Reviewed, UniProtKB/Swiss-Prot Q96J77 (TPD55_HUMAN)

Names and origin

Protein names

Recommended name:
    Tumor protein D55
      Short name=hD55
Alternative name(s):
    Tumor protein D52-like 3
    Testis development protein NYD-SP25

Gene names

Name:

TPD52L3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	140 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Tissue specificity	Specifically expressed in testis. Expressed at 5.6-fold higher levels in adult testis than in fetal testis. Ref.1
Sequence similarities	Belongs to the TPD52 family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Gene Ontology (GO)
Molecular function	protein binding Ref.1 Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TPD52L2	O43399-1	1	EBI-932162,EBI-782611
TPD52L2	O43399-2	1	EBI-932162,EBI-782616

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96J77-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96J77-2)

The sequence of this isoform differs from the canonical sequence as follows:
     125-140: MGTIKSKVSGGKRAWP → IFNKYTLNQGRN

Isoform 3 (identifier: Q96J77-3)

The sequence of this isoform differs from the canonical sequence as follows:
     124-140: LMGTIKSKVSGGKRAWP → NPKGEGSRI

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 140	140	Tumor protein D55		PRO_0000295856
Regions
	Coiled coil	28 – 57	30	Potential
Natural variations
	Alternative sequence	124 – 140	17	LMGTI…KRAWP → NPKGEGSRI in isoform 3.		VSP_027113
	Alternative sequence	125 – 140	16	MGTIK…KRAWP → IFNKYTLNQGRN in isoform 2.		VSP_027114
	Natural variant	118	1	L → F: dbSNP rs3847262. Ref.3		VAR_033372
Experimental info
	Sequence conflict	109	1	L → P in BAB71505. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 2F9F26E983B1E2C0	FASTA	140	15,469
	10 20 30 40 50 60 MPHARTETSV GTYESHSTSE LEDLTEPEQR ELKTKLTKLE AEIVTLRHVL AAKERRCGEL 70 80 90 100 110 120 KRKLGLTALV GLRQNLSKSW LDVQVSNTYV KQKTSAALST MGTLICRKLG GVKKSATLRS 130 140 FEGLMGTIKS KVSGGKRAWP
	Isoform 2. Checksum: FC4B618301A9C324	FASTA	136	15,234
	10 20 30 40 50 60 MPHARTETSV GTYESHSTSE LEDLTEPEQR ELKTKLTKLE AEIVTLRHVL AAKERRCGEL 70 80 90 100 110 120 KRKLGLTALV GLRQNLSKSW LDVQVSNTYV KQKTSAALST MGTLICRKLG GVKKSATLRS 130 FEGLIFNKYT LNQGRN
	Isoform 3. Checksum: 8A20E727D9FC7C90	FASTA	132	14,610
	10 20 30 40 50 60 MPHARTETSV GTYESHSTSE LEDLTEPEQR ELKTKLTKLE AEIVTLRHVL AAKERRCGEL 70 80 90 100 110 120 KRKLGLTALV GLRQNLSKSW LDVQVSNTYV KQKTSAALST MGTLICRKLG GVKKSATLRS 130 FEGNPKGEGS RI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins." Cao Q., Chen J., Zhu L., Liu Y., Zhou Z., Sha J., Wang S., Li J. Biochem. Biophys. Res. Commun. 344:798-806(2006) [PubMed: 16631610] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH TPD52L2, TISSUE SPECIFICITY. Tissue: Testis.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
[3]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PHE-118.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Brain and Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY032877 mRNA. Translation: AAK66820.1. AK057479 mRNA. Translation: BAB71505.1. AL133480 Genomic DNA. Translation: CAI13289.1. AL133480 Genomic DNA. Translation: CAI13290.1. AL133480 Genomic DNA. Translation: CAI13291.1. BC017589 mRNA. Translation: AAH17589.1. BC033792 mRNA. Translation: AAH33792.1. BC042113 mRNA. Translation: AAH42113.1.
IPI	IPI00384284. IPI00645582. IPI00783210.
RefSeq	NP_001001874.1. NP_001001875.1. NP_277051.3.
UniGene	Hs.351815
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96J77. 7 interactions.
Genome annotation databases
Ensembl	ENSG00000170777. Homo sapiens. [Contig view]
GeneID	89882.
KEGG	hsa:89882.
Organism-specific databases
GeneCards	GC09P006319.
HGNC	HGNC:23382. TPD52L3.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q96J77.
Gene expression databases
ArrayExpress	Q96J77.
Bgee	Q96J77.
CleanEx	HS_TPD52L3.
Family and domain databases
InterPro	IPR007327. TPD52. [Graphical view]
PANTHER	PTHR19307. TPD52. 1 hit.
Pfam	PF04201. TPD52. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	76390.

Entry information

Entry name

TPD55_HUMAN

Accession

Primary (citable) accession number: Q96J77
Secondary accession number(s): Q5TCR3 , Q5TCR4, Q5TCR5, Q8N4P5, Q8WWF7, Q96M09

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	December 1, 2001
Last modified:	February 10, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)