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Q96J66

- ABCCB_HUMAN

UniProt

Q96J66 - ABCCB_HUMAN

Protein

ATP-binding cassette sub-family C member 11

Gene

ABCC11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E217betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Probably functions to secrete earwax.3 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi544 – 5518ATP 1PROSITE-ProRule annotation
    Nucleotide bindingi1175 – 11828ATP 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. organic anion transmembrane transporter activity Source: UniProt
    4. purine nucleotide transmembrane transporter activity Source: UniProt

    GO - Biological processi

    1. organic anion transport Source: UniProt
    2. purine nucleotide transport Source: UniProt
    3. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_15480. ABC-family proteins mediated transport.

    Protein family/group databases

    TCDBi3.A.1.208.13. the atp-binding cassette (abc) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-binding cassette sub-family C member 11
    Alternative name(s):
    Multidrug resistance-associated protein 8
    Gene namesi
    Name:ABCC11
    Synonyms:MRP8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:14639. ABCC11.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of plasma membrane Source: UniProt
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    MIMi117800. phenotype.
    PharmGKBiPA24393.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13821382ATP-binding cassette sub-family C member 11PRO_0000225594Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi838 – 8381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi844 – 8441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi992 – 9921N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ96J66.
    PRIDEiQ96J66.

    PTM databases

    PhosphoSiteiQ96J66.

    Expressioni

    Tissue specificityi

    Expressed in many tissues. Not expressed in kidney, spleen and colon. Highly expressed in breast cancer. Expressed at moderate levels in normal breast and testis and at very low levels in liver, brain and placenta.2 Publications

    Gene expression databases

    ArrayExpressiQ96J66.
    BgeeiQ96J66.
    CleanExiHS_ABCC11.
    GenevestigatoriQ96J66.

    Organism-specific databases

    HPAiHPA031980.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000349017.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96J66.
    SMRiQ96J66. Positions 525-731, 806-1379.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 163163CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini439 – 806368CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1071 – 1382312CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei164 – 18421HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei195 – 21521HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei271 – 29121HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei297 – 31721HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei384 – 40421HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei418 – 43821HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei807 – 82721HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei864 – 88421HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei931 – 95121HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1050 – 107021HelicalPROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini163 – 443281ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini508 – 732225ABC transporter 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini806 – 1105300ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1141 – 1375235ABC transporter 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
    Contains 2 ABC transporter domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1132.
    HOVERGENiHBG108314.
    InParanoidiQ96J66.
    KOiK05671.
    OMAiWRTMIPF.
    OrthoDBiEOG7MWGW0.
    PhylomeDBiQ96J66.
    TreeFamiTF352085.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00664. ABC_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    [Graphical view]
    SMARTiSM00382. AAA. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    SSF90123. SSF90123. 2 hits.
    PROSITEiPS50929. ABC_TM1F. 2 hits.
    PS00211. ABC_TRANSPORTER_1. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96J66-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTRKRTYWVP NSSGGLVNRG IDIGDDMVSG LIYKTYTLQD GPWSQQERNP     50
    EAPGRAAVPP WGKYDAALRT MIPFRPKPRF PAPQPLDNAG LFSYLTVSWL 100
    TPLMIQSLRS RLDENTIPPL SVHDASDKNV QRLHRLWEEE VSRRGIEKAS 150
    VLLVMLRFQR TRLIFDALLG ICFCIASVLG PILIIPKILE YSEEQLGNVV 200
    HGVGLCFALF LSECVKSLSF SSSWIINQRT AIRFRAAVSS FAFEKLIQFK 250
    SVIHITSGEA ISFFTGDVNY LFEGVCYGPL VLITCASLVI CSISSYFIIG 300
    YTAFIAILCY LLVFPLAVFM TRMAVKAQHH TSEVSDQRIR VTSEVLTCIK 350
    LIKMYTWEKP FAKIIEDLRR KERKLLEKCG LVQSLTSITL FIIPTVATAV 400
    WVLIHTSLKL KLTASMAFSM LASLNLLRLS VFFVPIAVKG LTNSKSAVMR 450
    FKKFFLQESP VFYVQTLQDP SKALVFEEAT LSWQQTCPGI VNGALELERN 500
    GHASEGMTRP RDALGPEEEG NSLGPELHKI NLVVSKGMML GVCGNTGSGK 550
    SSLLSAILEE MHLLEGSVGV QGSLAYVPQQ AWIVSGNIRE NILMGGAYDK 600
    ARYLQVLHCC SLNRDLELLP FGDMTEIGER GLNLSGGQKQ RISLARAVYS 650
    DRQIYLLDDP LSAVDAHVGK HIFEECIKKT LRGKTVVLVT HQLQYLEFCG 700
    QIILLENGKI CENGTHSELM QKKGKYAQLI QKMHKEATSD MLQDTAKIAE 750
    KPKVESQALA TSLEESLNGN AVPEHQLTQE EEMEEGSLSW RVYHHYIQAA 800
    GGYMVSCIIF FFVVLIVFLT IFSFWWLSYW LEQGSGTNSS RESNGTMADL 850
    GNIADNPQLS FYQLVYGLNA LLLICVGVCS SGIFTKVTRK ASTALHNKLF 900
    NKVFRCPMSF FDTIPIGRLL NCFAGDLEQL DQLLPIFSEQ FLVLSLMVIA 950
    VLLIVSVLSP YILLMGAIIM VICFIYYMMF KKAIGVFKRL ENYSRSPLFS 1000
    HILNSLQGLS SIHVYGKTED FISQFKRLTD AQNNYLLLFL SSTRWMALRL 1050
    EIMTNLVTLA VALFVAFGIS STPYSFKVMA VNIVLQLASS FQATARIGLE 1100
    TEAQFTAVER ILQYMKMCVS EAPLHMEGTS CPQGWPQHGE IIFQDYHMKY 1150
    RDNTPTVLHG INLTIRGHEV VGIVGRTGSG KSSLGMALFR LVEPMAGRIL 1200
    IDGVDICSIG LEDLRSKLSV IPQDPVLLSG TIRFNLDPFD RHTDQQIWDA 1250
    LERTFLTKAI SKFPKKLHTD VVENGGNFSV GERQLLCIAR AVLRNSKIIL 1300
    IDEATASIDM ETDTLIQRTI REAFQGCTVL VIAHRVTTVL NCDHILVMGN 1350
    GKVVEFDRPE VLRKKPGSLF AALMATATSS LR 1382
    Length:1,382
    Mass (Da):154,301
    Last modified:December 1, 2001 - v1
    Checksum:i0F3C17DC69AE97F4
    GO
    Isoform 2 (identifier: Q96J66-2) [UniParc]FASTAAdd to Basket

    Also known as: Isoform A

    The sequence of this isoform differs from the canonical sequence as follows:
         1261-1298: Missing.

    Show »
    Length:1,344
    Mass (Da):150,093
    Checksum:i4859DCC95569B2C7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti199 – 1991V → A in AAK58869. (PubMed:11688999)Curated
    Sequence conflicti199 – 1991V → A in AAL99902. (PubMed:11688999)Curated
    Sequence conflicti311 – 3111L → P in AAK19755. (PubMed:11591886)Curated
    Sequence conflicti363 – 3631K → E in AAK58869. (PubMed:11688999)Curated
    Sequence conflicti363 – 3631K → E in AAL99902. (PubMed:11688999)Curated
    Sequence conflicti395 – 3951T → A in AAK19755. (PubMed:11591886)Curated
    Sequence conflicti632 – 6321L → P in AAK19755. (PubMed:11591886)Curated
    Sequence conflicti688 – 6881L → Q in AAK19755. (PubMed:11591886)Curated
    Sequence conflicti702 – 7021I → V in AAK19755. (PubMed:11591886)Curated
    Sequence conflicti982 – 9821K → E in AAK19755. (PubMed:11591886)Curated

    Polymorphismi

    The allele with Arg-184 is responsible for the dry earwax phenotype [MIMi:117800]. Human earwax is a Mendelian trait consisting of wet and dry types. The wet earwax is brownish and sticky, whereas the dry type lacks cerumen. The wet cerumen phenotype is completely dominant. The dry type is seen frequently (80-95%) among East Asians, but uncommon (0-3%) in populations of European and African origins. Intermediate frequencies (30-50%) of the dry type are seen in populations of Southern Asia, the Pacific Islands, Central Asia and Asia Minor, as well as among the Native North American and Inuit of Asian ancestry.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti19 – 191R → H.
    Corresponds to variant rs16945988 [ dbSNP | Ensembl ].
    VAR_025437
    Natural varianti180 – 1801G → R in dry earwax phenotype; reduced transport activity. 1 Publication
    Corresponds to variant rs17822931 [ dbSNP | Ensembl ].
    VAR_025438
    Natural varianti317 – 3171A → E.1 Publication
    Corresponds to variant rs11863236 [ dbSNP | Ensembl ].
    VAR_048144
    Natural varianti546 – 5461T → M.
    Corresponds to variant rs17822471 [ dbSNP | Ensembl ].
    VAR_048145
    Natural varianti648 – 6481V → I.
    Corresponds to variant rs16945930 [ dbSNP | Ensembl ].
    VAR_048146
    Natural varianti687 – 6871V → I.
    Corresponds to variant rs16945928 [ dbSNP | Ensembl ].
    VAR_048147
    Natural varianti735 – 7351K → R.
    Corresponds to variant rs16945926 [ dbSNP | Ensembl ].
    VAR_048148
    Natural varianti1344 – 13441H → R.1 Publication
    Corresponds to variant rs16945916 [ dbSNP | Ensembl ].
    VAR_048149

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1261 – 129838Missing in isoform 2. 1 PublicationVSP_017351Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY040219 mRNA. Translation: AAK76739.1.
    AF367202 mRNA. Translation: AAK58869.1.
    AF411579 mRNA. Translation: AAL99902.1.
    AF352582 mRNA. Translation: AAK19755.1.
    CCDSiCCDS10732.1. [Q96J66-1]
    CCDS10733.1. [Q96J66-2]
    RefSeqiNP_115972.2. NM_032583.3. [Q96J66-1]
    NP_149163.2. NM_033151.3. [Q96J66-1]
    NP_660187.1. NM_145186.2. [Q96J66-2]
    UniGeneiHs.652267.

    Genome annotation databases

    EnsembliENST00000353782; ENSP00000311326; ENSG00000121270. [Q96J66-2]
    ENST00000356608; ENSP00000349017; ENSG00000121270. [Q96J66-1]
    ENST00000394747; ENSP00000378230; ENSG00000121270. [Q96J66-1]
    ENST00000394748; ENSP00000378231; ENSG00000121270. [Q96J66-1]
    GeneIDi85320.
    KEGGihsa:85320.
    UCSCiuc002eff.1. human. [Q96J66-1]
    uc002efh.1. human. [Q96J66-2]

    Polymorphism databases

    DMDMi74762666.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Of earwax and migration - Issue 67 of February 2006

    ABCMdb

    Database for mutations in ABC proteins

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY040219 mRNA. Translation: AAK76739.1 .
    AF367202 mRNA. Translation: AAK58869.1 .
    AF411579 mRNA. Translation: AAL99902.1 .
    AF352582 mRNA. Translation: AAK19755.1 .
    CCDSi CCDS10732.1. [Q96J66-1 ]
    CCDS10733.1. [Q96J66-2 ]
    RefSeqi NP_115972.2. NM_032583.3. [Q96J66-1 ]
    NP_149163.2. NM_033151.3. [Q96J66-1 ]
    NP_660187.1. NM_145186.2. [Q96J66-2 ]
    UniGenei Hs.652267.

    3D structure databases

    ProteinModelPortali Q96J66.
    SMRi Q96J66. Positions 525-731, 806-1379.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000349017.

    Chemistry

    ChEMBLi CHEMBL2073702.
    DrugBanki DB00286. Conjugated Estrogens.
    DB00158. Folic Acid.
    DB00328. Indomethacin.
    DB00563. Methotrexate.
    DB01032. Probenecid.

    Protein family/group databases

    TCDBi 3.A.1.208.13. the atp-binding cassette (abc) superfamily.

    PTM databases

    PhosphoSitei Q96J66.

    Polymorphism databases

    DMDMi 74762666.

    Proteomic databases

    PaxDbi Q96J66.
    PRIDEi Q96J66.

    Protocols and materials databases

    DNASUi 85320.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000353782 ; ENSP00000311326 ; ENSG00000121270 . [Q96J66-2 ]
    ENST00000356608 ; ENSP00000349017 ; ENSG00000121270 . [Q96J66-1 ]
    ENST00000394747 ; ENSP00000378230 ; ENSG00000121270 . [Q96J66-1 ]
    ENST00000394748 ; ENSP00000378231 ; ENSG00000121270 . [Q96J66-1 ]
    GeneIDi 85320.
    KEGGi hsa:85320.
    UCSCi uc002eff.1. human. [Q96J66-1 ]
    uc002efh.1. human. [Q96J66-2 ]

    Organism-specific databases

    CTDi 85320.
    GeneCardsi GC16M048249.
    HGNCi HGNC:14639. ABCC11.
    HPAi HPA031980.
    MIMi 117800. phenotype.
    607040. gene.
    neXtProti NX_Q96J66.
    PharmGKBi PA24393.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1132.
    HOVERGENi HBG108314.
    InParanoidi Q96J66.
    KOi K05671.
    OMAi WRTMIPF.
    OrthoDBi EOG7MWGW0.
    PhylomeDBi Q96J66.
    TreeFami TF352085.

    Enzyme and pathway databases

    Reactomei REACT_15480. ABC-family proteins mediated transport.

    Miscellaneous databases

    GeneWikii ABCC11.
    GenomeRNAii 85320.
    NextBioi 75831.
    PROi Q96J66.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96J66.
    Bgeei Q96J66.
    CleanExi HS_ABCC11.
    Genevestigatori Q96J66.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00664. ABC_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    [Graphical view ]
    SMARTi SM00382. AAA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    SSF90123. SSF90123. 2 hits.
    PROSITEi PS50929. ABC_TM1F. 2 hits.
    PS00211. ABC_TRANSPORTER_1. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12."
      Tammur J., Prades C., Arnould I., Rzhetsky A., Hutchinson A., Adachi M., Schuetz J.D., Swoboda K.J., Ptacek L.J., Rosier M., Dean M., Allikmets R.
      Gene 273:89-96(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Testis.
    2. "Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12."
      Yabuuchi H., Shimizu H., Takayanagi S., Ishikawa T.
      Biochem. Biophys. Res. Commun. 288:933-939(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: Liver.
    3. "MRP8, a new member of ABC transporter superfamily, identified by EST database mining and gene prediction program, is highly expressed in breast cancer."
      Bera T.K., Lee S., Salvatore G., Lee B.K., Pastan I.H.
      Mol. Med. 7:509-516(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS GLU-317 AND ARG-1344.
      Tissue: Mammary gland.
    4. "MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine."
      Guo Y., Kotova E., Chen Z.S., Lee K., Hopper-Borge E., Belinsky M.G., Kruh G.D.
      J. Biol. Chem. 278:29509-29514(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN CYCLIC NUCLEOTIDE EFFLUX.
    5. "Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11)."
      Chen Z.S., Guo Y., Belinsky M.G., Kotova E., Kruh G.D.
      Mol. Pharmacol. 67:545-557(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. Cited for: VARIANT ARG-180, CHARACTERIZATION OF VARIANT ARG-180, FUNCTION IN SECRETION OF EARWAX.

    Entry informationi

    Entry nameiABCCB_HUMAN
    AccessioniPrimary (citable) accession number: Q96J66
    Secondary accession number(s): Q8TDJ0, Q96JA6, Q9BX80
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3