UniProtKB - Q96J42 (TXD15_HUMAN)
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Protein
Thioredoxin domain-containing protein 15
Gene
TXNDC15
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Thioredoxin domain-containing protein 15 |
Gene namesi | Name:TXNDC15 Synonyms:C5orf14 ORF Names:UNQ335/PRO534 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000113621.14. |
HGNCi | HGNC:20652. TXNDC15. |
MIMi | 617778. gene. |
neXtProti | NX_Q96J42. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 33 – 321 | ExtracellularSequence analysisAdd BLAST | 289 | |
Transmembranei | 322 – 342 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 343 – 360 | CytoplasmicSequence analysisAdd BLAST | 18 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 79770. |
OpenTargetsi | ENSG00000113621. |
PharmGKBi | PA162407473. |
Polymorphism and mutation databases
BioMutai | TXNDC15. |
DMDMi | 74732127. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 32 | Sequence analysisAdd BLAST | 32 | |
ChainiPRO_0000296094 | 33 – 360 | Thioredoxin domain-containing protein 15Add BLAST | 328 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 187 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 194 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 206 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 293 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q96J42. |
MaxQBi | Q96J42. |
PaxDbi | Q96J42. |
PeptideAtlasi | Q96J42. |
PRIDEi | Q96J42. |
TopDownProteomicsi | Q96J42-1. [Q96J42-1] |
PTM databases
iPTMneti | Q96J42. |
PhosphoSitePlusi | Q96J42. |
Expressioni
Gene expression databases
Bgeei | ENSG00000113621. |
CleanExi | HS_TXNDC15. |
ExpressionAtlasi | Q96J42. baseline and differential. |
Genevisiblei | Q96J42. HS. |
Organism-specific databases
HPAi | HPA015483. |
Interactioni
Protein-protein interaction databases
BioGridi | 122874. 48 interactors. |
IntActi | Q96J42. 3 interactors. |
Structurei
3D structure databases
ProteinModelPortali | Q96J42. |
SMRi | Q96J42. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 153 – 296 | ThioredoxinPROSITE-ProRule annotationAdd BLAST | 144 |
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2640. Eukaryota. ENOG4111M6Z. LUCA. |
GeneTreei | ENSGT00390000002845. |
HOGENOMi | HOG000154718. |
HOVERGENi | HBG054981. |
InParanoidi | Q96J42. |
OMAi | WWQVLLW. |
OrthoDBi | EOG091G0YYA. |
PhylomeDBi | Q96J42. |
TreeFami | TF323528. |
Family and domain databases
InterProi | View protein in InterPro IPR036249. Thioredoxin-like_sf. IPR013766. Thioredoxin_domain. |
Pfami | View protein in Pfam PF00085. Thioredoxin. 1 hit. |
SUPFAMi | SSF52833. SSF52833. 1 hit. |
PROSITEi | View protein in PROSITE PS51352. THIOREDOXIN_2. 1 hit. |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96J42-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MVPAAGRRPP RVMRLLGWWQ VLLWVLGLPV RGVEVAEESG RLWSEEQPAH
60 70 80 90 100
PLQVGAVYLG EEELLHDPMG QDRAAEEANA VLGLDTQGDH MVMLSVIPGE
110 120 130 140 150
AEDKVSSEPS GVTCGAGGAE DSRCNVRESL FSLDGAGAHF PDREEEYYTE
160 170 180 190 200
PEVAESDAAP TEDSNNTESL KSPKVNCEER NITGLENFTL KILNMSQDLM
210 220 230 240 250
DFLNPNGSDC TLVLFYTPWC RFSASLAPHF NSLPRAFPAL HFLALDASQH
260 270 280 290 300
SSLSTRFGTV AVPNILLFQG AKPMARFNHT DRTLETLKIF IFNQTGIEAK
310 320 330 340 350
KNVVVTQADQ IGPLPSTLIK SVDWLLVFSL FFLISFIMYA TIRTESIRWL
360
IPGQEQEHVE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 71 | Q → R in BAB15427 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 85 | D → G in BAB71199 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036172 | 248 | S → P in a breast cancer sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027129 | 45 – 61 | Missing in isoform 2. 1 PublicationAdd BLAST | 17 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358649 mRNA. Translation: AAQ89012.1. AK026278 mRNA. Translation: BAB15427.1. AK056512 mRNA. Translation: BAB71199.1. CH471062 Genomic DNA. Translation: EAW62231.1. CH471062 Genomic DNA. Translation: EAW62233.1. BC001615 mRNA. Translation: AAH01615.1. BC032568 mRNA. Translation: AAH32568.1. |
CCDSi | CCDS4180.1. [Q96J42-1] |
RefSeqi | NP_078991.3. NM_024715.3. [Q96J42-1] |
UniGenei | Hs.741304. |
Genome annotation databases
Ensembli | ENST00000358387; ENSP00000351157; ENSG00000113621. [Q96J42-1] |
GeneIDi | 79770. |
KEGGi | hsa:79770. |
UCSCi | uc003lac.2. human. [Q96J42-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | TXD15_HUMAN | |
Accessioni | Q96J42Primary (citable) accession number: Q96J42 Secondary accession number(s): D3DQA9, Q96MT2, Q9H639 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 24, 2007 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 28, 2018 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Caution
It is uncertain whether Met-1 or Met-13 is the initiator.Curated