Q96J94 (PIWL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Piwi-like protein 1

Gene names

Name:	PIWIL1
Synonyms:	HIWI

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	861 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability By similarity. Isoform 3 may be a negative developmental regulator. Ref.2 Ref.8 Ref.9
Subunit structure	Interacts (via Piwi domain) with DICER1, suggesting that it forms ribonucleoprotein RISC complexes. This interaction is regulated by HSP90AB1 activity. Interacts with MAEL, KIF17, PABPC1, PRMT5 and WDR77. Interacts (when methylated on arginine residues) with TDRD1, TDRKH/TDRD2, RNF17/TDRD4, TDRD6, TDRD7 and TDRD9 By similarity. Ref.8
Subcellular location	Cytoplasm By similarity. Note: Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis. Also present in chromatoid body By similarity.
Tissue specificity	Detected in most fetal and adult tissues. Expressed in testes, specifically in germline cells; detected in spermatocytes and spermatids during spermatogenesis. Increased expression in testicular tumors originating from embryonic germ cells with retention of germ cells phenotype. No expression in testicular tumors of somatic origin, such as Sertoli cell and Leydig cell tumors. Overexpressed in gastric cancer cells. Isoform 3 is ubiquitously expressed, and specifically in CD34+ hematopoietic progenitor cells but not in more differentiated cells. Ref.1 Ref.2 Ref.7
Induction	Isoform 3 is down-regulated in CD34+ hematopoietic cells during differentiation. Ref.1
Domain	The PAZ domain specifically recognizes binds the 2'-O-methylated 3'-end of piRNAs. Ref.10
Post-translational modification	Arginine methylation by PRMT5 is required for the interaction with Tudor domain-containing protein (TDRD1, TDRKH/TDRD2, RNF17/TDRD4, TDRD6, TDRD7 and TDRD9) and subsequent localization to the meiotic nuage, also named P granule By similarity.
Sequence similarities	Belongs to the argonaute family. Piwi subfamily. Contains 1 PAZ domain. Contains 1 Piwi domain.

Ontologies

Keywords
Biological process	Differentiation Meiosis RNA-mediated gene silencing Spermatogenesis Translation regulation
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	RNA-binding
Molecular function	Developmental protein
PTM	Methylation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	gene silencing by RNA Inferred from sequence or structural similarity. Source: UniProtKB meiosis Inferred from electronic annotation. Source: UniProtKB-KW multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW piRNA metabolic process Inferred from electronic annotation. Source: Compara regulation of translation Inferred from electronic annotation. Source: UniProtKB-KW spermatid development Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	P granule Inferred from sequence or structural similarity. Source: UniProtKB chromatoid body Inferred from sequence or structural similarity. Source: UniProtKB mRNA cap binding complex Inferred from electronic annotation. Source: Compara polysome Inferred from electronic annotation. Source: Compara
Molecular_function	mRNA binding Inferred from sequence or structural similarity. Source: UniProtKB piRNA binding Inferred from sequence or structural similarity. Source: UniProtKB single-stranded RNA binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
DICER1	Q9UPY3	2	EBI-527417,EBI-395506

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96J94-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96J94-2)

The sequence of this isoform differs from the canonical sequence as follows:
     824-829: GVIRVP → VSASTC
     830-861: Missing.

Isoform 3 (identifier: Q96J94-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-86: Missing.
     87-89: HDL → MIF

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 861

861

Piwi-like protein 1

PRO_0000234567

Regions

Domain

277 – 391

115

PAZ

Domain

555 – 847

293

Piwi

Region

316 – 318

3

Required for binding 2'-O-methylated 3'-end of piRNAs

Region

540 – 677

138

RNA-binding By similarity

Sites

Site

381

1

Required for binding 2'-O-methylated 3'-end of piRNAs

Amino acid modifications

Modified residue

14

1

Omega-N-methylarginine; by PRMT5; alternate By similarity

Modified residue

14

1

Symmetric dimethylarginine; by PRMT5; alternate By similarity

Modified residue

49

1

Omega-N-methylarginine; by PRMT5 By similarity

Modified residue

370

1

Omega-N-methylarginine; by PRMT5 By similarity

Natural variations

Alternative sequence

1 – 86

86

Missing in isoform 3.

VSP_018366

Alternative sequence

87 – 89

3

HDL → MIF in isoform 3.

VSP_018367

Alternative sequence

824 – 829

6

GVIRVP → VSASTC in isoform 2.

VSP_018368

Alternative sequence

830 – 861

32

Missing in isoform 2.

VSP_018369

Natural variant

491

1

K → N. Ref.5
Corresponds to variant rs17856812 [ dbSNP | Ensembl ].

VAR_026288

Natural variant

527

1

R → K. Ref.5
Corresponds to variant rs1106042 [ dbSNP | Ensembl ].

VAR_026289

Natural variant

575

1

L → P. Ref.5
Corresponds to variant rs17852568 [ dbSNP | Ensembl ].

VAR_026290

Experimental info

Mutagenesis

379

1

P → H: Impairs binding to 2'-O-methylated 3'-end of piRNAs; when associated with Y-381. Ref.10

Mutagenesis

381

1

M → Y: Impairs binding to 2'-O-methylated 3'-end of piRNAs; when associated with H-379. Ref.10

Sequence conflict

178

1

V → A in BAC04068. Ref.4

Sequence conflict

314

1

N → I in AAC97371. Ref.2

Sequence conflict

339

1

E → G in AAC97371. Ref.2

Sequence conflict

353

1

E → K in BAF49084. Ref.6

Secondary structure

1

.

.

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.

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861

Helix Strand Turn

Details...

Helix

279 – 285

7

Helix

286 – 288

3

Helix

292 – 303

12

Beta strand

307 – 310

4

Turn

311 – 314

4

Beta strand

316 – 318

3

Beta strand

321 – 323

3

Beta strand

331 – 333

3

Beta strand

335 – 337

3

Beta strand

339 – 341

3

Helix

342 – 350

9

Beta strand

361 – 364

4

Beta strand

370 – 375

6

Beta strand

380 – 382

3

Helix

384 – 386

3

Beta strand

387 – 389

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 58D7F6C7321DEFA4	FASTA	861	98,603
	10 20 30 40 50 60 MTGRARARAR GRARGQETAQ LVGSTASQQP GYIQPRPQPP PAEGELFGRG RQRGTAGGTA 70 80 90 100 110 120 KSQGLQISAG FQELSLAERG GRRRDFHDLG VNTRQNLDHV KESKTGSSGI IVRLSTNHFR 130 140 150 160 170 180 LTSRPQWALY QYHIDYNPLM EARRLRSALL FQHEDLIGKC HAFDGTILFL PKRLQQKVTE 190 200 210 220 230 240 VFSKTRNGED VRITITLTNE LPPTSPTCLQ FYNIIFRRLL KIMNLQQIGR NYYNPNDPID 250 260 270 280 290 300 IPSHRLVIWP GFTTSILQYE NSIMLCTDVS HKVLRSETVL DFMFNFYHQT EEHKFQEQVS 310 320 330 340 350 360 KELIGLVVLT KYNNKTYRVD DIDWDQNPKS TFKKADGSEV SFLEYYRKQY NQEITDLKQP 370 380 390 400 410 420 VLVSQPKRRR GPGGTLPGPA MLIPELCYLT GLTDKMRNDF NVMKDLAVHT RLTPEQRQRE 430 440 450 460 470 480 VGRLIDYIHK NDNVQRELRD WGLSFDSNLL SFSGRILQTE KIHQGGKTFD YNPQFADWSK 490 500 510 520 530 540 ETRGAPLISV KPLDNWLLIY TRRNYEAANS LIQNLFKVTP AMGMQMRKAI MIEVDDRTEA 550 560 570 580 590 600 YLRVLQQKVT ADTQIVVCLL SSNRKDKYDA IKKYLCTDCP TPSQCVVART LGKQQTVMAI 610 620 630 640 650 660 ATKIALQMNC KMGGELWRVD IPLKLVMIVG IDCYHDMTAG RRSIAGFVAS INEGMTRWFS 670 680 690 700 710 720 RCIFQDRGQE LVDGLKVCLQ AALRAWNSCN EYMPSRIIVY RDGVGDGQLK TLVNYEVPQF 730 740 750 760 770 780 LDCLKSIGRG YNPRLTVIVV KKRVNTRFFA QSGGRLQNPL PGTVIDVEVT RPEWYDFFIV 790 800 810 820 830 840 SQAVRSGSVS PTHYNVIYDN SGLKPDHIQR LTYKLCHIYY NWPGVIRVPA PCQYAHKLAF 850 860 LVGQSIHREP NLSLSNRLYY L
	Isoform 2 [UniParc]. Checksum: 03ADA415D1C159C3	FASTA	829	94,845
	10 20 30 40 50 60 MTGRARARAR GRARGQETAQ LVGSTASQQP GYIQPRPQPP PAEGELFGRG RQRGTAGGTA 70 80 90 100 110 120 KSQGLQISAG FQELSLAERG GRRRDFHDLG VNTRQNLDHV KESKTGSSGI IVRLSTNHFR 130 140 150 160 170 180 LTSRPQWALY QYHIDYNPLM EARRLRSALL FQHEDLIGKC HAFDGTILFL PKRLQQKVTE 190 200 210 220 230 240 VFSKTRNGED VRITITLTNE LPPTSPTCLQ FYNIIFRRLL KIMNLQQIGR NYYNPNDPID 250 260 270 280 290 300 IPSHRLVIWP GFTTSILQYE NSIMLCTDVS HKVLRSETVL DFMFNFYHQT EEHKFQEQVS 310 320 330 340 350 360 KELIGLVVLT KYNNKTYRVD DIDWDQNPKS TFKKADGSEV SFLEYYRKQY NQEITDLKQP 370 380 390 400 410 420 VLVSQPKRRR GPGGTLPGPA MLIPELCYLT GLTDKMRNDF NVMKDLAVHT RLTPEQRQRE 430 440 450 460 470 480 VGRLIDYIHK NDNVQRELRD WGLSFDSNLL SFSGRILQTE KIHQGGKTFD YNPQFADWSK 490 500 510 520 530 540 ETRGAPLISV KPLDNWLLIY TRRNYEAANS LIQNLFKVTP AMGMQMRKAI MIEVDDRTEA 550 560 570 580 590 600 YLRVLQQKVT ADTQIVVCLL SSNRKDKYDA IKKYLCTDCP TPSQCVVART LGKQQTVMAI 610 620 630 640 650 660 ATKIALQMNC KMGGELWRVD IPLKLVMIVG IDCYHDMTAG RRSIAGFVAS INEGMTRWFS 670 680 690 700 710 720 RCIFQDRGQE LVDGLKVCLQ AALRAWNSCN EYMPSRIIVY RDGVGDGQLK TLVNYEVPQF 730 740 750 760 770 780 LDCLKSIGRG YNPRLTVIVV KKRVNTRFFA QSGGRLQNPL PGTVIDVEVT RPEWYDFFIV 790 800 810 820 SQAVRSGSVS PTHYNVIYDN SGLKPDHIQR LTYKLCHIYY NWPVSASTC
	Isoform 3 [UniParc]. Checksum: DF169A2E9EAFD916	FASTA	775	89,484
	10 20 30 40 50 60 MIFGVNTRQN LDHVKESKTG SSGIIVRLST NHFRLTSRPQ WALYQYHIDY NPLMEARRLR 70 80 90 100 110 120 SALLFQHEDL IGKCHAFDGT ILFLPKRLQQ KVTEVFSKTR NGEDVRITIT LTNELPPTSP 130 140 150 160 170 180 TCLQFYNIIF RRLLKIMNLQ QIGRNYYNPN DPIDIPSHRL VIWPGFTTSI LQYENSIMLC 190 200 210 220 230 240 TDVSHKVLRS ETVLDFMFNF YHQTEEHKFQ EQVSKELIGL VVLTKYNNKT YRVDDIDWDQ 250 260 270 280 290 300 NPKSTFKKAD GSEVSFLEYY RKQYNQEITD LKQPVLVSQP KRRRGPGGTL PGPAMLIPEL 310 320 330 340 350 360 CYLTGLTDKM RNDFNVMKDL AVHTRLTPEQ RQREVGRLID YIHKNDNVQR ELRDWGLSFD 370 380 390 400 410 420 SNLLSFSGRI LQTEKIHQGG KTFDYNPQFA DWSKETRGAP LISVKPLDNW LLIYTRRNYE 430 440 450 460 470 480 AANSLIQNLF KVTPAMGMQM RKAIMIEVDD RTEAYLRVLQ QKVTADTQIV VCLLSSNRKD 490 500 510 520 530 540 KYDAIKKYLC TDCPTPSQCV VARTLGKQQT VMAIATKIAL QMNCKMGGEL WRVDIPLKLV 550 560 570 580 590 600 MIVGIDCYHD MTAGRRSIAG FVASINEGMT RWFSRCIFQD RGQELVDGLK VCLQAALRAW 610 620 630 640 650 660 NSCNEYMPSR IIVYRDGVGD GQLKTLVNYE VPQFLDCLKS IGRGYNPRLT VIVVKKRVNT 670 680 690 700 710 720 RFFAQSGGRL QNPLPGTVID VEVTRPEWYD FFIVSQAVRS GSVSPTHYNV IYDNSGLKPD 730 740 750 760 770 HIQRLTYKLC HIYYNWPGVI RVPAPCQYAH KLAFLVGQSI HREPNLSLSN RLYYL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human CD34+ stem cells express the hiwi gene, a human homologue of the Drosophila gene piwi." Sharma A.K., Nelson M.C., Brandt J.E., Wessman M., Mahmud N., Weller K.P., Hoffman R. Blood 97:426-434(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, INDUCTION. Tissue: Testis.
[2]	"Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas." Qiao D., Zeeman A.-M., Deng W., Looijenga L.H.J., Lin H. Oncogene 21:3988-3999(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY. Tissue: Testis.
[3]	"Cloning and identification of human piwi protein related to testis development." Sha J.H. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Testis.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ASN-491; LYS-527 AND PRO-575. Tissue: Testis.
[6]	"The induction of H3K9 methylation by PIWIL4 at the p16Ink4a locus." Sugimoto K., Kage H., Aki N., Sano A., Kitagawa H., Nagase T., Yatomi Y., Ohishi N., Takai D. Biochem. Biophys. Res. Commun. 359:497-502(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-530.
[7]	"Identification of eight members of the Argonaute family in the human genome." Sasaki T., Shiohama A., Minoshima S., Shimizu N. Genomics 82:323-330(2003) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[8]	"Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer." Tahbaz N., Kolb F.A., Zhang H., Jaronczyk K., Filipowicz W., Hobman T.C. EMBO Rep. 5:189-194(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH DICER1, FUNCTION.
[9]	"Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells." Liu X., Sun Y., Guo J., Ma H., Li J., Dong B., Jin G., Zhang J., Wu J., Meng L., Shou C. Int. J. Cancer 118:1922-1929(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[10]	"Structural basis for piRNA 2'-O-methylated 3'-end recognition by Piwi PAZ (Piwi/Argonaute/Zwille) domains." Tian Y., Simanshu D.K., Ma J.B., Patel D.J. Proc. Natl. Acad. Sci. U.S.A. 108:903-910(2011) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 277-399 IN COMPLEX WITH METHYLATED SMALL RNA, DOMAIN PAZ, MUTAGENESIS OF PRO-379 AND MET-381.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF264004 mRNA. Translation: AAK92281.1.
AF104260 mRNA. Translation: AAC97371.2.
AF387507 mRNA. Translation: AAK69348.1.
AK093133 mRNA. Translation: BAC04068.1.
BC028581 mRNA. Translation: AAH28581.1.
AB274731 mRNA. Translation: BAF49084.1.

