Q96IZ5 (RBM41_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RNA-binding protein 41

Alternative name(s):
RNA-binding motif protein 41

Gene names

Name:

RBM41

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	413 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May bind RNA Potential.
Sequence similarities	Contains 1 RRM (RNA recognition motif) domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	RNA-binding
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96IZ5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96IZ5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     406-413: Missing.

Isoform 3 (identifier: Q96IZ5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     174-174: Q → QAYHKKTSADKYMTSMKRKIKLGTK
     211-287: EPFASHSLVS...VPEDEIQRNR → LTSFPREDFQ...TRIGKLSFTP
     288-413: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 413

413

RNA-binding protein 41

PRO_0000256267

Regions

Domain

309 – 387

79

RRM

Amino acid modifications

Modified residue

232

1

Phosphoserine Ref.4

Natural variations

Alternative sequence

174

1

Q → QAYHKKTSADKYMTSMKRKI KLGTK in isoform 3.

VSP_021346

Alternative sequence

211 – 287

77

EPFAS…IQRNR → LTSFPREDFQNLSYEGTTSV LGAKWQKRTGRTSTFSILLV SLLSETVFTSSAMYGIPHLL TMSLKFSTRIGKLSFTP in isoform 3.

VSP_021347

Alternative sequence

288 – 413

126

Missing in isoform 3.

VSP_021348

Alternative sequence

406 – 413

8

Missing in isoform 2.

VSP_021349

Natural variant

376

1

H → Y. Ref.3
Corresponds to variant rs17850127 [ dbSNP | Ensembl ].

VAR_028897

Experimental info

Sequence conflict

61

1

K → E in BAB14660. Ref.1

Secondary structure

1

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413

Helix Strand Turn

Details...

Beta strand

291 – 293

3

Beta strand

309 – 314

6

Helix

322 – 328

7

Helix

330 – 334

5

Beta strand

335 – 338

4

Beta strand

341 – 345

5

Beta strand

347 – 349

3

Beta strand

351 – 356

6

Helix

360 – 369

10

Beta strand

381 – 384

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 31, 2006. Version 2. Checksum: 759B1BFF358943A8	FASTA	413	47,100
	10 20 30 40 50 60 MKRVNSCVKS DEHVLEELET EGERQLKSLL QHQLDTSVSI EECMSKKESF APGTMYKPFG 70 80 90 100 110 120 KEAAGTMTLS QFQTLHEKDQ ETASLRELGL NETEILIWKS HVSGEKKTKL RATPEAIQNR 130 140 150 160 170 180 LQDIEERISE RQRILCLPQR FAKSKQLTRR EMEIEKSLFQ GADRHSFLKA LYYQDEPQKK 190 200 210 220 230 240 NKGDPMNNLE SFYQEMIMKK RLEEFQLMRG EPFASHSLVS ATSVGDSGTA ESPSLLQDKG 250 260 270 280 290 300 KQAAQGKGPS LHVANVIDFS PEQCWTGPKK LTQPIEFVPE DEIQRNRLSE EEIRKIPMFS 310 320 330 340 350 360 SYNPGEPNKV LYLKNLSPRV TERDLVSLFA RFQEKKGPPI QFRMMTGRMR GQAFITFPNK 370 380 390 400 410 EIAWQALHLV NGYKLHGKIL VIEFGKNKKQ RSNLQATSLI SCATGSTTEI SGS
	Isoform 2 [UniParc]. Checksum: 703AF52FBC9CC486	FASTA	405	46,337
	10 20 30 40 50 60 MKRVNSCVKS DEHVLEELET EGERQLKSLL QHQLDTSVSI EECMSKKESF APGTMYKPFG 70 80 90 100 110 120 KEAAGTMTLS QFQTLHEKDQ ETASLRELGL NETEILIWKS HVSGEKKTKL RATPEAIQNR 130 140 150 160 170 180 LQDIEERISE RQRILCLPQR FAKSKQLTRR EMEIEKSLFQ GADRHSFLKA LYYQDEPQKK 190 200 210 220 230 240 NKGDPMNNLE SFYQEMIMKK RLEEFQLMRG EPFASHSLVS ATSVGDSGTA ESPSLLQDKG 250 260 270 280 290 300 KQAAQGKGPS LHVANVIDFS PEQCWTGPKK LTQPIEFVPE DEIQRNRLSE EEIRKIPMFS 310 320 330 340 350 360 SYNPGEPNKV LYLKNLSPRV TERDLVSLFA RFQEKKGPPI QFRMMTGRMR GQAFITFPNK 370 380 390 400 EIAWQALHLV NGYKLHGKIL VIEFGKNKKQ RSNLQATSLI SCATG
	Isoform 3 [UniParc]. Checksum: 5E5699E9D3352E2D	FASTA	311	35,962
	10 20 30 40 50 60 MKRVNSCVKS DEHVLEELET EGERQLKSLL QHQLDTSVSI EECMSKKESF APGTMYKPFG 70 80 90 100 110 120 KEAAGTMTLS QFQTLHEKDQ ETASLRELGL NETEILIWKS HVSGEKKTKL RATPEAIQNR 130 140 150 160 170 180 LQDIEERISE RQRILCLPQR FAKSKQLTRR EMEIEKSLFQ GADRHSFLKA LYYQAYHKKT 190 200 210 220 230 240 SADKYMTSMK RKIKLGTKDE PQKKNKGDPM NNLESFYQEM IMKKRLEEFQ LMRGLTSFPR 250 260 270 280 290 300 EDFQNLSYEG TTSVLGAKWQ KRTGRTSTFS ILLVSLLSET VFTSSAMYGI PHLLTMSLKF 310 STRIGKLSFT P

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Placenta.
[2]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT TYR-376. Tissue: Urinary bladder.
[4]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-232, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[5]	"Solution structure of RNA binding domain in hypothetical protein FLJ11016." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2005) to the PDB data bank Cited for: STRUCTURE BY NMR OF 291-392.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AK001878 mRNA. Translation: BAA91957.1.
AK023732 mRNA. Translation: BAB14660.1.
AL390039 Genomic DNA. Translation: CAC19636.1.
AL390039 Genomic DNA. Translation: CAI41564.1.
BC006986 mRNA. Translation: AAH06986.1.

IPI

IPI00306343.
IPI00643333.
IPI00844169.

RefSeq

NP_001164551.1. NM_001171080.1.
NP_060771.3. NM_018301.3.

UniGene

Hs.139053.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2CPX	NMR	-	A	291-392	[»]

ProteinModelPortal

Q96IZ5.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q96IZ5. 5 interactions.

MINT

MINT-1449430.

STRING

9606.ENSP00000361557.

PTM databases

PhosphoSite

Q96IZ5.

Polymorphism databases

DMDM

117949772.

Proteomic databases

PaxDb

Q96IZ5.

PRIDE

Q96IZ5.

Protocols and materials databases

DNASU

55285.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000203616; ENSP00000203616; ENSG00000089682.
ENST00000372479; ENSP00000361557; ENSG00000089682.
ENST00000372487; ENSP00000361565; ENSG00000089682.
ENST00000495517; ENSP00000433251; ENSG00000089682.

GeneID

55285.

KEGG

hsa:55285.

UCSC

uc004emy.2. human.

Organism-specific databases

CTD

55285.

GeneCards

GC0XM106307.

H-InvDB

HIX0020243.

HGNC

HGNC:25617. RBM41.

HPA

HPA042881.

neXtProt

NX_Q96IZ5.

PharmGKB

PA145148155.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG147711.

HOGENOM

HOG000231401.

HOVERGEN

HBG057264.

InParanoid

Q96IZ5.

OMA

REMEIEN.

OrthoDB

EOG4JT05J.

PhylomeDB

Q96IZ5.

Gene expression databases

ArrayExpress

Q96IZ5.

Bgee

Q96IZ5.

CleanEx

HS_RBM41.

Genevestigator

Q96IZ5.

GermOnline

ENSG00000089682. Homo sapiens.

Family and domain databases

Gene3D

3.30.70.330. 1 hit.

InterPro

IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]

Pfam

PF00076. RRM_1. 1 hit.
[Graphical view]

SMART

SM00360. RRM. 1 hit.
[Graphical view]

PROSITE

PS50102. RRM. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q96IZ5.

GenomeRNAi

55285.

NextBio

59448.

Entry information

Entry name

RBM41_HUMAN

Accession

Primary (citable) accession number: Q96IZ5
Secondary accession number(s): Q5JSN7 , Q5JSN8, Q9H8F7, Q9NV04

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	October 31, 2006
Last modified:	May 1, 2013
This is version 95 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.