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Q96IU2

- ZBED3_HUMAN

UniProt

Q96IU2 - ZBED3_HUMAN

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Protein

Zinc finger BED domain-containing protein 3

Gene

ZBED3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri43 – 10462BED-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. negative regulation of protein phosphorylation Source: UniProtKB
  2. positive regulation of canonical Wnt signaling pathway Source: UniProtKB
  3. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  4. protein stabilization Source: UniProtKB
  5. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger BED domain-containing protein 3
Alternative name(s):
Axin-interacting protein
Gene namesi
Name:ZBED3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:20711. ZBED3.

Subcellular locationi

Cytoplasm By similarity. Membrane By similarity
Note: Colocalizes with AXIN1 in the cytoplasm.By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134974972.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 234234Zinc finger BED domain-containing protein 3PRO_0000066562Add
BLAST

Proteomic databases

MaxQBiQ96IU2.
PaxDbiQ96IU2.
PRIDEiQ96IU2.

PTM databases

PhosphoSiteiQ96IU2.

Expressioni

Gene expression databases

BgeeiQ96IU2.
CleanExiHS_ZBED3.
ExpressionAtlasiQ96IU2. baseline and differential.
GenevestigatoriQ96IU2.

Organism-specific databases

HPAiHPA055995.

Interactioni

Subunit structurei

Interacts with AXIN1; the interaction is direct, enhanced by protein kinase GSK3B and casein kinase CSNK1E activities and decreases GSK3B-induced beta-catenin serine and threonine phosphorylations.By similarity

Protein-protein interaction databases

BioGridi124051. 1 interaction.
STRINGi9606.ENSP00000255198.

Structurei

3D structure databases

ProteinModelPortaliQ96IU2.
SMRiQ96IU2. Positions 47-113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi142 – 20261Arg-richAdd
BLAST

Sequence similaritiesi

Contains 1 BED-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri43 – 10462BED-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG236344.
GeneTreeiENSGT00390000013530.
HOGENOMiHOG000136530.
InParanoidiQ96IU2.
OMAiAAPEGDW.
OrthoDBiEOG74TX16.
PhylomeDBiQ96IU2.
TreeFamiTF338048.

Family and domain databases

InterProiIPR003656. Znf_BED.
[Graphical view]
PfamiPF02892. zf-BED. 1 hit.
[Graphical view]
SMARTiSM00614. ZnF_BED. 1 hit.
[Graphical view]
PROSITEiPS50808. ZF_BED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96IU2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRSGEPACTM DQARGLDDAA ARGGQCPGLG PAPTPTPPGR LGAPYSEAWG
60 70 80 90 100
YFHLAPGRPG HPSGHWATCR LCGEQVGRGP GFHAGTSALW RHLRSAHRRE
110 120 130 140 150
LESSGAGSSP PAAPCPPPPG PAAAPEGDWA RLLEQMGALA VRGSRREREL
160 170 180 190 200
ERRELAVEQG ERALERRRRA LQEEERAAAQ ARRELQAERE ALQARLRDVS
210 220 230
RREGALGWAP AAPPPLKDDP EGDRDGCVIT KVLL
Length:234
Mass (Da):25,132
Last modified:December 1, 2001 - v1
Checksum:i3E615F16B68EE3B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008581 Genomic DNA. No translation available.
BC007239 mRNA. Translation: AAH07239.1.
CCDSiCCDS4036.1.
RefSeqiNP_115743.1. NM_032367.2.
UniGeneiHs.584988.

Genome annotation databases

EnsembliENST00000255198; ENSP00000255198; ENSG00000132846.
GeneIDi84327.
KEGGihsa:84327.
UCSCiuc003kev.1. human.

Polymorphism databases

DMDMi34925646.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008581 Genomic DNA. No translation available.
BC007239 mRNA. Translation: AAH07239.1 .
CCDSi CCDS4036.1.
RefSeqi NP_115743.1. NM_032367.2.
UniGenei Hs.584988.

3D structure databases

ProteinModelPortali Q96IU2.
SMRi Q96IU2. Positions 47-113.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124051. 1 interaction.
STRINGi 9606.ENSP00000255198.

PTM databases

PhosphoSitei Q96IU2.

Polymorphism databases

DMDMi 34925646.

Proteomic databases

MaxQBi Q96IU2.
PaxDbi Q96IU2.
PRIDEi Q96IU2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000255198 ; ENSP00000255198 ; ENSG00000132846 .
GeneIDi 84327.
KEGGi hsa:84327.
UCSCi uc003kev.1. human.

Organism-specific databases

CTDi 84327.
GeneCardsi GC05M076367.
HGNCi HGNC:20711. ZBED3.
HPAi HPA055995.
MIMi 615250. gene.
neXtProti NX_Q96IU2.
PharmGKBi PA134974972.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG236344.
GeneTreei ENSGT00390000013530.
HOGENOMi HOG000136530.
InParanoidi Q96IU2.
OMAi AAPEGDW.
OrthoDBi EOG74TX16.
PhylomeDBi Q96IU2.
TreeFami TF338048.

Miscellaneous databases

GenomeRNAii 84327.
NextBioi 74071.
PROi Q96IU2.
SOURCEi Search...

Gene expression databases

Bgeei Q96IU2.
CleanExi HS_ZBED3.
ExpressionAtlasi Q96IU2. baseline and differential.
Genevestigatori Q96IU2.

Family and domain databases

InterProi IPR003656. Znf_BED.
[Graphical view ]
Pfami PF02892. zf-BED. 1 hit.
[Graphical view ]
SMARTi SM00614. ZnF_BED. 1 hit.
[Graphical view ]
PROSITEi PS50808. ZF_BED. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  3. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiZBED3_HUMAN
AccessioniPrimary (citable) accession number: Q96IU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3