Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q96IK0

- TM101_HUMAN

UniProt

Q96IK0 - TM101_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Transmembrane protein 101

Gene

TMEM101

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May activate NF-kappa-B signaling pathways.1 Publication

GO - Molecular functioni

  1. signal transducer activity Source: UniProtKB

GO - Biological processi

  1. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  2. signal transduction Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 101
Alternative name(s):
Putative NF-kappa-B-activating protein 130
Gene namesi
Name:TMEM101
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:28653. TMEM101.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4020HelicalSequence AnalysisAdd
BLAST
Transmembranei52 – 7221HelicalSequence AnalysisAdd
BLAST
Transmembranei77 – 9721HelicalSequence AnalysisAdd
BLAST
Transmembranei110 – 13021HelicalSequence AnalysisAdd
BLAST
Transmembranei139 – 15921HelicalSequence AnalysisAdd
BLAST
Transmembranei182 – 20221HelicalSequence AnalysisAdd
BLAST
Transmembranei206 – 22621HelicalSequence AnalysisAdd
BLAST
Transmembranei233 – 25321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670750.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257Transmembrane protein 101PRO_0000240864Add
BLAST

Proteomic databases

MaxQBiQ96IK0.
PaxDbiQ96IK0.
PeptideAtlasiQ96IK0.
PRIDEiQ96IK0.

Expressioni

Gene expression databases

BgeeiQ96IK0.
CleanExiHS_TMEM101.
ExpressionAtlasiQ96IK0. baseline and differential.
GenevestigatoriQ96IK0.

Interactioni

Protein-protein interaction databases

BioGridi124060. 2 interactions.
IntActiQ96IK0. 1 interaction.
STRINGi9606.ENSP00000206380.

Structurei

3D structure databases

ProteinModelPortaliQ96IK0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45597.
GeneTreeiENSGT00390000011938.
HOGENOMiHOG000232137.
HOVERGENiHBG057681.
InParanoidiQ96IK0.
OMAiNCFSMLM.
OrthoDBiEOG79PJS3.
PhylomeDBiQ96IK0.

Family and domain databases

InterProiIPR029371. TMEM101.
[Graphical view]
PfamiPF15111. TMEM101. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96IK0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASKIGSRRW MLQLIMQLGS VLLTRCPFWG CFSQLMLYAE RAEARRKPDI
60 70 80 90 100
PVPYLYFDMG AAVLCASFMS FGVKRRWFAL GAALQLAIST YAAYIGGYVH
110 120 130 140 150
YGDWLKVRMY SRTVAIIGGF LVLASGAGEL YRRKPRSRSL QSTGQVFLGI
160 170 180 190 200
YLICVAYSLQ HSKEDRLAYL NHLPGGELMI QLFFVLYGIL ALAFLSGYYV
210 220 230 240 250
TLAAQILAVL LPPVMLLIDG NVAYWHNTRR VEFWNQMKLL GESVGIFGTA

VILATDG
Length:257
Mass (Da):28,795
Last modified:December 1, 2001 - v1
Checksum:iF2939392B69AFB2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097008 mRNA. Translation: BAC77361.1.
AK313855 mRNA. Translation: BAG36583.1.
CH471178 Genomic DNA. Translation: EAW51642.1.
BC007438 mRNA. Translation: AAH07438.1.
CCDSiCCDS11474.1.
RefSeqiNP_115752.1. NM_032376.2.
XP_005257794.1. XM_005257737.1.
UniGeneiHs.514211.

Genome annotation databases

EnsembliENST00000206380; ENSP00000206380; ENSG00000091947.
ENST00000589334; ENSP00000468025; ENSG00000091947.
GeneIDi84336.
KEGGihsa:84336.
UCSCiuc002ieu.3. human.

Polymorphism databases

DMDMi74732068.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097008 mRNA. Translation: BAC77361.1 .
AK313855 mRNA. Translation: BAG36583.1 .
CH471178 Genomic DNA. Translation: EAW51642.1 .
BC007438 mRNA. Translation: AAH07438.1 .
CCDSi CCDS11474.1.
RefSeqi NP_115752.1. NM_032376.2.
XP_005257794.1. XM_005257737.1.
UniGenei Hs.514211.

3D structure databases

ProteinModelPortali Q96IK0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124060. 2 interactions.
IntActi Q96IK0. 1 interaction.
STRINGi 9606.ENSP00000206380.

Polymorphism databases

DMDMi 74732068.

Proteomic databases

MaxQBi Q96IK0.
PaxDbi Q96IK0.
PeptideAtlasi Q96IK0.
PRIDEi Q96IK0.

Protocols and materials databases

DNASUi 84336.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000206380 ; ENSP00000206380 ; ENSG00000091947 .
ENST00000589334 ; ENSP00000468025 ; ENSG00000091947 .
GeneIDi 84336.
KEGGi hsa:84336.
UCSCi uc002ieu.3. human.

Organism-specific databases

CTDi 84336.
GeneCardsi GC17M042088.
HGNCi HGNC:28653. TMEM101.
neXtProti NX_Q96IK0.
PharmGKBi PA142670750.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45597.
GeneTreei ENSGT00390000011938.
HOGENOMi HOG000232137.
HOVERGENi HBG057681.
InParanoidi Q96IK0.
OMAi NCFSMLM.
OrthoDBi EOG79PJS3.
PhylomeDBi Q96IK0.

Miscellaneous databases

GenomeRNAii 84336.
NextBioi 74113.
PROi Q96IK0.

Gene expression databases

Bgeei Q96IK0.
CleanExi HS_TMEM101.
ExpressionAtlasi Q96IK0. baseline and differential.
Genevestigatori Q96IK0.

Family and domain databases

InterProi IPR029371. TMEM101.
[Graphical view ]
Pfami PF15111. TMEM101. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
    Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S.
    Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], FUNCTION.
    Tissue: Lung.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skeletal muscle.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTM101_HUMAN
AccessioniPrimary (citable) accession number: Q96IK0
Secondary accession number(s): B2R9N6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM

External Data

Dasty 3