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Protein

Methyltransferase-like protein 2A

Gene

METTL2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Methyltransferase-like protein 2A (EC:2.1.1.-)
Gene namesi
Name:METTL2A
Synonyms:METTL2
ORF Names:HSPC266
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:25755. METTL2A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485532.

Polymorphism and mutation databases

BioMutaiMETTL2A.
DMDMi269849766.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 378377Methyltransferase-like protein 2APRO_0000204452Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei4 – 41PhosphoserineBy similarity
Modified residuei154 – 1541PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96IZ6.
MaxQBiQ96IZ6.
PaxDbiQ96IZ6.
PeptideAtlasiQ96IZ6.
PRIDEiQ96IZ6.

PTM databases

iPTMnetiQ96IZ6.
PhosphoSiteiQ96IZ6.

Expressioni

Gene expression databases

BgeeiENSG00000087995.
CleanExiHS_METTL2A.
ExpressionAtlasiQ96IZ6. baseline and differential.
GenevisibleiQ96IZ6. HS.

Organism-specific databases

HPAiCAB046454.
CAB046460.

Interactioni

Protein-protein interaction databases

BioGridi130836. 15 interactions.
IntActiQ96IZ6. 2 interactions.
MINTiMINT-3054259.
STRINGi9606.ENSP00000309610.

Structurei

3D structure databases

ProteinModelPortaliQ96IZ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2361. Eukaryota.
ENOG410YAN4. LUCA.
GeneTreeiENSGT00520000055554.
HOGENOMiHOG000182278.
HOVERGENiHBG075344.
InParanoidiQ96IZ6.
OMAiDIIVMIF.
OrthoDBiEOG091G1235.
PhylomeDBiQ96IZ6.
TreeFamiTF323232.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
InterProiIPR026113. MeTrfase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR22809. PTHR22809. 2 hits.
PIRSFiPIRSF037755. Mettl2_prd. 1 hit.
SUPFAMiSSF53335. SSF53335. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96IZ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGSYPEGAP AVLADKRQQF GSRFLRDPAR VFHHNAWDNV EWSEEQAAAA
60 70 80 90 100
ERKVQENSIQ RVCQEKQVDY EINAHKYWND FYKIHENGFF KDRHWLFTEF
110 120 130 140 150
PELAPSQNQN HLKDWFLENK SEVPECRNNE DGPGLIMEEQ HKCSSKSLEH
160 170 180 190 200
KTQTLPVEEN VTQKISDLEI CADEFPGSSA TYRILEVGCG VGNTVFPILQ
210 220 230 240 250
TNNDPGLFVY CCDFSSTAIE LVQTNSEYDP SRCFAFVHDL CDEEKSYPVP
260 270 280 290 300
KGSLDIIILI FVLSAIVPDK MQKAINRLSR LLKPGGMMLL RDYGRYDMAQ
310 320 330 340 350
LRFKKGQCLS GNFYVRGDGT RVYFFTQEEL DTLFTTAGLE KVQNLVDRRL
360 370
QVNRGKQLTM YRVWIQCKYC KPLLSSTS
Length:378
Mass (Da):43,537
Last modified:November 24, 2009 - v5
Checksum:i7469B30968C03BAD
GO
Isoform 2 (identifier: Q96IZ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-136: Missing.

Note: No experimental confirmation available.
Show »
Length:242
Mass (Da):27,491
Checksum:iE1ED3474006A61A7
GO

Sequence cautioni

The sequence BAB14260 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti118 – 1181E → K in AAF28944 (PubMed:11042152).Curated
Sequence conflicti142 – 1421K → R in BAB14260 (PubMed:14702039).Curated
Sequence conflicti155 – 1551L → P in AAH06985 (PubMed:15489334).Curated
Sequence conflicti155 – 1551L → P in AAF28944 (PubMed:11042152).Curated
Sequence conflicti155 – 1551L → P in BAB14260 (PubMed:14702039).Curated
Sequence conflicti262 – 2621V → G in AAF28944 (PubMed:11042152).Curated
Sequence conflicti273 – 2731K → R in AAF28944 (PubMed:11042152).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 136136Missing in isoform 2. 1 PublicationVSP_008477Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008026 Genomic DNA. No translation available.
BC006985 mRNA. Translation: AAH06985.1.
AF161384 mRNA. Translation: AAF28944.1.
AK022822 mRNA. Translation: BAB14260.1. Different initiation.
CCDSiCCDS45752.1. [Q96IZ6-1]
RefSeqiNP_859076.3. NM_181725.3. [Q96IZ6-1]
UniGeneiHs.381204.

Genome annotation databases

EnsembliENST00000311506; ENSP00000309610; ENSG00000087995. [Q96IZ6-1]
GeneIDi339175.
KEGGihsa:339175.
UCSCiuc002izv.3. human. [Q96IZ6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008026 Genomic DNA. No translation available.
BC006985 mRNA. Translation: AAH06985.1.
AF161384 mRNA. Translation: AAF28944.1.
AK022822 mRNA. Translation: BAB14260.1. Different initiation.
CCDSiCCDS45752.1. [Q96IZ6-1]
RefSeqiNP_859076.3. NM_181725.3. [Q96IZ6-1]
UniGeneiHs.381204.

3D structure databases

ProteinModelPortaliQ96IZ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130836. 15 interactions.
IntActiQ96IZ6. 2 interactions.
MINTiMINT-3054259.
STRINGi9606.ENSP00000309610.

PTM databases

iPTMnetiQ96IZ6.
PhosphoSiteiQ96IZ6.

Polymorphism and mutation databases

BioMutaiMETTL2A.
DMDMi269849766.

Proteomic databases

EPDiQ96IZ6.
MaxQBiQ96IZ6.
PaxDbiQ96IZ6.
PeptideAtlasiQ96IZ6.
PRIDEiQ96IZ6.

Protocols and materials databases

DNASUi339175.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311506; ENSP00000309610; ENSG00000087995. [Q96IZ6-1]
GeneIDi339175.
KEGGihsa:339175.
UCSCiuc002izv.3. human. [Q96IZ6-1]

Organism-specific databases

CTDi339175.
GeneCardsiMETTL2A.
H-InvDBHIX0022921.
HGNCiHGNC:25755. METTL2A.
HPAiCAB046454.
CAB046460.
MIMi607846. gene.
neXtProtiNX_Q96IZ6.
PharmGKBiPA143485532.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2361. Eukaryota.
ENOG410YAN4. LUCA.
GeneTreeiENSGT00520000055554.
HOGENOMiHOG000182278.
HOVERGENiHBG075344.
InParanoidiQ96IZ6.
OMAiDIIVMIF.
OrthoDBiEOG091G1235.
PhylomeDBiQ96IZ6.
TreeFamiTF323232.

Miscellaneous databases

ChiTaRSiMETTL2A. human.
GenomeRNAii339175.
PROiQ96IZ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000087995.
CleanExiHS_METTL2A.
ExpressionAtlasiQ96IZ6. baseline and differential.
GenevisibleiQ96IZ6. HS.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
InterProiIPR026113. MeTrfase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR22809. PTHR22809. 2 hits.
PIRSFiPIRSF037755. Mettl2_prd. 1 hit.
SUPFAMiSSF53335. SSF53335. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiMET2A_HUMAN
AccessioniPrimary (citable) accession number: Q96IZ6
Secondary accession number(s): A6NNC4
, Q9H9G9, Q9NUI8, Q9P0B5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: November 24, 2009
Last modified: September 7, 2016
This is version 135 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.