TXNDC15

Functionⁱ

GO - Biological processⁱ

cell redox homeostasis Source: InterPro

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Thioredoxin domain-containing protein 15
Gene namesⁱ	Name:TXNDC15 Synonyms:C5orf14 ORF Names:UNQ335/PRO534
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20652. TXNDC15.

HGNCⁱ

HGNC:20652. TXNDC15.

Subcellular locationⁱ

Membrane Curated; Single-pass type I membrane protein Curated

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	33 – 321	ExtracellularSequence analysisAdd BLAST	289
Transmembraneⁱ	322 – 342	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	343 – 360	CytoplasmicSequence analysisAdd BLAST	18

GO - Cellular componentⁱ

cell Source: GOC
integral component of membrane Source: UniProtKB-KW

Complete GO annotation...

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	79770.
Open Targets More...OpenTargetsⁱ	ENSG00000113621.
PharmGKBⁱ	PA162407473.

Polymorphism and mutation databases

BioMutaⁱ	TXNDC15.
DMDMⁱ	74732127.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 32	Sequence analysisAdd BLAST		32
ChainⁱPRO_0000296094	33 – 360	Thioredoxin domain-containing protein 15Add BLAST		328

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	187	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	194	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	206	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	293	N-linked (GlcNAc...) asparagine1 Publication	1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

EPDⁱ	Q96J42.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96J42.
PaxDbⁱ	Q96J42.
PeptideAtlas More...PeptideAtlasⁱ	Q96J42.
PRIDEⁱ	Q96J42.
TopDownProteomicsⁱ	Q96J42-1. [Q96J42-1]

PTM databases

iPTMnetⁱ	Q96J42.
PhosphoSitePlusⁱ	Q96J42.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000113621.
CleanExⁱ	HS_TXNDC15.
ExpressionAtlasⁱ	Q96J42. baseline and differential.
Genevisibleⁱ	Q96J42. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA015483.

HPAⁱ

HPA015483.

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	122874. 42 interactors.
IntActⁱ	Q96J42. 3 interactors.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96J42.
SMRⁱ	Q96J42.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	153 – 296	ThioredoxinPROSITE-ProRule annotationAdd BLAST		144

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG2640. Eukaryota. ENOG4111M6Z. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000002845.
HOGENOMⁱ	HOG000154718.
HOVERGENⁱ	HBG054981.
InParanoidⁱ	Q96J42.
OMAⁱ	WWQVLLW.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0YYA.
PhylomeDBⁱ	Q96J42.
TreeFamⁱ	TF323528.

Family and domain databases

InterProⁱ	View protein in InterPro IPR012336. Thioredoxin-like_fold. IPR013766. Thioredoxin_domain.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00085. Thioredoxin. 1 hit.
SUPFAMⁱ	SSF52833. SSF52833. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51352. THIOREDOXIN_2. 1 hit.

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q96J42-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVPAAGRRPP RVMRLLGWWQ VLLWVLGLPV RGVEVAEESG RLWSEEQPAH 
        60         70         80         90        100
PLQVGAVYLG EEELLHDPMG QDRAAEEANA VLGLDTQGDH MVMLSVIPGE 
       110        120        130        140        150
AEDKVSSEPS GVTCGAGGAE DSRCNVRESL FSLDGAGAHF PDREEEYYTE 
       160        170        180        190        200
PEVAESDAAP TEDSNNTESL KSPKVNCEER NITGLENFTL KILNMSQDLM 
       210        220        230        240        250
DFLNPNGSDC TLVLFYTPWC RFSASLAPHF NSLPRAFPAL HFLALDASQH 
       260        270        280        290        300
SSLSTRFGTV AVPNILLFQG AKPMARFNHT DRTLETLKIF IFNQTGIEAK 
       310        320        330        340        350
KNVVVTQADQ IGPLPSTLIK SVDWLLVFSL FFLISFIMYA TIRTESIRWL 
       360
IPGQEQEHVE

Length:360

Mass (Da):39,885

Last modified:December 1, 2001 - v1

Checksum:ⁱ708473B7238FCCF6

GO

Isoform 2 (identifier: Q96J42-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
45-61: Missing.

« Hide

        10         20         30         40         50
MVPAAGRRPP RVMRLLGWWQ VLLWVLGLPV RGVEVAEESG RLWSEELLHD 
        60         70         80         90        100
PMGQDRAAEE ANAVLGLDTQ GDHMVMLSVI PGEAEDKVSS EPSGVTCGAG 
       110        120        130        140        150
GAEDSRCNVR ESLFSLDGAG AHFPDREEEY YTEPEVAESD AAPTEDSNNT 
       160        170        180        190        200
ESLKSPKVNC EERNITGLEN FTLKILNMSQ DLMDFLNPNG SDCTLVLFYT 
       210        220        230        240        250
PWCRFSASLA PHFNSLPRAF PALHFLALDA SQHSSLSTRF GTVAVPNILL 
       260        270        280        290        300
FQGAKPMARF NHTDRTLETL KIFIFNQTGI EAKKNVVVTQ ADQIGPLPST 
       310        320        330        340 
LIKSVDWLLV FSLFFLISFI MYATIRTESI RWLIPGQEQE HVE

Note: No experimental confirmation available.

Show »

Length:343

Mass (Da):38,066

Checksum:ⁱA9FC7A48F76C877F

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	71	Q → R in BAB15427 (PubMed:14702039).Curated		1
Sequence conflictⁱ	85	D → G in BAB71199 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_036172	248	S → P in a breast cancer sample; somatic mutation. 1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_027129	45 – 61	Missing in isoform 2. 1 PublicationAdd BLAST		17

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY358649 mRNA. Translation: AAQ89012.1. AK026278 mRNA. Translation: BAB15427.1. AK056512 mRNA. Translation: BAB71199.1. CH471062 Genomic DNA. Translation: EAW62231.1. CH471062 Genomic DNA. Translation: EAW62233.1. BC001615 mRNA. Translation: AAH01615.1. BC032568 mRNA. Translation: AAH32568.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4180.1. [Q96J42-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_078991.3. NM_024715.3. [Q96J42-1]
UniGeneⁱ	Hs.741304.

Genome annotation databases

Ensemblⁱ	ENST00000358387; ENSP00000351157; ENSG00000113621. [Q96J42-1]
GeneIDⁱ	79770.
KEGGⁱ	hsa:79770.
UCSC genome browser More...UCSCⁱ	uc003lac.2. human. [Q96J42-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY358649 mRNA. Translation: AAQ89012.1. AK026278 mRNA. Translation: BAB15427.1. AK056512 mRNA. Translation: BAB71199.1. CH471062 Genomic DNA. Translation: EAW62231.1. CH471062 Genomic DNA. Translation: EAW62233.1. BC001615 mRNA. Translation: AAH01615.1. BC032568 mRNA. Translation: AAH32568.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4180.1. [Q96J42-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_078991.3. NM_024715.3. [Q96J42-1]
UniGeneⁱ	Hs.741304.

3D structure databases

ProteinModelPortalⁱ	Q96J42.
SMRⁱ	Q96J42.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122874. 42 interactors.
IntActⁱ	Q96J42. 3 interactors.

PTM databases

iPTMnetⁱ	Q96J42.
PhosphoSitePlusⁱ	Q96J42.

Polymorphism and mutation databases

BioMutaⁱ	TXNDC15.
DMDMⁱ	74732127.

Proteomic databases

EPDⁱ	Q96J42.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96J42.
PaxDbⁱ	Q96J42.
PeptideAtlas More...PeptideAtlasⁱ	Q96J42.
PRIDEⁱ	Q96J42.
TopDownProteomicsⁱ	Q96J42-1. [Q96J42-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	79770.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000358387; ENSP00000351157; ENSG00000113621. [Q96J42-1]
GeneIDⁱ	79770.
KEGGⁱ	hsa:79770.
UCSC genome browser More...UCSCⁱ	uc003lac.2. human. [Q96J42-1]

Organism-specific databases

CTDⁱ	79770.
DisGeNET More...DisGeNETⁱ	79770.
GeneCardsⁱ	TXNDC15.
H-InvDBⁱ	HIX0005189.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20652. TXNDC15.
Human Protein Atlas More...HPAⁱ	HPA015483.
neXtProtⁱ	NX_Q96J42.
Open Targets More...OpenTargetsⁱ	ENSG00000113621.
PharmGKBⁱ	PA162407473.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2640. Eukaryota. ENOG4111M6Z. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000002845.
HOGENOMⁱ	HOG000154718.
HOVERGENⁱ	HBG054981.
InParanoidⁱ	Q96J42.
OMAⁱ	WWQVLLW.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0YYA.
PhylomeDBⁱ	Q96J42.
TreeFamⁱ	TF323528.

Miscellaneous databases

GenomeRNAiⁱ	79770.
Protein Ontology More...PROⁱ	PR:Q96J42.

Gene expression databases

Bgeeⁱ	ENSG00000113621.
CleanExⁱ	HS_TXNDC15.
ExpressionAtlasⁱ	Q96J42. baseline and differential.
Genevisibleⁱ	Q96J42. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR012336. Thioredoxin-like_fold. IPR013766. Thioredoxin_domain.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00085. Thioredoxin. 1 hit.
SUPFAMⁱ	SSF52833. SSF52833. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51352. THIOREDOXIN_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TXD15_HUMAN
Accessionⁱ	Q96J42Primary (citable) accession number: Q96J42 Secondary accession number(s): D3DQA9, Q96MT2, Q9H639
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
	Last sequence update:	December 1, 2001
	Last modified:	May 10, 2017
	This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Caution

It is uncertain whether Met-1 or Met-13 is the initiator.Curated

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96J42 (TXD15_HUMAN)

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Thioredoxin domain-containing protein 15

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Documents

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequences (2)ⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