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Protein

Serine/Arginine-related protein 53

Gene

RSRC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in pre-mRNA splicing. Involved in both constitutive and alternative pre-mRNA splicing. May have a role in the recognition of the 3' splice site during the second step of splicing.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/Arginine-related protein 53
Short name:
SRrp53
Alternative name(s):
Arginine/serine-rich coiled-coil protein 1
Gene namesi
Name:RSRC1
Synonyms:SRRP53
ORF Names:BM-011
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:24152. RSRC1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670969.

Polymorphism and mutation databases

DMDMi61216831.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 334334Serine/Arginine-related protein 53PRO_0000097496Add
BLAST

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96IZ7.
MaxQBiQ96IZ7.
PaxDbiQ96IZ7.
PeptideAtlasiQ96IZ7.
PRIDEiQ96IZ7.

PTM databases

iPTMnetiQ96IZ7.
PhosphoSiteiQ96IZ7.

Miscellaneous databases

PMAP-CutDBQ96IZ7.

Expressioni

Gene expression databases

BgeeiQ96IZ7.
CleanExiHS_RSRC1.
ExpressionAtlasiQ96IZ7. baseline and differential.
GenevisibleiQ96IZ7. HS.

Organism-specific databases

HPAiHPA044792.

Interactioni

Subunit structurei

Interacts (via Arg/Ser-rich domain) with LUC7L3, RBM39 and RSF1.1 Publication

Protein-protein interaction databases

BioGridi119470. 38 interactions.
IntActiQ96IZ7. 16 interactions.
MINTiMINT-1389888.
STRINGi9606.ENSP00000295930.

Structurei

3D structure databases

ProteinModelPortaliQ96IZ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili180 – 23657Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 147145Arg/Ser-richAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3406. Eukaryota.
COG1358. LUCA.
GeneTreeiENSGT00730000111251.
HOGENOMiHOG000129917.
HOVERGENiHBG060410.
InParanoidiQ96IZ7.
OrthoDBiEOG73BVFZ.
PhylomeDBiQ96IZ7.
TreeFamiTF336021.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96IZ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRRSSDTEE ESRSKRKKKH RRRSSSSSSS DSRTYSRKKG GRKSRSKSRS
60 70 80 90 100
WSRDLQPRSH SYDRRRRHRS SSSSSYGSRR KRSRSRSRGR GKSYRVQRSR
110 120 130 140 150
SKSRTRRSRS RPRLRSHSRS SERSSHRRTR SRSRDRERRK GRDKEKREKE
160 170 180 190 200
KDKGKDKELH NIKRGESGNI KAGLEHLPPA EQAKARLQLV LEAAAKADEA
210 220 230 240 250
LKAKERNEEE AKRRKEEDQA TLVEQVKRVK EIEAIESDSF VQQTFRSSKE
260 270 280 290 300
VKKSVEPSEV KQATSTSGPA SAVADPPSTE KEIDPTSIPT AIKYQDDNSL
310 320 330
AHPNLFIEKA DAEEKWFKRL IALRQERLMG SPVA
Length:334
Mass (Da):38,677
Last modified:December 1, 2001 - v1
Checksum:iDF31CC8C953E790A
GO
Isoform 2 (identifier: Q96IZ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     108-165: Missing.

Note: No experimental confirmation available.
Show »
Length:276
Mass (Da):31,528
Checksum:i99834B6BC3BAF02A
GO

Sequence cautioni

The sequence AAF64267.1 differs from that shown. Reason: Frameshift at positions 159, 166, 174 and 178. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti150 – 1512EK → GE in AAF64267 (Ref. 3) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei108 – 16558Missing in isoform 2. 1 PublicationVSP_013120Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290334 mRNA. Translation: BAF83023.1.
BC006982 mRNA. Translation: AAH06982.1.
BC010357 mRNA. Translation: AAH10357.1.
AF208853 mRNA. Translation: AAF64267.1. Frameshift.
CCDSiCCDS3181.1. [Q96IZ7-1]
CCDS63822.1. [Q96IZ7-2]
RefSeqiNP_001258763.1. NM_001271834.1. [Q96IZ7-2]
NP_001258767.1. NM_001271838.1. [Q96IZ7-1]
NP_057709.2. NM_016625.3. [Q96IZ7-1]
UniGeneiHs.591283.

