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Protein

Cysteine and tyrosine-rich protein 1

Gene

CYYR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166265-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine and tyrosine-rich protein 1
Alternative name(s):
Proline-rich domain-containing protein
Gene namesi
Name:CYYR1
Synonyms:C21orf95
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:16274. CYYR1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 61ExtracellularSequence analysisAdd BLAST32
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 154CytoplasmicSequence analysisAdd BLAST72

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi116159.
OpenTargetsiENSG00000166265.
PharmGKBiPA27127.

Polymorphism and mutation databases

BioMutaiCYYR1.
DMDMi27151488.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000002105430 – 154Cysteine and tyrosine-rich protein 1Add BLAST125

Proteomic databases

PaxDbiQ96J86.
PeptideAtlasiQ96J86.
PRIDEiQ96J86.

PTM databases

PhosphoSitePlusiQ96J86.

Expressioni

Tissue specificityi

Widely expressed.2 Publications

Gene expression databases

BgeeiENSG00000166265.
CleanExiHS_CYYR1.
GenevisibleiQ96J86. HS.

Organism-specific databases

HPAiCAB034921.
HPA067685.

Interactioni

Protein-protein interaction databases

BioGridi125484. 3 interactors.
IntActiQ96J86. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ96J86.
SMRiQ96J86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi144 – 149Poly-Pro6

Sequence similaritiesi

Belongs to the CYYR1 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWAY. Eukaryota.
ENOG4111TRP. LUCA.
GeneTreeiENSGT00500000044986.
HOGENOMiHOG000015276.
HOVERGENiHBG051282.
InParanoidiQ96J86.
OMAiYINTVTQ.
OrthoDBiEOG091G15ZN.
PhylomeDBiQ96J86.
TreeFamiTF332064.

Family and domain databases

InterProiIPR022640. CYYR1.
[Graphical view]
PfamiPF10873. CYYR1. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96J86-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDAPRLPVRP GVLLPKLVLL FVYADDCLAQ CGKDCKSYCC DGTTPYCCSY
60 70 80 90 100
YAYIGNILSG TAIAGIVFGI VFIMGVIAGI AICICMCMKN HRATRVGILR
110 120 130 140 150
TTHINTVSSY PGPPPYGHDH EMEYCADLPP PYSPTPQGPA QRSPPPPYPG

NARK
Length:154
Mass (Da):16,626
Last modified:December 1, 2001 - v1
Checksum:i0B0E5BD3FEC65F7D
GO
Isoform 2 (identifier: Q96J86-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-111: P → PA

Show »
Length:155
Mass (Da):16,698
Checksum:i77B16E1075F55585
GO
Isoform 3 (identifier: Q96J86-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-132: GPPPYGHDHEMEYCADLPPPY → EYELHEAEILVYFVQHSIPSM
     133-154: Missing.

Show »
Length:132
Mass (Da):14,493
Checksum:i05053883B967D234
GO
Isoform 4 (identifier: Q96J86-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-112: GTAIAGIVFG...HINTVSSYPG → RTTTLRSRPR...IIYLPEQNMC
     113-154: Missing.

Show »
Length:112
Mass (Da):12,459
Checksum:i88278552F8F48CCA
GO
Isoform 5 (identifier: Q96J86-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-75: GTAIAGIVFGIVFIMG → REFKDHQTFEENIKYE
     76-154: Missing.

Show »
Length:75
Mass (Da):8,597
Checksum:i338BED9D4EDB6B28
GO
Isoform 6 (identifier: Q96J86-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-64: GTAIA → CCCPR
     65-154: Missing.

Show »
Length:64
Mass (Da):7,064
Checksum:i209D8C4D7CAF7D60
GO

Sequence cautioni

The sequence BAB70764 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04404295R → H.Corresponds to variant rs35253087dbSNPEnsembl.1
Natural variantiVAR_044043111P → S.1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05714360 – 112GTAIA…SSYPG → RTTTLRSRPRDGILCRLASS ILPHPTGSSTAFSTPSLSWK RKEIIYLPEQNMC in isoform 4. Add BLAST53
Alternative sequenceiVSP_05714460 – 75GTAIA…VFIMG → REFKDHQTFEENIKYE in isoform 5. Add BLAST16
Alternative sequenceiVSP_05714560 – 64GTAIA → CCCPR in isoform 6. 5
Alternative sequenceiVSP_05714665 – 154Missing in isoform 6. Add BLAST90
Alternative sequenceiVSP_05714776 – 154Missing in isoform 5. Add BLAST79
Alternative sequenceiVSP_034245111P → PA in isoform 2. 1 Publication1
Alternative sequenceiVSP_057148112 – 132GPPPY…LPPPY → EYELHEAEILVYFVQHSIPS M in isoform 3. Add BLAST21
Alternative sequenceiVSP_057149113 – 154Missing in isoform 4. Add BLAST42
Alternative sequenceiVSP_057150133 – 154Missing in isoform 3. Add BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF401639 mRNA. Translation: AAK84158.1.
AY061853 mRNA. Translation: AAL35737.1.
AK054581 mRNA. Translation: BAB70764.1. Different initiation.
AK313231 mRNA. Translation: BAG36042.1.
AK223576 mRNA. Translation: BAD97296.1.
AL833200 mRNA. Translation: CAI46188.1.
JF693912 mRNA. Translation: AFC01211.1.
JF693913 mRNA. Translation: AFC01212.1.
KC843341 mRNA. Translation: AGM21753.1.
KF154022 mRNA. Translation: AHY03237.1.
AP001596 Genomic DNA. No translation available.
AP001597 Genomic DNA. No translation available.
BC036761 mRNA. Translation: AAH36761.1.
RefSeqiNP_001307697.1. NM_001320768.1.
NP_443186.2. NM_052954.3.
UniGeneiHs.37445.

Genome annotation databases

EnsembliENST00000299340; ENSP00000299340; ENSG00000166265. [Q96J86-1]
ENST00000400043; ENSP00000382918; ENSG00000166265. [Q96J86-3]
GeneIDi116159.
KEGGihsa:116159.
UCSCiuc002ymd.4. human. [Q96J86-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF401639 mRNA. Translation: AAK84158.1.
AY061853 mRNA. Translation: AAL35737.1.
AK054581 mRNA. Translation: BAB70764.1. Different initiation.
AK313231 mRNA. Translation: BAG36042.1.
AK223576 mRNA. Translation: BAD97296.1.
AL833200 mRNA. Translation: CAI46188.1.
JF693912 mRNA. Translation: AFC01211.1.
JF693913 mRNA. Translation: AFC01212.1.
KC843341 mRNA. Translation: AGM21753.1.
KF154022 mRNA. Translation: AHY03237.1.
AP001596 Genomic DNA. No translation available.
AP001597 Genomic DNA. No translation available.
BC036761 mRNA. Translation: AAH36761.1.
RefSeqiNP_001307697.1. NM_001320768.1.
NP_443186.2. NM_052954.3.
UniGeneiHs.37445.

3D structure databases

ProteinModelPortaliQ96J86.
SMRiQ96J86.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125484. 3 interactors.
IntActiQ96J86. 1 interactor.

PTM databases

PhosphoSitePlusiQ96J86.

Polymorphism and mutation databases

BioMutaiCYYR1.
DMDMi27151488.

Proteomic databases

PaxDbiQ96J86.
PeptideAtlasiQ96J86.
PRIDEiQ96J86.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299340; ENSP00000299340; ENSG00000166265. [Q96J86-1]
ENST00000400043; ENSP00000382918; ENSG00000166265. [Q96J86-3]
GeneIDi116159.
KEGGihsa:116159.
UCSCiuc002ymd.4. human. [Q96J86-1]

Organism-specific databases

CTDi116159.
DisGeNETi116159.
GeneCardsiCYYR1.
HGNCiHGNC:16274. CYYR1.
HPAiCAB034921.
HPA067685.
MIMi616020. gene.
neXtProtiNX_Q96J86.
OpenTargetsiENSG00000166265.
PharmGKBiPA27127.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWAY. Eukaryota.
ENOG4111TRP. LUCA.
GeneTreeiENSGT00500000044986.
HOGENOMiHOG000015276.
HOVERGENiHBG051282.
InParanoidiQ96J86.
OMAiYINTVTQ.
OrthoDBiEOG091G15ZN.
PhylomeDBiQ96J86.
TreeFamiTF332064.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166265-MONOMER.

Miscellaneous databases

ChiTaRSiCYYR1. human.
GeneWikiiCYYR1.
GenomeRNAii116159.
PROiQ96J86.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166265.
CleanExiHS_CYYR1.
GenevisibleiQ96J86. HS.

Family and domain databases

InterProiIPR022640. CYYR1.
[Graphical view]
PfamiPF10873. CYYR1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYYR1_HUMAN
AccessioniPrimary (citable) accession number: Q96J86
Secondary accession number(s): A0A059TD09
, A8MTU9, B2R845, Q53ER3, Q5JPD0, Q96NV7, R9QAJ4, W8CQB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.