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Q96J88

- ESIP1_HUMAN

UniProt

Q96J88 - ESIP1_HUMAN

Protein

Epithelial-stromal interaction protein 1

Gene

EPSTI1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (15 Jan 2008)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Epithelial-stromal interaction protein 1
    Gene namesi
    Name:EPSTI1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:16465. EPSTI1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27840.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 318318Epithelial-stromal interaction protein 1PRO_0000314034Add
    BLAST

    Proteomic databases

    MaxQBiQ96J88.
    PaxDbiQ96J88.
    PRIDEiQ96J88.

    PTM databases

    PhosphoSiteiQ96J88.

    Expressioni

    Tissue specificityi

    Highly expressed in placenta, small intestine, spleen, kidney, thymus, liver, salivary gland and testes. Weakly expressed in breast, skeletal muscle and colon. Highly expressed in breast cancer upon interaction between tumor cells and stromal cells in vitro. Expressed in blood mononuclear cells from patients with systemic lupus erythematosus (SLE).2 Publications

    Inductioni

    Up-regulated in breast carcinomas.1 Publication

    Gene expression databases

    ArrayExpressiQ96J88.
    BgeeiQ96J88.
    CleanExiHS_EPSTI1.
    GenevestigatoriQ96J88.

    Organism-specific databases

    HPAiHPA017362.

    Interactioni

    Protein-protein interaction databases

    BioGridi125151. 1 interaction.
    IntActiQ96J88. 1 interaction.
    STRINGi9606.ENSP00000318982.

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili73 – 188116Sequence AnalysisAdd
    BLAST
    Coiled coili240 – 28041Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG44660.
    HOGENOMiHOG000112394.
    HOVERGENiHBG067189.
    InParanoidiQ96J88.
    OMAiSWAYRDS.
    OrthoDBiEOG7PS1H6.
    PhylomeDBiQ96J88.
    TreeFamiTF335788.

    Family and domain databases

    InterProiIPR026185. EPSTI1.
    [Graphical view]
    PANTHERiPTHR22529. PTHR22529. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96J88-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNTRNRVVNS GLGASPASRP TRDPQDPSGR QGELSPVEDQ REGLEAAPKG    50
    PSRESVVHAG QRRTSAYTLI APNINRRNEI QRIAEQELAN LEKWKEQNRA 100
    KPVHLVPRRL GGSQSETEVR QKQQLQLMQS KYKQKLKREE SVRIKKEAEE 150
    AELQKMKAIQ REKSNKLEEK KRLQENLRRE AFREHQQYKT AEFLSKLNTE 200
    SPDRSACQSA VCGPQSSTWK LPILPRDHSW ARSWAYRDSL KAEENRKLQK 250
    MKDEQHQKSE LLELKRQQQE QERAKIHQTE HRRVNNAFLD RLQGKSQPGG 300
    LEQSGGCWNM NSGNSWGI 318

    Note: No experimental confirmation available.

    Length:318
    Mass (Da):36,793
    Last modified:January 15, 2008 - v2
    Checksum:i28C04AE12042A01A
    GO
    Isoform 2 (identifier: Q96J88-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         219-229: Missing.

    Show »
    Length:307
    Mass (Da):35,450
    Checksum:i375033A69779CDB1
    GO
    Isoform 3 (identifier: Q96J88-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         318-318: I → SLLVFSRHLR...YCQGNATLFF

    Show »
    Length:410
    Mass (Da):47,490
    Checksum:iD2F8DB05B65FC826
    GO

    Sequence cautioni

    The sequence CAD38599.2 differs from that shown. Reason: Intron retention. Authors have ignored retained intron when translating.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti83 – 831Missing in CAD38599. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Isoform 3 (identifier: Q96J88-3)
    Natural varianti338 – 3381P → S.
    Corresponds to variant rs11557739 [ dbSNP | Ensembl ].
    Natural varianti399 – 3991N → K.
    Corresponds to variant rs1044856 [ dbSNP | Ensembl ].

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei219 – 22911Missing in isoform 2. 2 PublicationsVSP_030201Add
    BLAST
    Alternative sequencei318 – 3181I → SLLVFSRHLRVYEKILTPIW PSSTDLEKPHEMLFLNVILF SLTVFTLISTAHTLDRAVRS DWLLLVLIYACLEELIPELI FNLYCQGNATLFF in isoform 3. 1 PublicationVSP_030202

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF396928 mRNA. Translation: AAK73753.1.
    AK292461 mRNA. Translation: BAF85150.1.
    AL831953 mRNA. Translation: CAD38599.2. Sequence problems.
    AL137878, AL445217 Genomic DNA. Translation: CAH70578.1.
    AL445217, AL137878 Genomic DNA. Translation: CAI13478.1.
    AL137878, AL445217 Genomic DNA. Translation: CAM13100.1.
    AL445217, AL137878 Genomic DNA. Translation: CAM17275.1.
    CH471075 Genomic DNA. Translation: EAX08685.1.
    CH471075 Genomic DNA. Translation: EAX08686.1.
    BC023660 mRNA. Translation: AAH23660.1.
    CCDSiCCDS31964.1. [Q96J88-3]
    CCDS9387.1. [Q96J88-2]
    RefSeqiNP_001002264.1. NM_001002264.2. [Q96J88-3]
    NP_150280.1. NM_033255.3. [Q96J88-2]
    XP_005266654.1. XM_005266597.1. [Q96J88-1]
    UniGeneiHs.546467.

