ID   TM101_HUMAN             Reviewed;         257 AA.
AC   Q96IK0; B2R9N6;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   24-JAN-2024, entry version 139.
DE   RecName: Full=Transmembrane protein 101;
DE   AltName: Full=Putative NF-kappa-B-activating protein 130;
GN   Name=TMEM101;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND FUNCTION.
RC   TISSUE=Lung;
RX   PubMed=12761501; DOI=10.1038/sj.onc.1206406;
RA   Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y.,
RA   Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S.;
RT   "Large-scale identification and characterization of human genes that
RT   activate NF-kappaB and MAPK signaling pathways.";
RL   Oncogene 22:3307-3318(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Skeletal muscle;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Muscle;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA   Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA   Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA   Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT   "N-terminal acetylome analyses and functional insights of the N-terminal
RT   acetyltransferase NatB.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC   -!- FUNCTION: May activate NF-kappa-B signaling pathways.
CC       {ECO:0000269|PubMed:12761501}.
CC   -!- INTERACTION:
CC       Q96IK0; Q12983: BNIP3; NbExp=3; IntAct=EBI-3922699, EBI-749464;
CC       Q96IK0; Q8WVX3-2: C4orf3; NbExp=3; IntAct=EBI-3922699, EBI-12003442;
CC       Q96IK0; Q8WWP7: GIMAP1; NbExp=3; IntAct=EBI-3922699, EBI-11991950;
CC       Q96IK0; O95167: NDUFA3; NbExp=3; IntAct=EBI-3922699, EBI-1246131;
CC       Q96IK0; Q9NZG7: NINJ2; NbExp=3; IntAct=EBI-3922699, EBI-10317425;
CC       Q96IK0; Q13113: PDZK1IP1; NbExp=3; IntAct=EBI-3922699, EBI-716063;
CC       Q96IK0; Q99640-2: PKMYT1; NbExp=3; IntAct=EBI-3922699, EBI-12257782;
CC       Q96IK0; P0DN84: STRIT1; NbExp=3; IntAct=EBI-3922699, EBI-12200293;
CC       Q96IK0; O60499-2: STX10; NbExp=3; IntAct=EBI-3922699, EBI-12094584;
CC       Q96IK0; P57105: SYNJ2BP; NbExp=3; IntAct=EBI-3922699, EBI-1049004;
CC       Q96IK0; Q9BU79: TMEM243; NbExp=3; IntAct=EBI-3922699, EBI-12887458;
CC       Q96IK0; Q6PI78: TMEM65; NbExp=3; IntAct=EBI-3922699, EBI-6656213;
CC       Q96IK0; P23763-3: VAMP1; NbExp=3; IntAct=EBI-3922699, EBI-12097582;
CC       Q96IK0; P63027: VAMP2; NbExp=3; IntAct=EBI-3922699, EBI-520113;
CC       Q96IK0; O95292: VAPB; NbExp=3; IntAct=EBI-3922699, EBI-1188298;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB097008; BAC77361.1; -; mRNA.
DR   EMBL; AK313855; BAG36583.1; -; mRNA.
DR   EMBL; CH471178; EAW51642.1; -; Genomic_DNA.
DR   EMBL; BC007438; AAH07438.1; -; mRNA.
DR   CCDS; CCDS11474.1; -.
DR   RefSeq; NP_001291742.1; NM_001304813.1.
DR   RefSeq; NP_001291743.1; NM_001304814.1.
DR   RefSeq; NP_115752.1; NM_032376.3.
DR   RefSeq; XP_005257794.1; XM_005257737.2.
DR   RefSeq; XP_011523648.1; XM_011525346.1.
DR   RefSeq; XP_011523649.1; XM_011525347.1.
DR   RefSeq; XP_011523651.1; XM_011525349.1.
DR   RefSeq; XP_011523653.1; XM_011525351.1.
DR   AlphaFoldDB; Q96IK0; -.
DR   BioGRID; 124060; 30.
DR   IntAct; Q96IK0; 20.
DR   MINT; Q96IK0; -.
DR   STRING; 9606.ENSP00000468025; -.
DR   TCDB; 9.B.365.3.1; the putative 4 - 5 tms doxd (doxd) superfamily.
DR   SwissPalm; Q96IK0; -.
DR   BioMuta; TMEM101; -.
DR   DMDM; 74732068; -.
DR   EPD; Q96IK0; -.
DR   jPOST; Q96IK0; -.
DR   MassIVE; Q96IK0; -.
DR   MaxQB; Q96IK0; -.
DR   PaxDb; 9606-ENSP00000468025; -.
DR   PeptideAtlas; Q96IK0; -.
DR   ProteomicsDB; 76835; -.
DR   Pumba; Q96IK0; -.
DR   Antibodypedia; 54322; 87 antibodies from 20 providers.
DR   DNASU; 84336; -.
DR   Ensembl; ENST00000206380.8; ENSP00000206380.3; ENSG00000091947.10.
DR   Ensembl; ENST00000589334.5; ENSP00000468025.1; ENSG00000091947.10.
DR   GeneID; 84336; -.
DR   KEGG; hsa:84336; -.
DR   MANE-Select; ENST00000206380.8; ENSP00000206380.3; NM_032376.4; NP_115752.1.
DR   UCSC; uc002ieu.4; human.
DR   AGR; HGNC:28653; -.
DR   CTD; 84336; -.
DR   GeneCards; TMEM101; -.
DR   HGNC; HGNC:28653; TMEM101.
DR   HPA; ENSG00000091947; Low tissue specificity.
DR   neXtProt; NX_Q96IK0; -.
DR   OpenTargets; ENSG00000091947; -.
DR   PharmGKB; PA142670750; -.
DR   VEuPathDB; HostDB:ENSG00000091947; -.
DR   eggNOG; ENOG502QRKU; Eukaryota.
DR   GeneTree; ENSGT00390000011938; -.
DR   HOGENOM; CLU_094617_0_0_1; -.
DR   InParanoid; Q96IK0; -.
DR   OMA; QHSQEDR; -.
DR   OrthoDB; 2904377at2759; -.
DR   PhylomeDB; Q96IK0; -.
DR   PathwayCommons; Q96IK0; -.
DR   SignaLink; Q96IK0; -.
DR   BioGRID-ORCS; 84336; 9 hits in 1161 CRISPR screens.
DR   ChiTaRS; TMEM101; human.
DR   GenomeRNAi; 84336; -.
DR   Pharos; Q96IK0; Tdark.
DR   PRO; PR:Q96IK0; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; Q96IK0; Protein.
DR   Bgee; ENSG00000091947; Expressed in metanephros cortex and 154 other cell types or tissues.
DR   ExpressionAtlas; Q96IK0; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; HMP:UniProtKB.
DR   InterPro; IPR029371; TMEM101.
DR   PANTHER; PTHR31034; TRANSMEMBRANE PROTEIN 101; 1.
DR   PANTHER; PTHR31034:SF2; TRANSMEMBRANE PROTEIN 101; 1.
DR   Pfam; PF15111; TMEM101; 1.
DR   Genevisible; Q96IK0; HS.
PE   1: Evidence at protein level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..257
FT                   /note="Transmembrane protein 101"
FT                   /id="PRO_0000240864"
FT   TRANSMEM        21..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        52..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        206..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        233..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   257 AA;  28795 MW;  F2939392B69AFB2D CRC64;
     MASKIGSRRW MLQLIMQLGS VLLTRCPFWG CFSQLMLYAE RAEARRKPDI PVPYLYFDMG
     AAVLCASFMS FGVKRRWFAL GAALQLAIST YAAYIGGYVH YGDWLKVRMY SRTVAIIGGF
     LVLASGAGEL YRRKPRSRSL QSTGQVFLGI YLICVAYSLQ HSKEDRLAYL NHLPGGELMI
     QLFFVLYGIL ALAFLSGYYV TLAAQILAVL LPPVMLLIDG NVAYWHNTRR VEFWNQMKLL
     GESVGIFGTA VILATDG
//