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Protein

RNA-binding protein 41

Gene

RBM41

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May bind RNA.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 41
Alternative name(s):
RNA-binding motif protein 41
Gene namesi
Name:RBM41
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:25617. RBM41.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000089682.
PharmGKBiPA145148155.

Polymorphism and mutation databases

BioMutaiRBM41.
DMDMi117949772.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002562671 – 413RNA-binding protein 41Add BLAST413

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei232PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96IZ5.
MaxQBiQ96IZ5.
PaxDbiQ96IZ5.
PeptideAtlasiQ96IZ5.
PRIDEiQ96IZ5.

PTM databases

iPTMnetiQ96IZ5.
PhosphoSitePlusiQ96IZ5.

Expressioni

Gene expression databases

BgeeiENSG00000089682.
CleanExiHS_RBM41.
ExpressionAtlasiQ96IZ5. baseline and differential.
GenevisibleiQ96IZ5. HS.

Organism-specific databases

HPAiHPA042881.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GOLGA2Q083793EBI-740773,EBI-618309
HNRNPCP079105EBI-740773,EBI-357966
KRT40Q6A1623EBI-740773,EBI-10171697
LZTS2Q9BRK43EBI-740773,EBI-741037
MIPOL1Q8TD103EBI-740773,EBI-2548751
MKRN3Q130643EBI-740773,EBI-2340269
NINLQ9Y2I63EBI-740773,EBI-719716
PNMA1Q8ND903EBI-740773,EBI-302345
RALYLQ86SE54EBI-740773,EBI-741520
RINT1Q6NUQ15EBI-740773,EBI-726876
SPAG5Q96R063EBI-740773,EBI-413317
TRAF1Q130773EBI-740773,EBI-359224
TRAF2Q129335EBI-740773,EBI-355744
TRIM27P143733EBI-740773,EBI-719493
TRIM54Q9BYV23EBI-740773,EBI-2130429

Protein-protein interaction databases

BioGridi120573. 18 interactors.
IntActiQ96IZ5. 25 interactors.
MINTiMINT-1449430.
STRINGi9606.ENSP00000361557.

Structurei

Secondary structure

1413
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi291 – 293Combined sources3
Beta strandi309 – 314Combined sources6
Helixi322 – 328Combined sources7
Helixi330 – 334Combined sources5
Beta strandi335 – 338Combined sources4
Beta strandi341 – 345Combined sources5
Beta strandi347 – 349Combined sources3
Beta strandi351 – 356Combined sources6
Helixi360 – 369Combined sources10
Beta strandi381 – 384Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CPXNMR-A291-392[»]
ProteinModelPortaliQ96IZ5.
SMRiQ96IZ5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96IZ5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini309 – 387RRMPROSITE-ProRule annotationAdd BLAST79

Sequence similaritiesi

Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IH35. Eukaryota.
ENOG4111F4W. LUCA.
GeneTreeiENSGT00530000063786.
HOGENOMiHOG000231401.
HOVERGENiHBG057264.
InParanoidiQ96IZ5.
OMAiEGQRQLH.
OrthoDBiEOG091G0OCH.
PhylomeDBiQ96IZ5.
TreeFamiTF324298.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96IZ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRVNSCVKS DEHVLEELET EGERQLKSLL QHQLDTSVSI EECMSKKESF
60 70 80 90 100
APGTMYKPFG KEAAGTMTLS QFQTLHEKDQ ETASLRELGL NETEILIWKS
110 120 130 140 150
HVSGEKKTKL RATPEAIQNR LQDIEERISE RQRILCLPQR FAKSKQLTRR
160 170 180 190 200
EMEIEKSLFQ GADRHSFLKA LYYQDEPQKK NKGDPMNNLE SFYQEMIMKK
210 220 230 240 250
RLEEFQLMRG EPFASHSLVS ATSVGDSGTA ESPSLLQDKG KQAAQGKGPS
260 270 280 290 300
LHVANVIDFS PEQCWTGPKK LTQPIEFVPE DEIQRNRLSE EEIRKIPMFS
310 320 330 340 350
SYNPGEPNKV LYLKNLSPRV TERDLVSLFA RFQEKKGPPI QFRMMTGRMR
360 370 380 390 400
GQAFITFPNK EIAWQALHLV NGYKLHGKIL VIEFGKNKKQ RSNLQATSLI
410
SCATGSTTEI SGS
Length:413
Mass (Da):47,100
Last modified:October 31, 2006 - v2
Checksum:i759B1BFF358943A8
GO
Isoform 2 (identifier: Q96IZ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     406-413: Missing.

Show »
Length:405
Mass (Da):46,337
Checksum:i703AF52FBC9CC486
GO
Isoform 3 (identifier: Q96IZ5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     174-174: Q → QAYHKKTSADKYMTSMKRKIKLGTK
     211-287: EPFASHSLVS...VPEDEIQRNR → LTSFPREDFQ...TRIGKLSFTP
     288-413: Missing.

