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Protein

V-set and immunoglobulin domain-containing protein 2

Gene

VSIG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
V-set and immunoglobulin domain-containing protein 2
Alternative name(s):
Cortical thymocyte-like protein
Short name:
CT-like protein
Gene namesi
Name:VSIG2
Synonyms:CTH, CTXL
ORF Names:UNQ2770/PRO7154
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000019102.11.
HGNCiHGNC:17149. VSIG2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 243ExtracellularSequence analysisAdd BLAST220
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Topological domaini265 – 327CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23584.
OpenTargetsiENSG00000019102.
PharmGKBiPA134937463.

Polymorphism and mutation databases

BioMutaiVSIG2.
DMDMi68053314.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000001500424 – 327V-set and immunoglobulin domain-containing protein 2Add BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi45 ↔ 121PROSITE-ProRule annotation
Glycosylationi138N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi166 ↔ 217PROSITE-ProRule annotation
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96IQ7.
PeptideAtlasiQ96IQ7.
PRIDEiQ96IQ7.

PTM databases

iPTMnetiQ96IQ7.
PhosphoSitePlusiQ96IQ7.

Expressioni

Tissue specificityi

Highly expressed in stomach, colon, prostate, trachea and thyroid glands and weakly in bladder and lung.1 Publication

Gene expression databases

BgeeiENSG00000019102.
CleanExiHS_CTH.
HS_VSIG2.
GenevisibleiQ96IQ7. HS.

Organism-specific databases

HPAiHPA035919.
HPA050147.

Interactioni

Protein-protein interaction databases

BioGridi117119. 30 interactors.
STRINGi9606.ENSP00000318684.

Structurei

3D structure databases

ProteinModelPortaliQ96IQ7.
SMRiQ96IQ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 137Ig-like V-typeAdd BLAST114
Domaini144 – 233Ig-like C2-typeAdd BLAST90

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVJI. Eukaryota.
ENOG410YI21. LUCA.
GeneTreeiENSGT00760000119145.
HOGENOMiHOG000134690.
HOVERGENiHBG086709.
InParanoidiQ96IQ7.
OMAiNFALEWS.
OrthoDBiEOG091G05PI.
PhylomeDBiQ96IQ7.
TreeFamiTF330875.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
PfamiView protein in Pfam
PF07686. V-set. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SM00406. IGv. 1 hit.
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96IQ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAELPGPFLC GALLGFLCLS GLAVEVKVPT EPLSTPLGKT AELTCTYSTS
60 70 80 90 100
VGDSFALEWS FVQPGKPISE SHPILYFTNG HLYPTGSKSK RVSLLQNPPT
110 120 130 140 150
VGVATLKLTD VHPSDTGTYL CQVNNPPDFY TNGLGLINLT VLVPPSNPLC
160 170 180 190 200
SQSGQTSVGG STALRCSSSE GAPKPVYNWV RLGTFPTPSP GSMVQDEVSG
210 220 230 240 250
QLILTNLSLT SSGTYRCVAT NQMGSASCEL TLSVTEPSQG RVAGALIGVL
260 270 280 290 300
LGVLLLSVAA FCLVRFQKER GKKPKETYGG SDLREDAIAP GISEHTCMRA
310 320
DSSKGFLERP SSASTVTTTK SKLPMVV
Length:327
Mass (Da):34,348
Last modified:December 1, 2001 - v1
Checksum:iCF395AC7EF951AC1
GO
Isoform 2 (identifier: Q96IQ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     285-327: Missing.

Note: No experimental confirmation available.
Show »
Length:284
Mass (Da):29,829
Checksum:i1F9E09C60856B9A9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3E → D in AAD17522 (PubMed:9862345).Curated1
Sequence conflicti21Missing in AAD17522 (PubMed:9862345).Curated1
Sequence conflicti54S → T in AAD17522 (PubMed:9862345).Curated1
Sequence conflicti223M → L in AAD17522 (PubMed:9862345).Curated1
Sequence conflicti243A → T in AAD17522 (PubMed:9862345).Curated1
Sequence conflicti311Missing in AAD17522 (PubMed:9862345).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014119285 – 327Missing in isoform 2. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061022 Genomic DNA. Translation: AAD17522.1.
AY358897 mRNA. Translation: AAQ89256.1.
AK000460 mRNA. Translation: BAA91179.1.
BC007313 mRNA. Translation: AAH07313.1.
CCDSiCCDS8452.1. [Q96IQ7-1]
RefSeqiNP_001316849.1. NM_001329920.1. [Q96IQ7-2]
NP_055127.2. NM_014312.4. [Q96IQ7-1]
UniGeneiHs.112377.

Genome annotation databases

EnsembliENST00000326621; ENSP00000318684; ENSG00000019102. [Q96IQ7-1]
ENST00000403470; ENSP00000385013; ENSG00000019102. [Q96IQ7-2]
GeneIDi23584.
KEGGihsa:23584.
UCSCiuc001qas.4. human. [Q96IQ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiVSIG2_HUMAN
AccessioniPrimary (citable) accession number: Q96IQ7
Secondary accession number(s): O95791, Q9NX42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: December 1, 2001
Last modified: September 27, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot