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Protein

DPY30 domain-containing protein 2

Gene

DYDC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133665-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DPY30 domain-containing protein 2
Gene namesi
Name:DYDC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23468. DYDC2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000133665.
PharmGKBiPA134988160.

Polymorphism and mutation databases

BioMutaiDYDC2.
DMDMi74751940.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002475591 – 177DPY30 domain-containing protein 2Add BLAST177

Proteomic databases

PaxDbiQ96IM9.
PeptideAtlasiQ96IM9.
PRIDEiQ96IM9.

PTM databases

iPTMnetiQ96IM9.
PhosphoSitePlusiQ96IM9.

Expressioni

Gene expression databases

BgeeiENSG00000133665.
CleanExiHS_DYDC2.
ExpressionAtlasiQ96IM9. baseline and differential.
GenevisibleiQ96IM9. HS.

Organism-specific databases

HPAiHPA038006.
HPA038007.

Interactioni

Protein-protein interaction databases

BioGridi124056. 1 interactor.
IntActiQ96IM9. 1 interactor.
STRINGi9606.ENSP00000256039.

Structurei

3D structure databases

ProteinModelPortaliQ96IM9.
SMRiQ96IM9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dpy-30 family.Curated

Phylogenomic databases

eggNOGiENOG410J3GF. Eukaryota.
ENOG410XZ7N. LUCA.
GeneTreeiENSGT00530000063857.
HOGENOMiHOG000112299.
HOVERGENiHBG056883.
InParanoidiQ96IM9.
PhylomeDBiQ96IM9.
TreeFamiTF330747.

Family and domain databases

InterProiIPR007858. Dpy-30_motif.
[Graphical view]
PfamiPF05186. Dpy-30. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96IM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METNYLKRCF GNCLAQALAE VAKVRPSDPI EYLAHWLYHY RKTAKAKEEN
60 70 80 90 100
REKKIHLQEE YDSSLKEMEM TEMLKQEEYQ IQQNCEKCHK ELTSETVSTK
110 120 130 140 150
KTIFMQEDTN PLEKEALKQE FLPGTSSLIP GMPQQVPPSE SAGQIDQNFK
160 170
MPQEINYKEA FQHEVAHEMP PGSKSPF
Length:177
Mass (Da):20,586
Last modified:December 1, 2001 - v1
Checksum:i52EB61B200612A74
GO

Sequence cautioni

The sequence CAI13698 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048889143G → S.Corresponds to variant rs1047951dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093378 mRNA. Translation: BAC04148.1.
AL359195 Genomic DNA. Translation: CAI13698.1. Different initiation.
AL359195 Genomic DNA. Translation: CAI13703.1.
AL359195 Genomic DNA. Translation: CAI13704.1.
CH471142 Genomic DNA. Translation: EAW80391.1.
CH471142 Genomic DNA. Translation: EAW80392.1.
BC007374 mRNA. Translation: AAH07374.1.
CCDSiCCDS7367.1.
RefSeqiNP_001256970.1. NM_001270041.1.
NP_115748.1. NM_032372.5.
XP_011538569.1. XM_011540267.2.
XP_011538570.1. XM_011540268.1.
UniGeneiHs.741500.

Genome annotation databases

EnsembliENST00000256039; ENSP00000256039; ENSG00000133665.
ENST00000372197; ENSP00000361271; ENSG00000133665.
ENST00000372199; ENSP00000361273; ENSG00000133665.
ENST00000444807; ENSP00000410285; ENSG00000133665.
ENST00000616870; ENSP00000483479; ENSG00000133665.
GeneIDi84332.
KEGGihsa:84332.
UCSCiuc001kbz.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093378 mRNA. Translation: BAC04148.1.
AL359195 Genomic DNA. Translation: CAI13698.1. Different initiation.
AL359195 Genomic DNA. Translation: CAI13703.1.
AL359195 Genomic DNA. Translation: CAI13704.1.
CH471142 Genomic DNA. Translation: EAW80391.1.
CH471142 Genomic DNA. Translation: EAW80392.1.
BC007374 mRNA. Translation: AAH07374.1.
CCDSiCCDS7367.1.
RefSeqiNP_001256970.1. NM_001270041.1.
NP_115748.1. NM_032372.5.
XP_011538569.1. XM_011540267.2.
XP_011538570.1. XM_011540268.1.
UniGeneiHs.741500.

3D structure databases

ProteinModelPortaliQ96IM9.
SMRiQ96IM9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124056. 1 interactor.
IntActiQ96IM9. 1 interactor.
STRINGi9606.ENSP00000256039.

PTM databases

iPTMnetiQ96IM9.
PhosphoSitePlusiQ96IM9.

Polymorphism and mutation databases

BioMutaiDYDC2.
DMDMi74751940.

Proteomic databases

PaxDbiQ96IM9.
PeptideAtlasiQ96IM9.
PRIDEiQ96IM9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256039; ENSP00000256039; ENSG00000133665.
ENST00000372197; ENSP00000361271; ENSG00000133665.
ENST00000372199; ENSP00000361273; ENSG00000133665.
ENST00000444807; ENSP00000410285; ENSG00000133665.
ENST00000616870; ENSP00000483479; ENSG00000133665.
GeneIDi84332.
KEGGihsa:84332.
UCSCiuc001kbz.4. human.

Organism-specific databases

CTDi84332.
GeneCardsiDYDC2.
HGNCiHGNC:23468. DYDC2.
HPAiHPA038006.
HPA038007.
neXtProtiNX_Q96IM9.
OpenTargetsiENSG00000133665.
PharmGKBiPA134988160.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3GF. Eukaryota.
ENOG410XZ7N. LUCA.
GeneTreeiENSGT00530000063857.
HOGENOMiHOG000112299.
HOVERGENiHBG056883.
InParanoidiQ96IM9.
PhylomeDBiQ96IM9.
TreeFamiTF330747.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133665-MONOMER.

Miscellaneous databases

GenomeRNAii84332.
PROiQ96IM9.

Gene expression databases

BgeeiENSG00000133665.
CleanExiHS_DYDC2.
ExpressionAtlasiQ96IM9. baseline and differential.
GenevisibleiQ96IM9. HS.

Family and domain databases

InterProiIPR007858. Dpy-30_motif.
[Graphical view]
PfamiPF05186. Dpy-30. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDYDC2_HUMAN
AccessioniPrimary (citable) accession number: Q96IM9
Secondary accession number(s): D3DWD6, Q5QP07, Q5QP11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.