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Q96IW2 (SHD_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SH2 domain-containing adapter protein D
Gene names
Name:SHD
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May function as an adapter protein By similarity.

Post-translational modification

Tyrosine phosphorylated by ABL By similarity.

Sequence similarities

Contains 1 SH2 domain.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainSH2 domain
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 340340SH2 domain-containing adapter protein D
PRO_0000246773

Regions

Domain240 – 33596SH2

Natural variations

Natural variant1381G → S.
Corresponds to variant rs2287714 [ dbSNP | Ensembl ].
VAR_027043
Natural variant2701N → S. Ref.1
Corresponds to variant rs888930 [ dbSNP | Ensembl ].
VAR_027044

Experimental info

Sequence conflict1701M → V in BAB70981. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q96IW2 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 115EB4062BCA7105

FASTA34038,264
        10         20         30         40         50         60 
MAKWLRDYLS FGGRRPPPQP PTPDYTESDI LRAYRAQKNL DFEDPYEDAE SRLEPDPAGP 

        70         80         90        100        110        120 
GDSKNPGDAK YGSPKHRLIK VEAADMARAK ALLGGPGEEL EADTEYLDPF DAQPHPAPPD 

       130        140        150        160        170        180 
DGYMEPYDAQ WVMSELPGRG VQLYDTPYEE QDPETADGPP SGQKPRQSRM PQEDERPADE 

       190        200        210        220        230        240 
YDQPWEWKKD HISRAFAVQF DSPEWERTPG SAKELRRPPP RSPQPAERVD PALPLEKQPW 

       250        260        270        280        290        300 
FHGPLNRADA ESLLSLCKEG SYLVRLSETN PQDCSLSLRS SQGFLHLKFA RTRENQVVLG 

       310        320        330        340 
QHSGPFPSVP ELVLHYSSRP LPVQGAEHLA LLYPVVTQTP 

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-270.
Tissue: Neuroblastoma.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Neuroblastoma.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK055673 mRNA. Translation: BAB70981.1.
BC007206 mRNA. Translation: AAH07206.1.
RefSeqNP_064594.3. NM_020209.3.
UniGeneHs.7423.

3D structure databases

ProteinModelPortalQ96IW2.
SMRQ96IW2. Positions 235-318.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121283. 2 interactions.
STRING9606.ENSP00000221852.

PTM databases

PhosphoSiteQ96IW2.

Polymorphism databases

DMDM74751948.

Proteomic databases

PaxDbQ96IW2.
PRIDEQ96IW2.

Protocols and materials databases

DNASU56961.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000543264; ENSP00000446058; ENSG00000105251.
GeneID56961.
KEGGhsa:56961.
UCSCuc002lzw.2. human.

Organism-specific databases

CTD56961.
GeneCardsGC19P004278.
HGNCHGNC:30633. SHD.
HPAHPA017955.
MIM610481. gene.
neXtProtNX_Q96IW2.
PharmGKBPA142670918.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG80632.
HOGENOMHOG000038038.
HOVERGENHBG066172.
InParanoidQ96IW2.
OMAAYREQKN.
OrthoDBEOG793B9C.
PhylomeDBQ96IW2.
TreeFamTF325799.

Enzyme and pathway databases

SignaLinkQ96IW2.

Gene expression databases

ArrayExpressQ96IW2.
BgeeQ96IW2.
CleanExHS_SHD.
GenevestigatorQ96IW2.

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR000980. SH2.
[Graphical view]
PfamPF00017. SH2. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
SMARTSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMSSF55550. SSF55550. 1 hit.
PROSITEPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSHD. human.
GenomeRNAi56961.
NextBio62591.
PROQ96IW2.
SOURCESearch...

Entry information

Entry nameSHD_HUMAN
AccessionPrimary (citable) accession number: Q96IW2
Secondary accession number(s): Q96NC2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM