Reviewed,
UniProtKB/Swiss-Prot Q96IW2 (SHD_HUMAN)
Last modified
November 25, 2008.
Version 42.
History...
Clusters with 100%,
90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: SH2 domain-containing adapter protein D | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 340 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | May function as an adapter protein By similarity. |
| Post-translational modification | Tyrosine phosphorylated by ABL By similarity. |
| Sequence similarities | Contains 1 SH2 domain. |
Ontologies
Keywords | |
|---|---|
| Coding sequence diversity | Polymorphism |
| Domain | SH2 domain |
| PTM | Phosphoprotein |
Gene Ontology (GO) | |
| Molecular function | protein binding Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 340 | 340 | SH2 domain-containing adapter protein D | PRO_0000246773 | |||||
Regions | |||||||||
| Domain | 240 – 335 | 96 | SH2 | ||||||
Natural variations | |||||||||
| Natural variant | 138 | 1 | G → S: dbSNP rs2287714. | VAR_027043 | |||||
| Natural variant | 270 | 1 | N → S: dbSNP rs888930. | VAR_027044 | |||||
Experimental info | |||||||||
| Sequence conflict | 170 | 1 | M → V in BAB70981. Ref.1 | ||||||
Sequences
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References
| [1] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-270. Tissue: Neuroblastoma. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Neuroblastoma. |
Cross-references
Sequence databases | |
|---|---|
| AK055673 mRNA. Translation: BAB70981.1. BC007206 mRNA. Translation: AAH07206.1. | |
| RefSeq | NP_064594.2. |
| UniGene | Hs.7423 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1AB2 based on UniProtKB P00519. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q96IW2. |
Genome annotation databases | |
| Ensembl | ENSG00000105251. Homo sapiens. [Contig view] |
| GeneID | 56961. |
| KEGG | hsa:56961. |
Organism-specific databases | |
| HGNC | HGNC:30633. SHD. |
| HPA | HPA017955. |
| MIM | 610481. gene. |
| PharmGKB | PA142670918. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | Q96IW2. |
| HOVERGEN | Q96IW2. |
Gene expression databases | |
| ArrayExpress | Q96IW2. |
| CleanEx | HS_SHD. |
| GermOnline | ENSG00000105251. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000980. SH2. [Graphical view] |
| Gene3D | G3DSA:3.30.505.10. SH2. 1 hit. |
| Pfam | PF00017. SH2. 1 hit. [Graphical view] |
| PRINTS | PR00401. SH2DOMAIN. |
| ProDom | PD000093. SH2. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00252. SH2. 1 hit. [Graphical view] |
| PROSITE | PS50001. SH2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 62591. |
| SOURCE | Search... |
Entry information
| Entry name | SHD_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q96IW2 Secondary accession number(s): Q96NC2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 19 Human chromosome 19: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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