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Q96IV6 (FXDC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fatty acid hydroxylase domain-containing protein 2
Gene names
Name:FAXDC2
Synonyms:C5orf4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length333 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the sterol desaturase family.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processfatty acid biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioniron ion binding

Inferred from electronic annotation. Source: InterPro

oxidoreductase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 333333Fatty acid hydroxylase domain-containing protein 2
PRO_0000249848

Regions

Transmembrane29 – 4921Helical; Potential
Transmembrane77 – 9721Helical; Potential
Transmembrane134 – 15421Helical; Potential
Transmembrane168 – 18821Helical; Potential
Transmembrane215 – 23521Helical; Potential

Natural variations

Natural variant1331R → H.
Corresponds to variant rs17641488 [ dbSNP | Ensembl ].
VAR_048900

Sequences

Sequence LengthMass (Da)Tools
Q96IV6 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 48914C18C2D92CE3

FASTA33339,002
        10         20         30         40         50         60 
MKGEAGHMLH NEKSKQEGHI WGSMRRTAFI LGSGLLSFVA FWNSVTWHLQ RFWGASGYFW 

        70         80         90        100        110        120 
QAQWERLLTT FEGKEWILFF IGAIQVPCLF FWSFNGLLLV VDTTGKPNFI SRYRIQVGKN 

       130        140        150        160        170        180 
EPVDPVKLRQ SIRTVLFNQC MISFPMVVFL YPFLKWWRDP CRRELPTFHW FLLELAIFTL 

       190        200        210        220        230        240 
IEEVLFYYSH RLLHHPTFYK KIHKKHHEWT APIGVISLYA HPIEHAVSNM LPVIVGPLVM 

       250        260        270        280        290        300 
GSHLSSITMW FSLALIITTI SHCGYHLPFL PSPEFHDYHH LKFNQCYGVL GVLDHLHGTD 

       310        320        330 
TMFKQTKAYE RHVLLLGFTP LSESIPDSPK RME 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary and Skin.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-191.
Tissue: Placenta.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC004506 mRNA. Translation: AAH04506.2.
BC007216 mRNA. Translation: AAH07216.1.
AK023820 mRNA. No translation available.
RefSeqNP_115761.2. NM_032385.3.
UniGeneHs.519694.
Hs.713175.

3D structure databases

ProteinModelPortalQ96IV6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000320604.

PTM databases

PhosphoSiteQ96IV6.

Polymorphism databases

DMDM74751947.

Proteomic databases

PaxDbQ96IV6.
PRIDEQ96IV6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000326080; ENSP00000320604; ENSG00000170271.
GeneID10826.
KEGGhsa:10826.
UCSCuc003lvs.4. human.

Organism-specific databases

CTD10826.
GeneCardsGC05M154198.
H-InvDBHIX0005345.
HGNCHGNC:1334. FAXDC2.
HPAHPA014775.
neXtProtNX_Q96IV6.
PharmGKBPA25915.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG3000.
HOGENOMHOG000038020.
HOVERGENHBG067085.
InParanoidQ96IV6.
KOK07750.
OMAKAYERHV.
OrthoDBEOG73Z2TF.
PhylomeDBQ96IV6.
TreeFamTF313020.

Gene expression databases

ArrayExpressQ96IV6.
BgeeQ96IV6.
CleanExHS_C5orf4.
GenevestigatorQ96IV6.

Family and domain databases

InterProIPR006694. Fatty_acid_hydroxylase.
[Graphical view]
PfamPF04116. FA_hydroxylase. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi10826.
NextBio41120.

Entry information

Entry nameFXDC2_HUMAN
AccessionPrimary (citable) accession number: Q96IV6
Secondary accession number(s): Q9BSX6, Q9H8C7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: December 1, 2001
Last modified: February 19, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM