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Q96J88

- ESIP1_HUMAN

UniProt

Q96J88 - ESIP1_HUMAN

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Protein

Epithelial-stromal interaction protein 1

Gene

EPSTI1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Epithelial-stromal interaction protein 1
Gene namesi
Name:EPSTI1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:16465. EPSTI1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27840.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Epithelial-stromal interaction protein 1PRO_0000314034Add
BLAST

Proteomic databases

MaxQBiQ96J88.
PaxDbiQ96J88.
PRIDEiQ96J88.

PTM databases

PhosphoSiteiQ96J88.

Expressioni

Tissue specificityi

Highly expressed in placenta, small intestine, spleen, kidney, thymus, liver, salivary gland and testes. Weakly expressed in breast, skeletal muscle and colon. Highly expressed in breast cancer upon interaction between tumor cells and stromal cells in vitro. Expressed in blood mononuclear cells from patients with systemic lupus erythematosus (SLE).2 Publications

Inductioni

Up-regulated in breast carcinomas.1 Publication

Gene expression databases

BgeeiQ96J88.
CleanExiHS_EPSTI1.
ExpressionAtlasiQ96J88. baseline and differential.
GenevestigatoriQ96J88.

Organism-specific databases

HPAiHPA017362.

Interactioni

Protein-protein interaction databases

BioGridi125151. 1 interaction.
IntActiQ96J88. 1 interaction.
STRINGi9606.ENSP00000318982.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili73 – 188116Sequence AnalysisAdd
BLAST
Coiled coili240 – 28041Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG44660.
GeneTreeiENSGT00390000013820.
HOGENOMiHOG000112394.
HOVERGENiHBG067189.
InParanoidiQ96J88.
OMAiSWAYRDS.
OrthoDBiEOG7PS1H6.
PhylomeDBiQ96J88.
TreeFamiTF335788.

Family and domain databases

InterProiIPR026185. EPSTI1.
[Graphical view]
PANTHERiPTHR22529. PTHR22529. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96J88-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNTRNRVVNS GLGASPASRP TRDPQDPSGR QGELSPVEDQ REGLEAAPKG
60 70 80 90 100
PSRESVVHAG QRRTSAYTLI APNINRRNEI QRIAEQELAN LEKWKEQNRA
110 120 130 140 150
KPVHLVPRRL GGSQSETEVR QKQQLQLMQS KYKQKLKREE SVRIKKEAEE
160 170 180 190 200
AELQKMKAIQ REKSNKLEEK KRLQENLRRE AFREHQQYKT AEFLSKLNTE
210 220 230 240 250
SPDRSACQSA VCGPQSSTWK LPILPRDHSW ARSWAYRDSL KAEENRKLQK
260 270 280 290 300
MKDEQHQKSE LLELKRQQQE QERAKIHQTE HRRVNNAFLD RLQGKSQPGG
310
LEQSGGCWNM NSGNSWGI

Note: No experimental confirmation available.

Length:318
Mass (Da):36,793
Last modified:January 15, 2008 - v2
Checksum:i28C04AE12042A01A
GO
Isoform 2 (identifier: Q96J88-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     219-229: Missing.

Show »
Length:307
Mass (Da):35,450
Checksum:i375033A69779CDB1
GO
Isoform 3 (identifier: Q96J88-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     318-318: I → SLLVFSRHLR...YCQGNATLFF

Show »
Length:410
Mass (Da):47,490
Checksum:iD2F8DB05B65FC826
GO

Sequence cautioni

The sequence CAD38599.2 differs from that shown. Reason: Intron retention. Authors have ignored retained intron when translating.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti83 – 831Missing in CAD38599. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Isoform 3 (identifier: Q96J88-3)
Natural varianti338 – 3381P → S.
Corresponds to variant rs11557739 [ dbSNP | Ensembl ].
Natural varianti399 – 3991N → K.
Corresponds to variant rs1044856 [ dbSNP | Ensembl ].

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei219 – 22911Missing in isoform 2. 2 PublicationsVSP_030201Add
BLAST
Alternative sequencei318 – 3181I → SLLVFSRHLRVYEKILTPIW PSSTDLEKPHEMLFLNVILF SLTVFTLISTAHTLDRAVRS DWLLLVLIYACLEELIPELI FNLYCQGNATLFF in isoform 3. 1 PublicationVSP_030202

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF396928 mRNA. Translation: AAK73753.1.
AK292461 mRNA. Translation: BAF85150.1.
AL831953 mRNA. Translation: CAD38599.2. Sequence problems.
AL137878, AL445217 Genomic DNA. Translation: CAH70578.1.
AL445217, AL137878 Genomic DNA. Translation: CAI13478.1.
AL137878, AL445217 Genomic DNA. Translation: CAM13100.1.
AL445217, AL137878 Genomic DNA. Translation: CAM17275.1.
CH471075 Genomic DNA. Translation: EAX08685.1.
CH471075 Genomic DNA. Translation: EAX08686.1.
BC023660 mRNA. Translation: AAH23660.1.
CCDSiCCDS31964.1. [Q96J88-3]
CCDS9387.1. [Q96J88-2]
RefSeqiNP_001002264.1. NM_001002264.2. [Q96J88-3]
NP_150280.1. NM_033255.3. [Q96J88-2]
XP_005266654.1. XM_005266597.1. [Q96J88-1]
UniGeneiHs.546467.

Genome annotation databases

EnsembliENST00000313624; ENSP00000318643; ENSG00000133106. [Q96J88-2]
ENST00000313640; ENSP00000318982; ENSG00000133106. [Q96J88-3]
ENST00000398762; ENSP00000381746; ENSG00000133106. [Q96J88-1]
GeneIDi94240.
KEGGihsa:94240.
UCSCiuc001uyw.2. human. [Q96J88-3]
uc001uyx.2. human. [Q96J88-2]

Polymorphism databases

DMDMi166232399.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF396928 mRNA. Translation: AAK73753.1 .
AK292461 mRNA. Translation: BAF85150.1 .
AL831953 mRNA. Translation: CAD38599.2 . Sequence problems.
AL137878 , AL445217 Genomic DNA. Translation: CAH70578.1 .
AL445217 , AL137878 Genomic DNA. Translation: CAI13478.1 .
AL137878 , AL445217 Genomic DNA. Translation: CAM13100.1 .
AL445217 , AL137878 Genomic DNA. Translation: CAM17275.1 .
CH471075 Genomic DNA. Translation: EAX08685.1 .
CH471075 Genomic DNA. Translation: EAX08686.1 .
BC023660 mRNA. Translation: AAH23660.1 .
CCDSi CCDS31964.1. [Q96J88-3 ]
CCDS9387.1. [Q96J88-2 ]
RefSeqi NP_001002264.1. NM_001002264.2. [Q96J88-3 ]
NP_150280.1. NM_033255.3. [Q96J88-2 ]
XP_005266654.1. XM_005266597.1. [Q96J88-1 ]
UniGenei Hs.546467.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125151. 1 interaction.
IntActi Q96J88. 1 interaction.
STRINGi 9606.ENSP00000318982.

PTM databases

PhosphoSitei Q96J88.

Polymorphism databases

DMDMi 166232399.

Proteomic databases

MaxQBi Q96J88.
PaxDbi Q96J88.
PRIDEi Q96J88.

Protocols and materials databases

DNASUi 94240.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000313624 ; ENSP00000318643 ; ENSG00000133106 . [Q96J88-2 ]
ENST00000313640 ; ENSP00000318982 ; ENSG00000133106 . [Q96J88-3 ]
ENST00000398762 ; ENSP00000381746 ; ENSG00000133106 . [Q96J88-1 ]
GeneIDi 94240.
KEGGi hsa:94240.
UCSCi uc001uyw.2. human. [Q96J88-3 ]
uc001uyx.2. human. [Q96J88-2 ]

Organism-specific databases

CTDi 94240.
GeneCardsi GC13M043460.
HGNCi HGNC:16465. EPSTI1.
HPAi HPA017362.
MIMi 607441. gene.
neXtProti NX_Q96J88.
PharmGKBi PA27840.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44660.
GeneTreei ENSGT00390000013820.
HOGENOMi HOG000112394.
HOVERGENi HBG067189.
InParanoidi Q96J88.
OMAi SWAYRDS.
OrthoDBi EOG7PS1H6.
PhylomeDBi Q96J88.
TreeFami TF335788.

Miscellaneous databases

ChiTaRSi EPSTI1. human.
GenomeRNAii 94240.
NextBioi 78493.
PROi Q96J88.
SOURCEi Search...

Gene expression databases

Bgeei Q96J88.
CleanExi HS_EPSTI1.
ExpressionAtlasi Q96J88. baseline and differential.
Genevestigatori Q96J88.

Family and domain databases

InterProi IPR026185. EPSTI1.
[Graphical view ]
PANTHERi PTHR22529. PTHR22529. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of EPSTI1, a novel gene induced by epithelial-stromal interaction in human breast cancer."
    Nielsen H.L., Ronnov-Jessen L., Villadsen R., Petersen O.W.
    Genomics 79:703-710(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INDUCTION, TISSUE SPECIFICITY.
    Tissue: Mammary gland.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lymph node.
  4. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Colon.
  7. "Isolation and expression profiling of genes upregulated in the peripheral blood cells of systemic lupus erythematosus patients."
    Ishii T., Onda H., Tanigawa A., Ohshima S., Fujiwara H., Mima T., Katada Y., Deguchi H., Suemura M., Miyake T., Miyatake K., Kawase I., Zhao H., Tomiyama Y., Saeki Y., Nojima H.
    DNA Res. 12:429-439(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiESIP1_HUMAN
AccessioniPrimary (citable) accession number: Q96J88
Secondary accession number(s): Q8IVC7, Q8NDQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: October 29, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3