Reviewed, UniProtKB/Swiss-Prot Q96J86 (CYYR1_HUMAN)

Names and origin

Protein names

Recommended name:
    Cysteine and tyrosine-rich protein 1
Alternative name(s):
    Proline-rich domain-containing protein

Gene names

Name:	CYYR1
Synonyms:	C21orf95

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	154 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Tissue specificity	Widely expressed. Ref.2 Ref.8
Sequence similarities	Belongs to the CYYR1 family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane
Gene Ontology (GO)
Cellular component	integral to membrane Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96J86-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96J86-2)

The sequence of this isoform differs from the canonical sequence as follows:
     111-111: P → PA

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 29	29	Potential
	Chain	30 – 154	125	Cysteine and tyrosine-rich protein 1		PRO_0000021054
Regions
	Topological domain	30 – 61	32	Extracellular Potential
	Transmembrane	62 – 82	21	Potential
	Topological domain	83 – 154	72	Cytoplasmic Potential
	Compositional bias	144 – 149	6	Poly-Pro
Natural variations
	Alternative sequence	111	1	P → PA in isoform 2.		VSP_034245
	Natural variant	95	1	R → H: dbSNP rs35253087.		VAR_044042
	Natural variant	111	1	P → S Ref.8		VAR_044043

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 0B0E5BD3FEC65F7D	FASTA	154	16,626
	10 20 30 40 50 60 MDAPRLPVRP GVLLPKLVLL FVYADDCLAQ CGKDCKSYCC DGTTPYCCSY YAYIGNILSG 70 80 90 100 110 120 TAIAGIVFGI VFIMGVIAGI AICICMCMKN HRATRVGILR TTHINTVSSY PGPPPYGHDH 130 140 150 EMEYCADLPP PYSPTPQGPA QRSPPPPYPG NARK
	Isoform 2. Checksum: 77B16E1075F55585	FASTA	155	16,698
	10 20 30 40 50 60 MDAPRLPVRP GVLLPKLVLL FVYADDCLAQ CGKDCKSYCC DGTTPYCCSY YAYIGNILSG 70 80 90 100 110 120 TAIAGIVFGI VFIMGVIAGI AICICMCMKN HRATRVGILR TTHINTVSSY PAGPPPYGHD 130 140 150 HEMEYCADLP PPYSPTPQGP AQRSPPPPYP GNARK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cysteine and tyrosine-rich 1 (CYYR1), a novel unpredicted gene on human chromosome 21 (21q21.2), encodes a cysteine and tyrosine-rich protein and defines a new family of highly conserved vertebrate-specific genes." Vitale L., Casadei R., Canaider S., Lenzi L., Strippoli P., D'Addabbo P., Giannone S., Carinci P., Zannotti M. Gene 290:141-151(2002) [PubMed: 12062809] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"Nineteen additional unpredicted transcripts from human chromosome 21." Reymond A., Camargo A.A., Deutsch S., Stevenson B.J., Parmigiani R.B., Ucla C., Bettoni F., Rossier C., Lyle R., Guipponi M., de Souza S., Iseli C., Jongeneel C.V., Bucher P., Simpson A.J.G., Antonarakis S.E. Genomics 79:824-832(2002) [PubMed: 12036297] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Neuroblastoma.
[4]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Heart.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lymph node.
[6]	"The DNA sequence of human chromosome 21." Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L. Nature 405:311-319(2000) [PubMed: 10830953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Ovary.
[8]	"Sequence, 'subtle' alternative splicing and expression of the CYYR1 (cysteine/tyrosine-rich 1) mRNA in human neuroendocrine tumors." Vitale L., Frabetti F., Huntsman S.A., Canaider S., Casadei R., Lenzi L., Facchin F., Carinci P., Zannotti M., Coppola D., Strippoli P. BMC Cancer 7:66-66(2007) [PubMed: 17442112] [Abstract] Cited for: VARIANT SER-111, ALTERNATIVE SPLICING, TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF401639 mRNA. Translation: AAK84158.1. AY061853 mRNA. Translation: AAL35737.1. AK054581 mRNA. Translation: BAB70764.1. Different initiation. AK313231 mRNA. Translation: BAG36042.1. AK223576 mRNA. Translation: BAD97296.1. AL833200 mRNA. Translation: CAI46188.1. AP001596 Genomic DNA. No translation available. AP001597 Genomic DNA. No translation available. BC036761 mRNA. Translation: AAH36761.1.
IPI	IPI00792041. IPI00895948.
RefSeq	NP_443186.1.
UniGene	Hs.37445
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000166265. Homo sapiens. [Contig view]
GeneID	116159.
KEGG	hsa:116159.
Organism-specific databases
GeneCards	GC21M026760.
HGNC	HGNC:16274. CYYR1.
PharmGKB	PA27127.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q96J86.
OMA	Q96J86. SYDHEME.
Gene expression databases
ArrayExpress	Q96J86.
Bgee	Q96J86.
CleanEx	HS_CYYR1.
GermOnline	ENSG00000166265. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	79810.

Entry information

Entry name

CYYR1_HUMAN

Accession

Primary (citable) accession number: Q96J86
Secondary accession number(s): B2R845 , Q53ER3, Q5JPD0, Q96NV7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 13, 2002
Last sequence update:	December 1, 2001
Last modified:	June 16, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)