Genome annotation databases

EnsembliENST00000295930; ENSP00000295930; ENSG00000174891. [Q96IZ7-1]
ENST00000312179; ENSP00000308671; ENSG00000174891. [Q96IZ7-2]
ENST00000464171; ENSP00000419794; ENSG00000174891. [Q96IZ7-2]
ENST00000480820; ENSP00000420150; ENSG00000174891. [Q96IZ7-1]
ENST00000611884; ENSP00000481697; ENSG00000174891. [Q96IZ7-1]
GeneIDi51319.
KEGGihsa:51319.
UCSCiuc003fbt.4. human. [Q96IZ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290334 mRNA. Translation: BAF83023.1.
BC006982 mRNA. Translation: AAH06982.1.
BC010357 mRNA. Translation: AAH10357.1.
AF208853 mRNA. Translation: AAF64267.1. Frameshift.
CCDSiCCDS3181.1. [Q96IZ7-1]
CCDS63822.1. [Q96IZ7-2]
RefSeqiNP_001258763.1. NM_001271834.1. [Q96IZ7-2]
NP_001258767.1. NM_001271838.1. [Q96IZ7-1]
NP_057709.2. NM_016625.3. [Q96IZ7-1]
UniGeneiHs.591283.

3D structure databases

ProteinModelPortaliQ96IZ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119470. 38 interactions.
IntActiQ96IZ7. 16 interactions.
MINTiMINT-1389888.
STRINGi9606.ENSP00000295930.

PTM databases

iPTMnetiQ96IZ7.
PhosphoSiteiQ96IZ7.

Polymorphism and mutation databases

DMDMi61216831.

Proteomic databases

EPDiQ96IZ7.
MaxQBiQ96IZ7.
PaxDbiQ96IZ7.
PeptideAtlasiQ96IZ7.
PRIDEiQ96IZ7.

Protocols and materials databases

DNASUi51319.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295930; ENSP00000295930; ENSG00000174891. [Q96IZ7-1]
ENST00000312179; ENSP00000308671; ENSG00000174891. [Q96IZ7-2]
ENST00000464171; ENSP00000419794; ENSG00000174891. [Q96IZ7-2]
ENST00000480820; ENSP00000420150; ENSG00000174891. [Q96IZ7-1]
ENST00000611884; ENSP00000481697; ENSG00000174891. [Q96IZ7-1]
GeneIDi51319.
KEGGihsa:51319.
UCSCiuc003fbt.4. human. [Q96IZ7-1]

Organism-specific databases

CTDi51319.
GeneCardsiRSRC1.
HGNCiHGNC:24152. RSRC1.
HPAiHPA044792.
MIMi613352. gene.
neXtProtiNX_Q96IZ7.
PharmGKBiPA142670969.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3406. Eukaryota.
COG1358. LUCA.
GeneTreeiENSGT00730000111251.
HOGENOMiHOG000129917.
HOVERGENiHBG060410.
InParanoidiQ96IZ7.
OrthoDBiEOG73BVFZ.
PhylomeDBiQ96IZ7.
TreeFamiTF336021.

Miscellaneous databases

ChiTaRSiRSRC1. human.
GenomeRNAii51319.
PMAP-CutDBQ96IZ7.
PROiQ96IZ7.
SOURCEiSearch...

Gene expression databases

BgeeiQ96IZ7.
CleanExiHS_RSRC1.
ExpressionAtlasiQ96IZ7. baseline and differential.
GenevisibleiQ96IZ7. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Tongue.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Prostate and Urinary bladder.
  3. "A novel gene expressed in human bone marrow."
    Zhao M., Song H., Li N., Peng Y., Han Z., Chen Z.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-203.
    Tissue: Bone marrow.
  4. "A novel SR-related protein is required for the second step of pre-mRNA splicing."
    Cazalla D., Newton K., Caceres J.F.
    Mol. Cell. Biol. 25:2969-2980(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH RBM39; LUC7L3 AND RSF1.
  5. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRSRC1_HUMAN
AccessioniPrimary (citable) accession number: Q96IZ7
Secondary accession number(s): A8K2R9, Q96QK2, Q9NZE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.