Q96J88 (ESIP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Epithelial-stromal interaction protein 1

Gene names

Name:

EPSTI1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Tissue specificity	Highly expressed in placenta, small intestine, spleen, kidney, thymus, liver, salivary gland and testes. Weakly expressed in breast, skeletal muscle and colon. Highly expressed in breast cancer upon interaction between tumor cells and stromal cells in vitro. Expressed in blood mononuclear cells from patients with systemic lupus erythematosus (SLE). Ref.1 Ref.7
Induction	Up-regulated in breast carcinomas. Ref.1
Sequence caution	The sequence CAD38599.2 differs from that shown. Reason: Intron retention. Authors have ignored retained intron when translating.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96J88-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 (identifier: Q96J88-2) The sequence of this isoform differs from the canonical sequence as follows:      219-229: Missing.
Isoform 3 (identifier: Q96J88-3) The sequence of this isoform differs from the canonical sequence as follows:      318-318: I → SLLVFSRHLR...YCQGNATLFF
Sequence annotation (Features)
	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
	Natural variant	338	1	P → S. Corresponds to variant rs11557739 [ dbSNP | Ensembl ].
	Natural variant	399	1	N → K. Corresponds to variant rs1044856 [ dbSNP | Ensembl ].

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 318	318	Epithelial-stromal interaction protein 1		PRO_0000314034
Regions
	Coiled coil	73 – 188	116	Potential
	Coiled coil	240 – 280	41	Potential
Natural variations
	Alternative sequence	219 – 229	11	Missing in isoform 2.		VSP_030201
	Alternative sequence	318	1	I → SLLVFSRHLRVYEKILTPIW PSSTDLEKPHEMLFLNVILF SLTVFTLISTAHTLDRAVRS DWLLLVLIYACLEELIPELI FNLYCQGNATLFF in isoform 3.		VSP_030202
Experimental info
	Sequence conflict	83	1	Missing in CAD38599. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 15, 2008. Version 2. Checksum: 28C04AE12042A01A	FASTA	318	36,793
	10 20 30 40 50 60 MNTRNRVVNS GLGASPASRP TRDPQDPSGR QGELSPVEDQ REGLEAAPKG PSRESVVHAG 70 80 90 100 110 120 QRRTSAYTLI APNINRRNEI QRIAEQELAN LEKWKEQNRA KPVHLVPRRL GGSQSETEVR 130 140 150 160 170 180 QKQQLQLMQS KYKQKLKREE SVRIKKEAEE AELQKMKAIQ REKSNKLEEK KRLQENLRRE 190 200 210 220 230 240 AFREHQQYKT AEFLSKLNTE SPDRSACQSA VCGPQSSTWK LPILPRDHSW ARSWAYRDSL 250 260 270 280 290 300 KAEENRKLQK MKDEQHQKSE LLELKRQQQE QERAKIHQTE HRRVNNAFLD RLQGKSQPGG 310 LEQSGGCWNM NSGNSWGI
	Isoform 2 [UniParc]. Checksum: 375033A69779CDB1	FASTA	307	35,450
	10 20 30 40 50 60 MNTRNRVVNS GLGASPASRP TRDPQDPSGR QGELSPVEDQ REGLEAAPKG PSRESVVHAG 70 80 90 100 110 120 QRRTSAYTLI APNINRRNEI QRIAEQELAN LEKWKEQNRA KPVHLVPRRL GGSQSETEVR 130 140 150 160 170 180 QKQQLQLMQS KYKQKLKREE SVRIKKEAEE AELQKMKAIQ REKSNKLEEK KRLQENLRRE 190 200 210 220 230 240 AFREHQQYKT AEFLSKLNTE SPDRSACQSA VCGPQSSTWA RSWAYRDSLK AEENRKLQKM 250 260 270 280 290 300 KDEQHQKSEL LELKRQQQEQ ERAKIHQTEH RRVNNAFLDR LQGKSQPGGL EQSGGCWNMN SGNSWGI
	Isoform 3 [UniParc]. Checksum: D2F8DB05B65FC826	FASTA	410	47,490
