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Q96IZ5

- RBM41_HUMAN

UniProt

Q96IZ5 - RBM41_HUMAN

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Protein

RNA-binding protein 41

Gene

RBM41

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May bind RNA.Curated

GO - Molecular functioni

  1. nucleotide binding Source: InterPro
  2. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 41
Alternative name(s):
RNA-binding motif protein 41
Gene namesi
Name:RBM41
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:25617. RBM41.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145148155.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 413413RNA-binding protein 41PRO_0000256267Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei232 – 2321Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96IZ5.
PaxDbiQ96IZ5.
PRIDEiQ96IZ5.

PTM databases

PhosphoSiteiQ96IZ5.

Expressioni

Gene expression databases

BgeeiQ96IZ5.
CleanExiHS_RBM41.
GenevestigatoriQ96IZ5.

Organism-specific databases

HPAiHPA042881.

Interactioni

Protein-protein interaction databases

BioGridi120573. 5 interactions.
IntActiQ96IZ5. 5 interactions.
MINTiMINT-1449430.
STRINGi9606.ENSP00000361557.

Structurei

Secondary structure

1
413
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi291 – 2933Combined sources
Beta strandi309 – 3146Combined sources
Helixi322 – 3287Combined sources
Helixi330 – 3345Combined sources
Beta strandi335 – 3384Combined sources
Beta strandi341 – 3455Combined sources
Beta strandi347 – 3493Combined sources
Beta strandi351 – 3566Combined sources
Helixi360 – 36910Combined sources
Beta strandi381 – 3844Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CPXNMR-A291-392[»]
ProteinModelPortaliQ96IZ5.
SMRiQ96IZ5. Positions 289-393.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96IZ5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini309 – 38779RRMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG147711.
GeneTreeiENSGT00530000063786.
HOGENOMiHOG000231401.
HOVERGENiHBG057264.
InParanoidiQ96IZ5.
OMAiNENSLTH.
OrthoDBiEOG7JDQXS.
PhylomeDBiQ96IZ5.
TreeFamiTF324298.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96IZ5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRVNSCVKS DEHVLEELET EGERQLKSLL QHQLDTSVSI EECMSKKESF
60 70 80 90 100
APGTMYKPFG KEAAGTMTLS QFQTLHEKDQ ETASLRELGL NETEILIWKS
110 120 130 140 150
HVSGEKKTKL RATPEAIQNR LQDIEERISE RQRILCLPQR FAKSKQLTRR
160 170 180 190 200
EMEIEKSLFQ GADRHSFLKA LYYQDEPQKK NKGDPMNNLE SFYQEMIMKK
210 220 230 240 250
RLEEFQLMRG EPFASHSLVS ATSVGDSGTA ESPSLLQDKG KQAAQGKGPS
260 270 280 290 300
LHVANVIDFS PEQCWTGPKK LTQPIEFVPE DEIQRNRLSE EEIRKIPMFS
310 320 330 340 350
SYNPGEPNKV LYLKNLSPRV TERDLVSLFA RFQEKKGPPI QFRMMTGRMR
360 370 380 390 400
GQAFITFPNK EIAWQALHLV NGYKLHGKIL VIEFGKNKKQ RSNLQATSLI
410
SCATGSTTEI SGS
Length:413
Mass (Da):47,100
Last modified:October 31, 2006 - v2
Checksum:i759B1BFF358943A8
GO
Isoform 2 (identifier: Q96IZ5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     406-413: Missing.

Show »
Length:405
Mass (Da):46,337
Checksum:i703AF52FBC9CC486
GO
Isoform 3 (identifier: Q96IZ5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     174-174: Q → QAYHKKTSADKYMTSMKRKIKLGTK
     211-287: EPFASHSLVS...VPEDEIQRNR → LTSFPREDFQ...TRIGKLSFTP
     288-413: Missing.

Show »
Length:311
Mass (Da):35,962
Checksum:i5E5699E9D3352E2D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 611K → E in BAB14660. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti376 – 3761H → Y.1 Publication
Corresponds to variant rs17850127 [ dbSNP | Ensembl ].
VAR_028897

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei174 – 1741Q → QAYHKKTSADKYMTSMKRKI KLGTK in isoform 3. 1 PublicationVSP_021346
Alternative sequencei211 – 28777EPFAS…IQRNR → LTSFPREDFQNLSYEGTTSV LGAKWQKRTGRTSTFSILLV SLLSETVFTSSAMYGIPHLL TMSLKFSTRIGKLSFTP in isoform 3. 1 PublicationVSP_021347Add
BLAST
Alternative sequencei288 – 413126Missing in isoform 3. 1 PublicationVSP_021348Add
BLAST
Alternative sequencei406 – 4138Missing in isoform 2. 1 PublicationVSP_021349

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001878 mRNA. Translation: BAA91957.1.
AK023732 mRNA. Translation: BAB14660.1.
AL390039 Genomic DNA. Translation: CAC19636.1.
AL390039 Genomic DNA. Translation: CAI41564.1.
BC006986 mRNA. Translation: AAH06986.1.
CCDSiCCDS14526.1. [Q96IZ5-1]
CCDS55472.1. [Q96IZ5-2]
RefSeqiNP_001164551.1. NM_001171080.1. [Q96IZ5-2]
NP_060771.3. NM_018301.3. [Q96IZ5-1]
UniGeneiHs.139053.

Genome annotation databases

EnsembliENST00000372479; ENSP00000361557; ENSG00000089682. [Q96IZ5-1]
ENST00000372487; ENSP00000361565; ENSG00000089682. [Q96IZ5-2]
ENST00000495517; ENSP00000433251; ENSG00000089682. [Q96IZ5-3]
GeneIDi55285.
KEGGihsa:55285.
UCSCiuc004emy.2. human. [Q96IZ5-1]

Polymorphism databases

DMDMi117949772.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001878 mRNA. Translation: BAA91957.1 .
AK023732 mRNA. Translation: BAB14660.1 .
AL390039 Genomic DNA. Translation: CAC19636.1 .
AL390039 Genomic DNA. Translation: CAI41564.1 .
BC006986 mRNA. Translation: AAH06986.1 .
CCDSi CCDS14526.1. [Q96IZ5-1 ]
CCDS55472.1. [Q96IZ5-2 ]
RefSeqi NP_001164551.1. NM_001171080.1. [Q96IZ5-2 ]
NP_060771.3. NM_018301.3. [Q96IZ5-1 ]
UniGenei Hs.139053.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2CPX NMR - A 291-392 [» ]
ProteinModelPortali Q96IZ5.
SMRi Q96IZ5. Positions 289-393.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120573. 5 interactions.
IntActi Q96IZ5. 5 interactions.
MINTi MINT-1449430.
STRINGi 9606.ENSP00000361557.

PTM databases

PhosphoSitei Q96IZ5.

Polymorphism databases

DMDMi 117949772.

Proteomic databases

MaxQBi Q96IZ5.
PaxDbi Q96IZ5.
PRIDEi Q96IZ5.

Protocols and materials databases

DNASUi 55285.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000372479 ; ENSP00000361557 ; ENSG00000089682 . [Q96IZ5-1 ]
ENST00000372487 ; ENSP00000361565 ; ENSG00000089682 . [Q96IZ5-2 ]
ENST00000495517 ; ENSP00000433251 ; ENSG00000089682 . [Q96IZ5-3 ]
GeneIDi 55285.
KEGGi hsa:55285.
UCSCi uc004emy.2. human. [Q96IZ5-1 ]

Organism-specific databases

CTDi 55285.
GeneCardsi GC0XM106307.
H-InvDB HIX0020243.
HGNCi HGNC:25617. RBM41.
HPAi HPA042881.
neXtProti NX_Q96IZ5.
PharmGKBi PA145148155.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG147711.
GeneTreei ENSGT00530000063786.
HOGENOMi HOG000231401.
HOVERGENi HBG057264.
InParanoidi Q96IZ5.
OMAi NENSLTH.
OrthoDBi EOG7JDQXS.
PhylomeDBi Q96IZ5.
TreeFami TF324298.

Miscellaneous databases

EvolutionaryTracei Q96IZ5.
GenomeRNAii 55285.
NextBioi 59448.
PROi Q96IZ5.

Gene expression databases

Bgeei Q96IZ5.
CleanExi HS_RBM41.
Genevestigatori Q96IZ5.

Family and domain databases

Gene3Di 3.30.70.330. 1 hit.
InterProi IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view ]
Pfami PF00076. RRM_1. 1 hit.
[Graphical view ]
SMARTi SM00360. RRM. 1 hit.
[Graphical view ]
PROSITEi PS50102. RRM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Placenta.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT TYR-376.
    Tissue: Urinary bladder.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-232, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Solution structure of RNA binding domain in hypothetical protein FLJ11016."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 291-392.

Entry informationi

Entry nameiRBM41_HUMAN
AccessioniPrimary (citable) accession number: Q96IZ5
Secondary accession number(s): Q5JSN7
, Q5JSN8, Q9H8F7, Q9NV04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: November 26, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3