Reviewed, UniProtKB/Swiss-Prot Q96IW2 (SHD_HUMAN)

Names and origin

Protein names

Recommended name:
    SH2 domain-containing adapter protein D

Gene names

Name:

SHD

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	340 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May function as an adapter protein By similarity.
Post-translational modification	Tyrosine phosphorylated by ABL By similarity.
Sequence similarities	Contains 1 SH2 domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	SH2 domain
PTM	Phosphoprotein
Gene Ontology (GO)
Molecular function	protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 340	340	SH2 domain-containing adapter protein D		PRO_0000246773
Regions
	Domain	240 – 335	96	SH2
Natural variations
	Natural variant	138	1	G → S: dbSNP rs2287714.		VAR_027043
	Natural variant	270	1	N → S: dbSNP rs888930.		VAR_027044
Experimental info
	Sequence conflict	170	1	M → V in BAB70981. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q96IW2-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 115EB4062BCA7105	FASTA	340	38,264
	10 20 30 40 50 60 MAKWLRDYLS FGGRRPPPQP PTPDYTESDI LRAYRAQKNL DFEDPYEDAE SRLEPDPAGP 70 80 90 100 110 120 GDSKNPGDAK YGSPKHRLIK VEAADMARAK ALLGGPGEEL EADTEYLDPF DAQPHPAPPD 130 140 150 160 170 180 DGYMEPYDAQ WVMSELPGRG VQLYDTPYEE QDPETADGPP SGQKPRQSRM PQEDERPADE 190 200 210 220 230 240 YDQPWEWKKD HISRAFAVQF DSPEWERTPG SAKELRRPPP RSPQPAERVD PALPLEKQPW 250 260 270 280 290 300 FHGPLNRADA ESLLSLCKEG SYLVRLSETN PQDCSLSLRS SQGFLHLKFA RTRENQVVLG 310 320 330 340 QHSGPFPSVP ELVLHYSSRP LPVQGAEHLA LLYPVVTQTP

References

[1]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-270. Tissue: Neuroblastoma.

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Neuroblastoma.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK055673 mRNA. Translation: BAB70981.1. BC007206 mRNA. Translation: AAH07206.1.
RefSeq	NP_064594.2.
UniGene	Hs.7423
3D structure databases
HSSP	HSSP built from PDB template 1AB2 based on UniProtKB P00519.
ModBase	Search...
PTM databases
PhosphoSite	Q96IW2.
Genome annotation databases
Ensembl	ENSG00000105251. Homo sapiens. [Contig view]
GeneID	56961.
KEGG	hsa:56961.
Organism-specific databases
HGNC	HGNC:30633. SHD.
HPA	HPA017955.
MIM	610481. gene.
PharmGKB	PA142670918.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q96IW2.
HOVERGEN	Q96IW2.
Gene expression databases
ArrayExpress	Q96IW2.
CleanEx	HS_SHD.
GermOnline	ENSG00000105251. Homo sapiens.
Family and domain databases
InterPro	IPR000980. SH2. [Graphical view]
Gene3D	G3DSA:3.30.505.10. SH2. 1 hit.
Pfam	PF00017. SH2. 1 hit. [Graphical view]
PRINTS	PR00401. SH2DOMAIN.
ProDom	PD000093. SH2. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00252. SH2. 1 hit. [Graphical view]
PROSITE	PS50001. SH2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	62591.
SOURCE	Search...

Entry information

Entry name

SHD_HUMAN

Accession

Primary (citable) accession number: Q96IW2
Secondary accession number(s): Q96NC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	December 1, 2001
Last modified:	November 25, 2008
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)