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Protein

Thioredoxin domain-containing protein 15

Gene

TXNDC15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin domain-containing protein 15
Gene namesi
Name:TXNDC15
Synonyms:C5orf14
ORF Names:UNQ335/PRO534
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:20652. TXNDC15.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini33 – 321289ExtracellularSequence analysisAdd
BLAST
Transmembranei322 – 34221HelicalSequence analysisAdd
BLAST
Topological domaini343 – 36018CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162407473.

Polymorphism and mutation databases

BioMutaiTXNDC15.
DMDMi74732127.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence analysisAdd
BLAST
Chaini33 – 360328Thioredoxin domain-containing protein 15PRO_0000296094Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence analysis
Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence analysis
Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence analysis
Glycosylationi293 – 2931N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ96J42.
MaxQBiQ96J42.
PaxDbiQ96J42.
PeptideAtlasiQ96J42.
PRIDEiQ96J42.
TopDownProteomicsiQ96J42-1. [Q96J42-1]

PTM databases

iPTMnetiQ96J42.
PhosphoSiteiQ96J42.

Expressioni

Gene expression databases

BgeeiQ96J42.
CleanExiHS_TXNDC15.
ExpressionAtlasiQ96J42. baseline and differential.
GenevisibleiQ96J42. HS.

Organism-specific databases

HPAiHPA015483.

Interactioni

Protein-protein interaction databases

BioGridi122874. 41 interactions.
IntActiQ96J42. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ96J42.
SMRiQ96J42. Positions 206-304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini153 – 296144ThioredoxinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2640. Eukaryota.
ENOG4111M6Z. LUCA.
GeneTreeiENSGT00390000002845.
HOGENOMiHOG000154718.
HOVERGENiHBG054981.
InParanoidiQ96J42.
OMAiAFPALHF.
PhylomeDBiQ96J42.
TreeFamiTF323528.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96J42-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVPAAGRRPP RVMRLLGWWQ VLLWVLGLPV RGVEVAEESG RLWSEEQPAH
60 70 80 90 100
PLQVGAVYLG EEELLHDPMG QDRAAEEANA VLGLDTQGDH MVMLSVIPGE
110 120 130 140 150
AEDKVSSEPS GVTCGAGGAE DSRCNVRESL FSLDGAGAHF PDREEEYYTE
160 170 180 190 200
PEVAESDAAP TEDSNNTESL KSPKVNCEER NITGLENFTL KILNMSQDLM
210 220 230 240 250
DFLNPNGSDC TLVLFYTPWC RFSASLAPHF NSLPRAFPAL HFLALDASQH
260 270 280 290 300
SSLSTRFGTV AVPNILLFQG AKPMARFNHT DRTLETLKIF IFNQTGIEAK
310 320 330 340 350
KNVVVTQADQ IGPLPSTLIK SVDWLLVFSL FFLISFIMYA TIRTESIRWL
360
IPGQEQEHVE
Length:360
Mass (Da):39,885
Last modified:December 1, 2001 - v1
Checksum:i708473B7238FCCF6
GO
Isoform 2 (identifier: Q96J42-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     45-61: Missing.

Note: No experimental confirmation available.
Show »
Length:343
Mass (Da):38,066
Checksum:iA9FC7A48F76C877F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti71 – 711Q → R in BAB15427 (PubMed:14702039).Curated
Sequence conflicti85 – 851D → G in BAB71199 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti248 – 2481S → P in a breast cancer sample; somatic mutation. 1 Publication
VAR_036172

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei45 – 6117Missing in isoform 2. 1 PublicationVSP_027129Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358649 mRNA. Translation: AAQ89012.1.
AK026278 mRNA. Translation: BAB15427.1.
AK056512 mRNA. Translation: BAB71199.1.
CH471062 Genomic DNA. Translation: EAW62231.1.
CH471062 Genomic DNA. Translation: EAW62233.1.
BC001615 mRNA. Translation: AAH01615.1.
BC032568 mRNA. Translation: AAH32568.1.
CCDSiCCDS4180.1. [Q96J42-1]
RefSeqiNP_078991.3. NM_024715.3. [Q96J42-1]
UniGeneiHs.741304.

Genome annotation databases

EnsembliENST00000358387; ENSP00000351157; ENSG00000113621. [Q96J42-1]
GeneIDi79770.
KEGGihsa:79770.
UCSCiuc003lac.2. human. [Q96J42-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358649 mRNA. Translation: AAQ89012.1.
AK026278 mRNA. Translation: BAB15427.1.
AK056512 mRNA. Translation: BAB71199.1.
CH471062 Genomic DNA. Translation: EAW62231.1.
CH471062 Genomic DNA. Translation: EAW62233.1.
BC001615 mRNA. Translation: AAH01615.1.
BC032568 mRNA. Translation: AAH32568.1.
CCDSiCCDS4180.1. [Q96J42-1]
RefSeqiNP_078991.3. NM_024715.3. [Q96J42-1]
UniGeneiHs.741304.

3D structure databases

ProteinModelPortaliQ96J42.
SMRiQ96J42. Positions 206-304.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122874. 41 interactions.
IntActiQ96J42. 2 interactions.

PTM databases

iPTMnetiQ96J42.
PhosphoSiteiQ96J42.

Polymorphism and mutation databases

BioMutaiTXNDC15.
DMDMi74732127.

Proteomic databases

EPDiQ96J42.
MaxQBiQ96J42.
PaxDbiQ96J42.
PeptideAtlasiQ96J42.
PRIDEiQ96J42.
TopDownProteomicsiQ96J42-1. [Q96J42-1]

Protocols and materials databases

DNASUi79770.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358387; ENSP00000351157; ENSG00000113621. [Q96J42-1]
GeneIDi79770.
KEGGihsa:79770.
UCSCiuc003lac.2. human. [Q96J42-1]

Organism-specific databases

CTDi79770.
GeneCardsiTXNDC15.
H-InvDBHIX0005189.
HGNCiHGNC:20652. TXNDC15.
HPAiHPA015483.
neXtProtiNX_Q96J42.
PharmGKBiPA162407473.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2640. Eukaryota.
ENOG4111M6Z. LUCA.
GeneTreeiENSGT00390000002845.
HOGENOMiHOG000154718.
HOVERGENiHBG054981.
InParanoidiQ96J42.
OMAiAFPALHF.
PhylomeDBiQ96J42.
TreeFamiTF323528.

Miscellaneous databases

GenomeRNAii79770.
PROiQ96J42.

Gene expression databases

BgeeiQ96J42.
CleanExiHS_TXNDC15.
ExpressionAtlasiQ96J42. baseline and differential.
GenevisibleiQ96J42. HS.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Small intestine and Teratocarcinoma.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney and Pancreas.
  5. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-293.
    Tissue: Liver.
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] PRO-248.

Entry informationi

Entry nameiTXD15_HUMAN
AccessioniPrimary (citable) accession number: Q96J42
Secondary accession number(s): D3DQA9, Q96MT2, Q9H639
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-13 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.