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Q96IX5

- USMG5_HUMAN

UniProt

Q96IX5 - USMG5_HUMAN

Protein

Up-regulated during skeletal muscle growth protein 5

Gene

USMG5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Plays a critical role in maintaining the ATP synthase population in mitochondria.1 Publication

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Up-regulated during skeletal muscle growth protein 5
    Alternative name(s):
    Diabetes-associated protein in insulin-sensitive tissues
    HCV F-transactivated protein 2
    Gene namesi
    Name:USMG5
    Synonyms:DAPIT, HCVFTP2
    ORF Names:PD04912
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:30889. USMG5.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB-KW
    3. mitochondrial proton-transporting ATP synthase complex Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134968209.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 5857Up-regulated during skeletal muscle growth protein 5PRO_0000231578Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei16 – 161N6-acetyllysineBy similarity
    Modified residuei17 – 171N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ96IX5.
    PaxDbiQ96IX5.
    PRIDEiQ96IX5.

    PTM databases

    PhosphoSiteiQ96IX5.

    Expressioni

    Inductioni

    Transactivated by SBP1.1 Publication

    Gene expression databases

    BgeeiQ96IX5.
    CleanExiHS_USMG5.
    GenevestigatoriQ96IX5.

    Interactioni

    Subunit structurei

    Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68.By similarity

    Protein-protein interaction databases

    BioGridi124287. 4 interactions.
    IntActiQ96IX5. 6 interactions.
    MINTiMINT-2877574.
    STRINGi9606.ENSP00000311245.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96IX5.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei23 – 4523HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46170.
    HOGENOMiHOG000008547.
    HOVERGENiHBG094140.
    InParanoidiQ96IX5.
    KOiK18194.
    OMAiPETDAQF.
    OrthoDBiEOG7673FB.
    PhylomeDBiQ96IX5.
    TreeFamiTF324671.

    Family and domain databases

    InterProiIPR009125. DAPIT.
    [Graphical view]
    PRINTSiPR01821. DAPIT.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q96IX5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGPESDAQY QFTGIKKYFN SYTLTGRMNC VLATYGSIAL IVLYFKLRSK   50
    KTPAVKAT 58
    Length:58
    Mass (Da):6,458
    Last modified:December 1, 2001 - v1
    Checksum:i3BFC4C9E2920B126
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY740522 mRNA. Translation: AAU89079.1.
    AJ272056 mRNA. Translation: CAC81243.1.
    AK311888 mRNA. Translation: BAG34829.1.
    AL591408 Genomic DNA. Translation: CAI16748.1.
    CH471066 Genomic DNA. Translation: EAW49642.1.
    CH471066 Genomic DNA. Translation: EAW49643.1.
    CH471066 Genomic DNA. Translation: EAW49644.1.
    BC007087 mRNA. Translation: AAH07087.1.
    BC072683 mRNA. Translation: AAH72683.1.
    BC091507 mRNA. Translation: AAH91507.1.
    CCDSiCCDS7548.1.
    RefSeqiNP_001193355.1. NM_001206426.1.
    NP_001193356.1. NM_001206427.1.
    NP_116136.1. NM_032747.3.
    UniGeneiHs.500921.
    Hs.732499.

    Genome annotation databases

    EnsembliENST00000309579; ENSP00000311245; ENSG00000173915.
    ENST00000337003; ENSP00000337705; ENSG00000173915.
    ENST00000369811; ENSP00000358826; ENSG00000173915.
    ENST00000369815; ENSP00000358830; ENSG00000173915.
    ENST00000369825; ENSP00000358840; ENSG00000173915.
    GeneIDi84833.
    KEGGihsa:84833.
    UCSCiuc001kww.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY740522 mRNA. Translation: AAU89079.1 .
    AJ272056 mRNA. Translation: CAC81243.1 .
    AK311888 mRNA. Translation: BAG34829.1 .
    AL591408 Genomic DNA. Translation: CAI16748.1 .
    CH471066 Genomic DNA. Translation: EAW49642.1 .
    CH471066 Genomic DNA. Translation: EAW49643.1 .
    CH471066 Genomic DNA. Translation: EAW49644.1 .
    BC007087 mRNA. Translation: AAH07087.1 .
    BC072683 mRNA. Translation: AAH72683.1 .
    BC091507 mRNA. Translation: AAH91507.1 .
    CCDSi CCDS7548.1.
    RefSeqi NP_001193355.1. NM_001206426.1.
    NP_001193356.1. NM_001206427.1.
    NP_116136.1. NM_032747.3.
    UniGenei Hs.500921.
    Hs.732499.

    3D structure databases

    ProteinModelPortali Q96IX5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124287. 4 interactions.
    IntActi Q96IX5. 6 interactions.
    MINTi MINT-2877574.
    STRINGi 9606.ENSP00000311245.

    PTM databases

    PhosphoSitei Q96IX5.

    Proteomic databases

    MaxQBi Q96IX5.
    PaxDbi Q96IX5.
    PRIDEi Q96IX5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000309579 ; ENSP00000311245 ; ENSG00000173915 .
    ENST00000337003 ; ENSP00000337705 ; ENSG00000173915 .
    ENST00000369811 ; ENSP00000358826 ; ENSG00000173915 .
    ENST00000369815 ; ENSP00000358830 ; ENSG00000173915 .
    ENST00000369825 ; ENSP00000358840 ; ENSG00000173915 .
    GeneIDi 84833.
    KEGGi hsa:84833.
    UCSCi uc001kww.2. human.

    Organism-specific databases

    CTDi 84833.
    GeneCardsi GC10M105138.
    HGNCi HGNC:30889. USMG5.
    MIMi 615204. gene.
    neXtProti NX_Q96IX5.
    PharmGKBi PA134968209.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46170.
    HOGENOMi HOG000008547.
    HOVERGENi HBG094140.
    InParanoidi Q96IX5.
    KOi K18194.
    OMAi PETDAQF.
    OrthoDBi EOG7673FB.
    PhylomeDBi Q96IX5.
    TreeFami TF324671.

    Miscellaneous databases

    ChiTaRSi USMG5. human.
    GenomeRNAii 84833.
    NextBioi 75048.
    PROi Q96IX5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96IX5.
    CleanExi HS_USMG5.
    Genevestigatori Q96IX5.

    Family and domain databases

    InterProi IPR009125. DAPIT.
    [Graphical view ]
    PRINTSi PR01821. DAPIT.
    ProtoNeti Search...

    Publicationsi

    1. "Study of transactivating effect of pre-S2 protein of hepatitis B virus and cloning of genes transactivated by pre-S2 protein with suppression subtractive hybridization."
      Ji D., Cheng J., Chen G.-F., Liu Y., Wang L., Guo J.
      World J. Gastroenterol. 11:5438-5443(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION BY SBP1.
    2. "Study of 100 skeletal muscle full length mRNA."
      Frigimelica E., Lanfranchi G.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skeletal muscle.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.
    4. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Blood, Lung and Skeletal muscle.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Knockdown of DAPIT (diabetes-associated protein in insulin-sensitive tissue) results in loss of ATP synthase in mitochondria."
      Ohsakaya S., Fujikawa M., Hisabori T., Yoshida M.
      J. Biol. Chem. 286:20292-20296(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiUSMG5_HUMAN
    AccessioniPrimary (citable) accession number: Q96IX5
    Secondary accession number(s): B2R4N2, D3DR92
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3