Show »
Length:311
Mass (Da):35,962
Checksum:i5E5699E9D3352E2D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61K → E in BAB14660 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028897376H → Y.1 PublicationCorresponds to variant rs17850127dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021346174Q → QAYHKKTSADKYMTSMKRKI KLGTK in isoform 3. 1 Publication1
Alternative sequenceiVSP_021347211 – 287EPFAS…IQRNR → LTSFPREDFQNLSYEGTTSV LGAKWQKRTGRTSTFSILLV SLLSETVFTSSAMYGIPHLL TMSLKFSTRIGKLSFTP in isoform 3. 1 PublicationAdd BLAST77
Alternative sequenceiVSP_021348288 – 413Missing in isoform 3. 1 PublicationAdd BLAST126
Alternative sequenceiVSP_021349406 – 413Missing in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001878 mRNA. Translation: BAA91957.1.
AK023732 mRNA. Translation: BAB14660.1.
AL390039 Genomic DNA. Translation: CAC19636.1.
AL390039 Genomic DNA. Translation: CAI41564.1.
BC006986 mRNA. Translation: AAH06986.1.
CCDSiCCDS14526.1. [Q96IZ5-1]
CCDS55472.1. [Q96IZ5-2]
RefSeqiNP_001164551.1. NM_001171080.1. [Q96IZ5-2]
NP_060771.3. NM_018301.4. [Q96IZ5-1]
UniGeneiHs.139053.

Genome annotation databases

EnsembliENST00000372479; ENSP00000361557; ENSG00000089682. [Q96IZ5-1]
ENST00000372487; ENSP00000361565; ENSG00000089682. [Q96IZ5-2]
ENST00000495517; ENSP00000433251; ENSG00000089682. [Q96IZ5-3]
GeneIDi55285.
KEGGihsa:55285.
UCSCiuc004emy.3. human. [Q96IZ5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001878 mRNA. Translation: BAA91957.1.
AK023732 mRNA. Translation: BAB14660.1.
AL390039 Genomic DNA. Translation: CAC19636.1.
AL390039 Genomic DNA. Translation: CAI41564.1.
BC006986 mRNA. Translation: AAH06986.1.
CCDSiCCDS14526.1. [Q96IZ5-1]
CCDS55472.1. [Q96IZ5-2]
RefSeqiNP_001164551.1. NM_001171080.1. [Q96IZ5-2]
NP_060771.3. NM_018301.4. [Q96IZ5-1]
UniGeneiHs.139053.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CPXNMR-A291-392[»]
ProteinModelPortaliQ96IZ5.
SMRiQ96IZ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120573. 18 interactors.
IntActiQ96IZ5. 25 interactors.
MINTiMINT-1449430.
STRINGi9606.ENSP00000361557.

PTM databases

iPTMnetiQ96IZ5.
PhosphoSitePlusiQ96IZ5.

Polymorphism and mutation databases

BioMutaiRBM41.
DMDMi117949772.

Proteomic databases

EPDiQ96IZ5.
MaxQBiQ96IZ5.
PaxDbiQ96IZ5.
PeptideAtlasiQ96IZ5.
PRIDEiQ96IZ5.

Protocols and materials databases

DNASUi55285.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372479; ENSP00000361557; ENSG00000089682. [Q96IZ5-1]
ENST00000372487; ENSP00000361565; ENSG00000089682. [Q96IZ5-2]
ENST00000495517; ENSP00000433251; ENSG00000089682. [Q96IZ5-3]
GeneIDi55285.
KEGGihsa:55285.
UCSCiuc004emy.3. human. [Q96IZ5-1]

Organism-specific databases

CTDi55285.
GeneCardsiRBM41.
H-InvDBHIX0020243.
HGNCiHGNC:25617. RBM41.
HPAiHPA042881.
neXtProtiNX_Q96IZ5.
OpenTargetsiENSG00000089682.
PharmGKBiPA145148155.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH35. Eukaryota.
ENOG4111F4W. LUCA.
GeneTreeiENSGT00530000063786.
HOGENOMiHOG000231401.
HOVERGENiHBG057264.
InParanoidiQ96IZ5.
OMAiEGQRQLH.
OrthoDBiEOG091G0OCH.
PhylomeDBiQ96IZ5.
TreeFamiTF324298.

Miscellaneous databases

EvolutionaryTraceiQ96IZ5.
GenomeRNAii55285.
PROiQ96IZ5.

Gene expression databases

BgeeiENSG00000089682.
CleanExiHS_RBM41.
ExpressionAtlasiQ96IZ5. baseline and differential.
GenevisibleiQ96IZ5. HS.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRBM41_HUMAN
AccessioniPrimary (citable) accession number: Q96IZ5
Secondary accession number(s): Q5JSN7
, Q5JSN8, Q9H8F7, Q9NV04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: November 30, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.