Reviewed, UniProtKB/Swiss-Prot Q96J65 (MRP9_HUMAN)

Names and origin

Protein names

Recommended name:
    Multidrug resistance-associated protein 9
Alternative name(s):
    ATP-binding cassette transporter sub-family C member 12

Gene names

Name:	ABCC12
Synonyms:	MRP9

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1359 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Probable transporter By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Expressed in testis (at protein level). Widely expressed at low level. Isoform 5 is specifically expressed in brain, testis and breast cancer cells. Ref.1 Ref.2 Ref.3
Developmental stage	Expressed in fetal tissues. Ref.1
Sequence similarities	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification] Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Transmembrane
Ligand	ATP-binding Nucleotide-binding
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96J65-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96J65-2)

Also known as: A; C; D;

The sequence of this isoform differs from the canonical sequence as follows:
     142-143: VI → TV
     734-736: Missing.
     1013-1359: Missing.

Isoform 3 (identifier: Q96J65-3)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     142-143: VI → TV
     734-736: Missing.
     892-938: ILKSPMSFFD...NFLQQFFMVV → HFPQRSPGAQ...WQEGELHHLV
     939-1359: Missing.

Isoform 4 (identifier: Q96J65-4)

The sequence of this isoform differs from the canonical sequence as follows:
     142-143: VI → TV
     572-633: YQHTVRVCGL...YLLDDPLSAV → LGSGASTSLG...RRSGERQSSW
     634-1359: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 5 (identifier: Q96J65-5)

The sequence of this isoform differs from the canonical sequence as follows:
     142-143: VI → TV
     220-277: Missing.
     737-760: Missing.
     1013-1359: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1359	1359	Multidrug resistance-associated protein 9		PRO_0000253578
Regions
	Transmembrane	125 – 145	21	Potential
	Transmembrane	159 – 179	21	Potential
	Transmembrane	231 – 251	21	Potential
	Transmembrane	256 – 276	21	Potential
	Transmembrane	348 – 368	21	Potential
	Transmembrane	376 – 396	21	Potential
	Transmembrane	791 – 811	21	Potential
	Transmembrane	853 – 873	21	Potential
	Transmembrane	934 – 954	21	Potential
	Transmembrane	1031 – 1051	21	Potential
	Domain	123 – 403	281	ABC transmembrane type-1 1
	Domain	467 – 701	235	ABC transporter 1
	Domain	795 – 1082	288	ABC transmembrane type-1 2
	Domain	1120 – 1354	235	ABC transporter 2
	Nucleotide binding	513 – 520	8	ATP 1 Potential
	Nucleotide binding	1154 – 1161	8	ATP 2 Potential
Amino acid modifications
	Glycosylation	405	1	N-linked (GlcNAc...) Potential
	Glycosylation	438	1	N-linked (GlcNAc...) Potential
	Glycosylation	540	1	N-linked (GlcNAc...) Potential
	Glycosylation	981	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	142 – 143	2	VI → TV in isoform 2, isoform 3, isoform 4 and isoform 5.		VSP_021084
	Alternative sequence	220 – 277	58	Missing in isoform 5.		VSP_021085
	Alternative sequence	572 – 633	62	YQHTV…PLSAV → LGSGASTSLGGRGRGLAWPA LSTPTVSSTCWTTPCRPWTP TWGSTSLRSALRRRSGERQS SW in isoform 4.		VSP_021086
	Alternative sequence	634 – 1359	726	Missing in isoform 4.		VSP_021087
	Alternative sequence	734 – 736	3	Missing in isoform 2 and isoform 3.		VSP_021088
	Alternative sequence	737 – 760	24	Missing in isoform 5.		VSP_021089
	Alternative sequence	892 – 938	47	ILKSP…FFMVV → HFPQRSPGAQEGGECQPVTL VHPHHLLHAGPGHHSRLWQE GELHHLV in isoform 3.		VSP_021090
	Alternative sequence	939 – 1359	421	Missing in isoform 3.		VSP_021091
	Alternative sequence	1013 – 1359	347	Missing in isoform 2 and isoform 5.		VSP_021092
	Natural variant	9	1	I → L: dbSNP rs16945901.		VAR_028392
	Natural variant	102	1	A → E: dbSNP rs16945874.		VAR_028393
	Natural variant	587	1	N → Y: dbSNP rs16945816.		VAR_028394
	Natural variant	690	1	E → V: dbSNP rs34135219.		VAR_048139
	Natural variant	894	1	K → M: dbSNP rs8057474.		VAR_028395
	Natural variant	989	1	T → S: dbSNP rs6500305.		VAR_028396
	Natural variant	1013	1	Y → H: dbSNP rs6500304.		VAR_028397
	Natural variant	1117	1	R → C: dbSNP rs7193955. Ref.2		VAR_028398
	Natural variant	1187	1	I → T: dbSNP rs34106426.		VAR_048140
	Natural variant	1191	1	E → A: dbSNP rs16945787.		VAR_028399
	Natural variant	1349	1	F → L: dbSNP rs12373105.		VAR_028400
Experimental info
	Sequence conflict	73	1	T → A in BC036378. Ref.5
	Sequence conflict	448 – 450	3	SRK → RQE in AAL79528. Ref.1
	Sequence conflict	448 – 450	3	SRK → RQE in AAL79529. Ref.1
	Sequence conflict	448 – 450	3	SRK → RQE in AAL99900. Ref.1
	Sequence conflict	448 – 450	3	SRK → RQE in AAL99901. Ref.1
	Sequence conflict	853	1	W → R in AAL79528. Ref.1
	Sequence conflict	853	1	W → R in AAL79529. Ref.1
	Sequence conflict	853	1	W → R in AAL99900. Ref.1
	Sequence conflict	853	1	W → R in AAL99901. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 4, 2007. Version 2. Checksum: DA8AF5A3EE9B10E8	FASTA	1,359	152,297
	10 20 30 40 50 60 MVGEGPYLIS DLDQRGRRRS FAERYDPSLK TMIPVRPCAR LAPNPVDDAG LLSFATFSWL 70 80 90 100 110 120 TPVMVKGYRQ RLTVDTLPPL STYDSSDTNA KRFRVLWDEE VARVGPEKAS LSHVVWKFQR 130 140 150 160 170 180 TRVLMDIVAN ILCIIMAAIG PVILIHQILQ QTERTSGKVW VGIGLCIALF ATEFTKVFFW 190 200 210 220 230 240 ALAWAINYRT AIRLKVALST LVFENLVSFK TLTHISVGEV LNILSSDSYS LFEAALFCPL 250 260 270 280 290 300 PATIPILMVF CAAYAFFILG PTALIGISVY VIFIPVQMFM AKLNSAFRRS AILVTDKRVQ 310 320 330 340 350 360 TMNEFLTCIR LIKMYAWEKS FTNTIQDIRR RERKLLEKAG FVQSGNSALA PIVSTIAIVL 370 380 390 400 410 420 TLSCHILLRR KLTAPVAFSV IAMFNVMKFS IAILPFSIKA MAEANVSLRR MKKILIDKSP 430 440 450 460 470 480 PSYITQPEDP DTVLLLANAT LTWEHEASRK STPKKLQNQK RHLCKKQRSE AYSERSPPAK 490 500 510 520 530 540 GATGPEEQSD SLKSVLHSIS FVVRKGKILG ICGNVGSGKS SLLAALLGQM QLQKGVVAVN 550 560 570 580 590 600 GTLAYVSQQA WIFHGNVREN ILFGEKYDHQ RYQHTVRVCG LQKDLSNLPY GDLTEIGERG 610 620 630 640 650 660 LNLSGGQRQR ISLARAVYSD RQLYLLDDPL SAVDAHVGKH VFEECIKKTL RGKTVVLVTH 670 680 690 700 710 720 QLQFLESCDE VILLEDGEIC EKGTHKELME ERGRYAKLIH NLRGLQFKDP EHLYNAAMVE 730 740 750 760 770 780 AFKESPAERE EDAGIIVLAP GNEKDEGKES ETGSEFVDTK VPEHQLIQTE SPQEGTVTWK 790 800 810 820 830 840 TYHTYIKASG GYLLSLFTVF LFLLMIGSAA FSNWWLGLWL DKGSRMTCGP QGNRTMCEVG 850 860 870 880 890 900 AVLADIGQHV YQWVYTASMV FMLVFGVTKG FVFTKTTLMA SSSLHDTVFD KILKSPMSFF 910 920 930 940 950 960 DTTPTGRLMN RFSKDMDELD VRLPFHAENF LQQFFMVVFI LVILAAVFPA VLLVVASLAV 970 980 990 1000 1010 1020 GFFILLRIFH RGVQELKKVE NVSRSPWFTH ITSSMQGLGI IHAYGKKESC ITYHLLYFNC 1030 1040 1050 1060 1070 1080 ALRWFALRMD VLMNILTFTV ALLVTLSFSS ISTSSKGLSL SYIIQLSGLL QVCVRTGTET 1090 1100 1110 1120 1130 1140 QAKFTSVELL REYISTCVPE CTHPLKVGTC PKDWPSRGEI TFRDYQMRYR DNTPLVLDSL 1150 1160 1170 1180 1190 1200 NLNIQSGQTV GIVGRTGSGK SSLGMALFRL VEPASGTIFI DEVDICILSL EDLRTKLTVI 1210 1220 1230 1240 1250 1260 PQDPVLFVGT VRYNLDPFES HTDEMLWQVL ERTFMRDTIM KLPEKLQAEV TENGENFSVG 1270 1280 1290 1300 1310 1320 ERQLLCVARA LLRNSKIILL DEATASMDSK TDTLVQNTIK DAFKGCTVLT IAHRLNTVLN 1330 1340 1350 CDHVLVMENG KVIEFDKPEV LAEKPDSAFA MLLAAEVRL
	Isoform 2 (A) (C) (D). Checksum: 6491AA00FBC280E5	FASTA	1,009	113,163
	10 20 30 40 50 60 MVGEGPYLIS DLDQRGRRRS FAERYDPSLK TMIPVRPCAR LAPNPVDDAG LLSFATFSWL 70 80 90 100 110 120 TPVMVKGYRQ RLTVDTLPPL STYDSSDTNA KRFRVLWDEE VARVGPEKAS LSHVVWKFQR 130 140 150 160 170 180 TRVLMDIVAN ILCIIMAAIG PTVLIHQILQ QTERTSGKVW VGIGLCIALF ATEFTKVFFW 190 200 210 220 230 240 ALAWAINYRT AIRLKVALST LVFENLVSFK TLTHISVGEV LNILSSDSYS LFEAALFCPL 250 260 270 280 290 300 PATIPILMVF CAAYAFFILG PTALIGISVY VIFIPVQMFM AKLNSAFRRS AILVTDKRVQ 310 320 330 340 350 360 TMNEFLTCIR LIKMYAWEKS FTNTIQDIRR RERKLLEKAG FVQSGNSALA PIVSTIAIVL 370 380 390 400 410 420 TLSCHILLRR KLTAPVAFSV IAMFNVMKFS IAILPFSIKA MAEANVSLRR MKKILIDKSP 430 440 450 460 470 480 PSYITQPEDP DTVLLLANAT LTWEHEASRK STPKKLQNQK RHLCKKQRSE AYSERSPPAK 490 500 510 520 530 540 GATGPEEQSD SLKSVLHSIS FVVRKGKILG ICGNVGSGKS SLLAALLGQM QLQKGVVAVN 550 560 570 580 590 600 GTLAYVSQQA WIFHGNVREN ILFGEKYDHQ RYQHTVRVCG LQKDLSNLPY GDLTEIGERG 610 620 630 640 650 660 LNLSGGQRQR ISLARAVYSD RQLYLLDDPL SAVDAHVGKH VFEECIKKTL RGKTVVLVTH 670 680 690 700 710 720 QLQFLESCDE VILLEDGEIC EKGTHKELME ERGRYAKLIH NLRGLQFKDP EHLYNAAMVE 730 740 750 760 770 780 AFKESPAERE EDAVLAPGNE KDEGKESETG SEFVDTKVPE HQLIQTESPQ EGTVTWKTYH 790 800 810 820 830 840 TYIKASGGYL LSLFTVFLFL LMIGSAAFSN WWLGLWLDKG SRMTCGPQGN RTMCEVGAVL 850 860 870 880 890 900 ADIGQHVYQW VYTASMVFML VFGVTKGFVF TKTTLMASSS LHDTVFDKIL KSPMSFFDTT 910 920 930 940 950 960 PTGRLMNRFS KDMDELDVRL PFHAENFLQQ FFMVVFILVI LAAVFPAVLL VVASLAVGFF 970 980 990 1000 ILLRIFHRGV QELKKVENVS RSPWFTHITS SMQGLGIIHA YGKKESCIT
	Isoform 3 (B). Checksum: AD0715883A3971E2	FASTA	935	104,651
	10 20 30 40 50 60 MVGEGPYLIS DLDQRGRRRS FAERYDPSLK TMIPVRPCAR LAPNPVDDAG LLSFATFSWL 70 80 90 100 110 120 TPVMVKGYRQ RLTVDTLPPL STYDSSDTNA KRFRVLWDEE VARVGPEKAS LSHVVWKFQR 130 140 150 160 170 180 TRVLMDIVAN ILCIIMAAIG PTVLIHQILQ QTERTSGKVW VGIGLCIALF ATEFTKVFFW 190 200 210 220 230 240 ALAWAINYRT AIRLKVALST LVFENLVSFK TLTHISVGEV LNILSSDSYS LFEAALFCPL 250 260 270 280 290 300 PATIPILMVF CAAYAFFILG PTALIGISVY VIFIPVQMFM AKLNSAFRRS AILVTDKRVQ 310 320 330 340 350 360 TMNEFLTCIR LIKMYAWEKS FTNTIQDIRR RERKLLEKAG FVQSGNSALA PIVSTIAIVL 370 380 390 400 410 420 TLSCHILLRR KLTAPVAFSV IAMFNVMKFS IAILPFSIKA MAEANVSLRR MKKILIDKSP 430 440 450 460 470 480 PSYITQPEDP DTVLLLANAT LTWEHEASRK STPKKLQNQK RHLCKKQRSE AYSERSPPAK 490 500 510 520 530 540 GATGPEEQSD SLKSVLHSIS FVVRKGKILG ICGNVGSGKS SLLAALLGQM QLQKGVVAVN 550 560 570 580 590 600 GTLAYVSQQA WIFHGNVREN ILFGEKYDHQ RYQHTVRVCG LQKDLSNLPY GDLTEIGERG 610 620 630 640 650 660 LNLSGGQRQR ISLARAVYSD RQLYLLDDPL SAVDAHVGKH VFEECIKKTL RGKTVVLVTH 670 680 690 700 710 720 QLQFLESCDE VILLEDGEIC EKGTHKELME ERGRYAKLIH NLRGLQFKDP EHLYNAAMVE 730 740 750 760 770 780 AFKESPAERE EDAVLAPGNE KDEGKESETG SEFVDTKVPE HQLIQTESPQ EGTVTWKTYH 790 800 810 820 830 840 TYIKASGGYL LSLFTVFLFL LMIGSAAFSN WWLGLWLDKG SRMTCGPQGN RTMCEVGAVL 850 860 870 880 890 900 ADIGQHVYQW VYTASMVFML VFGVTKGFVF TKTTLMASSS LHDTVFDKHF PQRSPGAQEG 910 920 930 GECQPVTLVH PHHLLHAGPG HHSRLWQEGE LHHLV
	Isoform 4. Checksum: 66DEE4BFA9C4D7E4	FASTA	633	70,399
	10 20 30 40 50 60 MVGEGPYLIS DLDQRGRRRS FAERYDPSLK TMIPVRPCAR LAPNPVDDAG LLSFATFSWL 70 80 90 100 110 120 TPVMVKGYRQ RLTVDTLPPL STYDSSDTNA KRFRVLWDEE VARVGPEKAS LSHVVWKFQR 130 140 150 160 170 180 TRVLMDIVAN ILCIIMAAIG PTVLIHQILQ QTERTSGKVW VGIGLCIALF ATEFTKVFFW 190 200 210 220 230 240 ALAWAINYRT AIRLKVALST LVFENLVSFK TLTHISVGEV LNILSSDSYS LFEAALFCPL 250 260 270 280 290 300 PATIPILMVF CAAYAFFILG PTALIGISVY VIFIPVQMFM AKLNSAFRRS AILVTDKRVQ 310 320 330 340 350 360 TMNEFLTCIR LIKMYAWEKS FTNTIQDIRR RERKLLEKAG FVQSGNSALA PIVSTIAIVL 370 380 390 400 410 420 TLSCHILLRR KLTAPVAFSV IAMFNVMKFS IAILPFSIKA MAEANVSLRR MKKILIDKSP 430 440 450 460 470 480 PSYITQPEDP DTVLLLANAT LTWEHEASRK STPKKLQNQK RHLCKKQRSE AYSERSPPAK 490 500 510 520 530 540 GATGPEEQSD SLKSVLHSIS FVVRKGKILG ICGNVGSGKS SLLAALLGQM QLQKGVVAVN 550 560 570 580 590 600 GTLAYVSQQA WIFHGNVREN ILFGEKYDHQ RLGSGASTSL GGRGRGLAWP ALSTPTVSST 610 620 630 CWTTPCRPWT PTWGSTSLRS ALRRRSGERQ SSW
	Isoform 5. Checksum: 22A26E88E51CE234	FASTA	930	104,660
	10 20 30 40 50 60 MVGEGPYLIS DLDQRGRRRS FAERYDPSLK TMIPVRPCAR LAPNPVDDAG LLSFATFSWL 70 80 90 100 110 120 TPVMVKGYRQ RLTVDTLPPL STYDSSDTNA KRFRVLWDEE VARVGPEKAS LSHVVWKFQR 130 140 150 160 170 180 TRVLMDIVAN ILCIIMAAIG PTVLIHQILQ QTERTSGKVW VGIGLCIALF ATEFTKVFFW 190 200 210 220 230 240 ALAWAINYRT AIRLKVALST LVFENLVSFK TLTHISVGEM FMAKLNSAFR RSAILVTDKR 250 260 270 280 290 300 VQTMNEFLTC IRLIKMYAWE KSFTNTIQDI RRRERKLLEK AGFVQSGNSA LAPIVSTIAI 310 320 330 340 350 360 VLTLSCHILL RRKLTAPVAF SVIAMFNVMK FSIAILPFSI KAMAEANVSL RRMKKILIDK 370 380 390 400 410 420 SPPSYITQPE DPDTVLLLAN ATLTWEHEAS RKSTPKKLQN QKRHLCKKQR SEAYSERSPP 430 440 450 460 470 480 AKGATGPEEQ SDSLKSVLHS ISFVVRKGKI LGICGNVGSG KSSLLAALLG QMQLQKGVVA 490 500 510 520 530 540 VNGTLAYVSQ QAWIFHGNVR ENILFGEKYD HQRYQHTVRV CGLQKDLSNL PYGDLTEIGE 550 560 570 580 590 600 RGLNLSGGQR QRISLARAVY SDRQLYLLDD PLSAVDAHVG KHVFEECIKK TLRGKTVVLV 610 620 630 640 650 660 THQLQFLESC DEVILLEDGE ICEKGTHKEL MEERGRYAKL IHNLRGLQFK DPEHLYNAAM 670 680 690 700 710 720 VEAFKESPAE REEDAGIIVP EHQLIQTESP QEGTVTWKTY HTYIKASGGY LLSLFTVFLF 730 740 750 760 770 780 LLMIGSAAFS NWWLGLWLDK GSRMTCGPQG NRTMCEVGAV LADIGQHVYQ WVYTASMVFM 790 800 810 820 830 840 LVFGVTKGFV FTKTTLMASS SLHDTVFDKI LKSPMSFFDT TPTGRLMNRF SKDMDELDVR 850 860 870 880 890 900 LPFHAENFLQ QFFMVVFILV ILAAVFPAVL LVVASLAVGF FILLRIFHRG VQELKKVENV 910 920 930 SRSPWFTHIT SSMQGLGIIH AYGKKESCIT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12." Yabuuchi H., Shimizu H., Takayanagi S., Ishikawa T. Biochem. Biophys. Res. Commun. 288:933-939(2001) [PubMed: 11688999] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Tissue: Liver, Pancreas and Testis.
[2]	"Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12." Tammur J., Prades C., Arnould I., Rzhetsky A., Hutchinson A., Adachi M., Schuetz J.D., Swoboda K.J., Ptacek L.J., Rosier M., Dean M., Allikmets R. Gene 273:89-96(2001) [PubMed: 11483364] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT CYS-1117, TISSUE SPECIFICITY. Tissue: Testis.
[3]	"MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer." Bera T.K., Iavarone C., Kumar V., Lee S., Lee B., Pastan I. Proc. Natl. Acad. Sci. U.S.A. 99:6997-7002(2002) [PubMed: 12011458] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), TISSUE SPECIFICITY.
[4]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed: 15616553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF395908 mRNA. Translation: AAL79528.1. AF395909 mRNA. Translation: AAL79529.1. AF411577 mRNA. Translation: AAL99900.1. AF411578 mRNA. Translation: AAL99901.1. AY040220 mRNA. Translation: AAK76740.1. AY196326 mRNA. Translation: AAO40749.1. AC096996 Genomic DNA. No translation available. BC036378 mRNA. No translation available.
IPI	IPI00063878. IPI00291897. IPI00375288. IPI00646809. IPI00796878.
RefSeq	NP_150229.2.
UniGene	Hs.410111
3D structure databases
HSSP	HSSP built from PDB template 2CBZ based on UniProtKB P33527.
ModBase	Search...
Protein-protein interaction databases
STRING	Q96J65.
Proteomic databases
PRIDE	Q96J65.
Genome annotation databases
Ensembl	ENST00000311303; ENSP00000311030; ENSG00000140798; Homo sapiens. [Genome view]
GeneID	94160.
KEGG	hsa:94160.
UCSC	uc002efc.1. human. uc002efe.1. human.
Organism-specific databases
CTD	94160.
GeneCards	GC16M046674.
HGNC	HGNC:14640. ABCC12.
MIM	607041. gene.
PharmGKB	PA24394.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q96J65.
OMA	QRTRVLM
OrthoDB	EOG9N070W
Gene expression databases
ArrayExpress	Q96J65.
Bgee	Q96J65.
CleanEx	HS_ABCC12.
Genevestigator	Q96J65.
GermOnline	ENSG00000140798. Homo sapiens.
Family and domain databases
InterPro	IPR011527. ABC_TM_1. IPR001140. ABC_TM_transpt. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR003593. ATPase_AAA+_core. [Graphical view]
Pfam	PF00664. ABC_membrane. 2 hits. PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
PROSITE	PS50929. ABC_TM1F. 2 hits. PS00211. ABC_TRANSPORTER_1. 2 hits. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	78453.
SOURCE	Search...

Entry information

Entry name

MRP9_HUMAN

Accession

Primary (citable) accession number: Q96J65
Secondary accession number(s): Q49AL2, Q8TAF0, Q8TEY2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	December 4, 2007
Last modified:	November 24, 2009
This is version 55 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.