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Protein

Zinc finger BED domain-containing protein 3

Gene

ZBED3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri43 – 104BED-typePROSITE-ProRule annotationAdd BLAST62

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processWnt signaling pathway
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger BED domain-containing protein 3
Alternative name(s):
Axin-interacting protein
Gene namesi
Name:ZBED3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000132846.5
HGNCiHGNC:20711 ZBED3
MIMi615250 gene
neXtProtiNX_Q96IU2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000132846
PharmGKBiPA134974972

Polymorphism and mutation databases

DMDMi34925646

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000665621 – 234Zinc finger BED domain-containing protein 3Add BLAST234

Proteomic databases

MaxQBiQ96IU2
PaxDbiQ96IU2
PeptideAtlasiQ96IU2
PRIDEiQ96IU2

PTM databases

iPTMnetiQ96IU2
PhosphoSitePlusiQ96IU2

Expressioni

Gene expression databases

BgeeiENSG00000132846
CleanExiHS_ZBED3
ExpressionAtlasiQ96IU2 baseline and differential
GenevisibleiQ96IU2 HS

Organism-specific databases

HPAiHPA055995

Interactioni

Subunit structurei

Interacts with AXIN1; the interaction is direct, enhanced by protein kinase GSK3B and casein kinase CSNK1E activities and decreases GSK3B-induced beta-catenin serine and threonine phosphorylations.By similarity

Protein-protein interaction databases

BioGridi124051, 3 interactors
IntActiQ96IU2, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ96IU2
SMRiQ96IU2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi142 – 202Arg-richAdd BLAST61

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri43 – 104BED-typePROSITE-ProRule annotationAdd BLAST62

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IXJY Eukaryota
ENOG41115R7 LUCA
GeneTreeiENSGT00390000013530
HOGENOMiHOG000136530
InParanoidiQ96IU2
OMAiAAPEGDW
OrthoDBiEOG091G0JGE
PhylomeDBiQ96IU2
TreeFamiTF338048

Family and domain databases

InterProiView protein in InterPro
IPR033546 ZBED3
IPR003656 Znf_BED
IPR036236 Znf_C2H2_sf
PANTHERiPTHR35827:SF2 PTHR35827:SF2, 1 hit
PfamiView protein in Pfam
PF02892 zf-BED, 1 hit
SMARTiView protein in SMART
SM00614 ZnF_BED, 1 hit
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50808 ZF_BED, 1 hit

Sequencei

Sequence statusi: Complete.

Q96IU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSGEPACTM DQARGLDDAA ARGGQCPGLG PAPTPTPPGR LGAPYSEAWG
60 70 80 90 100
YFHLAPGRPG HPSGHWATCR LCGEQVGRGP GFHAGTSALW RHLRSAHRRE
110 120 130 140 150
LESSGAGSSP PAAPCPPPPG PAAAPEGDWA RLLEQMGALA VRGSRREREL
160 170 180 190 200
ERRELAVEQG ERALERRRRA LQEEERAAAQ ARRELQAERE ALQARLRDVS
210 220 230
RREGALGWAP AAPPPLKDDP EGDRDGCVIT KVLL
Length:234
Mass (Da):25,132
Last modified:December 1, 2001 - v1
Checksum:i3E615F16B68EE3B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008581 Genomic DNA No translation available.
BC007239 mRNA Translation: AAH07239.1
CCDSiCCDS4036.1
RefSeqiNP_001316493.1, NM_001329564.1
NP_115743.1, NM_032367.3
UniGeneiHs.584988

Genome annotation databases

EnsembliENST00000255198; ENSP00000255198; ENSG00000132846
GeneIDi84327
KEGGihsa:84327
UCSCiuc003kev.2 human

Similar proteinsi

Entry informationi

Entry nameiZBED3_HUMAN
AccessioniPrimary (citable) accession number: Q96IU2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health