Q96IK1 (BOD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Biorientation of chromosomes in cell division protein 1

Alternative name(s):
Biorientation defective protein 1
Protein FAM44B

Gene names

Name:	BOD1
Synonyms:	FAM44B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles. Ref.5
Subcellular location	Cytoplasm › cytoskeleton › centrosome. Chromosome › centromere › kinetochore. Note: Localizes at the centrosomes throughout the cell cycle, only dissociating during cytokinesis. Localizes at the kinetochore from prometaphase until anaphase. Ref.5
Sequence similarities	Belongs to the BOD1 family.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Cellular component	Centromere Chromosome Cytoplasm Cytoskeleton Kinetochore
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell division Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	condensed chromosome kinetochore Inferred from electronic annotation. Source: UniProtKB-SubCell cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW microtubule organizing center Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96IK1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96IK1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     122-129: SGMLEAGV → IRQTPFES
     130-185: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 185	185	Biorientation of chromosomes in cell division protein 1		PRO_0000187028
Regions
	Compositional bias	4 – 37	34	Gly-rich
Natural variations
	Alternative sequence	122 – 129	8	SGMLEAGV → IRQTPFES in isoform 2.		VSP_016161
	Alternative sequence	130 – 185	56	Missing in isoform 2.		VSP_016162

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2003. Version 2. Checksum: 7A2A64C441C8BE7D	FASTA	185	19,196
	10 20 30 40 50 60 MADGGGGGGT GAVGGGGTSQ ASAGAATGAT GASGGGGPIN PASLPPGDPQ LIALIVEQLK 70 80 90 100 110 120 SRGLFDSFRR DCLADVDTKP AYQNLRQKVD NFVSTHLDKQ EWNPTMNKNQ LRNGLRQSVV 130 140 150 160 170 180 QSGMLEAGVD RIISQVVDPK LNHIFRPQIE RAIHEFLAAQ KKAAVPAPPP EPEGQDPPAP SQDTS
	Isoform 2 [UniParc]. Checksum: 33D05637815EA078	FASTA	129	13,280
	10 20 30 40 50 60 MADGGGGGGT GAVGGGGTSQ ASAGAATGAT GASGGGGPIN PASLPPGDPQ LIALIVEQLK 70 80 90 100 110 120 SRGLFDSFRR DCLADVDTKP AYQNLRQKVD NFVSTHLDKQ EWNPTMNKNQ LRNGLRQSVV QIRQTPFES

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Li H., Ke R., Zhou G., Shen C., Zheng G., Lin L., Yang S. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Lung and Muscle.
[5]	"Bod1, a novel kinetochore protein required for chromosome biorientation." Porter I.M., McClelland S.E., Khoudoli G.A., Hunter C.J., Andersen J.S., McAinsh A.D., Blow J.J., Swedlow J.R. J. Cell Biol. 179:187-197(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY303777 mRNA. Translation: AAP76182.1. AK301982 mRNA. Translation: BAG63390.1. CH471062 Genomic DNA. Translation: EAW61396.1. BC003114 mRNA. Translation: AAH03114.2. BC007436 mRNA. Translation: AAH07436.2.
IPI	IPI00063667. IPI00165403.
RefSeq	NP_001153123.1. NM_001159651.1. NP_612378.1. NM_138369.2.
UniGene	Hs.425091.
3D structure databases
ProteinModelPortal	Q96IK1.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000309644.
PTM databases
PhosphoSite	Q96IK1.
Polymorphism databases
DMDM	74732069.
Proteomic databases
PaxDb	Q96IK1.
PRIDE	Q96IK1.
Protocols and materials databases
DNASU	91272.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000285908; ENSP00000285908; ENSG00000145919. ENST00000311086; ENSP00000309644; ENSG00000145919.
GeneID	91272.
KEGG	hsa:91272.
UCSC	uc003mcq.2. human. uc003mcr.2. human.
Organism-specific databases
CTD	91272.
GeneCards	GC05M172968.
HGNC	HGNC:25114. BOD1.
HPA	HPA036293.
neXtProt	NX_Q96IK1.
PharmGKB	PA164716651.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG78324.
HOGENOM	HOG000070153.
InParanoid	Q96IK1.
OMA	KEDTIPA.
OrthoDB	EOG40ZQWP.
PhylomeDB	Q96IK1.
Gene expression databases
ArrayExpress	Q96IK1.
Bgee	Q96IK1.
CleanEx	HS_FAM44B.
Genevestigator	Q96IK1.
GermOnline	ENSG00000145919. Homo sapiens.
Family and domain databases
InterPro	IPR026955. Bod1_like. [Graphical view]
PANTHER	PTHR31532. PTHR31532. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	91272.
NextBio	77151.

Entry information

Entry name

BOD1_HUMAN

Accession

Primary (citable) accession number: Q96IK1
Secondary accession number(s): B4DXH8, Q9BTW1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	October 1, 2003
Last modified:	April 3, 2013
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.