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Protein

Zinc finger protein 414

Gene

ZNF414

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri109 – 13325C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri145 – 16925C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri176 – 20126C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 414
Gene namesi
Name:ZNF414
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:20630. ZNF414.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670521.

Polymorphism and mutation databases

BioMutaiZNF414.
DMDMi125987870.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Zinc finger protein 414PRO_0000242163Add
BLAST

Proteomic databases

EPDiQ96IQ9.
MaxQBiQ96IQ9.
PaxDbiQ96IQ9.
PRIDEiQ96IQ9.

PTM databases

iPTMnetiQ96IQ9.

Expressioni

Gene expression databases

BgeeiQ96IQ9.
CleanExiHS_ZNF414.
ExpressionAtlasiQ96IQ9. baseline and differential.
GenevisibleiQ96IQ9. HS.

Organism-specific databases

HPAiHPA053769.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GOLGA2Q083793EBI-744257,EBI-618309
TERF2IPQ9NYB02EBI-744257,EBI-750109

Protein-protein interaction databases

BioGridi124054. 39 interactions.
IntActiQ96IQ9. 3 interactions.
MINTiMINT-1469011.
STRINGi9606.ENSP00000377504.

Structurei

3D structure databases

ProteinModelPortaliQ96IQ9.
SMRiQ96IQ9. Positions 110-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri109 – 13325C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri145 – 16925C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri176 – 20126C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00390000006876.
HOGENOMiHOG000015387.
HOVERGENiHBG083015.
InParanoidiQ96IQ9.
OMAiEGECPVF.
OrthoDBiEOG7NPFTS.
PhylomeDBiQ96IQ9.
TreeFamiTF337512.

Family and domain databases

InterProiIPR031799. Znf-C2H2_ribbon.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF15909. zf-C2H2_8. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96IQ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEKPSGPIP DMLATAEPSS SETDKEVLSP AVPAAAPSSS MSEEPGPEQA
60 70 80 90 100
ATPPVWERGG AGGMQQGSSP APDSCQPGPG PSPGLTSIVS GTSEDLRPPR
110 120 130 140 150
RRPPPGKQIP CSSPGCCLSF PSVRDLAQHL RTHCPPTQSL EGKLFRCSAL
160 170 180 190 200
SCTETFPSMQ ELVAHSKLHY KPNRYFKCEN CLLRFRTHRS LFKHLHVCAE
210 220 230 240 250
HAQSPAPPPP PALDREPPAP ERPPEVDPAS APGLPFPLLE PFTTPAPAPT
260 270 280 290 300
GPFLPYLNPA PFGLSPPRLR PFLAAAPGPP ASSAAVWKKS QGAGSSPRRP
310
QGGSDAPSGA CR
Length:312
Mass (Da):32,782
Last modified:February 6, 2007 - v2
Checksum:iB3DFB0C66CD09796
GO
Isoform 2 (identifier: Q96IQ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     310-312: ACR → HAAPSRIVWE...EGELPVFSQL

Note: No experimental confirmation available.Curated
Show »
Length:390
Mass (Da):40,994
Checksum:i63433534FF314166
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Isoform 2 (identifier: Q96IQ9-2)
Sequence conflicti357 – 3571A → P in AK074191 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti65 – 651Q → R.1 Publication
Corresponds to variant rs8100431 [ dbSNP | Ensembl ].
VAR_026847
Natural varianti77 – 771P → S.1 Publication
Corresponds to variant rs1064010 [ dbSNP | Ensembl ].
VAR_026848

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei310 – 3123ACR → HAAPSRIVWEHTRGRYSCMQ CAFSTASRPAMTLHLEDHRP GAPAAPAAGPPRPDAPADPA PLAPKVSPLLSEGELPVFSQ L in isoform 2. 1 PublicationVSP_045351

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074191 mRNA. No translation available.
AC092298 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW68915.1.
BC007310 mRNA. Translation: AAH07310.1.
BC071937 mRNA. Translation: AAH71937.1.
CCDSiCCDS12205.1. [Q96IQ9-1]
CCDS54211.1. [Q96IQ9-2]
RefSeqiNP_001139647.1. NM_001146175.1. [Q96IQ9-2]
NP_115746.2. NM_032370.2. [Q96IQ9-1]
UniGeneiHs.515114.

Genome annotation databases

EnsembliENST00000255616; ENSP00000255616; ENSG00000133250. [Q96IQ9-1]
ENST00000393927; ENSP00000377504; ENSG00000133250. [Q96IQ9-2]
GeneIDi84330.
KEGGihsa:84330.
UCSCiuc002mke.5. human. [Q96IQ9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074191 mRNA. No translation available.
AC092298 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW68915.1.
BC007310 mRNA. Translation: AAH07310.1.
BC071937 mRNA. Translation: AAH71937.1.
CCDSiCCDS12205.1. [Q96IQ9-1]
CCDS54211.1. [Q96IQ9-2]
RefSeqiNP_001139647.1. NM_001146175.1. [Q96IQ9-2]
NP_115746.2. NM_032370.2. [Q96IQ9-1]
UniGeneiHs.515114.

3D structure databases

ProteinModelPortaliQ96IQ9.
SMRiQ96IQ9. Positions 110-208.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124054. 39 interactions.
IntActiQ96IQ9. 3 interactions.
MINTiMINT-1469011.
STRINGi9606.ENSP00000377504.

PTM databases

iPTMnetiQ96IQ9.

Polymorphism and mutation databases

BioMutaiZNF414.
DMDMi125987870.

Proteomic databases

EPDiQ96IQ9.
MaxQBiQ96IQ9.
PaxDbiQ96IQ9.
PRIDEiQ96IQ9.

Protocols and materials databases

DNASUi84330.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255616; ENSP00000255616; ENSG00000133250. [Q96IQ9-1]
ENST00000393927; ENSP00000377504; ENSG00000133250. [Q96IQ9-2]
GeneIDi84330.
KEGGihsa:84330.
UCSCiuc002mke.5. human. [Q96IQ9-1]

Organism-specific databases

CTDi84330.
GeneCardsiZNF414.
HGNCiHGNC:20630. ZNF414.
HPAiHPA053769.
neXtProtiNX_Q96IQ9.
PharmGKBiPA142670521.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00390000006876.
HOGENOMiHOG000015387.
HOVERGENiHBG083015.
InParanoidiQ96IQ9.
OMAiEGECPVF.
OrthoDBiEOG7NPFTS.
PhylomeDBiQ96IQ9.
TreeFamiTF337512.

Miscellaneous databases

ChiTaRSiZNF414. human.
GenomeRNAii84330.
PROiQ96IQ9.

Gene expression databases

BgeeiQ96IQ9.
CleanExiHS_ZNF414.
ExpressionAtlasiQ96IQ9. baseline and differential.
GenevisibleiQ96IQ9. HS.

Family and domain databases

InterProiIPR031799. Znf-C2H2_ribbon.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF15909. zf-C2H2_8. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT SER-77.
    Tissue: Adipose tissue.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-65.
    Tissue: Eye and Pancreas.

Entry informationi

Entry nameiZN414_HUMAN
AccessioniPrimary (citable) accession number: Q96IQ9
Secondary accession number(s): A8MY94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: February 6, 2007
Last modified: June 8, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.