ID RBM41_HUMAN Reviewed; 413 AA. AC Q96IZ5; Q5JSN7; Q5JSN8; Q9H8F7; Q9NV04; DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot. DT 31-OCT-2006, sequence version 2. DT 27-MAR-2024, entry version 164. DE RecName: Full=RNA-binding protein 41; DE AltName: Full=RNA-binding motif protein 41; GN Name=RBM41; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). RC TISSUE=Placenta; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15772651; DOI=10.1038/nature03440; RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C., RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., RA Rogers J., Bentley D.R.; RT "The DNA sequence of the human X chromosome."; RL Nature 434:325-337(2005). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT TYR-376. RC TISSUE=Urinary bladder; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-232, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [5] RP STRUCTURE BY NMR OF 291-392. RG RIKEN structural genomics initiative (RSGI); RT "Solution structure of RNA binding domain in hypothetical protein RT FLJ11016."; RL Submitted (NOV-2005) to the PDB data bank. CC -!- FUNCTION: May bind RNA. {ECO:0000305}. CC -!- INTERACTION: CC Q96IZ5; Q8TD16-2: BICD2; NbExp=3; IntAct=EBI-740773, EBI-11975051; CC Q96IZ5; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-740773, EBI-10175300; CC Q96IZ5; P24863: CCNC; NbExp=3; IntAct=EBI-740773, EBI-395261; CC Q96IZ5; Q8TAP6: CEP76; NbExp=3; IntAct=EBI-740773, EBI-742887; CC Q96IZ5; Q9NRI5-2: DISC1; NbExp=3; IntAct=EBI-740773, EBI-11988027; CC Q96IZ5; Q08379: GOLGA2; NbExp=6; IntAct=EBI-740773, EBI-618309; CC Q96IZ5; P07910: HNRNPC; NbExp=5; IntAct=EBI-740773, EBI-357966; CC Q96IZ5; Q96ED9-2: HOOK2; NbExp=3; IntAct=EBI-740773, EBI-10961706; CC Q96IZ5; O75031: HSF2BP; NbExp=3; IntAct=EBI-740773, EBI-7116203; CC Q96IZ5; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-740773, EBI-14069005; CC Q96IZ5; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-740773, EBI-3044087; CC Q96IZ5; Q6A162: KRT40; NbExp=3; IntAct=EBI-740773, EBI-10171697; CC Q96IZ5; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-740773, EBI-741037; CC Q96IZ5; P50221: MEOX1; NbExp=3; IntAct=EBI-740773, EBI-2864512; CC Q96IZ5; Q8TD10: MIPOL1; NbExp=3; IntAct=EBI-740773, EBI-2548751; CC Q96IZ5; Q13064: MKRN3; NbExp=3; IntAct=EBI-740773, EBI-2340269; CC Q96IZ5; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-740773, EBI-11522433; CC Q96IZ5; Q8NI38: NFKBID; NbExp=3; IntAct=EBI-740773, EBI-10271199; CC Q96IZ5; Q9Y2I6: NINL; NbExp=3; IntAct=EBI-740773, EBI-719716; CC Q96IZ5; Q8ND90: PNMA1; NbExp=3; IntAct=EBI-740773, EBI-302345; CC Q96IZ5; Q86SE5: RALYL; NbExp=4; IntAct=EBI-740773, EBI-741520; CC Q96IZ5; Q6ZRY4: RBPMS2; NbExp=3; IntAct=EBI-740773, EBI-11987469; CC Q96IZ5; Q6NUQ1: RINT1; NbExp=6; IntAct=EBI-740773, EBI-726876; CC Q96IZ5; Q96R06: SPAG5; NbExp=3; IntAct=EBI-740773, EBI-413317; CC Q96IZ5; O43548: TGM5; NbExp=3; IntAct=EBI-740773, EBI-12027348; CC Q96IZ5; Q13077: TRAF1; NbExp=3; IntAct=EBI-740773, EBI-359224; CC Q96IZ5; Q12933: TRAF2; NbExp=6; IntAct=EBI-740773, EBI-355744; CC Q96IZ5; P14373: TRIM27; NbExp=3; IntAct=EBI-740773, EBI-719493; CC Q96IZ5; Q9BYV2: TRIM54; NbExp=3; IntAct=EBI-740773, EBI-2130429; CC Q96IZ5; Q96DT7-3: ZBTB10; NbExp=3; IntAct=EBI-740773, EBI-12017160; CC Q96IZ5; PRO_0000449629 [P0DTD1]: rep; Xeno; NbExp=3; IntAct=EBI-740773, EBI-25475885; CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q96IZ5-1; Sequence=Displayed; CC Name=2; CC IsoId=Q96IZ5-2; Sequence=VSP_021349; CC Name=3; CC IsoId=Q96IZ5-3; Sequence=VSP_021346, VSP_021347, VSP_021348; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK001878; BAA91957.1; -; mRNA. DR EMBL; AK023732; BAB14660.1; -; mRNA. DR EMBL; AL390039; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC006986; AAH06986.1; -; mRNA. DR CCDS; CCDS14526.1; -. [Q96IZ5-1] DR CCDS; CCDS55472.1; -. [Q96IZ5-2] DR RefSeq; NP_001164551.1; NM_001171080.1. [Q96IZ5-2] DR RefSeq; NP_060771.3; NM_018301.4. [Q96IZ5-1] DR PDB; 2CPX; NMR; -; A=291-392. DR PDBsum; 2CPX; -. DR AlphaFoldDB; Q96IZ5; -. DR SMR; Q96IZ5; -. DR BioGRID; 120573; 44. DR IntAct; Q96IZ5; 35. DR MINT; Q96IZ5; -. DR STRING; 9606.ENSP00000361557; -. DR GlyGen; Q96IZ5; 2 sites, 1 O-linked glycan (2 sites). DR iPTMnet; Q96IZ5; -. DR PhosphoSitePlus; Q96IZ5; -. DR BioMuta; RBM41; -. DR DMDM; 117949772; -. DR EPD; Q96IZ5; -. DR jPOST; Q96IZ5; -. DR MassIVE; Q96IZ5; -. DR MaxQB; Q96IZ5; -. DR PaxDb; 9606-ENSP00000361557; -. DR PeptideAtlas; Q96IZ5; -. DR ProteomicsDB; 76874; -. [Q96IZ5-1] DR ProteomicsDB; 76875; -. [Q96IZ5-2] DR ProteomicsDB; 76876; -. [Q96IZ5-3] DR Pumba; Q96IZ5; -. DR Antibodypedia; 29287; 144 antibodies from 19 providers. DR DNASU; 55285; -. DR Ensembl; ENST00000372479.7; ENSP00000361557.3; ENSG00000089682.17. [Q96IZ5-1] DR Ensembl; ENST00000372487.5; ENSP00000361565.1; ENSG00000089682.17. [Q96IZ5-2] DR Ensembl; ENST00000495517.5; ENSP00000433251.1; ENSG00000089682.17. [Q96IZ5-3] DR GeneID; 55285; -. DR KEGG; hsa:55285; -. DR UCSC; uc004emy.3; human. [Q96IZ5-1] DR AGR; HGNC:25617; -. DR CTD; 55285; -. DR GeneCards; RBM41; -. DR HGNC; HGNC:25617; RBM41. DR HPA; ENSG00000089682; Low tissue specificity. DR neXtProt; NX_Q96IZ5; -. DR OpenTargets; ENSG00000089682; -. DR PharmGKB; PA145148155; -. DR VEuPathDB; HostDB:ENSG00000089682; -. DR eggNOG; ENOG502RIV3; Eukaryota. DR GeneTree; ENSGT00530000063786; -. DR HOGENOM; CLU_054957_0_0_1; -. DR InParanoid; Q96IZ5; -. DR OMA; QCFAPAS; -. DR OrthoDB; 3029360at2759; -. DR PhylomeDB; Q96IZ5; -. DR TreeFam; TF324298; -. DR PathwayCommons; Q96IZ5; -. DR SignaLink; Q96IZ5; -. DR BioGRID-ORCS; 55285; 11 hits in 783 CRISPR screens. DR ChiTaRS; RBM41; human. DR EvolutionaryTrace; Q96IZ5; -. DR GenomeRNAi; 55285; -. DR Pharos; Q96IZ5; Tdark. DR PRO; PR:Q96IZ5; -. DR Proteomes; UP000005640; Chromosome X. DR RNAct; Q96IZ5; Protein. DR Bgee; ENSG00000089682; Expressed in calcaneal tendon and 194 other cell types or tissues. DR ExpressionAtlas; Q96IZ5; baseline and differential. DR GO; GO:0005689; C:U12-type spliceosomal