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Q96IW2

- SHD_HUMAN

UniProt

Q96IW2 - SHD_HUMAN

Protein

SH2 domain-containing adapter protein D

Gene

SHD

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    May function as an adapter protein.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Enzyme and pathway databases

    SignaLinkiQ96IW2.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SH2 domain-containing adapter protein D
    Gene namesi
    Name:SHD
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:30633. SHD.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670918.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 340340SH2 domain-containing adapter protein DPRO_0000246773Add
    BLAST

    Post-translational modificationi

    Tyrosine phosphorylated by ABL.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ96IW2.
    PRIDEiQ96IW2.

    PTM databases

    PhosphoSiteiQ96IW2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96IW2.
    BgeeiQ96IW2.
    CleanExiHS_SHD.
    GenevestigatoriQ96IW2.

    Organism-specific databases

    HPAiHPA017955.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    METP085812EBI-4402781,EBI-1039152

    Protein-protein interaction databases

    BioGridi121283. 2 interactions.
    IntActiQ96IW2. 1 interaction.
    STRINGi9606.ENSP00000221852.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96IW2.
    SMRiQ96IW2. Positions 235-318.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini240 – 33596SH2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Phylogenomic databases

    eggNOGiNOG80632.
    HOGENOMiHOG000038038.
    HOVERGENiHBG066172.
    InParanoidiQ96IW2.
    OMAiAYREQKN.
    OrthoDBiEOG793B9C.
    PhylomeDBiQ96IW2.
    TreeFamiTF325799.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR000980. SH2.
    [Graphical view]
    PfamiPF00017. SH2. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    SMARTiSM00252. SH2. 1 hit.
    [Graphical view]
    SUPFAMiSSF55550. SSF55550. 1 hit.
    PROSITEiPS50001. SH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96IW2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKWLRDYLS FGGRRPPPQP PTPDYTESDI LRAYRAQKNL DFEDPYEDAE    50
    SRLEPDPAGP GDSKNPGDAK YGSPKHRLIK VEAADMARAK ALLGGPGEEL 100
    EADTEYLDPF DAQPHPAPPD DGYMEPYDAQ WVMSELPGRG VQLYDTPYEE 150
    QDPETADGPP SGQKPRQSRM PQEDERPADE YDQPWEWKKD HISRAFAVQF 200
    DSPEWERTPG SAKELRRPPP RSPQPAERVD PALPLEKQPW FHGPLNRADA 250
    ESLLSLCKEG SYLVRLSETN PQDCSLSLRS SQGFLHLKFA RTRENQVVLG 300
    QHSGPFPSVP ELVLHYSSRP LPVQGAEHLA LLYPVVTQTP 340
    Length:340
    Mass (Da):38,264
    Last modified:December 1, 2001 - v1
    Checksum:i115EB4062BCA7105
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti170 – 1701M → V in BAB70981. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti138 – 1381G → S.
    Corresponds to variant rs2287714 [ dbSNP | Ensembl ].
    VAR_027043
    Natural varianti270 – 2701N → S.1 Publication
    Corresponds to variant rs888930 [ dbSNP | Ensembl ].
    VAR_027044

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK055673 mRNA. Translation: BAB70981.1.
    BC007206 mRNA. Translation: AAH07206.1.
    CCDSiCCDS12125.1.
    RefSeqiNP_064594.3. NM_020209.3.
    UniGeneiHs.7423.

    Genome annotation databases

    EnsembliENST00000543264; ENSP00000446058; ENSG00000105251.
    GeneIDi56961.
    KEGGihsa:56961.
    UCSCiuc002lzw.2. human.

    Polymorphism databases

    DMDMi74751948.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK055673 mRNA. Translation: BAB70981.1 .
    BC007206 mRNA. Translation: AAH07206.1 .
    CCDSi CCDS12125.1.
    RefSeqi NP_064594.3. NM_020209.3.
    UniGenei Hs.7423.

    3D structure databases

    ProteinModelPortali Q96IW2.
    SMRi Q96IW2. Positions 235-318.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121283. 2 interactions.
    IntActi Q96IW2. 1 interaction.
    STRINGi 9606.ENSP00000221852.

    PTM databases

    PhosphoSitei Q96IW2.

    Polymorphism databases

    DMDMi 74751948.

    Proteomic databases

    PaxDbi Q96IW2.
    PRIDEi Q96IW2.

    Protocols and materials databases

    DNASUi 56961.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000543264 ; ENSP00000446058 ; ENSG00000105251 .
    GeneIDi 56961.
    KEGGi hsa:56961.
    UCSCi uc002lzw.2. human.

    Organism-specific databases

    CTDi 56961.
    GeneCardsi GC19P004278.
    HGNCi HGNC:30633. SHD.
    HPAi HPA017955.
    MIMi 610481. gene.
    neXtProti NX_Q96IW2.
    PharmGKBi PA142670918.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG80632.
    HOGENOMi HOG000038038.
    HOVERGENi HBG066172.
    InParanoidi Q96IW2.
    OMAi AYREQKN.
    OrthoDBi EOG793B9C.
    PhylomeDBi Q96IW2.
    TreeFami TF325799.

    Enzyme and pathway databases

    SignaLinki Q96IW2.

    Miscellaneous databases

    ChiTaRSi SHD. human.
    GenomeRNAii 56961.
    NextBioi 62591.
    PROi Q96IW2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96IW2.
    Bgeei Q96IW2.
    CleanExi HS_SHD.
    Genevestigatori Q96IW2.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR000980. SH2.
    [Graphical view ]
    Pfami PF00017. SH2. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    SMARTi SM00252. SH2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55550. SSF55550. 1 hit.
    PROSITEi PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-270.
      Tissue: Neuroblastoma.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Neuroblastoma.

    Entry informationi

    Entry nameiSHD_HUMAN
    AccessioniPrimary (citable) accession number: Q96IW2
    Secondary accession number(s): Q96NC2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3