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Protein

V-set and immunoglobulin domain-containing protein 2

Gene

VSIG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000019102-MONOMER.

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
V-set and immunoglobulin domain-containing protein 2
Alternative name(s):
Cortical thymocyte-like protein
Short name:
CT-like protein
Gene namesi
Name:VSIG2
Synonyms:CTH, CTXL
ORF Names:UNQ2770/PRO7154
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:17149. VSIG2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 243ExtracellularSequence analysisAdd BLAST220
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Topological domaini265 – 327CytoplasmicSequence analysisAdd BLAST63

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23584.
OpenTargetsiENSG00000019102.
PharmGKBiPA134937463.

Polymorphism and mutation databases

BioMutaiVSIG2.
DMDMi68053314.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000001500424 – 327V-set and immunoglobulin domain-containing protein 2Add BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi45 ↔ 121PROSITE-ProRule annotation
Glycosylationi138N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi166 ↔ 217PROSITE-ProRule annotation
Glycosylationi206N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96IQ7.
PeptideAtlasiQ96IQ7.
PRIDEiQ96IQ7.

PTM databases

iPTMnetiQ96IQ7.
PhosphoSitePlusiQ96IQ7.

Expressioni

Tissue specificityi

Highly expressed in stomach, colon, prostate, trachea and thyroid glands and weakly in bladder and lung.1 Publication

Gene expression databases

BgeeiENSG00000019102.
CleanExiHS_CTH.
HS_VSIG2.
GenevisibleiQ96IQ7. HS.

Organism-specific databases

HPAiHPA035919.
HPA050147.

Interactioni

Protein-protein interaction databases

BioGridi117119. 29 interactors.
STRINGi9606.ENSP00000318684.

Structurei

3D structure databases

ProteinModelPortaliQ96IQ7.
SMRiQ96IQ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 137Ig-like V-typeAdd BLAST114
Domaini144 – 233Ig-like C2-typeAdd BLAST90

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVJI. Eukaryota.
ENOG410YI21. LUCA.
GeneTreeiENSGT00760000119145.
HOGENOMiHOG000134690.
HOVERGENiHBG086709.
InParanoidiQ96IQ7.
OMAiNFALEWS.
OrthoDBiEOG091G05PI.
PhylomeDBiQ96IQ7.
TreeFamiTF330875.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96IQ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAELPGPFLC GALLGFLCLS GLAVEVKVPT EPLSTPLGKT AELTCTYSTS
60 70 80 90 100
VGDSFALEWS FVQPGKPISE SHPILYFTNG HLYPTGSKSK RVSLLQNPPT
110 120 130 140 150
VGVATLKLTD VHPSDTGTYL CQVNNPPDFY TNGLGLINLT VLVPPSNPLC
160 170 180 190 200
SQSGQTSVGG STALRCSSSE GAPKPVYNWV RLGTFPTPSP GSMVQDEVSG
210 220 230 240 250
QLILTNLSLT SSGTYRCVAT NQMGSASCEL TLSVTEPSQG RVAGALIGVL
260 270 280 290 300
LGVLLLSVAA FCLVRFQKER GKKPKETYGG SDLREDAIAP GISEHTCMRA
310 320
DSSKGFLERP SSASTVTTTK SKLPMVV
Length:327
Mass (Da):34,348
Last modified:December 1, 2001 - v1
Checksum:iCF395AC7EF951AC1
GO
Isoform 2 (identifier: Q96IQ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     285-327: Missing.

Note: No experimental confirmation available.
Show »
Length:284
Mass (Da):29,829
Checksum:i1F9E09C60856B9A9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3E → D in AAD17522 (PubMed:9862345).Curated1
Sequence conflicti21Missing in AAD17522 (PubMed:9862345).Curated1
Sequence conflicti54S → T in AAD17522 (PubMed:9862345).Curated1
Sequence conflicti223M → L in AAD17522 (PubMed:9862345).Curated1
Sequence conflicti243A → T in AAD17522 (PubMed:9862345).Curated1
Sequence conflicti311Missing in AAD17522 (PubMed:9862345).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014119285 – 327Missing in isoform 2. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061022 Genomic DNA. Translation: AAD17522.1.
AY358897 mRNA. Translation: AAQ89256.1.
AK000460 mRNA. Translation: BAA91179.1.
BC007313 mRNA. Translation: AAH07313.1.
CCDSiCCDS8452.1. [Q96IQ7-1]
RefSeqiNP_001316849.1. NM_001329920.1.
NP_055127.2. NM_014312.4. [Q96IQ7-1]
UniGeneiHs.112377.

Genome annotation databases

EnsembliENST00000326621; ENSP00000318684; ENSG00000019102. [Q96IQ7-1]
ENST00000403470; ENSP00000385013; ENSG00000019102. [Q96IQ7-2]
GeneIDi23584.
KEGGihsa:23584.
UCSCiuc001qas.4. human. [Q96IQ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061022 Genomic DNA. Translation: AAD17522.1.
AY358897 mRNA. Translation: AAQ89256.1.
AK000460 mRNA. Translation: BAA91179.1.
BC007313 mRNA. Translation: AAH07313.1.
CCDSiCCDS8452.1. [Q96IQ7-1]
RefSeqiNP_001316849.1. NM_001329920.1.
NP_055127.2. NM_014312.4. [Q96IQ7-1]
UniGeneiHs.112377.

3D structure databases

ProteinModelPortaliQ96IQ7.
SMRiQ96IQ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117119. 29 interactors.
STRINGi9606.ENSP00000318684.

Protein family/group databases

MEROPSiI43.001.

PTM databases

iPTMnetiQ96IQ7.
PhosphoSitePlusiQ96IQ7.

Polymorphism and mutation databases

BioMutaiVSIG2.
DMDMi68053314.

Proteomic databases

PaxDbiQ96IQ7.
PeptideAtlasiQ96IQ7.
PRIDEiQ96IQ7.

Protocols and materials databases

DNASUi23584.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326621; ENSP00000318684; ENSG00000019102. [Q96IQ7-1]
ENST00000403470; ENSP00000385013; ENSG00000019102. [Q96IQ7-2]
GeneIDi23584.
KEGGihsa:23584.
UCSCiuc001qas.4. human. [Q96IQ7-1]

Organism-specific databases

CTDi23584.
DisGeNETi23584.
GeneCardsiVSIG2.
HGNCiHGNC:17149. VSIG2.
HPAiHPA035919.
HPA050147.
MIMi606011. gene.
neXtProtiNX_Q96IQ7.
OpenTargetsiENSG00000019102.
PharmGKBiPA134937463.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVJI. Eukaryota.
ENOG410YI21. LUCA.
GeneTreeiENSGT00760000119145.
HOGENOMiHOG000134690.
HOVERGENiHBG086709.
InParanoidiQ96IQ7.
OMAiNFALEWS.
OrthoDBiEOG091G05PI.
PhylomeDBiQ96IQ7.
TreeFamiTF330875.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000019102-MONOMER.

Miscellaneous databases

ChiTaRSiVSIG2. human.
GenomeRNAii23584.
PROiQ96IQ7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000019102.
CleanExiHS_CTH.
HS_VSIG2.
GenevisibleiQ96IQ7. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVSIG2_HUMAN
AccessioniPrimary (citable) accession number: Q96IQ7
Secondary accession number(s): O95791, Q9NX42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.