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Q96IK1

- BOD1_HUMAN

UniProt

Q96IK1 - BOD1_HUMAN

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Protein

Biorientation of chromosomes in cell division protein 1

Gene
BOD1, FAM44B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles.1 Publication

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Biorientation of chromosomes in cell division protein 1
Alternative name(s):
Biorientation defective protein 1
Protein FAM44B
Gene namesi
Name:BOD1
Synonyms:FAM44B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:25114. BOD1.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Chromosomecentromerekinetochore
Note: Localizes at the centrosomes throughout the cell cycle, only dissociating during cytokinesis. Localizes at the kinetochore from prometaphase until anaphase.1 Publication

GO - Cellular componenti

  1. condensed chromosome kinetochore Source: UniProtKB-SubCell
  2. cytoplasm Source: UniProtKB-KW
  3. microtubule organizing center Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164716651.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Biorientation of chromosomes in cell division protein 1PRO_0000187028Add
BLAST

Proteomic databases

MaxQBiQ96IK1.
PaxDbiQ96IK1.
PRIDEiQ96IK1.

PTM databases

PhosphoSiteiQ96IK1.

Expressioni

Gene expression databases

ArrayExpressiQ96IK1.
BgeeiQ96IK1.
CleanExiHS_FAM44B.
GenevestigatoriQ96IK1.

Organism-specific databases

HPAiHPA036293.

Interactioni

Protein-protein interaction databases

BioGridi124809. 2 interactions.
STRINGi9606.ENSP00000309644.

Structurei

3D structure databases

ProteinModelPortaliQ96IK1.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 3734Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the BOD1 family.

Phylogenomic databases

eggNOGiNOG78324.
HOGENOMiHOG000070153.
InParanoidiQ96IK1.
OMAiIGMIVEH.
OrthoDBiEOG7X3QQD.
PhylomeDBiQ96IK1.
TreeFamiTF325311.

Family and domain databases

InterProiIPR026955. Bod1_like.
[Graphical view]
PANTHERiPTHR31532. PTHR31532. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96IK1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MADGGGGGGT GAVGGGGTSQ ASAGAATGAT GASGGGGPIN PASLPPGDPQ    50
LIALIVEQLK SRGLFDSFRR DCLADVDTKP AYQNLRQKVD NFVSTHLDKQ 100
EWNPTMNKNQ LRNGLRQSVV QSGMLEAGVD RIISQVVDPK LNHIFRPQIE 150
RAIHEFLAAQ KKAAVPAPPP EPEGQDPPAP SQDTS 185
Length:185
Mass (Da):19,196
Last modified:October 1, 2003 - v2
Checksum:i7A2A64C441C8BE7D
GO
Isoform 2 (identifier: Q96IK1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-129: SGMLEAGV → IRQTPFES
     130-185: Missing.

Note: No experimental confirmation available.

Show »
Length:129
Mass (Da):13,280
Checksum:i33D05637815EA078
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei122 – 1298SGMLEAGV → IRQTPFES in isoform 2. VSP_016161
Alternative sequencei130 – 18556Missing in isoform 2. VSP_016162Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY303777 mRNA. Translation: AAP76182.1.
AK301982 mRNA. Translation: BAG63390.1.
CH471062 Genomic DNA. Translation: EAW61396.1.
BC003114 mRNA. Translation: AAH03114.2.
BC007436 mRNA. Translation: AAH07436.2.
CCDSiCCDS4389.1. [Q96IK1-1]
CCDS54951.1. [Q96IK1-2]
RefSeqiNP_001153123.1. NM_001159651.1. [Q96IK1-2]
NP_612378.1. NM_138369.2. [Q96IK1-1]
UniGeneiHs.425091.

Genome annotation databases

EnsembliENST00000285908; ENSP00000285908; ENSG00000145919. [Q96IK1-2]
ENST00000311086; ENSP00000309644; ENSG00000145919. [Q96IK1-1]
GeneIDi91272.
KEGGihsa:91272.
UCSCiuc003mcq.2. human. [Q96IK1-1]
uc003mcr.2. human. [Q96IK1-2]

Polymorphism databases

DMDMi74732069.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY303777 mRNA. Translation: AAP76182.1 .
AK301982 mRNA. Translation: BAG63390.1 .
CH471062 Genomic DNA. Translation: EAW61396.1 .
BC003114 mRNA. Translation: AAH03114.2 .
BC007436 mRNA. Translation: AAH07436.2 .
CCDSi CCDS4389.1. [Q96IK1-1 ]
CCDS54951.1. [Q96IK1-2 ]
RefSeqi NP_001153123.1. NM_001159651.1. [Q96IK1-2 ]
NP_612378.1. NM_138369.2. [Q96IK1-1 ]
UniGenei Hs.425091.

3D structure databases

ProteinModelPortali Q96IK1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124809. 2 interactions.
STRINGi 9606.ENSP00000309644.

PTM databases

PhosphoSitei Q96IK1.

Polymorphism databases

DMDMi 74732069.

Proteomic databases

MaxQBi Q96IK1.
PaxDbi Q96IK1.
PRIDEi Q96IK1.

Protocols and materials databases

DNASUi 91272.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000285908 ; ENSP00000285908 ; ENSG00000145919 . [Q96IK1-2 ]
ENST00000311086 ; ENSP00000309644 ; ENSG00000145919 . [Q96IK1-1 ]
GeneIDi 91272.
KEGGi hsa:91272.
UCSCi uc003mcq.2. human. [Q96IK1-1 ]
uc003mcr.2. human. [Q96IK1-2 ]

Organism-specific databases

CTDi 91272.
GeneCardsi GC05M172968.
HGNCi HGNC:25114. BOD1.
HPAi HPA036293.
neXtProti NX_Q96IK1.
PharmGKBi PA164716651.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG78324.
HOGENOMi HOG000070153.
InParanoidi Q96IK1.
OMAi IGMIVEH.
OrthoDBi EOG7X3QQD.
PhylomeDBi Q96IK1.
TreeFami TF325311.

Miscellaneous databases

GenomeRNAii 91272.
NextBioi 77151.
PROi Q96IK1.

Gene expression databases

ArrayExpressi Q96IK1.
Bgeei Q96IK1.
CleanExi HS_FAM44B.
Genevestigatori Q96IK1.

Family and domain databases

InterProi IPR026955. Bod1_like.
[Graphical view ]
PANTHERi PTHR31532. PTHR31532. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Li H., Ke R., Zhou G., Shen C., Zheng G., Lin L., Yang S.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Lung and Muscle.
  5. Cited for: FUNCTION, SUBCELLULAR LOCATION.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBOD1_HUMAN
AccessioniPrimary (citable) accession number: Q96IK1
Secondary accession number(s): B4DXH8, Q9BTW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2003
Last modified: September 3, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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