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Q96IK1

- BOD1_HUMAN

UniProt

Q96IK1 - BOD1_HUMAN

Protein

Biorientation of chromosomes in cell division protein 1

Gene

BOD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles.1 Publication

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Biorientation of chromosomes in cell division protein 1
    Alternative name(s):
    Biorientation defective protein 1
    Protein FAM44B
    Gene namesi
    Name:BOD1
    Synonyms:FAM44B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:25114. BOD1.

    Subcellular locationi

    Cytoplasmcytoskeletonmicrotubule organizing centercentrosome 1 Publication. Chromosomecentromerekinetochore 1 Publication
    Note: Localizes at the centrosomes throughout the cell cycle, only dissociating during cytokinesis. Localizes at the kinetochore from prometaphase until anaphase.

    GO - Cellular componenti

    1. condensed chromosome kinetochore Source: UniProtKB-SubCell
    2. cytoplasm Source: UniProtKB-KW
    3. microtubule organizing center Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164716651.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 185185Biorientation of chromosomes in cell division protein 1PRO_0000187028Add
    BLAST

    Proteomic databases

    MaxQBiQ96IK1.
    PaxDbiQ96IK1.
    PRIDEiQ96IK1.

    PTM databases

    PhosphoSiteiQ96IK1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96IK1.
    BgeeiQ96IK1.
    CleanExiHS_FAM44B.
    GenevestigatoriQ96IK1.

    Organism-specific databases

    HPAiHPA036293.

    Interactioni

    Protein-protein interaction databases

    BioGridi124809. 2 interactions.
    STRINGi9606.ENSP00000309644.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96IK1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi4 – 3734Gly-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the BOD1 family.Curated

    Phylogenomic databases

    eggNOGiNOG78324.
    HOGENOMiHOG000070153.
    InParanoidiQ96IK1.
    OMAiIGMIVEH.
    OrthoDBiEOG7X3QQD.
    PhylomeDBiQ96IK1.
    TreeFamiTF325311.

    Family and domain databases

    InterProiIPR026955. Bod1_like.
    [Graphical view]
    PANTHERiPTHR31532. PTHR31532. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96IK1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MADGGGGGGT GAVGGGGTSQ ASAGAATGAT GASGGGGPIN PASLPPGDPQ    50
    LIALIVEQLK SRGLFDSFRR DCLADVDTKP AYQNLRQKVD NFVSTHLDKQ 100
    EWNPTMNKNQ LRNGLRQSVV QSGMLEAGVD RIISQVVDPK LNHIFRPQIE 150
    RAIHEFLAAQ KKAAVPAPPP EPEGQDPPAP SQDTS 185
    Length:185
    Mass (Da):19,196
    Last modified:October 1, 2003 - v2
    Checksum:i7A2A64C441C8BE7D
    GO
    Isoform 2 (identifier: Q96IK1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         122-129: SGMLEAGV → IRQTPFES
         130-185: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:129
    Mass (Da):13,280
    Checksum:i33D05637815EA078
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei122 – 1298SGMLEAGV → IRQTPFES in isoform 2. 1 PublicationVSP_016161
    Alternative sequencei130 – 18556Missing in isoform 2. 1 PublicationVSP_016162Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY303777 mRNA. Translation: AAP76182.1.
    AK301982 mRNA. Translation: BAG63390.1.
    CH471062 Genomic DNA. Translation: EAW61396.1.
    BC003114 mRNA. Translation: AAH03114.2.
    BC007436 mRNA. Translation: AAH07436.2.
    CCDSiCCDS4389.1. [Q96IK1-1]
    CCDS54951.1. [Q96IK1-2]
    RefSeqiNP_001153123.1. NM_001159651.1. [Q96IK1-2]
    NP_612378.1. NM_138369.2. [Q96IK1-1]
    UniGeneiHs.425091.

    Genome annotation databases

    EnsembliENST00000285908; ENSP00000285908; ENSG00000145919. [Q96IK1-2]
    ENST00000311086; ENSP00000309644; ENSG00000145919. [Q96IK1-1]
    GeneIDi91272.
    KEGGihsa:91272.
    UCSCiuc003mcq.2. human. [Q96IK1-1]
    uc003mcr.2. human. [Q96IK1-2]

    Polymorphism databases

    DMDMi74732069.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY303777 mRNA. Translation: AAP76182.1 .
    AK301982 mRNA. Translation: BAG63390.1 .
    CH471062 Genomic DNA. Translation: EAW61396.1 .
    BC003114 mRNA. Translation: AAH03114.2 .
    BC007436 mRNA. Translation: AAH07436.2 .
    CCDSi CCDS4389.1. [Q96IK1-1 ]
    CCDS54951.1. [Q96IK1-2 ]
    RefSeqi NP_001153123.1. NM_001159651.1. [Q96IK1-2 ]
    NP_612378.1. NM_138369.2. [Q96IK1-1 ]
    UniGenei Hs.425091.

    3D structure databases

    ProteinModelPortali Q96IK1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124809. 2 interactions.
    STRINGi 9606.ENSP00000309644.

    PTM databases

    PhosphoSitei Q96IK1.

    Polymorphism databases

    DMDMi 74732069.

    Proteomic databases

    MaxQBi Q96IK1.
    PaxDbi Q96IK1.
    PRIDEi Q96IK1.

    Protocols and materials databases

    DNASUi 91272.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000285908 ; ENSP00000285908 ; ENSG00000145919 . [Q96IK1-2 ]
    ENST00000311086 ; ENSP00000309644 ; ENSG00000145919 . [Q96IK1-1 ]
    GeneIDi 91272.
    KEGGi hsa:91272.
    UCSCi uc003mcq.2. human. [Q96IK1-1 ]
    uc003mcr.2. human. [Q96IK1-2 ]

    Organism-specific databases

    CTDi 91272.
    GeneCardsi GC05M172968.
    HGNCi HGNC:25114. BOD1.
    HPAi HPA036293.
    neXtProti NX_Q96IK1.
    PharmGKBi PA164716651.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG78324.
    HOGENOMi HOG000070153.
    InParanoidi Q96IK1.
    OMAi IGMIVEH.
    OrthoDBi EOG7X3QQD.
    PhylomeDBi Q96IK1.
    TreeFami TF325311.

    Miscellaneous databases

    GenomeRNAii 91272.
    NextBioi 77151.
    PROi Q96IK1.

    Gene expression databases

    ArrayExpressi Q96IK1.
    Bgeei Q96IK1.
    CleanExi HS_FAM44B.
    Genevestigatori Q96IK1.

    Family and domain databases

    InterProi IPR026955. Bod1_like.
    [Graphical view ]
    PANTHERi PTHR31532. PTHR31532. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Li H., Ke R., Zhou G., Shen C., Zheng G., Lin L., Yang S.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Lung and Muscle.
    5. Cited for: FUNCTION, SUBCELLULAR LOCATION.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiBOD1_HUMAN
    AccessioniPrimary (citable) accession number: Q96IK1
    Secondary accession number(s): B4DXH8, Q9BTW1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3