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Protein

Tumor protein D55

Gene

TPD52L3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor protein D55
Short name:
hD55
Alternative name(s):
Testis development protein NYD-SP25
Tumor protein D52-like 3
Gene namesi
Name:TPD52L3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:23382. TPD52L3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670712.

Polymorphism and mutation databases

BioMutaiTPD52L3.
DMDMi313104031.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 140140Tumor protein D55PRO_0000295856Add
BLAST

Proteomic databases

PaxDbiQ96J77.
PRIDEiQ96J77.

PTM databases

PhosphoSiteiQ96J77.

Expressioni

Tissue specificityi

Specifically expressed in testis. Expressed at 5.6-fold higher levels in adult testis than in fetal testis.1 Publication

Gene expression databases

BgeeiQ96J77.
CleanExiHS_TPD52L3.
GenevisibleiQ96J77. HS.

Organism-specific databases

HPAiHPA023435.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AGTRAPQ6RW133EBI-932162,EBI-741181
CMTM5Q96DZ93EBI-932162,EBI-2548702

Protein-protein interaction databases

BioGridi124633. 4 interactions.
IntActiQ96J77. 7 interactions.
MINTiMINT-1459448.
STRINGi9606.ENSP00000341677.

Structurei

3D structure databases

ProteinModelPortaliQ96J77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili28 – 5730Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TPD52 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4010. Eukaryota.
ENOG4111M9H. LUCA.
GeneTreeiENSGT00390000015988.
HOGENOMiHOG000231968.
HOVERGENiHBG058643.
InParanoidiQ96J77.
OMAiSWHEVQV.
OrthoDBiEOG744TBQ.
PhylomeDBiQ96J77.
TreeFamiTF317562.

Family and domain databases

InterProiIPR007327. TPD52.
[Graphical view]
PANTHERiPTHR19307. PTHR19307. 1 hit.
PfamiPF04201. TPD52. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96J77-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPHARTETSV GTYESHSTSE LEDLTEPEQR ELKTKLTKLE AEIVTLRHVL
60 70 80 90 100
AAKERRCGEL KRKLGLTALV GLRQNLSKSW LDVQVSNTYV KQKTSAALST
110 120 130 140
MGTLICRKLG GVKKSATFRS FEGLMGTIKS KVSGGKRAWP
Length:140
Mass (Da):15,503
Last modified:November 30, 2010 - v2
Checksum:i759F26E983B1EFAD
GO
Isoform 2 (identifier: Q96J77-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-140: MGTIKSKVSGGKRAWP → IFNKYTLNQGRN

Show »
Length:136
Mass (Da):15,268
Checksum:iFC4B6CEE61A9C324
GO
Isoform 3 (identifier: Q96J77-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-140: LMGTIKSKVSGGKRAWP → NPKGEGSRI

Show »
Length:132
Mass (Da):14,644
Checksum:i8A20E727D9FC7432
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti109 – 1091L → P in BAB71505 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti118 – 1181F → L.3 Publications
Corresponds to variant rs3847262 [ dbSNP | Ensembl ].
VAR_033372

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei124 – 14017LMGTI…KRAWP → NPKGEGSRI in isoform 3. 1 PublicationVSP_027113Add
BLAST
Alternative sequencei125 – 14016MGTIK…KRAWP → IFNKYTLNQGRN in isoform 2. 1 PublicationVSP_027114Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032877 mRNA. Translation: AAK66820.1.
AK057479 mRNA. Translation: BAB71505.1.
AL133480 Genomic DNA. Translation: CAI13289.1.
AL133480 Genomic DNA. Translation: CAI13290.1.
AL133480 Genomic DNA. Translation: CAI13291.1.
BC017589 mRNA. Translation: AAH17589.1.
BC033792 mRNA. Translation: AAH33792.1.
BC042113 mRNA. Translation: AAH42113.1.
CCDSiCCDS34984.1. [Q96J77-2]
CCDS34985.1. [Q96J77-3]
CCDS34986.1. [Q96J77-1]
RefSeqiNP_001001874.1. NM_001001874.2.
NP_001001875.1. NM_001001875.3.
NP_277051.3. NM_033516.5.
UniGeneiHs.351815.

Genome annotation databases

EnsembliENST00000314556; ENSP00000318665; ENSG00000170777. [Q96J77-2]
ENST00000344545; ENSP00000341677; ENSG00000170777. [Q96J77-1]
ENST00000381428; ENSP00000370836; ENSG00000170777. [Q96J77-3]
GeneIDi89882.
KEGGihsa:89882.
UCSCiuc003zjv.4. human. [Q96J77-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032877 mRNA. Translation: AAK66820.1.
AK057479 mRNA. Translation: BAB71505.1.
AL133480 Genomic DNA. Translation: CAI13289.1.
AL133480 Genomic DNA. Translation: CAI13290.1.
AL133480 Genomic DNA. Translation: CAI13291.1.
BC017589 mRNA. Translation: AAH17589.1.
BC033792 mRNA. Translation: AAH33792.1.
BC042113 mRNA. Translation: AAH42113.1.
CCDSiCCDS34984.1. [Q96J77-2]
CCDS34985.1. [Q96J77-3]
CCDS34986.1. [Q96J77-1]
RefSeqiNP_001001874.1. NM_001001874.2.
NP_001001875.1. NM_001001875.3.
NP_277051.3. NM_033516.5.
UniGeneiHs.351815.

3D structure databases

ProteinModelPortaliQ96J77.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124633. 4 interactions.
IntActiQ96J77. 7 interactions.
MINTiMINT-1459448.
STRINGi9606.ENSP00000341677.

PTM databases

PhosphoSiteiQ96J77.

Polymorphism and mutation databases

BioMutaiTPD52L3.
DMDMi313104031.

Proteomic databases

PaxDbiQ96J77.
PRIDEiQ96J77.

Protocols and materials databases

DNASUi89882.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314556; ENSP00000318665; ENSG00000170777. [Q96J77-2]
ENST00000344545; ENSP00000341677; ENSG00000170777. [Q96J77-1]
ENST00000381428; ENSP00000370836; ENSG00000170777. [Q96J77-3]
GeneIDi89882.
KEGGihsa:89882.
UCSCiuc003zjv.4. human. [Q96J77-1]

Organism-specific databases

CTDi89882.
GeneCardsiTPD52L3.
HGNCiHGNC:23382. TPD52L3.
HPAiHPA023435.
neXtProtiNX_Q96J77.
PharmGKBiPA142670712.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4010. Eukaryota.
ENOG4111M9H. LUCA.
GeneTreeiENSGT00390000015988.
HOGENOMiHOG000231968.
HOVERGENiHBG058643.
InParanoidiQ96J77.
OMAiSWHEVQV.
OrthoDBiEOG744TBQ.
PhylomeDBiQ96J77.
TreeFamiTF317562.

Miscellaneous databases

GenomeRNAii89882.
NextBioi76390.
PROiQ96J77.

Gene expression databases

BgeeiQ96J77.
CleanExiHS_TPD52L3.
GenevisibleiQ96J77. HS.

Family and domain databases

InterProiIPR007327. TPD52.
[Graphical view]
PANTHERiPTHR19307. PTHR19307. 1 hit.
PfamiPF04201. TPD52. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins."
    Cao Q., Chen J., Zhu L., Liu Y., Zhou Z., Sha J., Wang S., Li J.
    Biochem. Biophys. Res. Commun. 344:798-806(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH TPD52L2, TISSUE SPECIFICITY, VARIANT LEU-118.
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-118.
    Tissue: Testis.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT LEU-118.
    Tissue: Brain and Testis.

Entry informationi

Entry nameiTPD55_HUMAN
AccessioniPrimary (citable) accession number: Q96J77
Secondary accession number(s): Q5TCR3
, Q5TCR4, Q5TCR5, Q8N4P5, Q8WWF7, Q96M09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: November 30, 2010
Last modified: March 16, 2016
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.