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Protein

Germ cell-less protein-like 1

Gene

GMCL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity).By similarity

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Germ cell-less protein-like 1
Gene namesi
Name:GMCL1
Synonyms:GCL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000087338.4
HGNCiHGNC:23843 GMCL1
neXtProtiNX_Q96IK5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi64395
OpenTargetsiENSG00000087338
PharmGKBiPA143485477

Polymorphism and mutation databases

BioMutaiGMCL1
DMDMi47605732

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000875201 – 515Germ cell-less protein-like 1Add BLAST515

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei66PhosphoserineBy similarity1
Modified residuei68PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96IK5
MaxQBiQ96IK5
PaxDbiQ96IK5
PeptideAtlasiQ96IK5
PRIDEiQ96IK5

PTM databases

iPTMnetiQ96IK5
PhosphoSitePlusiQ96IK5

Expressioni

Gene expression databases

BgeeiENSG00000087338
CleanExiHS_GMCL1
ExpressionAtlasiQ96IK5 baseline and differential
GenevisibleiQ96IK5 HS

Organism-specific databases

HPAiHPA039579

Interactioni

Subunit structurei

Interacts with TMPO-beta, TSG101 and TFDP2 (By similarity). Interacts with EMD.By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi122152, 104 interactors
IntActiQ96IK5, 69 interactors
MINTiQ96IK5
STRINGi9606.ENSP00000282570

Structurei

3D structure databases

ProteinModelPortaliQ96IK5
SMRiQ96IK5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini108 – 178BTBPROSITE-ProRule annotationAdd BLAST71

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi49 – 55Nuclear localization signalSequence analysis7
Motifi85 – 91Nuclear localization signalSequence analysis7

Phylogenomic databases

eggNOGiKOG4682 Eukaryota
ENOG410XPEJ LUCA
GeneTreeiENSGT00390000003212
HOVERGENiHBG051741
InParanoidiQ96IK5
KOiK10485
OMAiGHGFCYC
OrthoDBiEOG091G07ZV
PhylomeDBiQ96IK5
TreeFamiTF316048

Family and domain databases

InterProiView protein in InterPro
IPR011705 BACK
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequencei

Sequence statusi: Complete.

Q96IK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSLSSRVLR QPRPALAQQA QGARAGGSAR RPDTGDDAAG HGFCYCAGSH
60 70 80 90 100
KRKRSSGSFC YCHPDSETDE DEEEGDEQQR LLNTPRRKKL KSTSKYIYQT
110 120 130 140 150
LFLNGENSDI KICALGEEWS LHKIYLCQSG YFSSMFSGSW KESSMNIIEL
160 170 180 190 200
EIPDQNIDVE ALQVAFGSLY RDDVLIKPSR VVAILAAACL LQLDGLIQQC
210 220 230 240 250
GETMKETVNV KTVCGYYTSA GTYGLDSVKK KCLEWLLNNL MTHQNVELFK
260 270 280 290 300
ELSINVMKQL IGSSNLFVMQ VEMDIYTALK KWMFLQLVPS WNGSLKQLLT
310 320 330 340 350
ETDVWFSKQR KDFEGMAFLE TEQGKPFVSV FRHLRLQYII SDLASARIIE
360 370 380 390 400
QDAVVPSEWL SSVYKQQWFA MLRAEQDSEV GPQEINKEEL EGNSMRCGRK
410 420 430 440 450
LAKDGEYCWR WTGFNFGFDL LVTYTNRYII FKRNTLNQPC SGSVSLQPRR
460 470 480 490 500
SIAFRLRLAS FDSSGKLICS RTTGYQILTL EKDQEQVVMN LDSRLLIFPL
510
YICCNFLYIS PEKKN
Length:515
Mass (Da):58,685
Last modified:December 1, 2001 - v1
Checksum:iDA310AEE9CE1AEEE
GO

Sequence cautioni

The sequence BAB14494 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti157I → M in BAB14416 (PubMed:14702039).Curated1
Sequence conflicti160E → G in BAB14796 (PubMed:14702039).Curated1
Sequence conflicti160E → V in BAB14494 (PubMed:14702039).Curated1
Sequence conflicti207T → A in BAB14796 (PubMed:14702039).Curated1
Sequence conflicti325K → N in BAB14494 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023119 mRNA Translation: BAB14416.1
AK023261 mRNA Translation: BAB14494.1 Different initiation.
AK024042 mRNA Translation: BAB14796.1
BC007420 mRNA Translation: AAH07420.1
CCDSiCCDS1895.1
RefSeqiNP_848526.1, NM_178439.4
UniGeneiHs.293971
Hs.667102

Genome annotation databases

EnsembliENST00000282570; ENSP00000282570; ENSG00000087338
GeneIDi64395
KEGGihsa:64395
UCSCiuc002sfu.4 human

Similar proteinsi

Entry informationi

Entry nameiGMCL1_HUMAN
AccessioniPrimary (citable) accession number: Q96IK5
Secondary accession number(s): Q9H826, Q9H8V7, Q9H927
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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