    Genome annotation databases

    EnsembliENST00000313624; ENSP00000318643; ENSG00000133106. [Q96J88-2]
    ENST00000313640; ENSP00000318982; ENSG00000133106. [Q96J88-3]
    ENST00000398762; ENSP00000381746; ENSG00000133106. [Q96J88-1]
    GeneIDi94240.
    KEGGihsa:94240.
    UCSCiuc001uyw.2. human. [Q96J88-3]
    uc001uyx.2. human. [Q96J88-2]

    Polymorphism databases

    DMDMi166232399.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF396928 mRNA. Translation: AAK73753.1 .
    AK292461 mRNA. Translation: BAF85150.1 .
    AL831953 mRNA. Translation: CAD38599.2 . Sequence problems.
    AL137878 , AL445217 Genomic DNA. Translation: CAH70578.1 .
    AL445217 , AL137878 Genomic DNA. Translation: CAI13478.1 .
    AL137878 , AL445217 Genomic DNA. Translation: CAM13100.1 .
    AL445217 , AL137878 Genomic DNA. Translation: CAM17275.1 .
    CH471075 Genomic DNA. Translation: EAX08685.1 .
    CH471075 Genomic DNA. Translation: EAX08686.1 .
    BC023660 mRNA. Translation: AAH23660.1 .
    CCDSi CCDS31964.1. [Q96J88-3 ]
    CCDS9387.1. [Q96J88-2 ]
    RefSeqi NP_001002264.1. NM_001002264.2. [Q96J88-3 ]
    NP_150280.1. NM_033255.3. [Q96J88-2 ]
    XP_005266654.1. XM_005266597.1. [Q96J88-1 ]
    UniGenei Hs.546467.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125151. 1 interaction.
    IntActi Q96J88. 1 interaction.
    STRINGi 9606.ENSP00000318982.

    PTM databases

    PhosphoSitei Q96J88.

    Polymorphism databases

    DMDMi 166232399.

    Proteomic databases

    MaxQBi Q96J88.
    PaxDbi Q96J88.
    PRIDEi Q96J88.

    Protocols and materials databases

    DNASUi 94240.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000313624 ; ENSP00000318643 ; ENSG00000133106 . [Q96J88-2 ]
    ENST00000313640 ; ENSP00000318982 ; ENSG00000133106 . [Q96J88-3 ]
    ENST00000398762 ; ENSP00000381746 ; ENSG00000133106 . [Q96J88-1 ]
    GeneIDi 94240.
    KEGGi hsa:94240.
    UCSCi uc001uyw.2. human. [Q96J88-3 ]
    uc001uyx.2. human. [Q96J88-2 ]

    Organism-specific databases

    CTDi 94240.
    GeneCardsi GC13M043460.
    HGNCi HGNC:16465. EPSTI1.
    HPAi HPA017362.
    MIMi 607441. gene.
    neXtProti NX_Q96J88.
    PharmGKBi PA27840.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44660.
    HOGENOMi HOG000112394.
    HOVERGENi HBG067189.
    InParanoidi Q96J88.
    OMAi SWAYRDS.
    OrthoDBi EOG7PS1H6.
    PhylomeDBi Q96J88.
    TreeFami TF335788.

    Miscellaneous databases

    ChiTaRSi EPSTI1. human.
    GenomeRNAii 94240.
    NextBioi 78493.
    PROi Q96J88.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96J88.
    Bgeei Q96J88.
    CleanExi HS_EPSTI1.
    Genevestigatori Q96J88.

    Family and domain databases

    InterProi IPR026185. EPSTI1.
    [Graphical view ]
    PANTHERi PTHR22529. PTHR22529. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of EPSTI1, a novel gene induced by epithelial-stromal interaction in human breast cancer."
      Nielsen H.L., Ronnov-Jessen L., Villadsen R., Petersen O.W.
      Genomics 79:703-710(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INDUCTION, TISSUE SPECIFICITY.
      Tissue: Mammary gland.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lymph node.
    4. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Colon.
    7. "Isolation and expression profiling of genes upregulated in the peripheral blood cells of systemic lupus erythematosus patients."
      Ishii T., Onda H., Tanigawa A., Ohshima S., Fujiwara H., Mima T., Katada Y., Deguchi H., Suemura M., Miyake T., Miyatake K., Kawase I., Zhao H., Tomiyama Y., Saeki Y., Nojima H.
      DNA Res. 12:429-439(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiESIP1_HUMAN
    AccessioniPrimary (citable) accession number: Q96J88
    Secondary accession number(s): Q8IVC7, Q8NDQ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3