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Protein

Vesicle-trafficking protein SEC22a

Gene

SEC22A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in vesicle transport between the ER and the Golgi complex.By similarity

GO - Molecular functioni

  • SNAP receptor activity Source: GO_Central
  • SNARE binding Source: GO_Central
  • transporter activity Source: ProtInc

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: ProtInc
  • protein transport Source: UniProtKB-KW
  • vesicle fusion with Golgi apparatus Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000121542-MONOMER.
ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle-trafficking protein SEC22a
Alternative name(s):
SEC22 vesicle-trafficking protein homolog A
SEC22 vesicle-trafficking protein-like 2
Gene namesi
Name:SEC22A
Synonyms:SEC22L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:20260. SEC22A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 187CytoplasmicSequence analysisAdd BLAST186
Transmembranei188 – 208HelicalSequence analysisAdd BLAST21
Topological domaini209 – 226LumenalSequence analysisAdd BLAST18
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Topological domaini248 – 253CytoplasmicSequence analysis6
Transmembranei254 – 271HelicalSequence analysisAdd BLAST18
Topological domaini272 – 274LumenalSequence analysis3
Transmembranei275 – 295HelicalSequence analysisAdd BLAST21
Topological domaini296 – 307CytoplasmicSequence analysisAdd BLAST12

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: ProtInc
  • integral component of membrane Source: UniProtKB-KW
  • SNARE complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26984.
OpenTargetsiENSG00000121542.
PharmGKBiPA134921956.

Polymorphism and mutation databases

BioMutaiSEC22A.
DMDMi74732111.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002530432 – 307Vesicle-trafficking protein SEC22aAdd BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei6PhosphoserineCombined sources1
Modified residuei8PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96IW7.
MaxQBiQ96IW7.
PaxDbiQ96IW7.
PeptideAtlasiQ96IW7.
PRIDEiQ96IW7.

PTM databases

iPTMnetiQ96IW7.
PhosphoSitePlusiQ96IW7.

Expressioni

Gene expression databases

BgeeiENSG00000121542.
CleanExiHS_SEC22A.
ExpressionAtlasiQ96IW7. baseline and differential.
GenevisibleiQ96IW7. HS.

Organism-specific databases

HPAiHPA051639.
HPA055757.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DTX2Q4ZH493EBI-8652744,EBI-10192429
DTX2Q86UW96EBI-8652744,EBI-740376
EDAQ928385EBI-8652744,EBI-529425
ERLIN1O754775EBI-8652744,EBI-359299
FATE1Q969F05EBI-8652744,EBI-743099
MSR1P217573EBI-8652744,EBI-1776976
RNF5Q999423EBI-8652744,EBI-348482
SFTPCP116865EBI-8652744,EBI-10197617
STX4Q128465EBI-8652744,EBI-744942
SYNE4Q8N2053EBI-8652744,EBI-7131783
TMEM79Q9BSE25EBI-8652744,EBI-8649725

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117937. 16 interactors.
IntActiQ96IW7. 24 interactors.
STRINGi9606.ENSP00000310521.

Structurei

3D structure databases

ProteinModelPortaliQ96IW7.
SMRiQ96IW7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 119LonginPROSITE-ProRule annotationAdd BLAST112

Sequence similaritiesi

Belongs to the synaptobrevin family.Curated
Contains 1 longin domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0862. Eukaryota.
COG5143. LUCA.
GeneTreeiENSGT00510000046833.
HOGENOMiHOG000007733.
HOVERGENiHBG053258.
InParanoidiQ96IW7.
KOiK08520.
OMAiVQECRKY.
OrthoDBiEOG091G0MPE.
PhylomeDBiQ96IW7.
TreeFamiTF105933.

Family and domain databases

Gene3Di3.30.450.50. 1 hit.
InterProiIPR011012. Longin-like_dom.
IPR010908. Longin_dom.
IPR027152. Sec22a.
[Graphical view]
PANTHERiPTHR21136:SF68. PTHR21136:SF68. 1 hit.
PfamiPF13774. Longin. 1 hit.
[Graphical view]
SMARTiSM01270. Longin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS50859. LONGIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96IW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMILSASVI RVRDGLPLSA STDYEQSTGM QECRKYFKML SRKLAQLPDR
60 70 80 90 100
CTLKTGHYNI NFISSLGVSY MMLCTENYPN VLAFSFLDEL QKEFITTYNM
110 120 130 140 150
MKTNTAVRPY CFIEFDNFIQ RTKQRYNNPR SLSTKINLSD MQTEIKLRPP
160 170 180 190 200
YQISMCELGS ANGVTSAFSV DCKGAGKISS AHQRLEPATL SGIVGFILSL
210 220 230 240 250
LCGALNLIRG FHAIESLLQS DGDDFNYIIA FFLGTAACLY QCYLLVYYTG
260 270 280 290 300
WRNVKSFLTF GLICLCNMYL YELRNLWQLF FHVTVGAFVT LQIWLRQAQG

KAPDYDV
Length:307
Mass (Da):34,948
Last modified:December 1, 2001 - v1
Checksum:i227A7F6944EC621F
GO

Sequence cautioni

The sequence AAD43013 differs from that shown. Reason: Frameshift at positions 265 and 288.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61N → K in AAD43013 (PubMed:11042152).Curated1
Sequence conflicti116D → N in AAD43013 (PubMed:11042152).Curated1
Sequence conflicti295L → V (PubMed:11042152).Curated1
Sequence conflicti303 – 304PD → SR (PubMed:11042152).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF100749 mRNA. Translation: AAD43013.1. Frameshift.
AK315771 mRNA. Translation: BAG38123.1.
CH471052 Genomic DNA. Translation: EAW79451.1.
BC007122 mRNA. Translation: AAH07122.1.
CCDSiCCDS3021.1.
RefSeqiNP_036562.2. NM_012430.4.
XP_011510975.1. XM_011512673.2.
XP_011510977.1. XM_011512675.2.
XP_011510978.1. XM_011512676.2.
UniGeneiHs.477361.

Genome annotation databases

EnsembliENST00000309934; ENSP00000310521; ENSG00000121542.
ENST00000492595; ENSP00000417972; ENSG00000121542.
GeneIDi26984.
KEGGihsa:26984.
UCSCiuc003ege.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF100749 mRNA. Translation: AAD43013.1. Frameshift.
AK315771 mRNA. Translation: BAG38123.1.
CH471052 Genomic DNA. Translation: EAW79451.1.
BC007122 mRNA. Translation: AAH07122.1.
CCDSiCCDS3021.1.
RefSeqiNP_036562.2. NM_012430.4.
XP_011510975.1. XM_011512673.2.
XP_011510977.1. XM_011512675.2.
XP_011510978.1. XM_011512676.2.
UniGeneiHs.477361.

3D structure databases

ProteinModelPortaliQ96IW7.
SMRiQ96IW7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117937. 16 interactors.
IntActiQ96IW7. 24 interactors.
STRINGi9606.ENSP00000310521.

PTM databases

iPTMnetiQ96IW7.
PhosphoSitePlusiQ96IW7.

Polymorphism and mutation databases

BioMutaiSEC22A.
DMDMi74732111.

Proteomic databases

EPDiQ96IW7.
MaxQBiQ96IW7.
PaxDbiQ96IW7.
PeptideAtlasiQ96IW7.
PRIDEiQ96IW7.

Protocols and materials databases

DNASUi26984.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309934; ENSP00000310521; ENSG00000121542.
ENST00000492595; ENSP00000417972; ENSG00000121542.
GeneIDi26984.
KEGGihsa:26984.
UCSCiuc003ege.4. human.

Organism-specific databases

CTDi26984.
DisGeNETi26984.
GeneCardsiSEC22A.
HGNCiHGNC:20260. SEC22A.
HPAiHPA051639.
HPA055757.
MIMi612442. gene.
neXtProtiNX_Q96IW7.
OpenTargetsiENSG00000121542.
PharmGKBiPA134921956.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0862. Eukaryota.
COG5143. LUCA.
GeneTreeiENSGT00510000046833.
HOGENOMiHOG000007733.
HOVERGENiHBG053258.
InParanoidiQ96IW7.
KOiK08520.
OMAiVQECRKY.
OrthoDBiEOG091G0MPE.
PhylomeDBiQ96IW7.
TreeFamiTF105933.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000121542-MONOMER.
ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.

Miscellaneous databases

GeneWikiiSEC22A.
GenomeRNAii26984.
PROiQ96IW7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000121542.
CleanExiHS_SEC22A.
ExpressionAtlasiQ96IW7. baseline and differential.
GenevisibleiQ96IW7. HS.

Family and domain databases

Gene3Di3.30.450.50. 1 hit.
InterProiIPR011012. Longin-like_dom.
IPR010908. Longin_dom.
IPR027152. Sec22a.
[Graphical view]
PANTHERiPTHR21136:SF68. PTHR21136:SF68. 1 hit.
PfamiPF13774. Longin. 1 hit.
[Graphical view]
SMARTiSM01270. Longin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS50859. LONGIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSC22A_HUMAN
AccessioniPrimary (citable) accession number: Q96IW7
Secondary accession number(s): B2RE26, Q9Y682
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.