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Q96IR7

- HPDL_HUMAN

UniProt

Q96IR7 - HPDL_HUMAN

Protein

4-hydroxyphenylpyruvate dioxygenase-like protein

Gene

HPDL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    May have dioxygenase activity.Curated

    Cofactori

    Binds 1 iron ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi163 – 1631IronBy similarity
    Metal bindingi258 – 2581IronBy similarity
    Metal bindingi339 – 3391IronBy similarity

    GO - Molecular functioni

    1. 4-hydroxyphenylpyruvate dioxygenase activity Source: InterPro
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. aromatic amino acid family metabolic process Source: InterPro

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Ligandi

    Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-hydroxyphenylpyruvate dioxygenase-like protein (EC:1.13.-.-)
    Alternative name(s):
    Glyoxalase domain-containing protein 1
    Gene namesi
    Name:HPDL
    Synonyms:GLOXD1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:28242. HPDL.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162391595.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3713714-hydroxyphenylpyruvate dioxygenase-like proteinPRO_0000271119Add
    BLAST

    Proteomic databases

    MaxQBiQ96IR7.
    PaxDbiQ96IR7.
    PRIDEiQ96IR7.

    PTM databases

    PhosphoSiteiQ96IR7.

    Expressioni

    Gene expression databases

    BgeeiQ96IR7.
    CleanExiHS_HPDL.
    GenevestigatoriQ96IR7.

    Organism-specific databases

    HPAiHPA031997.

    Interactioni

    Protein-protein interaction databases

    BioGridi124294. 15 interactions.
    STRINGi9606.ENSP00000335060.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96IR7.
    SMRiQ96IR7. Positions 29-367.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the 4HPPD family.Curated

    Phylogenomic databases

    eggNOGiCOG3185.
    HOGENOMiHOG000231418.
    HOVERGENiHBG059537.
    InParanoidiQ96IR7.
    OMAiPSATNLC.
    OrthoDBiEOG7BS49H.
    PhylomeDBiQ96IR7.
    TreeFamiTF300622.

    Family and domain databases

    Gene3Di3.10.180.10. 2 hits.
    InterProiIPR005956. 4OHPhenylPyrv_dOase.
    IPR029068. Glyas_Bleomycin-R_OHBP_Dase.
    [Graphical view]
    PANTHERiPTHR11959. PTHR11959. 1 hit.
    PIRSFiPIRSF009283. HPP_dOase. 1 hit.
    SUPFAMiSSF54593. SSF54593. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q96IR7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAPALRLCH IAFHVPAGQP LARNLQRLFG FQPLASREVD GWRQLALRSG    50
    DAVFLVNEGA GSGEPLYGLD PRHAVPSATN LCFDVADAGA ATRELAALGC 100
    SVPVPPVRVR DAQGAATYAV VSSPAGILSL TLLERAGYRG PFLPGFRPVS 150
    SAPGPGWVSR VDHLTLACTP GSSPTLLRWF HDCLGFCHLP LSPGEDPELG 200
    LEMTAGFGLG GLRLTALQAQ PGSIVPTLVL AESLPGATTR QDQVEQFLAR 250
    HKGPGLQHVG LYTPNIVEAT EGVATAGGQF LAPPGAYYQQ PGKERQIRAA 300
    GHEPHLLARQ GILLDGDKGK FLLQVFTKSL FTEDTFFLEL IQRQGATGFG 350
    QGNIRALWQS VQEQSARSQE A 371
    Length:371
    Mass (Da):39,386
    Last modified:December 1, 2001 - v1
    Checksum:iC52721F188E43C38
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK313714 mRNA. Translation: BAG36457.1.
    AL359540 Genomic DNA. Translation: CAI21712.1.
    CH471059 Genomic DNA. Translation: EAX07002.1.
    BC007293 mRNA. Translation: AAH07293.1.
    CCDSiCCDS519.1.
    RefSeqiNP_116145.1. NM_032756.2.
    UniGeneiHs.162717.

    Genome annotation databases

    EnsembliENST00000334815; ENSP00000335060; ENSG00000186603.
    GeneIDi84842.
    KEGGihsa:84842.
    UCSCiuc001cne.3. human.

    Polymorphism databases

    DMDMi74751942.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK313714 mRNA. Translation: BAG36457.1 .
    AL359540 Genomic DNA. Translation: CAI21712.1 .
    CH471059 Genomic DNA. Translation: EAX07002.1 .
    BC007293 mRNA. Translation: AAH07293.1 .
    CCDSi CCDS519.1.
    RefSeqi NP_116145.1. NM_032756.2.
    UniGenei Hs.162717.

    3D structure databases

    ProteinModelPortali Q96IR7.
    SMRi Q96IR7. Positions 29-367.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124294. 15 interactions.
    STRINGi 9606.ENSP00000335060.

    PTM databases

    PhosphoSitei Q96IR7.

    Polymorphism databases

    DMDMi 74751942.

    Proteomic databases

    MaxQBi Q96IR7.
    PaxDbi Q96IR7.
    PRIDEi Q96IR7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000334815 ; ENSP00000335060 ; ENSG00000186603 .
    GeneIDi 84842.
    KEGGi hsa:84842.
    UCSCi uc001cne.3. human.

    Organism-specific databases

    CTDi 84842.
    GeneCardsi GC01P045792.
    H-InvDB HIX0000527.
    HGNCi HGNC:28242. HPDL.
    HPAi HPA031997.
    neXtProti NX_Q96IR7.
    PharmGKBi PA162391595.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG3185.
    HOGENOMi HOG000231418.
    HOVERGENi HBG059537.
    InParanoidi Q96IR7.
    OMAi PSATNLC.
    OrthoDBi EOG7BS49H.
    PhylomeDBi Q96IR7.
    TreeFami TF300622.

    Miscellaneous databases

    GenomeRNAii 84842.
    NextBioi 75074.
    PROi Q96IR7.

    Gene expression databases

    Bgeei Q96IR7.
    CleanExi HS_HPDL.
    Genevestigatori Q96IR7.

    Family and domain databases

    Gene3Di 3.10.180.10. 2 hits.
    InterProi IPR005956. 4OHPhenylPyrv_dOase.
    IPR029068. Glyas_Bleomycin-R_OHBP_Dase.
    [Graphical view ]
    PANTHERi PTHR11959. PTHR11959. 1 hit.
    PIRSFi PIRSF009283. HPP_dOase. 1 hit.
    SUPFAMi SSF54593. SSF54593. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiHPDL_HUMAN
    AccessioniPrimary (citable) accession number: Q96IR7
    Secondary accession number(s): B2R9B0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3