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Protein

4-hydroxyphenylpyruvate dioxygenase-like protein

Gene

HPDL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have dioxygenase activity.Curated

Cofactori

Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi163IronBy similarity1
Metal bindingi258IronBy similarity1
Metal bindingi339IronBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxyphenylpyruvate dioxygenase-like protein (EC:1.13.-.-)
Alternative name(s):
Glyoxalase domain-containing protein 1
Gene namesi
Name:HPDL
Synonyms:GLOXD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000186603.5
HGNCiHGNC:28242 HPDL
neXtProtiNX_Q96IR7

Pathology & Biotechi

Organism-specific databases

DisGeNETi84842
OpenTargetsiENSG00000186603
PharmGKBiPA162391595

Polymorphism and mutation databases

BioMutaiHPDL
DMDMi74751942

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002711191 – 3714-hydroxyphenylpyruvate dioxygenase-like proteinAdd BLAST371

Proteomic databases

EPDiQ96IR7
MaxQBiQ96IR7
PaxDbiQ96IR7
PeptideAtlasiQ96IR7
PRIDEiQ96IR7

PTM databases

iPTMnetiQ96IR7
PhosphoSitePlusiQ96IR7

Expressioni

Gene expression databases

BgeeiENSG00000186603
CleanExiHS_HPDL
GenevisibleiQ96IR7 HS

Organism-specific databases

HPAiHPA031997
HPA057346

Interactioni

Protein-protein interaction databases

BioGridi124294, 16 interactors
STRINGi9606.ENSP00000335060

Structurei

3D structure databases

ProteinModelPortaliQ96IR7
SMRiQ96IR7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 135VOC 1PROSITE-ProRule annotationAdd BLAST129
Domaini160 – 328VOC 2PROSITE-ProRule annotationAdd BLAST169

Sequence similaritiesi

Belongs to the 4HPPD family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0638 Eukaryota
COG3185 LUCA
GeneTreeiENSGT00530000063474
HOGENOMiHOG000231418
HOVERGENiHBG059537
InParanoidiQ96IR7
OMAiVFTKSLF
OrthoDBiEOG091G0BTD
PhylomeDBiQ96IR7
TreeFamiTF300622

Family and domain databases

Gene3Di3.10.180.10, 2 hits
InterProiView protein in InterPro
IPR005956 4OHPhenylPyrv_dOase
IPR029068 Glyas_Bleomycin-R_OHBP_Dase
IPR037523 VOC
PANTHERiPTHR11959 PTHR11959, 1 hit
PIRSFiPIRSF009283 HPP_dOase, 1 hit
SUPFAMiSSF54593 SSF54593, 1 hit
PROSITEiView protein in PROSITE
PS51819 VOC, 2 hits

Sequencei

Sequence statusi: Complete.

Q96IR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPALRLCH IAFHVPAGQP LARNLQRLFG FQPLASREVD GWRQLALRSG
60 70 80 90 100
DAVFLVNEGA GSGEPLYGLD PRHAVPSATN LCFDVADAGA ATRELAALGC
110 120 130 140 150
SVPVPPVRVR DAQGAATYAV VSSPAGILSL TLLERAGYRG PFLPGFRPVS
160 170 180 190 200
SAPGPGWVSR VDHLTLACTP GSSPTLLRWF HDCLGFCHLP LSPGEDPELG
210 220 230 240 250
LEMTAGFGLG GLRLTALQAQ PGSIVPTLVL AESLPGATTR QDQVEQFLAR
260 270 280 290 300
HKGPGLQHVG LYTPNIVEAT EGVATAGGQF LAPPGAYYQQ PGKERQIRAA
310 320 330 340 350
GHEPHLLARQ GILLDGDKGK FLLQVFTKSL FTEDTFFLEL IQRQGATGFG
360 370
QGNIRALWQS VQEQSARSQE A
Length:371
Mass (Da):39,386
Last modified:December 1, 2001 - v1
Checksum:iC52721F188E43C38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK313714 mRNA Translation: BAG36457.1
AL359540 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07002.1
BC007293 mRNA Translation: AAH07293.1
CCDSiCCDS519.1
RefSeqiNP_116145.1, NM_032756.2
UniGeneiHs.162717

Genome annotation databases

EnsembliENST00000334815; ENSP00000335060; ENSG00000186603
GeneIDi84842
KEGGihsa:84842
UCSCiuc001cne.4 human

Similar proteinsi

Entry informationi

Entry nameiHPDL_HUMAN
AccessioniPrimary (citable) accession number: Q96IR7
Secondary accession number(s): B2R9B0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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