Q96IV6 (FXDC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fatty acid hydroxylase domain-containing protein 2

Gene names

Name:	FAXDC2
Synonyms:	C5orf4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	333 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the sterol desaturase family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	fatty acid biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	iron ion binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 333	333	Fatty acid hydroxylase domain-containing protein 2		PRO_0000249848
Regions
	Transmembrane	29 – 49	21	Helical; Potential
	Transmembrane	77 – 97	21	Helical; Potential
	Transmembrane	134 – 154	21	Helical; Potential
	Transmembrane	168 – 188	21	Helical; Potential
	Transmembrane	215 – 235	21	Helical; Potential
Natural variations
	Natural variant	133	1	R → H. Corresponds to variant rs17641488 [ dbSNP | Ensembl ].		VAR_048900

Sequences

	Sequence		Length	Mass (Da)
	Q96IV6 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 48914C18C2D92CE3	FASTA	333	39,002
	10 20 30 40 50 60 MKGEAGHMLH NEKSKQEGHI WGSMRRTAFI LGSGLLSFVA FWNSVTWHLQ RFWGASGYFW 70 80 90 100 110 120 QAQWERLLTT FEGKEWILFF IGAIQVPCLF FWSFNGLLLV VDTTGKPNFI SRYRIQVGKN 130 140 150 160 170 180 EPVDPVKLRQ SIRTVLFNQC MISFPMVVFL YPFLKWWRDP CRRELPTFHW FLLELAIFTL 190 200 210 220 230 240 IEEVLFYYSH RLLHHPTFYK KIHKKHHEWT APIGVISLYA HPIEHAVSNM LPVIVGPLVM 250 260 270 280 290 300 GSHLSSITMW FSLALIITTI SHCGYHLPFL PSPEFHDYHH LKFNQCYGVL GVLDHLHGTD 310 320 330 TMFKQTKAYE RHVLLLGFTP LSESIPDSPK RME

References

[1]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary and Skin.

[2]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-191. Tissue: Placenta.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC004506 mRNA. Translation: AAH04506.2. BC007216 mRNA. Translation: AAH07216.1. AK023820 mRNA. No translation available.
IPI	IPI00063851.
RefSeq	NP_115761.2. NM_032385.3.
UniGene	Hs.519694. Hs.713175.
3D structure databases
ProteinModelPortal	Q96IV6.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000320604.
PTM databases
PhosphoSite	Q96IV6.
Polymorphism databases
DMDM	74751947.
Proteomic databases
PaxDb	Q96IV6.
PRIDE	Q96IV6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000326080; ENSP00000320604; ENSG00000170271.
GeneID	10826.
KEGG	hsa:10826.
UCSC	uc003lvs.4. human.
Organism-specific databases
CTD	10826.
GeneCards	GC05M154178.
H-InvDB	HIX0005345.
HGNC	HGNC:1334. FAXDC2.
HPA	HPA014775.
neXtProt	NX_Q96IV6.
PharmGKB	PA25915.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG3000.
HOGENOM	HOG000038020.
HOVERGEN	HBG067085.
InParanoid	Q96IV6.
KO	K07750.
OMA	LSSITMW.
PhylomeDB	Q96IV6.
Gene expression databases
ArrayExpress	Q96IV6.
Bgee	Q96IV6.
CleanEx	HS_C5orf4.
Genevestigator	Q96IV6.
GermOnline	ENSG00000170271. Homo sapiens.
Family and domain databases
InterPro	IPR006694. Fatty_acid_hydroxylase. [Graphical view]
Pfam	PF04116. FA_hydroxylase. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	10826.
NextBio	41120.

Entry information

Entry name

FXDC2_HUMAN

Accession

Primary (citable) accession number: Q96IV6
Secondary accession number(s): Q9BSX6, Q9H8C7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2006
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.