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Q96IY4

- CBPB2_HUMAN

UniProt

Q96IY4 - CBPB2_HUMAN

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Protein

Carboxypeptidase B2

Gene

CPB2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.1 Publication

Catalytic activityi

Release of C-terminal Arg and Lys from a polypeptide.1 Publication

Cofactori

Zn2+Note: Binds 1 zinc ion per subunit.

Enzyme regulationi

TAFI/CPB2 is unique among carboxypeptidases in that it spontaneously inactivates with a short half-life, a property that is crucial for its role in controlling blood clot lysis. The zymogen is stabilized by interactions with the activation peptide. Release of the activation peptide increases a dynamic flap mobility and in time this leads to conformational changes that disrupt the catalytic site and expose a cryptic thrombin-cleavage site present at Arg-324.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi181 – 1811Zinc; catalytic
Metal bindingi184 – 1841Zinc; catalytic
Metal bindingi310 – 3101Zinc; catalytic
Sitei324 – 3252Cleavage; by thrombin
Active sitei385 – 3851Nucleophile1 Publication

GO - Molecular functioni

  1. metallocarboxypeptidase activity Source: ProtInc
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. blood coagulation Source: UniProtKB-KW
  2. cellular response to glucose stimulus Source: Ensembl
  3. fibrinolysis Source: UniProtKB-KW
  4. liver regeneration Source: Ensembl
  5. negative regulation of fibrinolysis Source: Ensembl
  6. negative regulation of hepatocyte proliferation Source: Ensembl
  7. negative regulation of plasminogen activation Source: Ensembl
  8. positive regulation of extracellular matrix constituent secretion Source: Ensembl
  9. proteolysis Source: ProtInc
  10. response to drug Source: Ensembl
  11. response to heat Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Biological processi

Blood coagulation, Fibrinolysis, Hemostasis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_147707. Metabolism of Angiotensinogen to Angiotensins.

Protein family/group databases

MEROPSiM14.009.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase B2 (EC:3.4.17.20)
Alternative name(s):
Carboxypeptidase U
Short name:
CPU
Plasma carboxypeptidase B
Short name:
pCPB
Thrombin-activable fibrinolysis inhibitor
Short name:
TAFI
Gene namesi
Name:CPB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:2300. CPB2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: ProtInc
  2. extracellular vesicular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26822.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Propeptidei23 – 11492Activation peptidePRO_0000004377Add
BLAST
Chaini115 – 423309Carboxypeptidase B2PRO_0000004378Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi44 – 441N-linked (GlcNAc...)3 Publications
Glycosylationi73 – 731N-linked (GlcNAc...)3 Publications
Glycosylationi85 – 851N-linked (GlcNAc...)2 Publications
Glycosylationi108 – 1081N-linked (GlcNAc...) (complex)5 Publications
Disulfide bondi178 ↔ 191
Glycosylationi241 – 2411N-linked (GlcNAc...); partial1 Publication
Disulfide bondi250 ↔ 274
Disulfide bondi265 ↔ 279

Post-translational modificationi

N-glycosylated. N-glycan at Asn-108: Hex5HexNAc4.5 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiQ96IY4.
PaxDbiQ96IY4.
PRIDEiQ96IY4.

PTM databases

PhosphoSiteiQ96IY4.

Miscellaneous databases

PMAP-CutDBA8K464.

Expressioni

Tissue specificityi

Plasma; synthesized in the liver.

Gene expression databases

BgeeiQ96IY4.
CleanExiHS_CPB2.
GenevestigatoriQ96IY4.

Organism-specific databases

HPAiHPA004146.

Interactioni

Protein-protein interaction databases

BioGridi107753. 7 interactions.
IntActiQ96IY4. 1 interaction.
STRINGi9606.ENSP00000181383.

Structurei

Secondary structure

1
423
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi26 – 316Combined sources
Helixi36 – 4813Combined sources
Beta strandi51 – 588Combined sources
Helixi59 – 613Combined sources
Beta strandi68 – 736Combined sources
Helixi74 – 763Combined sources
Helixi77 – 8711Combined sources
Beta strandi91 – 966Combined sources
Helixi98 – 10710Combined sources
Turni108 – 1103Combined sources
Helixi117 – 1215Combined sources
Helixi126 – 13914Combined sources
Turni141 – 1433Combined sources
Beta strandi144 – 1518Combined sources
Beta strandi157 – 1637Combined sources
Beta strandi172 – 1776Combined sources
Helixi186 – 20116Combined sources
Turni202 – 2043Combined sources
Helixi206 – 2149Combined sources
Beta strandi215 – 2217Combined sources
Helixi225 – 2339Combined sources
Helixi255 – 2573Combined sources
Turni262 – 2654Combined sources
Beta strandi269 – 2713Combined sources
Helixi287 – 29812Combined sources
Turni299 – 3024Combined sources
Beta strandi303 – 31917Combined sources
Beta strandi321 – 3255Combined sources
Helixi330 – 34718Combined sources
Beta strandi354 – 3585Combined sources
Turni359 – 3624Combined sources
Helixi369 – 3746Combined sources
Turni375 – 3773Combined sources
Beta strandi380 – 3878Combined sources
Beta strandi389 – 3924Combined sources
Helixi393 – 3953Combined sources
Helixi398 – 4003Combined sources
Helixi401 – 42222Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3D66X-ray3.10A/B/C24-423[»]
3D67X-ray3.40A/B/C24-423[»]
3D68X-ray2.80A/B/C24-423[»]
3LMSX-ray2.50A115-423[»]
4P10X-ray2.00A23-423[»]
ProteinModelPortaliQ96IY4.
SMRiQ96IY4. Positions 25-423.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96IY4.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M14 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2866.
GeneTreeiENSGT00760000119103.
HOGENOMiHOG000252968.
HOVERGENiHBG050815.
InParanoidiQ96IY4.
KOiK01300.
OMAiEIYSWIE.
OrthoDBiEOG7RZ5Q9.
PhylomeDBiQ96IY4.
TreeFamiTF317197.

Family and domain databases

Gene3Di3.30.70.340. 1 hit.
InterProiIPR000834. Peptidase_M14.
IPR003146. Prot_inh_M14A.
IPR009020. Prot_inh_propept.
[Graphical view]
PfamiPF00246. Peptidase_M14. 1 hit.
PF02244. Propep_M14. 1 hit.
[Graphical view]
PRINTSiPR00765. CRBOXYPTASEA.
SMARTiSM00631. Zn_pept. 1 hit.
[Graphical view]
SUPFAMiSSF54897. SSF54897. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96IY4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLCSLAVLV PIVLFCEQHV FAFQSGQVLA ALPRTSRQVQ VLQNLTTTYE
60 70 80 90 100
IVLWQPVTAD LIVKKKQVHF FVNASDVDNV KAHLNVSGIP CSVLLADVED
110 120 130 140 150
LIQQQISNDT VSPRASASYY EQYHSLNEIY SWIEFITERH PDMLTKIHIG
160 170 180 190 200
SSFEKYPLYV LKVSGKEQAA KNAIWIDCGI HAREWISPAF CLWFIGHITQ
210 220 230 240 250
FYGIIGQYTN LLRLVDFYVM PVVNVDGYDY SWKKNRMWRK NRSFYANNHC
260 270 280 290 300
IGTDLNRNFA SKHWCEEGAS SSSCSETYCG LYPESEPEVK AVASFLRRNI
310 320 330 340 350
NQIKAYISMH SYSQHIVFPY SYTRSKSKDH EELSLVASEA VRAIEKISKN
360 370 380 390 400
TRYTHGHGSE TLYLAPGGGD DWIYDLGIKY SFTIELRDTG TYGFLLPERY
410 420
IKPTCREAFA AVSKIAWHVI RNV
Length:423
Mass (Da):48,424
Last modified:January 11, 2011 - v2
Checksum:iB4D20E03ECDD55EF
GO
Isoform 2 (identifier: Q96IY4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     198-234: Missing.
     384-423: IELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVIRNV → SNPPVEKLLPLSLK

Show »
Length:360
Mass (Da):40,922
Checksum:i2C011F6D4265F4B8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251S → T in BAA90475. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti169 – 1691A → T.2 Publications
Corresponds to variant rs3742264 [ dbSNP | Ensembl ].
VAR_032565
Natural varianti347 – 3471I → T.5 Publications
Corresponds to variant rs1926447 [ dbSNP | Ensembl ].
VAR_022258

