Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q96IK1 (BOD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Biorientation of chromosomes in cell division protein 1
Alternative name(s):
Biorientation defective protein 1
Protein FAM44B
Gene names
Name:BOD1
Synonyms:FAM44B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length185 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles. Ref.5

Subcellular location

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Chromosomecentromerekinetochore. Note: Localizes at the centrosomes throughout the cell cycle, only dissociating during cytokinesis. Localizes at the kinetochore from prometaphase until anaphase. Ref.5

Sequence similarities

Belongs to the BOD1 family.

Ontologies

Keywords
   Biological processCell cycle
Cell division
Mitosis
   Cellular componentCentromere
Chromosome
Cytoplasm
Cytoskeleton
Kinetochore
   Coding sequence diversityAlternative splicing
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmitosis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcondensed chromosome kinetochore

Inferred from electronic annotation. Source: UniProtKB-SubCell

cytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

microtubule organizing center

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96IK1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96IK1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     122-129: SGMLEAGV → IRQTPFES
     130-185: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 185185Biorientation of chromosomes in cell division protein 1
PRO_0000187028

Regions

Compositional bias4 – 3734Gly-rich

Natural variations

Alternative sequence122 – 1298SGMLEAGV → IRQTPFES in isoform 2.
VSP_016161
Alternative sequence130 – 18556Missing in isoform 2.
VSP_016162

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2003. Version 2.
Checksum: 7A2A64C441C8BE7D

FASTA18519,196
        10         20         30         40         50         60 
MADGGGGGGT GAVGGGGTSQ ASAGAATGAT GASGGGGPIN PASLPPGDPQ LIALIVEQLK 

        70         80         90        100        110        120 
SRGLFDSFRR DCLADVDTKP AYQNLRQKVD NFVSTHLDKQ EWNPTMNKNQ LRNGLRQSVV 

       130        140        150        160        170        180 
QSGMLEAGVD RIISQVVDPK LNHIFRPQIE RAIHEFLAAQ KKAAVPAPPP EPEGQDPPAP 


SQDTS 

« Hide

Isoform 2 [UniParc].

Checksum: 33D05637815EA078
Show »

FASTA12913,280

References

« Hide 'large scale' references
[1]Li H., Ke R., Zhou G., Shen C., Zheng G., Lin L., Yang S.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Testis.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Lung and Muscle.
[5]"Bod1, a novel kinetochore protein required for chromosome biorientation."
Porter I.M., McClelland S.E., Khoudoli G.A., Hunter C.J., Andersen J.S., McAinsh A.D., Blow J.J., Swedlow J.R.
J. Cell Biol. 179:187-197(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY303777 mRNA. Translation: AAP76182.1.
AK301982 mRNA. Translation: BAG63390.1.
CH471062 Genomic DNA. Translation: EAW61396.1.
BC003114 mRNA. Translation: AAH03114.2.
BC007436 mRNA. Translation: AAH07436.2.
RefSeqNP_001153123.1. NM_001159651.1.
NP_612378.1. NM_138369.2.
UniGeneHs.425091.

3D structure databases

ProteinModelPortalQ96IK1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124809. 2 interactions.
STRING9606.ENSP00000309644.

PTM databases

PhosphoSiteQ96IK1.

Polymorphism databases

DMDM74732069.

Proteomic databases

PaxDbQ96IK1.
PRIDEQ96IK1.

Protocols and materials databases

DNASU91272.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000285908; ENSP00000285908; ENSG00000145919. [Q96IK1-2]
ENST00000311086; ENSP00000309644; ENSG00000145919. [Q96IK1-1]
GeneID91272.
KEGGhsa:91272.
UCSCuc003mcq.2. human. [Q96IK1-1]
uc003mcr.2. human. [Q96IK1-2]

Organism-specific databases

CTD91272.
GeneCardsGC05M172968.
HGNCHGNC:25114. BOD1.
HPAHPA036293.
neXtProtNX_Q96IK1.
PharmGKBPA164716651.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG78324.
HOGENOMHOG000070153.
InParanoidQ96IK1.
OMAIGMIVEH.
OrthoDBEOG7X3QQD.
PhylomeDBQ96IK1.
TreeFamTF325311.

Gene expression databases

ArrayExpressQ96IK1.
BgeeQ96IK1.
CleanExHS_FAM44B.
GenevestigatorQ96IK1.

Family and domain databases

InterProIPR026955. Bod1_like.
[Graphical view]
PANTHERPTHR31532. PTHR31532. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi91272.
NextBio77151.
PROQ96IK1.

Entry information

Entry nameBOD1_HUMAN
AccessionPrimary (citable) accession number: Q96IK1
Secondary accession number(s): B4DXH8, Q9BTW1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2003
Last modified: March 19, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM