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Q96J88 (ESIP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Epithelial-stromal interaction protein 1
Gene names
Name:EPSTI1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Tissue specificity

Highly expressed in placenta, small intestine, spleen, kidney, thymus, liver, salivary gland and testes. Weakly expressed in breast, skeletal muscle and colon. Highly expressed in breast cancer upon interaction between tumor cells and stromal cells in vitro. Expressed in blood mononuclear cells from patients with systemic lupus erythematosus (SLE). Ref.1 Ref.7

Induction

Up-regulated in breast carcinomas. Ref.1

Sequence caution

The sequence CAD38599.2 differs from that shown. Reason: Intron retention. Authors have ignored retained intron when translating.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96J88-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 (identifier: Q96J88-2)

The sequence of this isoform differs from the canonical sequence as follows:
     219-229: Missing.
Isoform 3 (identifier: Q96J88-3)

The sequence of this isoform differs from the canonical sequence as follows:
     318-318: I → SLLVFSRHLR...YCQGNATLFF

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 318318Epithelial-stromal interaction protein 1
PRO_0000314034

Regions

Coiled coil73 – 188116 Potential
Coiled coil240 – 28041 Potential

Natural variations

Alternative sequence219 – 22911Missing in isoform 2.
VSP_030201
Alternative sequence3181I → SLLVFSRHLRVYEKILTPIW PSSTDLEKPHEMLFLNVILF SLTVFTLISTAHTLDRAVRS DWLLLVLIYACLEELIPELI FNLYCQGNATLFF in isoform 3.
VSP_030202
Isoform 3:
Natural variant3381P → S.
Corresponds to variant rs11557739 [ dbSNP | Ensembl ].
Natural variant3991N → K.
Corresponds to variant rs1044856 [ dbSNP | Ensembl ].

Experimental info

Sequence conflict831Missing in CAD38599. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 15, 2008. Version 2.
Checksum: 28C04AE12042A01A

FASTA31836,793
        10         20         30         40         50         60 
MNTRNRVVNS GLGASPASRP TRDPQDPSGR QGELSPVEDQ REGLEAAPKG PSRESVVHAG 

        70         80         90        100        110        120 
QRRTSAYTLI APNINRRNEI QRIAEQELAN LEKWKEQNRA KPVHLVPRRL GGSQSETEVR 

       130        140        150        160        170        180 
QKQQLQLMQS KYKQKLKREE SVRIKKEAEE AELQKMKAIQ REKSNKLEEK KRLQENLRRE 

       190        200        210        220        230        240 
AFREHQQYKT AEFLSKLNTE SPDRSACQSA VCGPQSSTWK LPILPRDHSW ARSWAYRDSL 

       250        260        270        280        290        300 
KAEENRKLQK MKDEQHQKSE LLELKRQQQE QERAKIHQTE HRRVNNAFLD RLQGKSQPGG 

       310 
LEQSGGCWNM NSGNSWGI 

« Hide

Isoform 2 [UniParc].

Checksum: 375033A69779CDB1
Show »

FASTA30735,450
Isoform 3 [UniParc].

Checksum: D2F8DB05B65FC826
Show »

FASTA41047,490

References

« Hide 'large scale' references
[1]"Identification of EPSTI1, a novel gene induced by epithelial-stromal interaction in human breast cancer."
Nielsen H.L., Ronnov-Jessen L., Villadsen R., Petersen O.W.
Genomics 79:703-710(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INDUCTION, TISSUE SPECIFICITY.
Tissue: Mammary gland.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Testis.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Lymph node.
[4]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Colon.
[7]"Isolation and expression profiling of genes upregulated in the peripheral blood cells of systemic lupus erythematosus patients."
Ishii T., Onda H., Tanigawa A., Ohshima S., Fujiwara H., Mima T., Katada Y., Deguchi H., Suemura M., Miyake T., Miyatake K., Kawase I., Zhao H., Tomiyama Y., Saeki Y., Nojima H.
DNA Res. 12:429-439(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF396928 mRNA. Translation: AAK73753.1.
AK292461 mRNA. Translation: BAF85150.1.
AL831953 mRNA. Translation: CAD38599.2. Sequence problems.
AL137878, AL445217 Genomic DNA. Translation: CAH70578.1.
AL445217, AL137878 Genomic DNA. Translation: CAI13478.1.
AL137878, AL445217 Genomic DNA. Translation: CAM13100.1.
AL445217, AL137878 Genomic DNA. Translation: CAM17275.1.
CH471075 Genomic DNA. Translation: EAX08685.1.
CH471075 Genomic DNA. Translation: EAX08686.1.
BC023660 mRNA. Translation: AAH23660.1.
CCDSCCDS31964.1. [Q96J88-3]
CCDS9387.1. [Q96J88-2]
RefSeqNP_001002264.1. NM_001002264.2. [Q96J88-3]
NP_150280.1. NM_033255.3. [Q96J88-2]
XP_005266654.1. XM_005266597.1. [Q96J88-1]
UniGeneHs.546467.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125151. 1 interaction.
IntActQ96J88. 1 interaction.
STRING9606.ENSP00000318982.

PTM databases

PhosphoSiteQ96J88.

Polymorphism databases

DMDM166232399.

Proteomic databases

MaxQBQ96J88.
PaxDbQ96J88.
PRIDEQ96J88.

Protocols and materials databases

DNASU94240.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000313624; ENSP00000318643; ENSG00000133106. [Q96J88-2]
ENST00000313640; ENSP00000318982; ENSG00000133106. [Q96J88-3]
ENST00000398762; ENSP00000381746; ENSG00000133106. [Q96J88-1]
GeneID94240.
KEGGhsa:94240.
UCSCuc001uyw.2. human. [Q96J88-3]
uc001uyx.2. human. [Q96J88-2]

Organism-specific databases

CTD94240.
GeneCardsGC13M043460.
HGNCHGNC:16465. EPSTI1.
HPAHPA017362.
MIM607441. gene.
neXtProtNX_Q96J88.
PharmGKBPA27840.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44660.
HOGENOMHOG000112394.
HOVERGENHBG067189.
InParanoidQ96J88.
OMASWAYRDS.
OrthoDBEOG7PS1H6.
PhylomeDBQ96J88.
TreeFamTF335788.

Gene expression databases

ArrayExpressQ96J88.
BgeeQ96J88.
CleanExHS_EPSTI1.
GenevestigatorQ96J88.

Family and domain databases

InterProIPR026185. EPSTI1.
[Graphical view]
PANTHERPTHR22529. PTHR22529. 1 hit.
ProtoNetSearch...

Other

ChiTaRSEPSTI1. human.
GenomeRNAi94240.
NextBio78493.
PROQ96J88.
SOURCESearch...

Entry information

Entry nameESIP1_HUMAN
AccessionPrimary (citable) accession number: Q96J88
Secondary accession number(s): Q8IVC7, Q8NDQ7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: July 9, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM