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Protein

4-hydroxyphenylpyruvate dioxygenase-like protein

Gene

HPDL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May have dioxygenase activity.Curated

Cofactori

Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi163 – 1631IronBy similarity
Metal bindingi258 – 2581IronBy similarity
Metal bindingi339 – 3391IronBy similarity

GO - Molecular functioni

  1. 4-hydroxyphenylpyruvate dioxygenase activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. aromatic amino acid family metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxyphenylpyruvate dioxygenase-like protein (EC:1.13.-.-)
Alternative name(s):
Glyoxalase domain-containing protein 1
Gene namesi
Name:HPDL
Synonyms:GLOXD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:28242. HPDL.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162391595.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3713714-hydroxyphenylpyruvate dioxygenase-like proteinPRO_0000271119Add
BLAST

Proteomic databases

MaxQBiQ96IR7.
PaxDbiQ96IR7.
PRIDEiQ96IR7.

PTM databases

PhosphoSiteiQ96IR7.

Expressioni

Gene expression databases

BgeeiQ96IR7.
CleanExiHS_HPDL.
GenevestigatoriQ96IR7.

Organism-specific databases

HPAiHPA031997.

Interactioni

Protein-protein interaction databases

BioGridi124294. 15 interactions.
STRINGi9606.ENSP00000335060.

Structurei

3D structure databases

ProteinModelPortaliQ96IR7.
SMRiQ96IR7. Positions 29-367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 4HPPD family.Curated

Phylogenomic databases

eggNOGiCOG3185.
GeneTreeiENSGT00530000063474.
HOGENOMiHOG000231418.
HOVERGENiHBG059537.
InParanoidiQ96IR7.
OMAiPSATNLC.
OrthoDBiEOG7BS49H.
PhylomeDBiQ96IR7.
TreeFamiTF300622.

Family and domain databases

Gene3Di3.10.180.10. 2 hits.
InterProiIPR005956. 4OHPhenylPyrv_dOase.
IPR029068. Glyas_Bleomycin-R_OHBP_Dase.
[Graphical view]
PANTHERiPTHR11959. PTHR11959. 1 hit.
PIRSFiPIRSF009283. HPP_dOase. 1 hit.
SUPFAMiSSF54593. SSF54593. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96IR7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAPALRLCH IAFHVPAGQP LARNLQRLFG FQPLASREVD GWRQLALRSG
60 70 80 90 100
DAVFLVNEGA GSGEPLYGLD PRHAVPSATN LCFDVADAGA ATRELAALGC
110 120 130 140 150
SVPVPPVRVR DAQGAATYAV VSSPAGILSL TLLERAGYRG PFLPGFRPVS
160 170 180 190 200
SAPGPGWVSR VDHLTLACTP GSSPTLLRWF HDCLGFCHLP LSPGEDPELG
210 220 230 240 250
LEMTAGFGLG GLRLTALQAQ PGSIVPTLVL AESLPGATTR QDQVEQFLAR
260 270 280 290 300
HKGPGLQHVG LYTPNIVEAT EGVATAGGQF LAPPGAYYQQ PGKERQIRAA
310 320 330 340 350
GHEPHLLARQ GILLDGDKGK FLLQVFTKSL FTEDTFFLEL IQRQGATGFG
360 370
QGNIRALWQS VQEQSARSQE A
Length:371
Mass (Da):39,386
Last modified:December 1, 2001 - v1
Checksum:iC52721F188E43C38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK313714 mRNA. Translation: BAG36457.1.
AL359540 Genomic DNA. Translation: CAI21712.1.
CH471059 Genomic DNA. Translation: EAX07002.1.
BC007293 mRNA. Translation: AAH07293.1.
CCDSiCCDS519.1.
RefSeqiNP_116145.1. NM_032756.2.
UniGeneiHs.162717.

Genome annotation databases

EnsembliENST00000334815; ENSP00000335060; ENSG00000186603.
GeneIDi84842.
KEGGihsa:84842.
UCSCiuc001cne.3. human.

Polymorphism databases

DMDMi74751942.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK313714 mRNA. Translation: BAG36457.1.
AL359540 Genomic DNA. Translation: CAI21712.1.
CH471059 Genomic DNA. Translation: EAX07002.1.
BC007293 mRNA. Translation: AAH07293.1.
CCDSiCCDS519.1.
RefSeqiNP_116145.1. NM_032756.2.
UniGeneiHs.162717.

3D structure databases

ProteinModelPortaliQ96IR7.
SMRiQ96IR7. Positions 29-367.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124294. 15 interactions.
STRINGi9606.ENSP00000335060.

PTM databases

PhosphoSiteiQ96IR7.

Polymorphism databases

DMDMi74751942.

Proteomic databases

MaxQBiQ96IR7.
PaxDbiQ96IR7.
PRIDEiQ96IR7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334815; ENSP00000335060; ENSG00000186603.
GeneIDi84842.
KEGGihsa:84842.
UCSCiuc001cne.3. human.

Organism-specific databases

CTDi84842.
GeneCardsiGC01P045792.
H-InvDBHIX0000527.
HGNCiHGNC:28242. HPDL.
HPAiHPA031997.
neXtProtiNX_Q96IR7.
PharmGKBiPA162391595.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG3185.
GeneTreeiENSGT00530000063474.
HOGENOMiHOG000231418.
HOVERGENiHBG059537.
InParanoidiQ96IR7.
OMAiPSATNLC.
OrthoDBiEOG7BS49H.
PhylomeDBiQ96IR7.
TreeFamiTF300622.

Miscellaneous databases

GenomeRNAii84842.
NextBioi75074.
PROiQ96IR7.

Gene expression databases

BgeeiQ96IR7.
CleanExiHS_HPDL.
GenevestigatoriQ96IR7.

Family and domain databases

Gene3Di3.10.180.10. 2 hits.
InterProiIPR005956. 4OHPhenylPyrv_dOase.
IPR029068. Glyas_Bleomycin-R_OHBP_Dase.
[Graphical view]
PANTHERiPTHR11959. PTHR11959. 1 hit.
PIRSFiPIRSF009283. HPP_dOase. 1 hit.
SUPFAMiSSF54593. SSF54593. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHPDL_HUMAN
AccessioniPrimary (citable) accession number: Q96IR7
Secondary accession number(s): B2R9B0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 1, 2001
Last modified: January 7, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.