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Protein

SH2 domain-containing adapter protein D

Gene

SHD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May function as an adapter protein.By similarity

Enzyme and pathway databases

SignaLinkiQ96IW2.

Names & Taxonomyi

Protein namesi
Recommended name:
SH2 domain-containing adapter protein D
Gene namesi
Name:SHD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:30633. SHD.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670918.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340SH2 domain-containing adapter protein DPRO_0000246773Add
BLAST

Post-translational modificationi

Tyrosine phosphorylated by ABL.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ96IW2.
PRIDEiQ96IW2.

PTM databases

PhosphoSiteiQ96IW2.

Expressioni

Gene expression databases

BgeeiQ96IW2.
CleanExiHS_SHD.
ExpressionAtlasiQ96IW2. baseline and differential.
GenevestigatoriQ96IW2.

Organism-specific databases

HPAiHPA017955.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
METP085812EBI-4402781,EBI-1039152

Protein-protein interaction databases

BioGridi121283. 2 interactions.
IntActiQ96IW2. 1 interaction.
STRINGi9606.ENSP00000221852.

Structurei

3D structure databases

ProteinModelPortaliQ96IW2.
SMRiQ96IW2. Positions 235-318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini240 – 33596SH2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiNOG80632.
GeneTreeiENSGT00390000015203.
HOGENOMiHOG000038038.
HOVERGENiHBG066172.
InParanoidiQ96IW2.
OMAiAYREQKN.
OrthoDBiEOG793B9C.
PhylomeDBiQ96IW2.
TreeFamiTF325799.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96IW2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKWLRDYLS FGGRRPPPQP PTPDYTESDI LRAYRAQKNL DFEDPYEDAE
60 70 80 90 100
SRLEPDPAGP GDSKNPGDAK YGSPKHRLIK VEAADMARAK ALLGGPGEEL
110 120 130 140 150
EADTEYLDPF DAQPHPAPPD DGYMEPYDAQ WVMSELPGRG VQLYDTPYEE
160 170 180 190 200
QDPETADGPP SGQKPRQSRM PQEDERPADE YDQPWEWKKD HISRAFAVQF
210 220 230 240 250
DSPEWERTPG SAKELRRPPP RSPQPAERVD PALPLEKQPW FHGPLNRADA
260 270 280 290 300
ESLLSLCKEG SYLVRLSETN PQDCSLSLRS SQGFLHLKFA RTRENQVVLG
310 320 330 340
QHSGPFPSVP ELVLHYSSRP LPVQGAEHLA LLYPVVTQTP
Length:340
Mass (Da):38,264
Last modified:December 1, 2001 - v1
Checksum:i115EB4062BCA7105
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti170 – 1701M → V in BAB70981. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti138 – 1381G → S.
Corresponds to variant rs2287714 [ dbSNP | Ensembl ].
VAR_027043
Natural varianti270 – 2701N → S.1 Publication
Corresponds to variant rs888930 [ dbSNP | Ensembl ].
VAR_027044

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055673 mRNA. Translation: BAB70981.1.
BC007206 mRNA. Translation: AAH07206.1.
CCDSiCCDS12125.1.
RefSeqiNP_064594.3. NM_020209.3.
UniGeneiHs.7423.

Genome annotation databases

EnsembliENST00000543264; ENSP00000446058; ENSG00000105251.
GeneIDi56961.
KEGGihsa:56961.
UCSCiuc002lzw.2. human.

Polymorphism databases

DMDMi74751948.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055673 mRNA. Translation: BAB70981.1.
BC007206 mRNA. Translation: AAH07206.1.
CCDSiCCDS12125.1.
RefSeqiNP_064594.3. NM_020209.3.
UniGeneiHs.7423.

3D structure databases

ProteinModelPortaliQ96IW2.
SMRiQ96IW2. Positions 235-318.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121283. 2 interactions.
IntActiQ96IW2. 1 interaction.
STRINGi9606.ENSP00000221852.

PTM databases

PhosphoSiteiQ96IW2.

Polymorphism databases

DMDMi74751948.

Proteomic databases

PaxDbiQ96IW2.
PRIDEiQ96IW2.

Protocols and materials databases

DNASUi56961.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000543264; ENSP00000446058; ENSG00000105251.
GeneIDi56961.
KEGGihsa:56961.
UCSCiuc002lzw.2. human.

Organism-specific databases

CTDi56961.
GeneCardsiGC19P004278.
HGNCiHGNC:30633. SHD.
HPAiHPA017955.
MIMi610481. gene.
neXtProtiNX_Q96IW2.
PharmGKBiPA142670918.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG80632.
GeneTreeiENSGT00390000015203.
HOGENOMiHOG000038038.
HOVERGENiHBG066172.
InParanoidiQ96IW2.
OMAiAYREQKN.
OrthoDBiEOG793B9C.
PhylomeDBiQ96IW2.
TreeFamiTF325799.

Enzyme and pathway databases

SignaLinkiQ96IW2.

Miscellaneous databases

ChiTaRSiSHD. human.
GenomeRNAii56961.
NextBioi62591.
PROiQ96IW2.
SOURCEiSearch...

Gene expression databases

BgeeiQ96IW2.
CleanExiHS_SHD.
ExpressionAtlasiQ96IW2. baseline and differential.
GenevestigatoriQ96IW2.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-270.
    Tissue: Neuroblastoma.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Neuroblastoma.

Entry informationi

Entry nameiSHD_HUMAN
AccessioniPrimary (citable) accession number: Q96IW2
Secondary accession number(s): Q96NC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: December 1, 2001
Last modified: February 4, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.