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Q96IU2

- ZBED3_HUMAN

UniProt

Q96IU2 - ZBED3_HUMAN

Protein

Zinc finger BED domain-containing protein 3

Gene

ZBED3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri43 – 10462BED-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. negative regulation of protein phosphorylation Source: UniProtKB
    2. positive regulation of canonical Wnt signaling pathway Source: UniProtKB
    3. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    4. protein stabilization Source: UniProtKB
    5. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Biological processi

    Wnt signaling pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger BED domain-containing protein 3
    Alternative name(s):
    Axin-interacting protein
    Gene namesi
    Name:ZBED3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:20711. ZBED3.

    Subcellular locationi

    Cytoplasm By similarity. Membrane By similarity
    Note: Colocalizes with AXIN1 in the cytoplasm.By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134974972.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 234234Zinc finger BED domain-containing protein 3PRO_0000066562Add
    BLAST

    Proteomic databases

    MaxQBiQ96IU2.
    PaxDbiQ96IU2.
    PRIDEiQ96IU2.

    PTM databases

    PhosphoSiteiQ96IU2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96IU2.
    BgeeiQ96IU2.
    CleanExiHS_ZBED3.
    GenevestigatoriQ96IU2.

    Organism-specific databases

    HPAiHPA055995.

    Interactioni

    Subunit structurei

    Interacts with AXIN1; the interaction is direct, enhanced by protein kinase GSK3B and casein kinase CSNK1E activities and decreases GSK3B-induced beta-catenin serine and threonine phosphorylations.By similarity

    Protein-protein interaction databases

    BioGridi124051. 1 interaction.
    STRINGi9606.ENSP00000255198.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96IU2.
    SMRiQ96IU2. Positions 47-113.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi142 – 20261Arg-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 BED-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri43 – 10462BED-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG236344.
    HOGENOMiHOG000136530.
    InParanoidiQ96IU2.
    OMAiAAPEGDW.
    OrthoDBiEOG74TX16.
    PhylomeDBiQ96IU2.
    TreeFamiTF338048.

    Family and domain databases

    InterProiIPR003656. Znf_BED_prd.
    [Graphical view]
    PfamiPF02892. zf-BED. 1 hit.
    [Graphical view]
    SMARTiSM00614. ZnF_BED. 1 hit.
    [Graphical view]
    PROSITEiPS50808. ZF_BED. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96IU2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRSGEPACTM DQARGLDDAA ARGGQCPGLG PAPTPTPPGR LGAPYSEAWG    50
    YFHLAPGRPG HPSGHWATCR LCGEQVGRGP GFHAGTSALW RHLRSAHRRE 100
    LESSGAGSSP PAAPCPPPPG PAAAPEGDWA RLLEQMGALA VRGSRREREL 150
    ERRELAVEQG ERALERRRRA LQEEERAAAQ ARRELQAERE ALQARLRDVS 200
    RREGALGWAP AAPPPLKDDP EGDRDGCVIT KVLL 234
    Length:234
    Mass (Da):25,132
    Last modified:December 1, 2001 - v1
    Checksum:i3E615F16B68EE3B2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC008581 Genomic DNA. No translation available.
    BC007239 mRNA. Translation: AAH07239.1.
    CCDSiCCDS4036.1.
    RefSeqiNP_115743.1. NM_032367.2.
    UniGeneiHs.584988.

    Genome annotation databases

    EnsembliENST00000255198; ENSP00000255198; ENSG00000132846.
    GeneIDi84327.
    KEGGihsa:84327.
    UCSCiuc003kev.1. human.

    Polymorphism databases

    DMDMi34925646.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC008581 Genomic DNA. No translation available.
    BC007239 mRNA. Translation: AAH07239.1 .
    CCDSi CCDS4036.1.
    RefSeqi NP_115743.1. NM_032367.2.
    UniGenei Hs.584988.

    3D structure databases

    ProteinModelPortali Q96IU2.
    SMRi Q96IU2. Positions 47-113.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124051. 1 interaction.
    STRINGi 9606.ENSP00000255198.

    PTM databases

    PhosphoSitei Q96IU2.

    Polymorphism databases

    DMDMi 34925646.

    Proteomic databases

    MaxQBi Q96IU2.
    PaxDbi Q96IU2.
    PRIDEi Q96IU2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000255198 ; ENSP00000255198 ; ENSG00000132846 .
    GeneIDi 84327.
    KEGGi hsa:84327.
    UCSCi uc003kev.1. human.

    Organism-specific databases

    CTDi 84327.
    GeneCardsi GC05M076367.
    HGNCi HGNC:20711. ZBED3.
    HPAi HPA055995.
    MIMi 615250. gene.
    neXtProti NX_Q96IU2.
    PharmGKBi PA134974972.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG236344.
    HOGENOMi HOG000136530.
    InParanoidi Q96IU2.
    OMAi AAPEGDW.
    OrthoDBi EOG74TX16.
    PhylomeDBi Q96IU2.
    TreeFami TF338048.

    Miscellaneous databases

    GenomeRNAii 84327.
    NextBioi 74071.
    PROi Q96IU2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96IU2.
    Bgeei Q96IU2.
    CleanExi HS_ZBED3.
    Genevestigatori Q96IU2.

    Family and domain databases

    InterProi IPR003656. Znf_BED_prd.
    [Graphical view ]
    Pfami PF02892. zf-BED. 1 hit.
    [Graphical view ]
    SMARTi SM00614. ZnF_BED. 1 hit.
    [Graphical view ]
    PROSITEi PS50808. ZF_BED. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.
    3. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiZBED3_HUMAN
    AccessioniPrimary (citable) accession number: Q96IU2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3