complex; IBA:GO_Central. DR GO; GO:0097157; F:pre-mRNA intronic binding; IBA:GO_Central. DR GO; GO:0030626; F:U12 snRNA binding; IBA:GO_Central. DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central. DR CDD; cd12239; RRM2_RBM40_like; 1. DR Gene3D; 3.30.70.330; -; 1. DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf. DR InterPro; IPR035979; RBD_domain_sf. DR InterPro; IPR045164; RBM41/RNPC3. DR InterPro; IPR000504; RRM_dom. DR PANTHER; PTHR16105:SF2; RNA-BINDING PROTEIN 41; 1. DR PANTHER; PTHR16105; UNCHARACTERIZED; 1. DR Pfam; PF00076; RRM_1; 1. DR SMART; SM00360; RRM; 1. DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1. DR PROSITE; PS50102; RRM; 1. DR Genevisible; Q96IZ5; HS. PE 1: Evidence at protein level; KW 3D-structure; Alternative splicing; Phosphoprotein; Reference proteome; KW RNA-binding. FT CHAIN 1..413 FT /note="RNA-binding protein 41" FT /id="PRO_0000256267" FT DOMAIN 309..387 FT /note="RRM" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176" FT REGION 223..247 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 223..239 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 232 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:18669648" FT VAR_SEQ 174 FT /note="Q -> QAYHKKTSADKYMTSMKRKIKLGTK (in isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_021346" FT VAR_SEQ 211..287 FT /note="EPFASHSLVSATSVGDSGTAESPSLLQDKGKQAAQGKGPSLHVANVIDFSPE FT QCWTGPKKLTQPIEFVPEDEIQRNR -> LTSFPREDFQNLSYEGTTSVLGAKWQKRTG FT RTSTFSILLVSLLSETVFTSSAMYGIPHLLTMSLKFSTRIGKLSFTP (in isoform FT 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_021347" FT VAR_SEQ 288..413 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_021348" FT VAR_SEQ 406..413 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_021349" FT VARIANT 376 FT /note="H -> Y (in dbSNP:rs17850127)" FT /evidence="ECO:0000269|PubMed:15489334" FT /id="VAR_028897" FT CONFLICT 61 FT /note="K -> E (in Ref. 1; BAB14660)" FT /evidence="ECO:0000305" FT STRAND 291..293 FT /evidence="ECO:0007829|PDB:2CPX" FT STRAND 309..314 FT /evidence="ECO:0007829|PDB:2CPX" FT HELIX 322..328 FT /evidence="ECO:0007829|PDB:2CPX" FT HELIX 330..334 FT /evidence="ECO:0007829|PDB:2CPX" FT STRAND 335..338 FT /evidence="ECO:0007829|PDB:2CPX" FT STRAND 341..345 FT /evidence="ECO:0007829|PDB:2CPX" FT STRAND 347..349 FT /evidence="ECO:0007829|PDB:2CPX" FT STRAND 351..356 FT /evidence="ECO:0007829|PDB:2CPX" FT HELIX 360..369 FT /evidence="ECO:0007829|PDB:2CPX" FT STRAND 381..384 FT /evidence="ECO:0007829|PDB:2CPX" SQ SEQUENCE 413 AA; 47100 MW; 759B1BFF358943A8 CRC64; MKRVNSCVKS DEHVLEELET EGERQLKSLL QHQLDTSVSI EECMSKKESF APGTMYKPFG KEAAGTMTLS QFQTLHEKDQ ETASLRELGL NETEILIWKS HVSGEKKTKL RATPEAIQNR LQDIEERISE RQRILCLPQR FAKSKQLTRR EMEIEKSLFQ GADRHSFLKA LYYQDEPQKK NKGDPMNNLE SFYQEMIMKK RLEEFQLMRG EPFASHSLVS ATSVGDSGTA ESPSLLQDKG KQAAQGKGPS LHVANVIDFS PEQCWTGPKK LTQPIEFVPE DEIQRNRLSE EEIRKIPMFS SYNPGEPNKV LYLKNLSPRV TERDLVSLFA RFQEKKGPPI QFRMMTGRMR GQAFITFPNK EIAWQALHLV NGYKLHGKIL VIEFGKNKKQ RSNLQATSLI SCATGSTTEI SGS //