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Protein

Biorientation of chromosomes in cell division protein 1

Gene

BOD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles.1 Publication

GO - Biological processi

  1. cell division Source: UniProtKB-KW
  2. mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Biorientation of chromosomes in cell division protein 1
Alternative name(s):
Biorientation defective protein 1
Protein FAM44B
Gene namesi
Name:BOD1
Synonyms:FAM44B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:25114. BOD1.

Subcellular locationi

  1. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome 1 Publication
  2. Chromosomecentromerekinetochore 1 Publication

  3. Note: Localizes at the centrosomes throughout the cell cycle, only dissociating during cytokinesis. Localizes at the kinetochore from prometaphase until anaphase.

GO - Cellular componenti

  1. condensed chromosome kinetochore Source: UniProtKB-SubCell
  2. cytoplasm Source: UniProtKB-KW
  3. microtubule organizing center Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164716651.

Polymorphism and mutation databases

BioMutaiBOD1.
DMDMi74732069.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Biorientation of chromosomes in cell division protein 1PRO_0000187028Add
BLAST

Proteomic databases

MaxQBiQ96IK1.
PaxDbiQ96IK1.
PRIDEiQ96IK1.

PTM databases

PhosphoSiteiQ96IK1.

Expressioni

Gene expression databases

BgeeiQ96IK1.
CleanExiHS_FAM44B.
ExpressionAtlasiQ96IK1. baseline and differential.
GenevestigatoriQ96IK1.

Organism-specific databases

HPAiHPA036293.

Interactioni

Protein-protein interaction databases

BioGridi124809. 11 interactions.
STRINGi9606.ENSP00000309644.

Structurei

3D structure databases

ProteinModelPortaliQ96IK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 3734Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the BOD1 family.Curated

Phylogenomic databases

eggNOGiNOG78324.
GeneTreeiENSGT00530000063517.
HOGENOMiHOG000070153.
InParanoidiQ96IK1.
OMAiIGMIVEH.
OrthoDBiEOG7X3QQD.
PhylomeDBiQ96IK1.
TreeFamiTF325311.

Family and domain databases

InterProiIPR026955. Bod1_like.
[Graphical view]
PANTHERiPTHR31532. PTHR31532. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96IK1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADGGGGGGT GAVGGGGTSQ ASAGAATGAT GASGGGGPIN PASLPPGDPQ
60 70 80 90 100
LIALIVEQLK SRGLFDSFRR DCLADVDTKP AYQNLRQKVD NFVSTHLDKQ
110 120 130 140 150
EWNPTMNKNQ LRNGLRQSVV QSGMLEAGVD RIISQVVDPK LNHIFRPQIE
160 170 180
RAIHEFLAAQ KKAAVPAPPP EPEGQDPPAP SQDTS
Length:185
Mass (Da):19,196
Last modified:October 1, 2003 - v2
Checksum:i7A2A64C441C8BE7D
GO
Isoform 2 (identifier: Q96IK1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-129: SGMLEAGV → IRQTPFES
     130-185: Missing.

Note: No experimental confirmation available.

Show »
Length:129
Mass (Da):13,280
Checksum:i33D05637815EA078
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei122 – 1298SGMLEAGV → IRQTPFES in isoform 2. 1 PublicationVSP_016161
Alternative sequencei130 – 18556Missing in isoform 2. 1 PublicationVSP_016162Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY303777 mRNA. Translation: AAP76182.1.
AK301982 mRNA. Translation: BAG63390.1.
CH471062 Genomic DNA. Translation: EAW61396.1.
BC003114 mRNA. Translation: AAH03114.2.
BC007436 mRNA. Translation: AAH07436.2.
CCDSiCCDS4389.1. [Q96IK1-1]
CCDS54951.1. [Q96IK1-2]
RefSeqiNP_001153123.1. NM_001159651.1. [Q96IK1-2]
NP_612378.1. NM_138369.2. [Q96IK1-1]
UniGeneiHs.425091.

Genome annotation databases

EnsembliENST00000285908; ENSP00000285908; ENSG00000145919. [Q96IK1-2]
ENST00000311086; ENSP00000309644; ENSG00000145919. [Q96IK1-1]
GeneIDi91272.
KEGGihsa:91272.
UCSCiuc003mcq.2. human. [Q96IK1-1]
uc003mcr.2. human. [Q96IK1-2]

Polymorphism and mutation databases

BioMutaiBOD1.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY303777 mRNA. Translation: AAP76182.1.
AK301982 mRNA. Translation: BAG63390.1.
CH471062 Genomic DNA. Translation: EAW61396.1.
BC003114 mRNA. Translation: AAH03114.2.
BC007436 mRNA. Translation: AAH07436.2.
CCDSiCCDS4389.1. [Q96IK1-1]
CCDS54951.1. [Q96IK1-2]
RefSeqiNP_001153123.1. NM_001159651.1. [Q96IK1-2]
NP_612378.1. NM_138369.2. [Q96IK1-1]
UniGeneiHs.425091.

3D structure databases

ProteinModelPortaliQ96IK1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124809. 11 interactions.
STRINGi9606.ENSP00000309644.

PTM databases

PhosphoSiteiQ96IK1.

Polymorphism and mutation databases

BioMutaiBOD1.
DMDMi74732069.

Proteomic databases

MaxQBiQ96IK1.
PaxDbiQ96IK1.
PRIDEiQ96IK1.

Protocols and materials databases

DNASUi91272.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285908; ENSP00000285908; ENSG00000145919. [Q96IK1-2]
ENST00000311086; ENSP00000309644; ENSG00000145919. [Q96IK1-1]
GeneIDi91272.
KEGGihsa:91272.
UCSCiuc003mcq.2. human. [Q96IK1-1]
uc003mcr.2. human. [Q96IK1-2]

Organism-specific databases

CTDi91272.
GeneCardsiGC05M172968.
HGNCiHGNC:25114. BOD1.
HPAiHPA036293.
neXtProtiNX_Q96IK1.
PharmGKBiPA164716651.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG78324.
GeneTreeiENSGT00530000063517.
HOGENOMiHOG000070153.
InParanoidiQ96IK1.
OMAiIGMIVEH.
OrthoDBiEOG7X3QQD.
PhylomeDBiQ96IK1.
TreeFamiTF325311.

Miscellaneous databases

ChiTaRSiBOD1. human.
GenomeRNAii91272.
NextBioi77151.
PROiQ96IK1.

Gene expression databases

BgeeiQ96IK1.
CleanExiHS_FAM44B.
ExpressionAtlasiQ96IK1. baseline and differential.
GenevestigatoriQ96IK1.

Family and domain databases

InterProiIPR026955. Bod1_like.
[Graphical view]
PANTHERiPTHR31532. PTHR31532. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Li H., Ke R., Zhou G., Shen C., Zheng G., Lin L., Yang S.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Lung and Muscle.
  5. Cited for: FUNCTION, SUBCELLULAR LOCATION.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBOD1_HUMAN
AccessioniPrimary (citable) accession number: Q96IK1
Secondary accession number(s): B4DXH8, Q9BTW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2003
Last modified: April 29, 2015
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.