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Q96IU2 (ZBED3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger BED domain-containing protein 3
Alternative name(s):
Axin-interacting protein
Gene names
Name:ZBED3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length234 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression By similarity.

Subunit structure

Interacts with AXIN1; the interaction is direct, enhanced by protein kinase GSK3B and casein kinase CSNK1E activities and decreases GSK3B-induced beta-catenin serine and threonine phosphorylations By similarity.

Subcellular location

Cytoplasm By similarity. Membrane By similarity. Note: Colocalizes with AXIN1 in the cytoplasm By similarity.

Sequence similarities

Contains 1 BED-type zinc finger.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 234234Zinc finger BED domain-containing protein 3
PRO_0000066562

Regions

Zinc finger43 – 10462BED-type
Compositional bias142 – 20261Arg-rich

Sequences

Sequence LengthMass (Da)Tools
Q96IU2 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 3E615F16B68EE3B2

FASTA23425,132
        10         20         30         40         50         60 
MRSGEPACTM DQARGLDDAA ARGGQCPGLG PAPTPTPPGR LGAPYSEAWG YFHLAPGRPG 

        70         80         90        100        110        120 
HPSGHWATCR LCGEQVGRGP GFHAGTSALW RHLRSAHRRE LESSGAGSSP PAAPCPPPPG 

       130        140        150        160        170        180 
PAAAPEGDWA RLLEQMGALA VRGSRREREL ERRELAVEQG ERALERRRRA LQEEERAAAQ 

       190        200        210        220        230 
ARRELQAERE ALQARLRDVS RREGALGWAP AAPPPLKDDP EGDRDGCVIT KVLL 

« Hide

References

[1]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
[3]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC008581 Genomic DNA. No translation available.
BC007239 mRNA. Translation: AAH07239.1.
CCDSCCDS4036.1.
RefSeqNP_115743.1. NM_032367.2.
UniGeneHs.584988.

3D structure databases

ProteinModelPortalQ96IU2.
SMRQ96IU2. Positions 47-113.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124051. 1 interaction.
STRING9606.ENSP00000255198.

PTM databases

PhosphoSiteQ96IU2.

Polymorphism databases

DMDM34925646.

Proteomic databases

MaxQBQ96IU2.
PaxDbQ96IU2.
PRIDEQ96IU2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000255198; ENSP00000255198; ENSG00000132846.
GeneID84327.
KEGGhsa:84327.
UCSCuc003kev.1. human.

Organism-specific databases

CTD84327.
GeneCardsGC05M076367.
HGNCHGNC:20711. ZBED3.
HPAHPA055995.
MIM615250. gene.
neXtProtNX_Q96IU2.
PharmGKBPA134974972.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG236344.
HOGENOMHOG000136530.
InParanoidQ96IU2.
OMAAAPEGDW.
OrthoDBEOG74TX16.
PhylomeDBQ96IU2.
TreeFamTF338048.

Gene expression databases

ArrayExpressQ96IU2.
BgeeQ96IU2.
CleanExHS_ZBED3.
GenevestigatorQ96IU2.

Family and domain databases

InterProIPR003656. Znf_BED_prd.
[Graphical view]
PfamPF02892. zf-BED. 1 hit.
[Graphical view]
SMARTSM00614. ZnF_BED. 1 hit.
[Graphical view]
PROSITEPS50808. ZF_BED. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi84327.
NextBio74071.
PROQ96IU2.
SOURCESearch...

Entry information

Entry nameZBED3_HUMAN
AccessionPrimary (citable) accession number: Q96IU2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM