Q96IU2 (ZBED3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger BED domain-containing protein 3

Alternative name(s):
Axin-interacting protein

Gene names

Name:

ZBED3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	234 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression By similarity.
Subunit structure	Interacts with AXIN1; the interaction is direct, enhanced by protein kinase GSK3B and casein kinase CSNK1E activities and decreases GSK3B-induced beta-catenin serine and threonine phosphorylations By similarity.
Subcellular location	Cytoplasm By similarity. Membrane By similarity. Note: Colocalizes with AXIN1 in the cytoplasm By similarity.
Sequence similarities	Contains 1 BED-type zinc finger.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Cytoplasm Membrane
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of protein phosphorylation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of canonical Wnt receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of transcription from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: UniProtKB protein stabilization Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cytosol Inferred from sequence or structural similarity. Source: UniProtKB membrane Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 234	234	Zinc finger BED domain-containing protein 3		PRO_0000066562
Regions
	Zinc finger	43 – 104	62	BED-type
	Compositional bias	142 – 202	61	Arg-rich

Sequences

	Sequence		Length	Mass (Da)
	Q96IU2 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 3E615F16B68EE3B2	FASTA	234	25,132
	10 20 30 40 50 60 MRSGEPACTM DQARGLDDAA ARGGQCPGLG PAPTPTPPGR LGAPYSEAWG YFHLAPGRPG 70 80 90 100 110 120 HPSGHWATCR LCGEQVGRGP GFHAGTSALW RHLRSAHRRE LESSGAGSSP PAAPCPPPPG 130 140 150 160 170 180 PAAAPEGDWA RLLEQMGALA VRGSRREREL ERRELAVEQG ERALERRRRA LQEEERAAAQ 190 200 210 220 230 ARRELQAERE ALQARLRDVS RREGALGWAP AAPPPLKDDP EGDRDGCVIT KVLL

References

[1]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[3]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC008581 Genomic DNA. No translation available. BC007239 mRNA. Translation: AAH07239.1.
IPI	IPI00063826.
RefSeq	NP_115743.1. NM_032367.2.
UniGene	Hs.584988.
3D structure databases
ProteinModelPortal	Q96IU2.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000255198.
PTM databases
PhosphoSite	Q96IU2.
Polymorphism databases
DMDM	34925646.
Proteomic databases
PaxDb	Q96IU2.
PRIDE	Q96IU2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000255198; ENSP00000255198; ENSG00000132846.
GeneID	84327.
KEGG	hsa:84327.
UCSC	uc003kev.1. human.
Organism-specific databases
CTD	84327.
GeneCards	GC05M076367.
HGNC	HGNC:20711. ZBED3.
neXtProt	NX_Q96IU2.
PharmGKB	PA134974972.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG236344.
HOGENOM	HOG000136530.
InParanoid	Q96IU2.
OMA	AAPEGDW.
OrthoDB	EOG48GW4P.
PhylomeDB	Q96IU2.
Gene expression databases
ArrayExpress	Q96IU2.
Bgee	Q96IU2.
CleanEx	HS_ZBED3.
Genevestigator	Q96IU2.
GermOnline	ENSG00000132846. Homo sapiens.
Family and domain databases
InterPro	IPR003656. Znf_BED_prd. [Graphical view]
Pfam	PF02892. zf-BED. 1 hit. [Graphical view]
SMART	SM00614. ZnF_BED. 1 hit. [Graphical view]
PROSITE	PS50808. ZF_BED. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	84327.
NextBio	74071.

Entry information

Entry name

ZBED3_HUMAN

Accession

Primary (citable) accession number: Q96IU2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2003
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.