	10 20 30 40 50 60 MNTRNRVVNS GLGASPASRP TRDPQDPSGR QGELSPVEDQ REGLEAAPKG PSRESVVHAG 70 80 90 100 110 120 QRRTSAYTLI APNINRRNEI QRIAEQELAN LEKWKEQNRA KPVHLVPRRL GGSQSETEVR 130 140 150 160 170 180 QKQQLQLMQS KYKQKLKREE SVRIKKEAEE AELQKMKAIQ REKSNKLEEK KRLQENLRRE 190 200 210 220 230 240 AFREHQQYKT AEFLSKLNTE SPDRSACQSA VCGPQSSTWK LPILPRDHSW ARSWAYRDSL 250 260 270 280 290 300 KAEENRKLQK MKDEQHQKSE LLELKRQQQE QERAKIHQTE HRRVNNAFLD RLQGKSQPGG 310 320 330 340 350 360 LEQSGGCWNM NSGNSWGSLL VFSRHLRVYE KILTPIWPSS TDLEKPHEML FLNVILFSLT 370 380 390 400 410 VFTLISTAHT LDRAVRSDWL LLVLIYACLE ELIPELIFNL YCQGNATLFF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of EPSTI1, a novel gene induced by epithelial-stromal interaction in human breast cancer." Nielsen H.L., Ronnov-Jessen L., Villadsen R., Petersen O.W. Genomics 79:703-710(2002) [PubMed: 11991720] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INDUCTION, TISSUE SPECIFICITY. Tissue: Mammary gland.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lymph node.
[4]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Colon.
[7]	"Isolation and expression profiling of genes upregulated in the peripheral blood cells of systemic lupus erythematosus patients." Ishii T., Onda H., Tanigawa A., Ohshima S., Fujiwara H., Mima T., Katada Y., Deguchi H., Suemura M., Miyake T., Miyatake K., Kawase I., Zhao H., Tomiyama Y., Saeki Y., Nojima H. DNA Res. 12:429-439(2005) [PubMed: 16769699] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF396928 mRNA. Translation: AAK73753.1. AK292461 mRNA. Translation: BAF85150.1. AL831953 mRNA. Translation: CAD38599.2. Sequence problems. AL137878, AL445217 Genomic DNA. Translation: CAH70578.1. AL445217, AL137878 Genomic DNA. Translation: CAI13478.1. AL137878, AL445217 Genomic DNA. Translation: CAM13100.1. AL445217, AL137878 Genomic DNA. Translation: CAM17275.1. CH471075 Genomic DNA. Translation: EAX08685.1. CH471075 Genomic DNA. Translation: EAX08686.1. BC023660 mRNA. Translation: AAH23660.1.
IPI	IPI00063925. IPI00216980. IPI00878914.
RefSeq	NP_001002264.1. NM_001002264.1. NP_150280.1. NM_033255.2.
UniGene	Hs.546467.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96J88. 1 interaction.
STRING	Q96J88.
PTM databases
PhosphoSite	Q96J88.
Polymorphism databases
DMDM	166232399.
Proteomic databases
PRIDE	Q96J88.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000398762; ENSP00000381746; ENSG00000133106.
GeneID	94240.
KEGG	hsa:94240.
UCSC	uc001uyw.1. human. uc001uyx.1. human.
Organism-specific databases
CTD	94240.
GeneCards	GC13M043460.
HGNC	HGNC:16465. EPSTI1.
HPA	HPA017362.
MIM	607441. gene.
neXtProt	NX_Q96J88.
PharmGKB	PA27840.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG15253.
GeneTree	ENSGT00390000013820.
HOVERGEN	HBG067189.
InParanoid	Q96J88.
OMA	NSWSPLL.
Gene expression databases
ArrayExpress	Q96J88.
Bgee	Q96J88.
CleanEx	HS_EPSTI1.
Genevestigator	Q96J88.
Family and domain databases
ProtoNet	Search...
Other
NextBio	78493.
SOURCE	Search...

Entry information

Entry name

ESIP1_HUMAN

Accession

Primary (citable) accession number: Q96J88
Secondary accession number(s): Q8IVC7, Q8NDQ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	January 25, 2012
This is version 65 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.