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Q96IK0 (TM101_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 101
Alternative name(s):
Putative NF-kappa-B-activating protein 130
Gene names
Name:TMEM101
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length257 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May activate NF-kappa-B signaling pathways. Ref.1

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 257257Transmembrane protein 101
PRO_0000240864

Regions

Transmembrane21 – 4020Helical; Potential
Transmembrane52 – 7221Helical; Potential
Transmembrane77 – 9721Helical; Potential
Transmembrane110 – 13021Helical; Potential
Transmembrane139 – 15921Helical; Potential
Transmembrane182 – 20221Helical; Potential
Transmembrane206 – 22621Helical; Potential
Transmembrane233 – 25321Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q96IK0 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: F2939392B69AFB2D

FASTA25728,795
        10         20         30         40         50         60 
MASKIGSRRW MLQLIMQLGS VLLTRCPFWG CFSQLMLYAE RAEARRKPDI PVPYLYFDMG 

        70         80         90        100        110        120 
AAVLCASFMS FGVKRRWFAL GAALQLAIST YAAYIGGYVH YGDWLKVRMY SRTVAIIGGF 

       130        140        150        160        170        180 
LVLASGAGEL YRRKPRSRSL QSTGQVFLGI YLICVAYSLQ HSKEDRLAYL NHLPGGELMI 

       190        200        210        220        230        240 
QLFFVLYGIL ALAFLSGYYV TLAAQILAVL LPPVMLLIDG NVAYWHNTRR VEFWNQMKLL 

       250 
GESVGIFGTA VILATDG 

« Hide

References

[1]"Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S.
Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], FUNCTION.
Tissue: Lung.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skeletal muscle.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Muscle.
[5]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB097008 mRNA. Translation: BAC77361.1.
AK313855 mRNA. Translation: BAG36583.1.
CH471178 Genomic DNA. Translation: EAW51642.1.
BC007438 mRNA. Translation: AAH07438.1.
RefSeqNP_115752.1. NM_032376.2.
XP_005257794.1. XM_005257737.1.
UniGeneHs.514211.

3D structure databases

ProteinModelPortalQ96IK0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124060. 2 interactions.
IntActQ96IK0. 1 interaction.
STRING9606.ENSP00000206380.

Polymorphism databases

DMDM74732068.

Proteomic databases

PaxDbQ96IK0.
PeptideAtlasQ96IK0.
PRIDEQ96IK0.

Protocols and materials databases

DNASU84336.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000206380; ENSP00000206380; ENSG00000091947.
ENST00000589334; ENSP00000468025; ENSG00000091947.
GeneID84336.
KEGGhsa:84336.
UCSCuc002ieu.3. human.

Organism-specific databases

CTD84336.
GeneCardsGC17M042088.
HGNCHGNC:28653. TMEM101.
neXtProtNX_Q96IK0.
PharmGKBPA142670750.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45597.
HOGENOMHOG000232137.
HOVERGENHBG057681.
InParanoidQ96IK0.
OMANCFSMLM.
OrthoDBEOG79PJS3.
PhylomeDBQ96IK0.

Gene expression databases

ArrayExpressQ96IK0.
BgeeQ96IK0.
CleanExHS_TMEM101.
GenevestigatorQ96IK0.

Family and domain databases

ProtoNetSearch...

Other

GenomeRNAi84336.
NextBio74113.
PROQ96IK0.

Entry information

Entry nameTM101_HUMAN
AccessionPrimary (citable) accession number: Q96IK0
Secondary accession number(s): B2R9N6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM