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Protein

RNA-binding protein 41

Gene

RBM41

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May bind RNA.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 41
Alternative name(s):
RNA-binding motif protein 41
Gene namesi
Name:RBM41
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000089682.16
HGNCiHGNC:25617 RBM41
neXtProtiNX_Q96IZ5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000089682
PharmGKBiPA145148155

Polymorphism and mutation databases

BioMutaiRBM41
DMDMi117949772

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002562671 – 413RNA-binding protein 41Add BLAST413

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei232PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96IZ5
MaxQBiQ96IZ5
PaxDbiQ96IZ5
PeptideAtlasiQ96IZ5
PRIDEiQ96IZ5
ProteomicsDBi76874
76875 [Q96IZ5-2]
76876 [Q96IZ5-3]

PTM databases

iPTMnetiQ96IZ5
PhosphoSitePlusiQ96IZ5

Expressioni

Gene expression databases

BgeeiENSG00000089682
CleanExiHS_RBM41
ExpressionAtlasiQ96IZ5 baseline and differential
GenevisibleiQ96IZ5 HS

Organism-specific databases

HPAiHPA042881

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120573, 18 interactors
IntActiQ96IZ5, 30 interactors
MINTiQ96IZ5
STRINGi9606.ENSP00000361557

Structurei

Secondary structure

1413
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi291 – 293Combined sources3
Beta strandi309 – 314Combined sources6
Helixi322 – 328Combined sources7
Helixi330 – 334Combined sources5
Beta strandi335 – 338Combined sources4
Beta strandi341 – 345Combined sources5
Beta strandi347 – 349Combined sources3
Beta strandi351 – 356Combined sources6
Helixi360 – 369Combined sources10
Beta strandi381 – 384Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CPXNMR-A291-392[»]
ProteinModelPortaliQ96IZ5
SMRiQ96IZ5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96IZ5

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini309 – 387RRMPROSITE-ProRule annotationAdd BLAST79

Phylogenomic databases

eggNOGiENOG410IH35 Eukaryota
ENOG4111F4W LUCA
GeneTreeiENSGT00530000063786
HOGENOMiHOG000231401
HOVERGENiHBG057264
InParanoidiQ96IZ5
OMAiDNSPEQC
OrthoDBiEOG091G0OCH
PhylomeDBiQ96IZ5
TreeFamiTF324298

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96IZ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRVNSCVKS DEHVLEELET EGERQLKSLL QHQLDTSVSI EECMSKKESF
60 70 80 90 100
APGTMYKPFG KEAAGTMTLS QFQTLHEKDQ ETASLRELGL NETEILIWKS
110 120 130 140 150
HVSGEKKTKL RATPEAIQNR LQDIEERISE RQRILCLPQR FAKSKQLTRR
160 170 180 190 200
EMEIEKSLFQ GADRHSFLKA LYYQDEPQKK NKGDPMNNLE SFYQEMIMKK
210 220 230 240 250
RLEEFQLMRG EPFASHSLVS ATSVGDSGTA ESPSLLQDKG KQAAQGKGPS
260 270 280 290 300
LHVANVIDFS PEQCWTGPKK LTQPIEFVPE DEIQRNRLSE EEIRKIPMFS
310 320 330 340 350
SYNPGEPNKV LYLKNLSPRV TERDLVSLFA RFQEKKGPPI QFRMMTGRMR
360 370 380 390 400
GQAFITFPNK EIAWQALHLV NGYKLHGKIL VIEFGKNKKQ RSNLQATSLI
410
SCATGSTTEI SGS
Length:413
Mass (Da):47,100
Last modified:October 31, 2006 - v2
Checksum:i759B1BFF358943A8
GO
Isoform 2 (identifier: Q96IZ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     406-413: Missing.

Show »
Length:405
Mass (Da):46,337
Checksum:i703AF52FBC9CC486
GO
Isoform 3 (identifier: Q96IZ5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     174-174: Q → QAYHKKTSADKYMTSMKRKIKLGTK
     211-287: EPFASHSLVS...VPEDEIQRNR → LTSFPREDFQ...TRIGKLSFTP
     288-413: Missing.

Show »
Length:311
Mass (Da):35,962
Checksum:i5E5699E9D3352E2D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61K → E in BAB14660 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028897376H → Y1 PublicationCorresponds to variant dbSNP:rs17850127Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021346174Q → QAYHKKTSADKYMTSMKRKI KLGTK in isoform 3. 1 Publication1
Alternative sequenceiVSP_021347211 – 287EPFAS…IQRNR → LTSFPREDFQNLSYEGTTSV LGAKWQKRTGRTSTFSILLV SLLSETVFTSSAMYGIPHLL TMSLKFSTRIGKLSFTP in isoform 3. 1 PublicationAdd BLAST77
Alternative sequenceiVSP_021348288 – 413Missing in isoform 3. 1 PublicationAdd BLAST126
Alternative sequenceiVSP_021349406 – 413Missing in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001878 mRNA Translation: BAA91957.1
AK023732 mRNA Translation: BAB14660.1
AL390039 Genomic DNA No translation available.
BC006986 mRNA Translation: AAH06986.1
CCDSiCCDS14526.1 [Q96IZ5-1]
CCDS55472.1 [Q96IZ5-2]
RefSeqiNP_001164551.1, NM_001171080.1 [Q96IZ5-2]
NP_060771.3, NM_018301.4 [Q96IZ5-1]
UniGeneiHs.139053

Genome annotation databases

EnsembliENST00000372479; ENSP00000361557; ENSG00000089682 [Q96IZ5-1]
ENST00000372487; ENSP00000361565; ENSG00000089682 [Q96IZ5-2]
ENST00000495517; ENSP00000433251; ENSG00000089682 [Q96IZ5-3]
GeneIDi55285
KEGGihsa:55285
UCSCiuc004emy.3 human [Q96IZ5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRBM41_HUMAN
AccessioniPrimary (citable) accession number: Q96IZ5
Secondary accession number(s): Q5JSN7
, Q5JSN8, Q9H8F7, Q9NV04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: June 20, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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