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Q96IV6

- FXDC2_HUMAN

UniProt

Q96IV6 - FXDC2_HUMAN

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Protein
Fatty acid hydroxylase domain-containing protein 2
Gene
FAXDC2, C5orf4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. oxidoreductase activity Source: InterPro

GO - Biological processi

  1. fatty acid biosynthetic process Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid hydroxylase domain-containing protein 2
Gene namesi
Name:FAXDC2
Synonyms:C5orf4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:1334. FAXDC2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei29 – 4921Helical; Reviewed prediction
Add
BLAST
Transmembranei77 – 9721Helical; Reviewed prediction
Add
BLAST
Transmembranei134 – 15421Helical; Reviewed prediction
Add
BLAST
Transmembranei168 – 18821Helical; Reviewed prediction
Add
BLAST
Transmembranei215 – 23521Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25915.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 333333Fatty acid hydroxylase domain-containing protein 2
PRO_0000249848Add
BLAST

Proteomic databases

PaxDbiQ96IV6.
PRIDEiQ96IV6.

PTM databases

PhosphoSiteiQ96IV6.

Expressioni

Gene expression databases

ArrayExpressiQ96IV6.
BgeeiQ96IV6.
CleanExiHS_C5orf4.
GenevestigatoriQ96IV6.

Organism-specific databases

HPAiHPA014775.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000320604.

Structurei

3D structure databases

ProteinModelPortaliQ96IV6.

Family & Domainsi

Sequence similaritiesi

Belongs to the sterol desaturase family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG3000.
HOGENOMiHOG000038020.
HOVERGENiHBG067085.
InParanoidiQ96IV6.
KOiK07750.
OMAiKAYERHV.
OrthoDBiEOG73Z2TF.
PhylomeDBiQ96IV6.
TreeFamiTF313020.

Family and domain databases

InterProiIPR006694. Fatty_acid_hydroxylase.
[Graphical view]
PfamiPF04116. FA_hydroxylase. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96IV6-1 [UniParc]FASTAAdd to Basket

« Hide

MKGEAGHMLH NEKSKQEGHI WGSMRRTAFI LGSGLLSFVA FWNSVTWHLQ    50
RFWGASGYFW QAQWERLLTT FEGKEWILFF IGAIQVPCLF FWSFNGLLLV 100
VDTTGKPNFI SRYRIQVGKN EPVDPVKLRQ SIRTVLFNQC MISFPMVVFL 150
YPFLKWWRDP CRRELPTFHW FLLELAIFTL IEEVLFYYSH RLLHHPTFYK 200
KIHKKHHEWT APIGVISLYA HPIEHAVSNM LPVIVGPLVM GSHLSSITMW 250
FSLALIITTI SHCGYHLPFL PSPEFHDYHH LKFNQCYGVL GVLDHLHGTD 300
TMFKQTKAYE RHVLLLGFTP LSESIPDSPK RME 333
Length:333
Mass (Da):39,002
Last modified:December 1, 2001 - v1
Checksum:i48914C18C2D92CE3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti133 – 1331R → H.
Corresponds to variant rs17641488 [ dbSNP | Ensembl ].
VAR_048900

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC004506 mRNA. Translation: AAH04506.2.
BC007216 mRNA. Translation: AAH07216.1.
AK023820 mRNA. No translation available.
CCDSiCCDS43390.1.
RefSeqiNP_115761.2. NM_032385.3.
XP_006714816.1. XM_006714753.1.
UniGeneiHs.519694.
Hs.713175.

Genome annotation databases

EnsembliENST00000326080; ENSP00000320604; ENSG00000170271.
GeneIDi10826.
KEGGihsa:10826.
UCSCiuc003lvs.4. human.

Polymorphism databases

DMDMi74751947.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC004506 mRNA. Translation: AAH04506.2 .
BC007216 mRNA. Translation: AAH07216.1 .
AK023820 mRNA. No translation available.
CCDSi CCDS43390.1.
RefSeqi NP_115761.2. NM_032385.3.
XP_006714816.1. XM_006714753.1.
UniGenei Hs.519694.
Hs.713175.

3D structure databases

ProteinModelPortali Q96IV6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000320604.

PTM databases

PhosphoSitei Q96IV6.

Polymorphism databases

DMDMi 74751947.

Proteomic databases

PaxDbi Q96IV6.
PRIDEi Q96IV6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000326080 ; ENSP00000320604 ; ENSG00000170271 .
GeneIDi 10826.
KEGGi hsa:10826.
UCSCi uc003lvs.4. human.

Organism-specific databases

CTDi 10826.
GeneCardsi GC05M154198.
H-InvDB HIX0005345.
HGNCi HGNC:1334. FAXDC2.
HPAi HPA014775.
neXtProti NX_Q96IV6.
PharmGKBi PA25915.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG3000.
HOGENOMi HOG000038020.
HOVERGENi HBG067085.
InParanoidi Q96IV6.
KOi K07750.
OMAi KAYERHV.
OrthoDBi EOG73Z2TF.
PhylomeDBi Q96IV6.
TreeFami TF313020.

Miscellaneous databases

GenomeRNAii 10826.
NextBioi 41120.

Gene expression databases

ArrayExpressi Q96IV6.
Bgeei Q96IV6.
CleanExi HS_C5orf4.
Genevestigatori Q96IV6.

Family and domain databases

InterProi IPR006694. Fatty_acid_hydroxylase.
[Graphical view ]
Pfami PF04116. FA_hydroxylase. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary and Skin.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-191.
    Tissue: Placenta.

Entry informationi

Entry nameiFXDC2_HUMAN
AccessioniPrimary (citable) accession number: Q96IV6
Secondary accession number(s): Q9BSX6, Q9H8C7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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