Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

V-set and immunoglobulin domain-containing protein 2

Gene

VSIG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
V-set and immunoglobulin domain-containing protein 2
Alternative name(s):
Cortical thymocyte-like protein
Short name:
CT-like protein
Gene namesi
Name:VSIG2
Synonyms:CTH, CTXL
ORF Names:UNQ2770/PRO7154
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:17149. VSIG2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 243220ExtracellularSequence analysisAdd
BLAST
Transmembranei244 – 26421HelicalSequence analysisAdd
BLAST
Topological domaini265 – 32763CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134937463.

Polymorphism and mutation databases

BioMutaiVSIG2.
DMDMi68053314.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 327304V-set and immunoglobulin domain-containing protein 2PRO_0000015004Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi45 ↔ 121PROSITE-ProRule annotation
Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence analysis
Disulfide bondi166 ↔ 217PROSITE-ProRule annotation
Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96IQ7.
PeptideAtlasiQ96IQ7.
PRIDEiQ96IQ7.

PTM databases

iPTMnetiQ96IQ7.
PhosphoSiteiQ96IQ7.

Expressioni

Tissue specificityi

Highly expressed in stomach, colon, prostate, trachea and thyroid glands and weakly in bladder and lung.1 Publication

Gene expression databases

BgeeiQ96IQ7.
CleanExiHS_CTH.
HS_VSIG2.
GenevisibleiQ96IQ7. HS.

Organism-specific databases

HPAiHPA035919.

Interactioni

Protein-protein interaction databases

BioGridi117119. 29 interactions.
STRINGi9606.ENSP00000318684.

Structurei

3D structure databases

ProteinModelPortaliQ96IQ7.
SMRiQ96IQ7. Positions 29-238.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 137114Ig-like V-typeAdd
BLAST
Domaini144 – 23390Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVJI. Eukaryota.
ENOG410YI21. LUCA.
GeneTreeiENSGT00760000119145.
HOGENOMiHOG000134690.
HOVERGENiHBG086709.
InParanoidiQ96IQ7.
OMAiNFALEWS.
OrthoDBiEOG7MH0Z1.
PhylomeDBiQ96IQ7.
TreeFamiTF330875.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96IQ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAELPGPFLC GALLGFLCLS GLAVEVKVPT EPLSTPLGKT AELTCTYSTS
60 70 80 90 100
VGDSFALEWS FVQPGKPISE SHPILYFTNG HLYPTGSKSK RVSLLQNPPT
110 120 130 140 150
VGVATLKLTD VHPSDTGTYL CQVNNPPDFY TNGLGLINLT VLVPPSNPLC
160 170 180 190 200
SQSGQTSVGG STALRCSSSE GAPKPVYNWV RLGTFPTPSP GSMVQDEVSG
210 220 230 240 250
QLILTNLSLT SSGTYRCVAT NQMGSASCEL TLSVTEPSQG RVAGALIGVL
260 270 280 290 300
LGVLLLSVAA FCLVRFQKER GKKPKETYGG SDLREDAIAP GISEHTCMRA
310 320
DSSKGFLERP SSASTVTTTK SKLPMVV
Length:327
Mass (Da):34,348
Last modified:December 1, 2001 - v1
Checksum:iCF395AC7EF951AC1
GO
Isoform 2 (identifier: Q96IQ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     285-327: Missing.

Note: No experimental confirmation available.
Show »
Length:284
Mass (Da):29,829
Checksum:i1F9E09C60856B9A9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31E → D in AAD17522 (PubMed:9862345).Curated
Sequence conflicti21 – 211Missing in AAD17522 (PubMed:9862345).Curated
Sequence conflicti54 – 541S → T in AAD17522 (PubMed:9862345).Curated
Sequence conflicti223 – 2231M → L in AAD17522 (PubMed:9862345).Curated
Sequence conflicti243 – 2431A → T in AAD17522 (PubMed:9862345).Curated
Sequence conflicti311 – 3111Missing in AAD17522 (PubMed:9862345).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei285 – 32743Missing in isoform 2. 1 PublicationVSP_014119Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061022 Genomic DNA. Translation: AAD17522.1.
AY358897 mRNA. Translation: AAQ89256.1.
AK000460 mRNA. Translation: BAA91179.1.
BC007313 mRNA. Translation: AAH07313.1.
CCDSiCCDS8452.1. [Q96IQ7-1]
RefSeqiNP_055127.2. NM_014312.3. [Q96IQ7-1]
UniGeneiHs.112377.

Genome annotation databases

EnsembliENST00000326621; ENSP00000318684; ENSG00000019102. [Q96IQ7-1]
ENST00000403470; ENSP00000385013; ENSG00000019102. [Q96IQ7-2]
GeneIDi23584.
KEGGihsa:23584.
UCSCiuc001qas.4. human. [Q96IQ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061022 Genomic DNA. Translation: AAD17522.1.
AY358897 mRNA. Translation: AAQ89256.1.
AK000460 mRNA. Translation: BAA91179.1.
BC007313 mRNA. Translation: AAH07313.1.
CCDSiCCDS8452.1. [Q96IQ7-1]
RefSeqiNP_055127.2. NM_014312.3. [Q96IQ7-1]
UniGeneiHs.112377.

3D structure databases

ProteinModelPortaliQ96IQ7.
SMRiQ96IQ7. Positions 29-238.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117119. 29 interactions.
STRINGi9606.ENSP00000318684.

Protein family/group databases

MEROPSiI43.001.

PTM databases

iPTMnetiQ96IQ7.
PhosphoSiteiQ96IQ7.

Polymorphism and mutation databases

BioMutaiVSIG2.
DMDMi68053314.

Proteomic databases

PaxDbiQ96IQ7.
PeptideAtlasiQ96IQ7.
PRIDEiQ96IQ7.

Protocols and materials databases

DNASUi23584.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326621; ENSP00000318684; ENSG00000019102. [Q96IQ7-1]
ENST00000403470; ENSP00000385013; ENSG00000019102. [Q96IQ7-2]
GeneIDi23584.
KEGGihsa:23584.
UCSCiuc001qas.4. human. [Q96IQ7-1]

Organism-specific databases

CTDi23584.
GeneCardsiVSIG2.
HGNCiHGNC:17149. VSIG2.
HPAiHPA035919.
MIMi606011. gene.
neXtProtiNX_Q96IQ7.
PharmGKBiPA134937463.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVJI. Eukaryota.
ENOG410YI21. LUCA.
GeneTreeiENSGT00760000119145.
HOGENOMiHOG000134690.
HOVERGENiHBG086709.
InParanoidiQ96IQ7.
OMAiNFALEWS.
OrthoDBiEOG7MH0Z1.
PhylomeDBiQ96IQ7.
TreeFamiTF330875.

Miscellaneous databases

ChiTaRSiVSIG2. human.
GenomeRNAii23584.
PROiQ96IQ7.
SOURCEiSearch...

Gene expression databases

BgeeiQ96IQ7.
CleanExiHS_CTH.
HS_VSIG2.
GenevisibleiQ96IQ7. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "CTX, a Xenopus thymocyte receptor, defines a molecular family conserved throughout vertebrates."
    Chretien I., Marcuz A., Courtet M., Katevuo K., Vainio O., Heath J.K., White S.J., Du Pasquier L.
    Eur. J. Immunol. 28:4094-4104(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon.
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-38.

Entry informationi

Entry nameiVSIG2_HUMAN
AccessioniPrimary (citable) accession number: Q96IQ7
Secondary accession number(s): O95791, Q9NX42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.