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Protein

Transmembrane protein 101

Gene

TMEM101

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May activate NF-kappa-B signaling pathways.1 Publication

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 101
Alternative name(s):
Putative NF-kappa-B-activating protein 130
Gene namesi
Name:TMEM101
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000091947.9
HGNCiHGNC:28653 TMEM101
neXtProtiNX_Q96IK0

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 40HelicalSequence analysisAdd BLAST20
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Transmembranei110 – 130HelicalSequence analysisAdd BLAST21
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi84336
OpenTargetsiENSG00000091947
PharmGKBiPA142670750

Polymorphism and mutation databases

BioMutaiTMEM101
DMDMi74732068

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002408641 – 257Transmembrane protein 101Add BLAST257

Proteomic databases

EPDiQ96IK0
MaxQBiQ96IK0
PaxDbiQ96IK0
PeptideAtlasiQ96IK0
PRIDEiQ96IK0

Expressioni

Gene expression databases

BgeeiENSG00000091947
CleanExiHS_TMEM101
ExpressionAtlasiQ96IK0 baseline and differential
GenevisibleiQ96IK0 HS

Organism-specific databases

HPAiHPA039739

Interactioni

Protein-protein interaction databases

BioGridi124060, 3 interactors
IntActiQ96IK0, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ96IK0
SMRiQ96IK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG43 Eukaryota
ENOG410XR0V LUCA
GeneTreeiENSGT00390000011938
HOGENOMiHOG000232137
HOVERGENiHBG057681
InParanoidiQ96IK0
OMAiNCFSMLM
OrthoDBiEOG091G0G3S
PhylomeDBiQ96IK0

Family and domain databases

InterProiView protein in InterPro
IPR029371 TMEM101
PANTHERiPTHR31034 PTHR31034, 1 hit
PfamiView protein in Pfam
PF15111 TMEM101, 1 hit

Sequencei

Sequence statusi: Complete.

Q96IK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKIGSRRW MLQLIMQLGS VLLTRCPFWG CFSQLMLYAE RAEARRKPDI
60 70 80 90 100
PVPYLYFDMG AAVLCASFMS FGVKRRWFAL GAALQLAIST YAAYIGGYVH
110 120 130 140 150
YGDWLKVRMY SRTVAIIGGF LVLASGAGEL YRRKPRSRSL QSTGQVFLGI
160 170 180 190 200
YLICVAYSLQ HSKEDRLAYL NHLPGGELMI QLFFVLYGIL ALAFLSGYYV
210 220 230 240 250
TLAAQILAVL LPPVMLLIDG NVAYWHNTRR VEFWNQMKLL GESVGIFGTA

VILATDG
Length:257
Mass (Da):28,795
Last modified:December 1, 2001 - v1
Checksum:iF2939392B69AFB2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097008 mRNA Translation: BAC77361.1
AK313855 mRNA Translation: BAG36583.1
CH471178 Genomic DNA Translation: EAW51642.1
BC007438 mRNA Translation: AAH07438.1
CCDSiCCDS11474.1
RefSeqiNP_001291742.1, NM_001304813.1
NP_001291743.1, NM_001304814.1
NP_115752.1, NM_032376.3
XP_005257794.1, XM_005257737.2
XP_011523648.1, XM_011525346.1
XP_011523649.1, XM_011525347.1
XP_011523651.1, XM_011525349.1
XP_011523653.1, XM_011525351.1
UniGeneiHs.514211

Genome annotation databases

EnsembliENST00000206380; ENSP00000206380; ENSG00000091947
ENST00000589334; ENSP00000468025; ENSG00000091947
GeneIDi84336
KEGGihsa:84336
UCSCiuc002ieu.4 human

Similar proteinsi

Entry informationi

Entry nameiTM101_HUMAN
AccessioniPrimary (citable) accession number: Q96IK0
Secondary accession number(s): B2R9N6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health