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Q96IL0 (APOP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Apoptogenic protein 1, mitochondrial

Short name=APOP-1
Gene names
Name:APOPT1
Synonyms:APOP1, C14orf153
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length206 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a role in the regulation of apoptosis. Mediates mitochondria-induced cell death in vascular smooth muscle cells through the release of cytochrome c from mitochondria, followed by the activation of the caspase cascade By similarity.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the APOPT family.

Caution

It is uncertain whether Met-1 or Met-14 is the initiator.

Sequence caution

The sequence AAH07412.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAD96812.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAD96823.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3939Mitochondrion Potential
Chain40 – 206167Apoptogenic protein 1, mitochondrial
PRO_0000019559

Natural variations

Natural variant271P → A. Ref.4
Corresponds to variant rs2274268 [ dbSNP | Ensembl ].
VAR_023000
Natural variant881N → S.
Corresponds to variant rs35960830 [ dbSNP | Ensembl ].
VAR_033745

Experimental info

Sequence conflict1911E → G in CB136383. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q96IL0 [UniParc].

Last modified December 14, 2011. Version 3.
Checksum: 7ABC3470215F2244

FASTA20624,153
        10         20         30         40         50         60 
MLPCAAGARG RGAMVVLRAG KKTFLPPLCR AFACRGCQLA PERGAERRDT APSGVSRFCP 

        70         80         90        100        110        120 
PRKSCHDWIG PPDKYSNLRP VHFYIPENES PLEQKLRKLR QETQEWNQQF WANQNLTFSK 

       130        140        150        160        170        180 
EKEEFIHSRL KTKGLGLRTE SGQKATLNAE EMADFYKEFL SKNFQKHMYY NRDWYKRNFA 

       190        200 
ITFFMGKVAL ERIWNKLKQK QKKRSN 

« Hide

References

[1]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags."
Wang A.G., Yoon S.Y., Oh J.H., Jeon Y.J., Kim M., Kim J.M., Byun S.S., Yang J.O., Kim J.H., Kim D.G., Yeom Y.I., Yoo H.S., Kim Y.S., Kim N.S.
Biochem. Biophys. Res. Commun. 345:1022-1032(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-197.
Tissue: Ovary.
[3]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-206.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 12-206, VARIANT ALA-27.
Tissue: Ovary.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL139300 Genomic DNA. No translation available.
CB136383 mRNA. No translation available.
AK223092 mRNA. Translation: BAD96812.1. Different initiation.
AK223103 mRNA. Translation: BAD96823.1. Different initiation.
BC007412 mRNA. Translation: AAH07412.1. Different initiation.
CCDSCCDS9983.2.
RefSeqNP_115750.2. NM_032374.3.
UniGeneHs.598441.

3D structure databases

ProteinModelPortalQ96IL0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124058. 2 interactions.

PTM databases

PhosphoSiteQ96IL0.

Polymorphism databases

DMDM363548522.

Proteomic databases

MaxQBQ96IL0.
PaxDbQ96IL0.
PRIDEQ96IL0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000247618; ENSP00000247618; ENSG00000256053.
ENST00000409074; ENSP00000386485; ENSG00000256053.
GeneID84334.
KEGGhsa:84334.
UCSCuc010tyc.2. human.

Organism-specific databases

CTD84334.
GeneCardsGC14P104032.
HGNCHGNC:20492. APOPT1.
neXtProtNX_Q96IL0.
PharmGKBPA134961925.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0457.
HOGENOMHOG000111828.
HOVERGENHBG074760.
InParanoidQ96IL0.
OMANRDWYRR.
PhylomeDBQ96IL0.
TreeFamTF315168.

Gene expression databases

ArrayExpressQ96IL0.
BgeeQ96IL0.
GenevestigatorQ96IL0.

Family and domain databases

InterProIPR018796. UPF0671.
[Graphical view]
PfamPF10231. DUF2315. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSAPOPT1. human.
GenomeRNAi84334.
NextBio74101.
PROQ96IL0.

Entry information

Entry nameAPOP1_HUMAN
AccessionPrimary (citable) accession number: Q96IL0
Secondary accession number(s): Q53G28
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: December 14, 2011
Last modified: July 9, 2014
This is version 87 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM