Q96IG6 (Q96IG6_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Aminomethyltransferase RuleBase RU003981
EC=2.1.2.10 RuleBase RU003981

Gene names

Name:

AMT EMBL AAH07546.2

Organism

Homo sapiens (Human) EMBL AAH07546.2

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	383 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. RuleBase RU003981
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. RuleBase RU003981
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity. RuleBase RU003981
Sequence similarities	Belongs to the GcvT family. RuleBase RU003980

Ontologies

Keywords
Molecular function	Aminotransferase RuleBase RU003981 Transferase
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAH07546.2

Sequences

	Sequence		Length	Mass (Da)
	Q96IG6 [UniParc]. Last modified March 29, 2005. Version 2. Checksum: 937ABE50697FDC76	FASTA	383	41,365
	10 20 30 40 50 60 AVSVVARLGF RLQAFPPALC RPLSCAQEVL RRTPLYDFHL AHGGKMVAFA GWSLPVQYRD 70 80 90 100 110 120 SHTDSHLHTR QHCSLFDVSH MLQTKILGSD RVKLMESLVV GDIAELRPNQ GTLSLFTNEA 130 140 150 160 170 180 GGILDDLIVT NTSEGHLYVV SNAGCWEKDL ALMQDKVREL QNQGRDVGLE VLDNALLALQ 190 200 210 220 230 240 GPTAAQVLQA GVADDLRKLP FMTSAVMEVF GVSGCRVTRC GYTGEDGVEI SVPVAGAVHL 250 260 270 280 290 300 ATAILKNPEV KLAGLAARDS LRLEAGLCLY GNDIDEHTTP VEGSLSWTLG KRRRAAMDFP 310 320 330 340 350 360 GAKVIVPQLK GRVQRRRVGL MCEGAPMRAH SPILNMEGTK IGTVTSGCPS PSLKKNVAMG 370 380 YVPCEYSRPG TMLLVELPSG PCF

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon EMBL AAH07546.2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC007546 mRNA. Translation: AAH07546.2.
IPI	IPI00793058.
RefSeq	NP_001158184.1. NM_001164712.1.
UniGene	Hs.102.
3D structure databases
ProteinModelPortal	Q96IG6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q96IG6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	275.
KEGG	hsa:275.
UCSC	uc003cwx.2. human.
Organism-specific databases
CTD	275.
Phylogenomic databases
GeneTree	ENSGT00510000047333.
HOVERGEN	HBG005822.
OrthoDB	EOG45MN5K.
PhylomeDB	Q96IG6.
Gene expression databases
ArrayExpress	Q96IG6.
Bgee	Q96IG6.
Family and domain databases
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q96IG6_HUMAN

Accession

Primary (citable) accession number: Q96IG6

Entry history

Integrated into UniProtKB/TrEMBL:	December 1, 2001
Last sequence update:	March 29, 2005
Last modified:	November 16, 2011
This is version 66 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.