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Protein

Transmembrane protein 101

Gene

TMEM101

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May activate NF-kappa-B signaling pathways.1 Publication

GO - Molecular functioni

  1. signal transducer activity Source: UniProtKB

GO - Biological processi

  1. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  2. signal transduction Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 101
Alternative name(s):
Putative NF-kappa-B-activating protein 130
Gene namesi
Name:TMEM101
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:28653. TMEM101.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4020HelicalSequence AnalysisAdd
BLAST
Transmembranei52 – 7221HelicalSequence AnalysisAdd
BLAST
Transmembranei77 – 9721HelicalSequence AnalysisAdd
BLAST
Transmembranei110 – 13021HelicalSequence AnalysisAdd
BLAST
Transmembranei139 – 15921HelicalSequence AnalysisAdd
BLAST
Transmembranei182 – 20221HelicalSequence AnalysisAdd
BLAST
Transmembranei206 – 22621HelicalSequence AnalysisAdd
BLAST
Transmembranei233 – 25321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670750.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257Transmembrane protein 101PRO_0000240864Add
BLAST

Proteomic databases

MaxQBiQ96IK0.
PaxDbiQ96IK0.
PeptideAtlasiQ96IK0.
PRIDEiQ96IK0.

Expressioni

Gene expression databases

BgeeiQ96IK0.
CleanExiHS_TMEM101.
ExpressionAtlasiQ96IK0. baseline and differential.
GenevestigatoriQ96IK0.

Interactioni

Protein-protein interaction databases

BioGridi124060. 2 interactions.
IntActiQ96IK0. 1 interaction.
STRINGi9606.ENSP00000206380.

Structurei

3D structure databases

ProteinModelPortaliQ96IK0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45597.
GeneTreeiENSGT00390000011938.
HOGENOMiHOG000232137.
HOVERGENiHBG057681.
InParanoidiQ96IK0.
OMAiNCFSMLM.
OrthoDBiEOG79PJS3.
PhylomeDBiQ96IK0.

Family and domain databases

InterProiIPR029371. TMEM101.
[Graphical view]
PfamiPF15111. TMEM101. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96IK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKIGSRRW MLQLIMQLGS VLLTRCPFWG CFSQLMLYAE RAEARRKPDI
60 70 80 90 100
PVPYLYFDMG AAVLCASFMS FGVKRRWFAL GAALQLAIST YAAYIGGYVH
110 120 130 140 150
YGDWLKVRMY SRTVAIIGGF LVLASGAGEL YRRKPRSRSL QSTGQVFLGI
160 170 180 190 200
YLICVAYSLQ HSKEDRLAYL NHLPGGELMI QLFFVLYGIL ALAFLSGYYV
210 220 230 240 250
TLAAQILAVL LPPVMLLIDG NVAYWHNTRR VEFWNQMKLL GESVGIFGTA

VILATDG
Length:257
Mass (Da):28,795
Last modified:December 1, 2001 - v1
Checksum:iF2939392B69AFB2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097008 mRNA. Translation: BAC77361.1.
AK313855 mRNA. Translation: BAG36583.1.
CH471178 Genomic DNA. Translation: EAW51642.1.
BC007438 mRNA. Translation: AAH07438.1.
CCDSiCCDS11474.1.
RefSeqiNP_115752.1. NM_032376.2.
XP_005257794.1. XM_005257737.1.
UniGeneiHs.514211.

Genome annotation databases

EnsembliENST00000206380; ENSP00000206380; ENSG00000091947.
ENST00000589334; ENSP00000468025; ENSG00000091947.
GeneIDi84336.
KEGGihsa:84336.
UCSCiuc002ieu.3. human.

Polymorphism databases

DMDMi74732068.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097008 mRNA. Translation: BAC77361.1.
AK313855 mRNA. Translation: BAG36583.1.
CH471178 Genomic DNA. Translation: EAW51642.1.
BC007438 mRNA. Translation: AAH07438.1.
CCDSiCCDS11474.1.
RefSeqiNP_115752.1. NM_032376.2.
XP_005257794.1. XM_005257737.1.
UniGeneiHs.514211.

3D structure databases

ProteinModelPortaliQ96IK0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124060. 2 interactions.
IntActiQ96IK0. 1 interaction.
STRINGi9606.ENSP00000206380.

Polymorphism databases

DMDMi74732068.

Proteomic databases

MaxQBiQ96IK0.
PaxDbiQ96IK0.
PeptideAtlasiQ96IK0.
PRIDEiQ96IK0.

Protocols and materials databases

DNASUi84336.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000206380; ENSP00000206380; ENSG00000091947.
ENST00000589334; ENSP00000468025; ENSG00000091947.
GeneIDi84336.
KEGGihsa:84336.
UCSCiuc002ieu.3. human.

Organism-specific databases

CTDi84336.
GeneCardsiGC17M042088.
HGNCiHGNC:28653. TMEM101.
neXtProtiNX_Q96IK0.
PharmGKBiPA142670750.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG45597.
GeneTreeiENSGT00390000011938.
HOGENOMiHOG000232137.
HOVERGENiHBG057681.
InParanoidiQ96IK0.
OMAiNCFSMLM.
OrthoDBiEOG79PJS3.
PhylomeDBiQ96IK0.

Miscellaneous databases

GenomeRNAii84336.
NextBioi74113.
PROiQ96IK0.

Gene expression databases

BgeeiQ96IK0.
CleanExiHS_TMEM101.
ExpressionAtlasiQ96IK0. baseline and differential.
GenevestigatoriQ96IK0.

Family and domain databases

InterProiIPR029371. TMEM101.
[Graphical view]
PfamiPF15111. TMEM101. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
    Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S.
    Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], FUNCTION.
    Tissue: Lung.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skeletal muscle.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTM101_HUMAN
AccessioniPrimary (citable) accession number: Q96IK0
Secondary accession number(s): B2R9N6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 1, 2001
Last modified: January 7, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.