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei198 – 23437Missing in isoform 2. 1 PublicationVSP_013446Add
BLAST
Alternative sequencei384 – 42340IELRD…VIRNV → SNPPVEKLLPLSLK in isoform 2. 1 PublicationVSP_013447Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75106 mRNA. Translation: AAA60042.1.
AB011969 mRNA. Translation: BAA90475.1.
BT006936 mRNA. Translation: AAP35582.1.
AK290829 mRNA. Translation: BAF83518.1.
AY714780 Genomic DNA. Translation: AAT97987.1.
AL157758, AL137141 Genomic DNA. Translation: CAI10904.1.
AL157758, AL137141 Genomic DNA. Translation: CAI10905.1.
AL137141, AL157758 Genomic DNA. Translation: CAI12170.1.
AL137141, AL157758 Genomic DNA. Translation: CAI12171.1.
BC007057 mRNA. Translation: AAH07057.1.
CCDSiCCDS9401.1. [Q96IY4-1]
PIRiA41204.
RefSeqiNP_001265470.1. NM_001278541.1.
NP_001863.3. NM_001872.4. [Q96IY4-1]
UniGeneiHs.512937.

Genome annotation databases

EnsembliENST00000181383; ENSP00000181383; ENSG00000080618. [Q96IY4-1]
GeneIDi1361.
KEGGihsa:1361.
UCSCiuc001vaw.3. human. [Q96IY4-1]

Polymorphism databases

DMDMi317373332.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75106 mRNA. Translation: AAA60042.1 .
AB011969 mRNA. Translation: BAA90475.1 .
BT006936 mRNA. Translation: AAP35582.1 .
AK290829 mRNA. Translation: BAF83518.1 .
AY714780 Genomic DNA. Translation: AAT97987.1 .
AL157758 , AL137141 Genomic DNA. Translation: CAI10904.1 .
AL157758 , AL137141 Genomic DNA. Translation: CAI10905.1 .
AL137141 , AL157758 Genomic DNA. Translation: CAI12170.1 .
AL137141 , AL157758 Genomic DNA. Translation: CAI12171.1 .
BC007057 mRNA. Translation: AAH07057.1 .
CCDSi CCDS9401.1. [Q96IY4-1 ]
PIRi A41204.
RefSeqi NP_001265470.1. NM_001278541.1.
NP_001863.3. NM_001872.4. [Q96IY4-1 ]
UniGenei Hs.512937.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3D66 X-ray 3.10 A/B/C 24-423 [» ]
3D67 X-ray 3.40 A/B/C 24-423 [» ]
3D68 X-ray 2.80 A/B/C 24-423 [» ]
3LMS X-ray 2.50 A 115-423 [» ]
4P10 X-ray 2.00 A 23-423 [» ]
ProteinModelPortali Q96IY4.
SMRi Q96IY4. Positions 25-423.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107753. 7 interactions.
IntActi Q96IY4. 1 interaction.
STRINGi 9606.ENSP00000181383.

Chemistry

BindingDBi Q96IY4.
ChEMBLi CHEMBL3419.

Protein family/group databases

MEROPSi M14.009.

PTM databases

PhosphoSitei Q96IY4.

Polymorphism databases

DMDMi 317373332.

Proteomic databases

MaxQBi Q96IY4.
PaxDbi Q96IY4.
PRIDEi Q96IY4.

Protocols and materials databases

DNASUi 1361.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000181383 ; ENSP00000181383 ; ENSG00000080618 . [Q96IY4-1 ]
GeneIDi 1361.
KEGGi hsa:1361.
UCSCi uc001vaw.3. human. [Q96IY4-1 ]

Organism-specific databases

CTDi 1361.
GeneCardsi GC13M046627.
HGNCi HGNC:2300. CPB2.
HPAi HPA004146.
MIMi 603101. gene.
neXtProti NX_Q96IY4.
PharmGKBi PA26822.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2866.
GeneTreei ENSGT00760000119103.
HOGENOMi HOG000252968.
HOVERGENi HBG050815.
InParanoidi Q96IY4.
KOi K01300.
OMAi EIYSWIE.
OrthoDBi EOG7RZ5Q9.
PhylomeDBi Q96IY4.
TreeFami TF317197.

Enzyme and pathway databases

Reactomei REACT_147707. Metabolism of Angiotensinogen to Angiotensins.

Miscellaneous databases

EvolutionaryTracei Q96IY4.
GeneWikii Carboxypeptidase_B2.
GenomeRNAii 1361.
NextBioi 5513.
PMAP-CutDB A8K464.
PROi Q96IY4.
SOURCEi Search...

Gene expression databases

Bgeei Q96IY4.
CleanExi HS_CPB2.
Genevestigatori Q96IY4.

Family and domain databases

Gene3Di 3.30.70.340. 1 hit.
InterProi IPR000834. Peptidase_M14.
IPR003146. Prot_inh_M14A.
IPR009020. Prot_inh_propept.
[Graphical view ]
Pfami PF00246. Peptidase_M14. 1 hit.
PF02244. Propep_M14. 1 hit.
[Graphical view ]
PRINTSi PR00765. CRBOXYPTASEA.
SMARTi SM00631. Zn_pept. 1 hit.
[Graphical view ]
SUPFAMi SSF54897. SSF54897. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation, molecular cloning, and partial characterization of a novel carboxypeptidase B from human plasma."
    Eaton D.L., Malloy B.E., Tsai S.P., Henzel W., Drayna D.
    J. Biol. Chem. 266:21833-21838(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE, INTERACTION WITH PLASMINOGEN, VARIANTS THR-169 AND THR-347.
    Tissue: Liver.
  2. "Isolation, molecular cloning, and partial characterization of a novel carboxypeptidase B from human plasma."
    Matsumoto A.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-347.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS THR-169 AND THR-347.
    Tissue: Liver.
  5. SeattleSNPs variation discovery resource
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-347.
  6. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-347.
    Tissue: Skeletal muscle.
  8. "Characterization of plasmin-mediated activation of plasma procarboxypeptidase B. Modulation by glycosaminoglycans."
    Mao S.S., Cooper C.M., Wood T., Shafer J.A., Gardell S.J.
    J. Biol. Chem. 274:35046-35052(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY.
  9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-44; ASN-73 AND ASN-108.
    Tissue: Plasma.
  10. "Post-translational modifications of human thrombin-activatable fibrinolysis inhibitor (TAFI): evidence for a large shift in the isoelectric point and reduced solubility upon activation."
    Valnickova Z., Christensen T., Skottrup P., Thogersen I.B., Hojrup P., Enghild J.J.
    Biochemistry 45:1525-1535(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-44; ASN-73; ASN-85; ASN-108 AND ASN-241, DISULFIDE BONDS.
  11. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-108.
    Tissue: Liver.
  12. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
    Halim A., Nilsson J., Ruetschi U., Hesse C., Larson G.
    Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-108, STRUCTURE OF CARBOHYDRATES, IDENTIFICATION BY MASS SPECTROMETRY.
  13. "Crystal structures of TAFI elucidate the inactivation mechanism of activated TAFI: a novel mechanism for enzyme autoregulation."
    Marx P.F., Brondijk T.H., Plug T., Romijn R.A., Hemrika W., Meijers J.C., Huizinga E.G.
    Blood 112:2803-2809(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 24-423 ALONE AND IN COMPLEX WITH INHIBITOR, GLYCOSYLATION AT ASN-44; ASN-73; ASN-85 AND ASN-108, ACTIVE SITE, ZINC-BINDING SITES, ENZYME REGULATION, DISULFIDE BONDS.
  14. "Insights into the molecular inactivation mechanism of human activated thrombin-activatable fibrinolysis inhibitor."
    Sanglas L., Arolas J.L., Valnickova Z., Aviles F.X., Enghild J.J., Gomis-Ruth F.X.
    J. Thromb. Haemost. 8:1056-1065(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 115-423 IN COMPLEX WITH INHIBITOR, DISULFIDE BONDS.

Entry informationi

Entry nameiCBPB2_HUMAN
AccessioniPrimary (citable) accession number: Q96IY4
Secondary accession number(s): A8K464
, Q15114, Q5T9K1, Q5T9K2, Q9P2Y6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: January 11, 2011
Last modified: November 26, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Peptidase families
    Classification of peptidase families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3