J.
    Proteomics 13:1200-1210(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  11. "Structural basis for piRNA 2'-O-methylated 3'-end recognition by Piwi PAZ (Piwi/Argonaute/Zwille) domains."
    Tian Y., Simanshu D.K., Ma J.B., Patel D.J.
    Proc. Natl. Acad. Sci. U.S.A. 108:903-910(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 277-399 IN COMPLEX WITH METHYLATED SMALL RNA, DOMAIN PAZ, MUTAGENESIS OF PRO-379 AND MET-381.

Entry informationi

Entry nameiPIWL1_HUMAN
AccessioniPrimary (citable) accession number: Q96J94
Secondary accession number(s): A4F266
, O95404, Q8NA60, Q8TBY5, Q96JD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi