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Protein

Multidrug resistance-associated protein 9

Gene

ABCC12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable transporter.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi513 – 520ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1154 – 1161ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Protein family/group databases

TCDBi3.A.1.208.29. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-associated protein 9
Alternative name(s):
ATP-binding cassette sub-family C member 12
Gene namesi
Name:ABCC12
Synonyms:MRP9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:14640. ABCC12.

Subcellular locationi

  • Membrane PROSITE-ProRule annotation; Multi-pass membrane protein PROSITE-ProRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei125 – 145HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei159 – 179HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei231 – 251HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei256 – 276HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei348 – 368HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei376 – 396HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei791 – 811HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei853 – 873HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei934 – 954HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1031 – 1051HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi94160.
OpenTargetsiENSG00000140798.
PharmGKBiPA24394.

Polymorphism and mutation databases

BioMutaiABCC12.
DMDMi161788999.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002535781 – 1359Multidrug resistance-associated protein 9Add BLAST1359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi405N-linked (GlcNAc...)Sequence analysis1
Glycosylationi438N-linked (GlcNAc...)Sequence analysis1
Glycosylationi540N-linked (GlcNAc...)Sequence analysis1
Glycosylationi981N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96J65.
PeptideAtlasiQ96J65.
PRIDEiQ96J65.

PTM databases

iPTMnetiQ96J65.
PhosphoSitePlusiQ96J65.

Expressioni

Tissue specificityi

Expressed in testis (at protein level). Widely expressed at low level. Isoform 5 is specifically expressed in brain, testis and breast cancer cells.3 Publications

Developmental stagei

Expressed in fetal tissues.1 Publication

Gene expression databases

BgeeiENSG00000140798.
CleanExiHS_ABCC12.
ExpressionAtlasiQ96J65. baseline and differential.
GenevisibleiQ96J65. HS.

Organism-specific databases

HPAiHPA043100.

Interactioni

Protein-protein interaction databases

BioGridi125142. 1 interactor.
IntActiQ96J65. 1 interactor.
STRINGi9606.ENSP00000311030.

Structurei

3D structure databases

ProteinModelPortaliQ96J65.
SMRiQ96J65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini123 – 403ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST281
Domaini467 – 701ABC transporter 1PROSITE-ProRule annotationAdd BLAST235
Domaini795 – 1082ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST288
Domaini1120 – 1354ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00860000133722.
HOVERGENiHBG108314.
InParanoidiQ96J65.
KOiK05672.
OMAiVPECTHP.
OrthoDBiEOG091G01TC.
PhylomeDBiQ96J65.
TreeFamiTF105202.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030250. MRP9.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF10. PTHR24223:SF10. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96J65-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVGEGPYLIS DLDQRGRRRS FAERYDPSLK TMIPVRPCAR LAPNPVDDAG
60 70 80 90 100
LLSFATFSWL TPVMVKGYRQ RLTVDTLPPL STYDSSDTNA KRFRVLWDEE
110 120 130 140 150
VARVGPEKAS LSHVVWKFQR TRVLMDIVAN ILCIIMAAIG PVILIHQILQ
160 170 180 190 200
QTERTSGKVW VGIGLCIALF ATEFTKVFFW ALAWAINYRT AIRLKVALST
210 220 230 240 250
LVFENLVSFK TLTHISVGEV LNILSSDSYS LFEAALFCPL PATIPILMVF
260 270 280 290 300
CAAYAFFILG PTALIGISVY VIFIPVQMFM AKLNSAFRRS AILVTDKRVQ
310 320 330 340 350
TMNEFLTCIR LIKMYAWEKS FTNTIQDIRR RERKLLEKAG FVQSGNSALA
360 370 380 390 400
PIVSTIAIVL TLSCHILLRR KLTAPVAFSV IAMFNVMKFS IAILPFSIKA
410 420 430 440 450
MAEANVSLRR MKKILIDKSP PSYITQPEDP DTVLLLANAT LTWEHEASRK
460 470 480 490 500
STPKKLQNQK RHLCKKQRSE AYSERSPPAK GATGPEEQSD SLKSVLHSIS
510 520 530 540 550
FVVRKGKILG ICGNVGSGKS SLLAALLGQM QLQKGVVAVN GTLAYVSQQA
560 570 580 590 600
WIFHGNVREN ILFGEKYDHQ RYQHTVRVCG LQKDLSNLPY GDLTEIGERG
610 620 630 640 650
LNLSGGQRQR ISLARAVYSD RQLYLLDDPL SAVDAHVGKH VFEECIKKTL
660 670 680 690 700
RGKTVVLVTH QLQFLESCDE VILLEDGEIC EKGTHKELME ERGRYAKLIH
710 720 730 740 750
NLRGLQFKDP EHLYNAAMVE AFKESPAERE EDAGIIVLAP GNEKDEGKES
760 770 780 790 800
ETGSEFVDTK VPEHQLIQTE SPQEGTVTWK TYHTYIKASG GYLLSLFTVF
810 820 830 840 850
LFLLMIGSAA FSNWWLGLWL DKGSRMTCGP QGNRTMCEVG AVLADIGQHV
860 870 880 890 900
YQWVYTASMV FMLVFGVTKG FVFTKTTLMA SSSLHDTVFD KILKSPMSFF
910 920 930 940 950
DTTPTGRLMN RFSKDMDELD VRLPFHAENF LQQFFMVVFI LVILAAVFPA
960 970 980 990 1000
VLLVVASLAV GFFILLRIFH RGVQELKKVE NVSRSPWFTH ITSSMQGLGI
1010 1020 1030 1040 1050
IHAYGKKESC ITYHLLYFNC ALRWFALRMD VLMNILTFTV ALLVTLSFSS
1060 1070 1080 1090 1100
ISTSSKGLSL SYIIQLSGLL QVCVRTGTET QAKFTSVELL REYISTCVPE
1110 1120 1130 1140 1150
CTHPLKVGTC PKDWPSRGEI TFRDYQMRYR DNTPLVLDSL NLNIQSGQTV
1160 1170 1180 1190 1200
GIVGRTGSGK SSLGMALFRL VEPASGTIFI DEVDICILSL EDLRTKLTVI
1210 1220 1230 1240 1250
PQDPVLFVGT VRYNLDPFES HTDEMLWQVL ERTFMRDTIM KLPEKLQAEV
1260 1270 1280 1290 1300
TENGENFSVG ERQLLCVARA LLRNSKIILL DEATASMDSK TDTLVQNTIK
1310 1320 1330 1340 1350
DAFKGCTVLT IAHRLNTVLN CDHVLVMENG KVIEFDKPEV LAEKPDSAFA

MLLAAEVRL
Length:1,359
Mass (Da):152,297
Last modified:December 4, 2007 - v2
Checksum:iDA8AF5A3EE9B10E8
GO
Isoform 2 (identifier: Q96J65-2) [UniParc]FASTAAdd to basket
Also known as: A, C, D

The sequence of this isoform differs from the canonical sequence as follows:
     142-143: VI → TV
     734-736: Missing.
     1013-1359: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:1,009
Mass (Da):113,163
Checksum:i6491AA00FBC280E5
GO
Isoform 3 (identifier: Q96J65-3) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     142-143: VI → TV
     734-736: Missing.
     892-938: ILKSPMSFFD...NFLQQFFMVV → HFPQRSPGAQ...WQEGELHHLV
     939-1359: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:935
Mass (Da):104,651
Checksum:iAD0715883A3971E2
GO
Isoform 4 (identifier: Q96J65-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-143: VI → TV
     572-633: YQHTVRVCGL...YLLDDPLSAV → LGSGASTSLG...RRSGERQSSW
     634-1359: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:633
Mass (Da):70,399
Checksum:i66DEE4BFA9C4D7E4
GO
Isoform 5 (identifier: Q96J65-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-143: VI → TV
     220-277: Missing.
     737-760: Missing.
     1013-1359: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:930
Mass (Da):104,660
Checksum:i22A26E88E51CE234
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73T → A in BC036378 (PubMed:15489334).Curated1
Sequence conflicti448 – 450SRK → RQE in AAL79528 (PubMed:11688999).Curated3
Sequence conflicti448 – 450SRK → RQE in AAL79529 (PubMed:11688999).Curated3
Sequence conflicti448 – 450SRK → RQE in AAL99900 (PubMed:11688999).Curated3
Sequence conflicti448 – 450SRK → RQE in AAL99901 (PubMed:11688999).Curated3
Sequence conflicti853W → R in AAL79528 (PubMed:11688999).Curated1
Sequence conflicti853W → R in AAL79529 (PubMed:11688999).Curated1
Sequence conflicti853W → R in AAL99900 (PubMed:11688999).Curated1
Sequence conflicti853W → R in AAL99901 (PubMed:11688999).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0283929I → L.Corresponds to variant rs16945901dbSNPEnsembl.1
Natural variantiVAR_028393102A → E.Corresponds to variant rs16945874dbSNPEnsembl.1
Natural variantiVAR_028394587N → Y.Corresponds to variant rs16945816dbSNPEnsembl.1
Natural variantiVAR_048139690E → V.Corresponds to variant rs34135219dbSNPEnsembl.1
Natural variantiVAR_028395894K → M.Corresponds to variant rs8057474dbSNPEnsembl.1
Natural variantiVAR_028396989T → S.Corresponds to variant rs6500305dbSNPEnsembl.1
Natural variantiVAR_0283971013Y → H.Corresponds to variant rs6500304dbSNPEnsembl.1
Natural variantiVAR_0283981117R → C.1 PublicationCorresponds to variant rs7193955dbSNPEnsembl.1
Natural variantiVAR_0481401187I → T.Corresponds to variant rs34106426dbSNPEnsembl.1
Natural variantiVAR_0283991191E → A.Corresponds to variant rs16945787dbSNPEnsembl.1
Natural variantiVAR_0284001349F → L.Corresponds to variant rs12373105dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021084142 – 143VI → TV in isoform 2, isoform 3, isoform 4 and isoform 5. 3 Publications2
Alternative sequenceiVSP_021085220 – 277Missing in isoform 5. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_021086572 – 633YQHTV…PLSAV → LGSGASTSLGGRGRGLAWPA LSTPTVSSTCWTTPCRPWTP TWGSTSLRSALRRRSGERQS SW in isoform 4. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_021087634 – 1359Missing in isoform 4. 1 PublicationAdd BLAST726
Alternative sequenceiVSP_021088734 – 736Missing in isoform 2 and isoform 3. 1 Publication3
Alternative sequenceiVSP_021089737 – 760Missing in isoform 5. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_021090892 – 938ILKSP…FFMVV → HFPQRSPGAQEGGECQPVTL VHPHHLLHAGPGHHSRLWQE GELHHLV in isoform 3. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_021091939 – 1359Missing in isoform 3. 1 PublicationAdd BLAST421
Alternative sequenceiVSP_0210921013 – 1359Missing in isoform 2 and isoform 5. 2 PublicationsAdd BLAST347

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395908 mRNA. Translation: AAL79528.1.
AF395909 mRNA. Translation: AAL79529.1.
AF411577 mRNA. Translation: AAL99900.1.
AF411578 mRNA. Translation: AAL99901.1.
AY040220 mRNA. Translation: AAK76740.1.
AY196326 mRNA. Translation: AAO40749.1.
AC096996 Genomic DNA. No translation available.
BC036378 mRNA. No translation available.
CCDSiCCDS10730.1. [Q96J65-1]
RefSeqiNP_150229.2. NM_033226.2. [Q96J65-1]
UniGeneiHs.410111.

Genome annotation databases

EnsembliENST00000311303; ENSP00000311030; ENSG00000140798. [Q96J65-1]
ENST00000497206; ENSP00000431232; ENSG00000140798. [Q96J65-2]
ENST00000529084; ENSP00000434510; ENSG00000140798. [Q96J65-4]
ENST00000529504; ENSP00000433333; ENSG00000140798. [Q96J65-3]
ENST00000532494; ENSP00000437047; ENSG00000140798. [Q96J65-2]
ENST00000534418; ENSP00000431354; ENSG00000140798. [Q96J65-5]
GeneIDi94160.
KEGGihsa:94160.
UCSCiuc002efc.1. human. [Q96J65-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395908 mRNA. Translation: AAL79528.1.
AF395909 mRNA. Translation: AAL79529.1.
AF411577 mRNA. Translation: AAL99900.1.
AF411578 mRNA. Translation: AAL99901.1.
AY040220 mRNA. Translation: AAK76740.1.
AY196326 mRNA. Translation: AAO40749.1.
AC096996 Genomic DNA. No translation available.
BC036378 mRNA. No translation available.
CCDSiCCDS10730.1. [Q96J65-1]
RefSeqiNP_150229.2. NM_033226.2. [Q96J65-1]
UniGeneiHs.410111.

3D structure databases

ProteinModelPortaliQ96J65.
SMRiQ96J65.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125142. 1 interactor.
IntActiQ96J65. 1 interactor.
STRINGi9606.ENSP00000311030.

Protein family/group databases

TCDBi3.A.1.208.29. the atp-binding cassette (abc) superfamily.

PTM databases

iPTMnetiQ96J65.
PhosphoSitePlusiQ96J65.

Polymorphism and mutation databases

BioMutaiABCC12.
DMDMi161788999.

Proteomic databases

PaxDbiQ96J65.
PeptideAtlasiQ96J65.
PRIDEiQ96J65.

Protocols and materials databases

DNASUi94160.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311303; ENSP00000311030; ENSG00000140798. [Q96J65-1]
ENST00000497206; ENSP00000431232; ENSG00000140798. [Q96J65-2]
ENST00000529084; ENSP00000434510; ENSG00000140798. [Q96J65-4]
ENST00000529504; ENSP00000433333; ENSG00000140798. [Q96J65-3]
ENST00000532494; ENSP00000437047; ENSG00000140798. [Q96J65-2]
ENST00000534418; ENSP00000431354; ENSG00000140798. [Q96J65-5]
GeneIDi94160.
KEGGihsa:94160.
UCSCiuc002efc.1. human. [Q96J65-1]

Organism-specific databases

CTDi94160.
DisGeNETi94160.
GeneCardsiABCC12.
H-InvDBHIX0026945.
HGNCiHGNC:14640. ABCC12.
HPAiHPA043100.
MIMi607041. gene.
neXtProtiNX_Q96J65.
OpenTargetsiENSG00000140798.
PharmGKBiPA24394.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00860000133722.
HOVERGENiHBG108314.
InParanoidiQ96J65.
KOiK05672.
OMAiVPECTHP.
OrthoDBiEOG091G01TC.
PhylomeDBiQ96J65.
TreeFamiTF105202.

Miscellaneous databases

GeneWikiiABCC12.
GenomeRNAii94160.
PROiQ96J65.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140798.
CleanExiHS_ABCC12.
ExpressionAtlasiQ96J65. baseline and differential.
GenevisibleiQ96J65. HS.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030250. MRP9.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF10. PTHR24223:SF10. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMRP9_HUMAN
AccessioniPrimary (citable) accession number: Q96J65
Secondary accession number(s): Q49AL2, Q8TAF0, Q8TEY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: December 4, 2007
Last modified: November 30, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.