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Protein

Up-regulated during skeletal muscle growth protein 5

Gene

USMG5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a critical role in maintaining the ATP synthase population in mitochondria.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Up-regulated during skeletal muscle growth protein 5
Alternative name(s):
Diabetes-associated protein in insulin-sensitive tissues
HCV F-transactivated protein 2
Gene namesi
Name:USMG5
Synonyms:DAPIT, HCVFTP2
ORF Names:PD04912
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:30889. USMG5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei23 – 4523HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. mitochondrial proton-transporting ATP synthase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134968209.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 5857Up-regulated during skeletal muscle growth protein 5PRO_0000231578Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei16 – 161N6-acetyllysineBy similarity
Modified residuei17 – 171N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ96IX5.
PaxDbiQ96IX5.
PRIDEiQ96IX5.

PTM databases

PhosphoSiteiQ96IX5.

Expressioni

Inductioni

Transactivated by SBP1.1 Publication

Gene expression databases

BgeeiQ96IX5.
CleanExiHS_USMG5.
GenevestigatoriQ96IX5.

Interactioni

Subunit structurei

Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68.By similarity

Protein-protein interaction databases

BioGridi124287. 4 interactions.
IntActiQ96IX5. 6 interactions.
MINTiMINT-2877574.
STRINGi9606.ENSP00000311245.

Structurei

3D structure databases

ProteinModelPortaliQ96IX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46170.
GeneTreeiENSGT00390000015489.
HOGENOMiHOG000008547.
HOVERGENiHBG094140.
InParanoidiQ96IX5.
KOiK18194.
OMAiPETDAQF.
OrthoDBiEOG7673FB.
PhylomeDBiQ96IX5.
TreeFamiTF324671.

Family and domain databases

InterProiIPR009125. DAPIT.
[Graphical view]
PRINTSiPR01821. DAPIT.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96IX5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGPESDAQY QFTGIKKYFN SYTLTGRMNC VLATYGSIAL IVLYFKLRSK

KTPAVKAT
Length:58
Mass (Da):6,458
Last modified:December 1, 2001 - v1
Checksum:i3BFC4C9E2920B126
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY740522 mRNA. Translation: AAU89079.1.
AJ272056 mRNA. Translation: CAC81243.1.
AK311888 mRNA. Translation: BAG34829.1.
AL591408 Genomic DNA. Translation: CAI16748.1.
CH471066 Genomic DNA. Translation: EAW49642.1.
CH471066 Genomic DNA. Translation: EAW49643.1.
CH471066 Genomic DNA. Translation: EAW49644.1.
BC007087 mRNA. Translation: AAH07087.1.
BC072683 mRNA. Translation: AAH72683.1.
BC091507 mRNA. Translation: AAH91507.1.
CCDSiCCDS7548.1.
RefSeqiNP_001193355.1. NM_001206426.1.
NP_001193356.1. NM_001206427.1.
NP_116136.1. NM_032747.3.
UniGeneiHs.500921.
Hs.732499.

Genome annotation databases

EnsembliENST00000309579; ENSP00000311245; ENSG00000173915.
ENST00000337003; ENSP00000337705; ENSG00000173915.
ENST00000369811; ENSP00000358826; ENSG00000173915.
ENST00000369815; ENSP00000358830; ENSG00000173915.
ENST00000369825; ENSP00000358840; ENSG00000173915.
GeneIDi84833.
KEGGihsa:84833.
UCSCiuc001kww.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY740522 mRNA. Translation: AAU89079.1.
AJ272056 mRNA. Translation: CAC81243.1.
AK311888 mRNA. Translation: BAG34829.1.
AL591408 Genomic DNA. Translation: CAI16748.1.
CH471066 Genomic DNA. Translation: EAW49642.1.
CH471066 Genomic DNA. Translation: EAW49643.1.
CH471066 Genomic DNA. Translation: EAW49644.1.
BC007087 mRNA. Translation: AAH07087.1.
BC072683 mRNA. Translation: AAH72683.1.
BC091507 mRNA. Translation: AAH91507.1.
CCDSiCCDS7548.1.
RefSeqiNP_001193355.1. NM_001206426.1.
NP_001193356.1. NM_001206427.1.
NP_116136.1. NM_032747.3.
UniGeneiHs.500921.
Hs.732499.

3D structure databases

ProteinModelPortaliQ96IX5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124287. 4 interactions.
IntActiQ96IX5. 6 interactions.
MINTiMINT-2877574.
STRINGi9606.ENSP00000311245.

PTM databases

PhosphoSiteiQ96IX5.

Proteomic databases

MaxQBiQ96IX5.
PaxDbiQ96IX5.
PRIDEiQ96IX5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309579; ENSP00000311245; ENSG00000173915.
ENST00000337003; ENSP00000337705; ENSG00000173915.
ENST00000369811; ENSP00000358826; ENSG00000173915.
ENST00000369815; ENSP00000358830; ENSG00000173915.
ENST00000369825; ENSP00000358840; ENSG00000173915.
GeneIDi84833.
KEGGihsa:84833.
UCSCiuc001kww.2. human.

Organism-specific databases

CTDi84833.
GeneCardsiGC10M105138.
HGNCiHGNC:30889. USMG5.
MIMi615204. gene.
neXtProtiNX_Q96IX5.
PharmGKBiPA134968209.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG46170.
GeneTreeiENSGT00390000015489.
HOGENOMiHOG000008547.
HOVERGENiHBG094140.
InParanoidiQ96IX5.
KOiK18194.
OMAiPETDAQF.
OrthoDBiEOG7673FB.
PhylomeDBiQ96IX5.
TreeFamiTF324671.

Miscellaneous databases

ChiTaRSiUSMG5. human.
GenomeRNAii84833.
NextBioi75048.
PROiQ96IX5.
SOURCEiSearch...

Gene expression databases

BgeeiQ96IX5.
CleanExiHS_USMG5.
GenevestigatoriQ96IX5.

Family and domain databases

InterProiIPR009125. DAPIT.
[Graphical view]
PRINTSiPR01821. DAPIT.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Study of transactivating effect of pre-S2 protein of hepatitis B virus and cloning of genes transactivated by pre-S2 protein with suppression subtractive hybridization."
    Ji D., Cheng J., Chen G.-F., Liu Y., Wang L., Guo J.
    World J. Gastroenterol. 11:5438-5443(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION BY SBP1.
  2. "Study of 100 skeletal muscle full length mRNA."
    Frigimelica E., Lanfranchi G.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skeletal muscle.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  4. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood, Lung and Skeletal muscle.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Knockdown of DAPIT (diabetes-associated protein in insulin-sensitive tissue) results in loss of ATP synthase in mitochondria."
    Ohsakaya S., Fujikawa M., Hisabori T., Yoshida M.
    J. Biol. Chem. 286:20292-20296(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiUSMG5_HUMAN
AccessioniPrimary (citable) accession number: Q96IX5
Secondary accession number(s): B2R4N2, D3DR92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 1, 2001
Last modified: January 7, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.