IPI

IPI00290933.
IPI00746870.
IPI00747208.

RefSeq

NP_001177900.1. NM_001190971.1.
NP_004755.2. NM_004764.4.

UniGene

Hs.405659.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2L5C	NMR	-	A	266-399	[»]
2L5D	NMR	-	A	266-399	[»]
3O3I	X-ray	2.80	X	276-399	[»]
3O6E	X-ray	2.90	X	276-399	[»]
3O7V	X-ray	2.10	X	276-399	[»]

ProteinModelPortal

Q96J94.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-33534N.

IntAct

Q96J94. 1 interaction.

STRING

9606.ENSP00000245255.

PTM databases

PhosphoSite

Q96J94.

Polymorphism databases

DMDM

74716803.

Proteomic databases

PaxDb

Q96J94.

PRIDE

Q96J94.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000245255; ENSP00000245255; ENSG00000125207.

GeneID

9271.

KEGG

hsa:9271.

UCSC

uc001uij.2. human.
uc001uik.3. human.

Organism-specific databases

CTD

9271.

GeneCards

GC12P130822.

HGNC

HGNC:9007. PIWIL1.

HPA

CAB012217.

MIM

605571. gene.

neXtProt

NX_Q96J94.

PharmGKB

PA33341.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG286051.

HOGENOM

HOG000254789.

HOVERGEN

HBG049411.

InParanoid

Q96J94.

KO

K02156.

OMA

PGYIQPR.

OrthoDB

EOG47SSD7.

PhylomeDB

Q96J94.

Gene expression databases

ArrayExpress

Q96J94.

Bgee

Q96J94.

CleanEx

HS_PIWIL1.

Genevestigator

Q96J94.

GermOnline

ENSG00000125207. Homo sapiens.

Family and domain databases

InterPro

IPR008625. GAGE.
IPR003100. PAZ.
IPR003165. Piwi.
IPR012337. RNaseH-like_dom.
[Graphical view]

Pfam

PF05831. GAGE. 1 hit.
PF02170. PAZ. 1 hit.
PF02171. Piwi. 1 hit.
[Graphical view]

SMART

SM00949. PAZ. 1 hit.
SM00950. Piwi. 1 hit.
[Graphical view]

SUPFAM

SSF101690. PAZ. 1 hit.
SSF53098. RNaseH_fold. 1 hit.

PROSITE

PS50821. PAZ. 1 hit.
PS50822. PIWI. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q96J94.

GenomeRNAi

9271.

NextBio

34751.

SOURCE

Search...

Entry information

Entry name

PIWL1_HUMAN

Accession

Primary (citable) accession number: Q96J94
Secondary accession number(s): A4F266 , O95404, Q8NA60, Q8TBY5, Q96JD5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.