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Q96IX5

- USMG5_HUMAN

UniProt

Q96IX5 - USMG5_HUMAN

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Protein

Up-regulated during skeletal muscle growth protein 5

Gene
USMG5, DAPIT, HCVFTP2, PD04912
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a critical role in maintaining the ATP synthase population in mitochondria.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Up-regulated during skeletal muscle growth protein 5
Alternative name(s):
Diabetes-associated protein in insulin-sensitive tissues
HCV F-transactivated protein 2
Gene namesi
Name:USMG5
Synonyms:DAPIT, HCVFTP2
ORF Names:PD04912
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:30889. USMG5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei23 – 4523Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: UniProtKB-KW
  3. mitochondrial proton-transporting ATP synthase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134968209.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 5857Up-regulated during skeletal muscle growth protein 5PRO_0000231578Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei16 – 161N6-acetyllysine By similarity
Modified residuei17 – 171N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ96IX5.
PaxDbiQ96IX5.
PRIDEiQ96IX5.

PTM databases

PhosphoSiteiQ96IX5.

Expressioni

Inductioni

Transactivated by SBP1.1 Publication

Gene expression databases

BgeeiQ96IX5.
CleanExiHS_USMG5.
GenevestigatoriQ96IX5.

Interactioni

Subunit structurei

Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 By similarity.

Protein-protein interaction databases

BioGridi124287. 4 interactions.
IntActiQ96IX5. 6 interactions.
MINTiMINT-2877574.
STRINGi9606.ENSP00000311245.

Structurei

3D structure databases

ProteinModelPortaliQ96IX5.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46170.
HOGENOMiHOG000008547.
HOVERGENiHBG094140.
InParanoidiQ96IX5.
KOiK18194.
OMAiPETDAQF.
OrthoDBiEOG7673FB.
PhylomeDBiQ96IX5.
TreeFamiTF324671.

Family and domain databases

InterProiIPR009125. DAPIT.
[Graphical view]
PRINTSiPR01821. DAPIT.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96IX5-1 [UniParc]FASTAAdd to Basket

« Hide

MAGPESDAQY QFTGIKKYFN SYTLTGRMNC VLATYGSIAL IVLYFKLRSK   50
KTPAVKAT 58
Length:58
Mass (Da):6,458
Last modified:December 1, 2001 - v1
Checksum:i3BFC4C9E2920B126
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY740522 mRNA. Translation: AAU89079.1.
AJ272056 mRNA. Translation: CAC81243.1.
AK311888 mRNA. Translation: BAG34829.1.
AL591408 Genomic DNA. Translation: CAI16748.1.
CH471066 Genomic DNA. Translation: EAW49642.1.
CH471066 Genomic DNA. Translation: EAW49643.1.
CH471066 Genomic DNA. Translation: EAW49644.1.
BC007087 mRNA. Translation: AAH07087.1.
BC072683 mRNA. Translation: AAH72683.1.
BC091507 mRNA. Translation: AAH91507.1.
CCDSiCCDS7548.1.
RefSeqiNP_001193355.1. NM_001206426.1.
NP_001193356.1. NM_001206427.1.
NP_116136.1. NM_032747.3.
UniGeneiHs.500921.
Hs.732499.

Genome annotation databases

EnsembliENST00000309579; ENSP00000311245; ENSG00000173915.
ENST00000337003; ENSP00000337705; ENSG00000173915.
ENST00000369811; ENSP00000358826; ENSG00000173915.
ENST00000369815; ENSP00000358830; ENSG00000173915.
ENST00000369825; ENSP00000358840; ENSG00000173915.
GeneIDi84833.
KEGGihsa:84833.
UCSCiuc001kww.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY740522 mRNA. Translation: AAU89079.1 .
AJ272056 mRNA. Translation: CAC81243.1 .
AK311888 mRNA. Translation: BAG34829.1 .
AL591408 Genomic DNA. Translation: CAI16748.1 .
CH471066 Genomic DNA. Translation: EAW49642.1 .
CH471066 Genomic DNA. Translation: EAW49643.1 .
CH471066 Genomic DNA. Translation: EAW49644.1 .
BC007087 mRNA. Translation: AAH07087.1 .
BC072683 mRNA. Translation: AAH72683.1 .
BC091507 mRNA. Translation: AAH91507.1 .
CCDSi CCDS7548.1.
RefSeqi NP_001193355.1. NM_001206426.1.
NP_001193356.1. NM_001206427.1.
NP_116136.1. NM_032747.3.
UniGenei Hs.500921.
Hs.732499.

3D structure databases

ProteinModelPortali Q96IX5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124287. 4 interactions.
IntActi Q96IX5. 6 interactions.
MINTi MINT-2877574.
STRINGi 9606.ENSP00000311245.

PTM databases

PhosphoSitei Q96IX5.

Proteomic databases

MaxQBi Q96IX5.
PaxDbi Q96IX5.
PRIDEi Q96IX5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000309579 ; ENSP00000311245 ; ENSG00000173915 .
ENST00000337003 ; ENSP00000337705 ; ENSG00000173915 .
ENST00000369811 ; ENSP00000358826 ; ENSG00000173915 .
ENST00000369815 ; ENSP00000358830 ; ENSG00000173915 .
ENST00000369825 ; ENSP00000358840 ; ENSG00000173915 .
GeneIDi 84833.
KEGGi hsa:84833.
UCSCi uc001kww.2. human.

Organism-specific databases

CTDi 84833.
GeneCardsi GC10M105138.
HGNCi HGNC:30889. USMG5.
MIMi 615204. gene.
neXtProti NX_Q96IX5.
PharmGKBi PA134968209.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46170.
HOGENOMi HOG000008547.
HOVERGENi HBG094140.
InParanoidi Q96IX5.
KOi K18194.
OMAi PETDAQF.
OrthoDBi EOG7673FB.
PhylomeDBi Q96IX5.
TreeFami TF324671.

Miscellaneous databases

ChiTaRSi USMG5. human.
GenomeRNAii 84833.
NextBioi 75048.
PROi Q96IX5.
SOURCEi Search...

Gene expression databases

Bgeei Q96IX5.
CleanExi HS_USMG5.
Genevestigatori Q96IX5.

Family and domain databases

InterProi IPR009125. DAPIT.
[Graphical view ]
PRINTSi PR01821. DAPIT.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Study of transactivating effect of pre-S2 protein of hepatitis B virus and cloning of genes transactivated by pre-S2 protein with suppression subtractive hybridization."
    Ji D., Cheng J., Chen G.-F., Liu Y., Wang L., Guo J.
    World J. Gastroenterol. 11:5438-5443(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION BY SBP1.
  2. "Study of 100 skeletal muscle full length mRNA."
    Frigimelica E., Lanfranchi G.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skeletal muscle.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  4. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood, Lung and Skeletal muscle.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Knockdown of DAPIT (diabetes-associated protein in insulin-sensitive tissue) results in loss of ATP synthase in mitochondria."
    Ohsakaya S., Fujikawa M., Hisabori T., Yoshida M.
    J. Biol. Chem. 286:20292-20296(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiUSMG5_HUMAN
AccessioniPrimary (citable) accession number: Q96IX5
Secondary accession number(s): B2R4N2, D3DR92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi