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Q96IZ5

- RBM41_HUMAN

UniProt

Q96IZ5 - RBM41_HUMAN

Protein

RNA-binding protein 41

Gene

RBM41

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (31 Oct 2006)
      Previous versions | rss
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    Functioni

    May bind RNA.Curated

    GO - Molecular functioni

    1. nucleotide binding Source: InterPro
    2. RNA binding Source: UniProtKB-KW

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-binding protein 41
    Alternative name(s):
    RNA-binding motif protein 41
    Gene namesi
    Name:RBM41
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:25617. RBM41.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA145148155.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 413413RNA-binding protein 41PRO_0000256267Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei232 – 2321Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ96IZ5.
    PaxDbiQ96IZ5.
    PRIDEiQ96IZ5.

    PTM databases

    PhosphoSiteiQ96IZ5.

    Expressioni

    Gene expression databases

    BgeeiQ96IZ5.
    CleanExiHS_RBM41.
    GenevestigatoriQ96IZ5.

    Organism-specific databases

    HPAiHPA042881.

    Interactioni

    Protein-protein interaction databases

    BioGridi120573. 5 interactions.
    IntActiQ96IZ5. 5 interactions.
    MINTiMINT-1449430.
    STRINGi9606.ENSP00000361557.

    Structurei

    Secondary structure

    1
    413
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi291 – 2933
    Beta strandi309 – 3146
    Helixi322 – 3287
    Helixi330 – 3345
    Beta strandi335 – 3384
    Beta strandi341 – 3455
    Beta strandi347 – 3493
    Beta strandi351 – 3566
    Helixi360 – 36910
    Beta strandi381 – 3844

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2CPXNMR-A291-392[»]
    ProteinModelPortaliQ96IZ5.
    SMRiQ96IZ5. Positions 289-393.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ96IZ5.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini309 – 38779RRMPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG147711.
    HOGENOMiHOG000231401.
    HOVERGENiHBG057264.
    InParanoidiQ96IZ5.
    OMAiNENSLTH.
    OrthoDBiEOG7JDQXS.
    PhylomeDBiQ96IZ5.
    TreeFamiTF324298.

    Family and domain databases

    Gene3Di3.30.70.330. 1 hit.
    InterProiIPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view]
    PfamiPF00076. RRM_1. 1 hit.
    [Graphical view]
    SMARTiSM00360. RRM. 1 hit.
    [Graphical view]
    PROSITEiPS50102. RRM. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96IZ5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKRVNSCVKS DEHVLEELET EGERQLKSLL QHQLDTSVSI EECMSKKESF    50
    APGTMYKPFG KEAAGTMTLS QFQTLHEKDQ ETASLRELGL NETEILIWKS 100
    HVSGEKKTKL RATPEAIQNR LQDIEERISE RQRILCLPQR FAKSKQLTRR 150
    EMEIEKSLFQ GADRHSFLKA LYYQDEPQKK NKGDPMNNLE SFYQEMIMKK 200
    RLEEFQLMRG EPFASHSLVS ATSVGDSGTA ESPSLLQDKG KQAAQGKGPS 250
    LHVANVIDFS PEQCWTGPKK LTQPIEFVPE DEIQRNRLSE EEIRKIPMFS 300
    SYNPGEPNKV LYLKNLSPRV TERDLVSLFA RFQEKKGPPI QFRMMTGRMR 350
    GQAFITFPNK EIAWQALHLV NGYKLHGKIL VIEFGKNKKQ RSNLQATSLI 400
    SCATGSTTEI SGS 413
    Length:413
    Mass (Da):47,100
    Last modified:October 31, 2006 - v2
    Checksum:i759B1BFF358943A8
    GO
    Isoform 2 (identifier: Q96IZ5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         406-413: Missing.

    Show »
    Length:405
    Mass (Da):46,337
    Checksum:i703AF52FBC9CC486
    GO
    Isoform 3 (identifier: Q96IZ5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         174-174: Q → QAYHKKTSADKYMTSMKRKIKLGTK
         211-287: EPFASHSLVS...VPEDEIQRNR → LTSFPREDFQ...TRIGKLSFTP
         288-413: Missing.

    Show »
    Length:311
    Mass (Da):35,962
    Checksum:i5E5699E9D3352E2D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti61 – 611K → E in BAB14660. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti376 – 3761H → Y.1 Publication
    Corresponds to variant rs17850127 [ dbSNP | Ensembl ].
    VAR_028897

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei174 – 1741Q → QAYHKKTSADKYMTSMKRKI KLGTK in isoform 3. 1 PublicationVSP_021346
    Alternative sequencei211 – 28777EPFAS…IQRNR → LTSFPREDFQNLSYEGTTSV LGAKWQKRTGRTSTFSILLV SLLSETVFTSSAMYGIPHLL TMSLKFSTRIGKLSFTP in isoform 3. 1 PublicationVSP_021347Add
    BLAST
    Alternative sequencei288 – 413126Missing in isoform 3. 1 PublicationVSP_021348Add
    BLAST
    Alternative sequencei406 – 4138Missing in isoform 2. 1 PublicationVSP_021349

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001878 mRNA. Translation: BAA91957.1.
    AK023732 mRNA. Translation: BAB14660.1.
    AL390039 Genomic DNA. Translation: CAC19636.1.
    AL390039 Genomic DNA. Translation: CAI41564.1.
    BC006986 mRNA. Translation: AAH06986.1.
    CCDSiCCDS14526.1. [Q96IZ5-1]
    CCDS55472.1. [Q96IZ5-2]
    RefSeqiNP_001164551.1. NM_001171080.1. [Q96IZ5-2]
    NP_060771.3. NM_018301.3. [Q96IZ5-1]
    UniGeneiHs.139053.

    Genome annotation databases

    EnsembliENST00000372479; ENSP00000361557; ENSG00000089682. [Q96IZ5-1]
    ENST00000372487; ENSP00000361565; ENSG00000089682. [Q96IZ5-2]
    ENST00000495517; ENSP00000433251; ENSG00000089682. [Q96IZ5-3]
    GeneIDi55285.
    KEGGihsa:55285.
    UCSCiuc004emy.2. human. [Q96IZ5-1]

    Polymorphism databases

    DMDMi117949772.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001878 mRNA. Translation: BAA91957.1 .
    AK023732 mRNA. Translation: BAB14660.1 .
    AL390039 Genomic DNA. Translation: CAC19636.1 .
    AL390039 Genomic DNA. Translation: CAI41564.1 .
    BC006986 mRNA. Translation: AAH06986.1 .
    CCDSi CCDS14526.1. [Q96IZ5-1 ]
    CCDS55472.1. [Q96IZ5-2 ]
    RefSeqi NP_001164551.1. NM_001171080.1. [Q96IZ5-2 ]
    NP_060771.3. NM_018301.3. [Q96IZ5-1 ]
    UniGenei Hs.139053.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2CPX NMR - A 291-392 [» ]
    ProteinModelPortali Q96IZ5.
    SMRi Q96IZ5. Positions 289-393.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120573. 5 interactions.
    IntActi Q96IZ5. 5 interactions.
    MINTi MINT-1449430.
    STRINGi 9606.ENSP00000361557.

    PTM databases

    PhosphoSitei Q96IZ5.

    Polymorphism databases

    DMDMi 117949772.

    Proteomic databases

    MaxQBi Q96IZ5.
    PaxDbi Q96IZ5.
    PRIDEi Q96IZ5.

    Protocols and materials databases

    DNASUi 55285.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372479 ; ENSP00000361557 ; ENSG00000089682 . [Q96IZ5-1 ]
    ENST00000372487 ; ENSP00000361565 ; ENSG00000089682 . [Q96IZ5-2 ]
    ENST00000495517 ; ENSP00000433251 ; ENSG00000089682 . [Q96IZ5-3 ]
    GeneIDi 55285.
    KEGGi hsa:55285.
    UCSCi uc004emy.2. human. [Q96IZ5-1 ]

    Organism-specific databases

    CTDi 55285.
    GeneCardsi GC0XM106307.
    H-InvDB HIX0020243.
    HGNCi HGNC:25617. RBM41.
    HPAi HPA042881.
    neXtProti NX_Q96IZ5.
    PharmGKBi PA145148155.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG147711.
    HOGENOMi HOG000231401.
    HOVERGENi HBG057264.
    InParanoidi Q96IZ5.
    OMAi NENSLTH.
    OrthoDBi EOG7JDQXS.
    PhylomeDBi Q96IZ5.
    TreeFami TF324298.

    Miscellaneous databases

    EvolutionaryTracei Q96IZ5.
    GenomeRNAii 55285.
    NextBioi 59448.
    PROi Q96IZ5.

    Gene expression databases

    Bgeei Q96IZ5.
    CleanExi HS_RBM41.
    Genevestigatori Q96IZ5.

    Family and domain databases

    Gene3Di 3.30.70.330. 1 hit.
    InterProi IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view ]
    Pfami PF00076. RRM_1. 1 hit.
    [Graphical view ]
    SMARTi SM00360. RRM. 1 hit.
    [Graphical view ]
    PROSITEi PS50102. RRM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Placenta.
    2. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT TYR-376.
      Tissue: Urinary bladder.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-232, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. "Solution structure of RNA binding domain in hypothetical protein FLJ11016."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 291-392.

    Entry informationi

    Entry nameiRBM41_HUMAN
    AccessioniPrimary (citable) accession number: Q96IZ5
    Secondary accession number(s): Q5JSN7
    , Q5JSN8, Q9H8F7, Q9NV04
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3