Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q96IK0

- TM101_HUMAN

UniProt

Q96IK0 - TM101_HUMAN

Protein

Transmembrane protein 101

Gene

TMEM101

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May activate NF-kappa-B signaling pathways.1 Publication

    GO - Molecular functioni

    1. signal transducer activity Source: UniProtKB

    GO - Biological processi

    1. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
    2. signal transduction Source: GOC

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 101
    Alternative name(s):
    Putative NF-kappa-B-activating protein 130
    Gene namesi
    Name:TMEM101
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:28653. TMEM101.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670750.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 257257Transmembrane protein 101PRO_0000240864Add
    BLAST

    Proteomic databases

    MaxQBiQ96IK0.
    PaxDbiQ96IK0.
    PeptideAtlasiQ96IK0.
    PRIDEiQ96IK0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96IK0.
    BgeeiQ96IK0.
    CleanExiHS_TMEM101.
    GenevestigatoriQ96IK0.

    Interactioni

    Protein-protein interaction databases

    BioGridi124060. 2 interactions.
    IntActiQ96IK0. 1 interaction.
    STRINGi9606.ENSP00000206380.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96IK0.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4020HelicalSequence AnalysisAdd
    BLAST
    Transmembranei52 – 7221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei77 – 9721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei110 – 13021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei139 – 15921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei182 – 20221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei206 – 22621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei233 – 25321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45597.
    HOGENOMiHOG000232137.
    HOVERGENiHBG057681.
    InParanoidiQ96IK0.
    OMAiNCFSMLM.
    OrthoDBiEOG79PJS3.
    PhylomeDBiQ96IK0.

    Family and domain databases

    InterProiIPR029371. TMEM101.
    [Graphical view]
    PfamiPF15111. TMEM101. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96IK0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASKIGSRRW MLQLIMQLGS VLLTRCPFWG CFSQLMLYAE RAEARRKPDI    50
    PVPYLYFDMG AAVLCASFMS FGVKRRWFAL GAALQLAIST YAAYIGGYVH 100
    YGDWLKVRMY SRTVAIIGGF LVLASGAGEL YRRKPRSRSL QSTGQVFLGI 150
    YLICVAYSLQ HSKEDRLAYL NHLPGGELMI QLFFVLYGIL ALAFLSGYYV 200
    TLAAQILAVL LPPVMLLIDG NVAYWHNTRR VEFWNQMKLL GESVGIFGTA 250
    VILATDG 257
    Length:257
    Mass (Da):28,795
    Last modified:December 1, 2001 - v1
    Checksum:iF2939392B69AFB2D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB097008 mRNA. Translation: BAC77361.1.
    AK313855 mRNA. Translation: BAG36583.1.
    CH471178 Genomic DNA. Translation: EAW51642.1.
    BC007438 mRNA. Translation: AAH07438.1.
    CCDSiCCDS11474.1.
    RefSeqiNP_115752.1. NM_032376.2.
    XP_005257794.1. XM_005257737.1.
    UniGeneiHs.514211.

    Genome annotation databases

    EnsembliENST00000206380; ENSP00000206380; ENSG00000091947.
    ENST00000589334; ENSP00000468025; ENSG00000091947.
    GeneIDi84336.
    KEGGihsa:84336.
    UCSCiuc002ieu.3. human.

    Polymorphism databases

    DMDMi74732068.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB097008 mRNA. Translation: BAC77361.1 .
    AK313855 mRNA. Translation: BAG36583.1 .
    CH471178 Genomic DNA. Translation: EAW51642.1 .
    BC007438 mRNA. Translation: AAH07438.1 .
    CCDSi CCDS11474.1.
    RefSeqi NP_115752.1. NM_032376.2.
    XP_005257794.1. XM_005257737.1.
    UniGenei Hs.514211.

    3D structure databases

    ProteinModelPortali Q96IK0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124060. 2 interactions.
    IntActi Q96IK0. 1 interaction.
    STRINGi 9606.ENSP00000206380.

    Polymorphism databases

    DMDMi 74732068.

    Proteomic databases

    MaxQBi Q96IK0.
    PaxDbi Q96IK0.
    PeptideAtlasi Q96IK0.
    PRIDEi Q96IK0.

    Protocols and materials databases

    DNASUi 84336.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000206380 ; ENSP00000206380 ; ENSG00000091947 .
    ENST00000589334 ; ENSP00000468025 ; ENSG00000091947 .
    GeneIDi 84336.
    KEGGi hsa:84336.
    UCSCi uc002ieu.3. human.

    Organism-specific databases

    CTDi 84336.
    GeneCardsi GC17M042088.
    HGNCi HGNC:28653. TMEM101.
    neXtProti NX_Q96IK0.
    PharmGKBi PA142670750.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45597.
    HOGENOMi HOG000232137.
    HOVERGENi HBG057681.
    InParanoidi Q96IK0.
    OMAi NCFSMLM.
    OrthoDBi EOG79PJS3.
    PhylomeDBi Q96IK0.

    Miscellaneous databases

    GenomeRNAii 84336.
    NextBioi 74113.
    PROi Q96IK0.

    Gene expression databases

    ArrayExpressi Q96IK0.
    Bgeei Q96IK0.
    CleanExi HS_TMEM101.
    Genevestigatori Q96IK0.

    Family and domain databases

    InterProi IPR029371. TMEM101.
    [Graphical view ]
    Pfami PF15111. TMEM101. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
      Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S.
      Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], FUNCTION.
      Tissue: Lung.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skeletal muscle.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Muscle.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTM101_HUMAN
    AccessioniPrimary (citable) accession number: Q96IK0
    Secondary accession number(s): B2R9N6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM

    External Data

    Dasty 3