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Protein

Germ cell-less protein-like 1

Gene

GMCL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Germ cell-less protein-like 1
Gene namesi
Name:GMCL1
Synonyms:GCL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:23843. GMCL1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485477.

Polymorphism and mutation databases

BioMutaiGMCL1.
DMDMi47605732.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 515515Germ cell-less protein-like 1PRO_0000087520Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei66 – 661PhosphoserineBy similarity
Modified residuei68 – 681PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96IK5.
PaxDbiQ96IK5.
PRIDEiQ96IK5.

PTM databases

PhosphoSiteiQ96IK5.

Expressioni

Gene expression databases

BgeeiQ96IK5.
CleanExiHS_GMCL1.
ExpressionAtlasiQ96IK5. baseline and differential.
GenevisibleiQ96IK5. HS.

Organism-specific databases

HPAiHPA039579.

Interactioni

Subunit structurei

Interacts with TMPO-beta, TSG101 and TFDP2 (By similarity). Interacts with EMD.By similarity1 Publication

Protein-protein interaction databases

BioGridi122152. 99 interactions.
IntActiQ96IK5. 4 interactions.
STRINGi9606.ENSP00000282570.

Structurei

3D structure databases

ProteinModelPortaliQ96IK5.
SMRiQ96IK5. Positions 109-283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini108 – 17871BTBPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi49 – 557Nuclear localization signalSequence analysis
Motifi85 – 917Nuclear localization signalSequence analysis

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4682. Eukaryota.
ENOG410XPEJ. LUCA.
GeneTreeiENSGT00390000003212.
HOVERGENiHBG051741.
InParanoidiQ96IK5.
KOiK10485.
OMAiKWRWTGF.
OrthoDBiEOG7X6M0J.
PhylomeDBiQ96IK5.
TreeFamiTF316048.

Family and domain databases

InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96IK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSLSSRVLR QPRPALAQQA QGARAGGSAR RPDTGDDAAG HGFCYCAGSH
60 70 80 90 100
KRKRSSGSFC YCHPDSETDE DEEEGDEQQR LLNTPRRKKL KSTSKYIYQT
110 120 130 140 150
LFLNGENSDI KICALGEEWS LHKIYLCQSG YFSSMFSGSW KESSMNIIEL
160 170 180 190 200
EIPDQNIDVE ALQVAFGSLY RDDVLIKPSR VVAILAAACL LQLDGLIQQC
210 220 230 240 250
GETMKETVNV KTVCGYYTSA GTYGLDSVKK KCLEWLLNNL MTHQNVELFK
260 270 280 290 300
ELSINVMKQL IGSSNLFVMQ VEMDIYTALK KWMFLQLVPS WNGSLKQLLT
310 320 330 340 350
ETDVWFSKQR KDFEGMAFLE TEQGKPFVSV FRHLRLQYII SDLASARIIE
360 370 380 390 400
QDAVVPSEWL SSVYKQQWFA MLRAEQDSEV GPQEINKEEL EGNSMRCGRK
410 420 430 440 450
LAKDGEYCWR WTGFNFGFDL LVTYTNRYII FKRNTLNQPC SGSVSLQPRR
460 470 480 490 500
SIAFRLRLAS FDSSGKLICS RTTGYQILTL EKDQEQVVMN LDSRLLIFPL
510
YICCNFLYIS PEKKN
Length:515
Mass (Da):58,685
Last modified:December 1, 2001 - v1
Checksum:iDA310AEE9CE1AEEE
GO

Sequence cautioni

The sequence BAB14494.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti157 – 1571I → M in BAB14416 (PubMed:14702039).Curated
Sequence conflicti160 – 1601E → G in BAB14796 (PubMed:14702039).Curated
Sequence conflicti160 – 1601E → V in BAB14494 (PubMed:14702039).Curated
Sequence conflicti207 – 2071T → A in BAB14796 (PubMed:14702039).Curated
Sequence conflicti325 – 3251K → N in BAB14494 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023119 mRNA. Translation: BAB14416.1.
AK023261 mRNA. Translation: BAB14494.1. Different initiation.
AK024042 mRNA. Translation: BAB14796.1.
BC007420 mRNA. Translation: AAH07420.1.
CCDSiCCDS1895.1.
RefSeqiNP_848526.1. NM_178439.4.
UniGeneiHs.293971.
Hs.667102.

Genome annotation databases

EnsembliENST00000282570; ENSP00000282570; ENSG00000087338.
GeneIDi64395.
KEGGihsa:64395.
UCSCiuc002sfu.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023119 mRNA. Translation: BAB14416.1.
AK023261 mRNA. Translation: BAB14494.1. Different initiation.
AK024042 mRNA. Translation: BAB14796.1.
BC007420 mRNA. Translation: AAH07420.1.
CCDSiCCDS1895.1.
RefSeqiNP_848526.1. NM_178439.4.
UniGeneiHs.293971.
Hs.667102.

3D structure databases

ProteinModelPortaliQ96IK5.
SMRiQ96IK5. Positions 109-283.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122152. 99 interactions.
IntActiQ96IK5. 4 interactions.
STRINGi9606.ENSP00000282570.

PTM databases

PhosphoSiteiQ96IK5.

Polymorphism and mutation databases

BioMutaiGMCL1.
DMDMi47605732.

Proteomic databases

MaxQBiQ96IK5.
PaxDbiQ96IK5.
PRIDEiQ96IK5.

Protocols and materials databases

DNASUi64395.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282570; ENSP00000282570; ENSG00000087338.
GeneIDi64395.
KEGGihsa:64395.
UCSCiuc002sfu.4. human.

Organism-specific databases

CTDi64395.
GeneCardsiGMCL1.
HGNCiHGNC:23843. GMCL1.
HPAiHPA039579.
neXtProtiNX_Q96IK5.
PharmGKBiPA143485477.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4682. Eukaryota.
ENOG410XPEJ. LUCA.
GeneTreeiENSGT00390000003212.
HOVERGENiHBG051741.
InParanoidiQ96IK5.
KOiK10485.
OMAiKWRWTGF.
OrthoDBiEOG7X6M0J.
PhylomeDBiQ96IK5.
TreeFamiTF316048.

Miscellaneous databases

ChiTaRSiGMCL1. human.
GenomeRNAii64395.
NextBioi66327.
PROiQ96IK5.

Gene expression databases

BgeeiQ96IK5.
CleanExiHS_GMCL1.
ExpressionAtlasiQ96IK5. baseline and differential.
GenevisibleiQ96IK5. HS.

Family and domain databases

InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  3. "Transcriptional repressor germ cell-less (GCL) and barrier to autointegration factor (BAF) compete for binding to emerin in vitro."
    Holaska J.M., Lee K.K., Kowalski A.K., Wilson K.L.
    J. Biol. Chem. 278:6969-6975(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH EMD.

Entry informationi

Entry nameiGMCL1_HUMAN
AccessioniPrimary (citable) accession number: Q96IK5
Secondary accession number(s): Q9H826, Q9H8V7, Q9H927
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.