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Protein

F-box/LRR-repeat protein 20

Gene

FBXL20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 20
Alternative name(s):
F-box and leucine-rich repeat protein 20
F-box/LRR-repeat protein 2-like
Gene namesi
Name:FBXL20
Synonyms:FBL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:24679. FBXL20.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134976410.

Polymorphism and mutation databases

BioMutaiFBXL20.
DMDMi38503141.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436F-box/LRR-repeat protein 20PRO_0000119870Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei417 – 4171PhosphothreonineCombined sources
Modified residuei421 – 4211PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96IG2.
MaxQBiQ96IG2.
PaxDbiQ96IG2.
PRIDEiQ96IG2.

PTM databases

iPTMnetiQ96IG2.
PhosphoSiteiQ96IG2.
SwissPalmiQ96IG2.

Expressioni

Gene expression databases

BgeeiQ96IG2.
CleanExiHS_FBXL20.
ExpressionAtlasiQ96IG2. baseline and differential.
GenevisibleiQ96IG2. HS.

Organism-specific databases

HPAiHPA044748.
HPA050397.

Interactioni

Subunit structurei

Interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

BioGridi124392. 6 interactions.
STRINGi9606.ENSP00000264658.

Structurei

3D structure databases

ProteinModelPortaliQ96IG2.
SMRiQ96IG2. Positions 28-389.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 6847F-boxPROSITE-ProRule annotationAdd
BLAST
Repeati74 – 10027LRR 1Add
BLAST
Repeati101 – 12626LRR 2Add
BLAST
Repeati127 – 15226LRR 3Add
BLAST
Repeati153 – 17826LRR 4Add
BLAST
Repeati179 – 20426LRR 5Add
BLAST
Repeati205 – 23026LRR 6Add
BLAST
Repeati231 – 25626LRR 7Add
BLAST
Repeati257 – 28226LRR 8Add
BLAST
Repeati283 – 30826LRR 9Add
BLAST
Repeati309 – 33426LRR 10Add
BLAST
Repeati335 – 36329LRR 11Add
BLAST
Repeati364 – 38825LRR 12Add
BLAST
Repeati389 – 41426LRR 13Add
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 13 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG4341. Eukaryota.
ENOG410XQ54. LUCA.
GeneTreeiENSGT00760000119059.
HOGENOMiHOG000230659.
HOVERGENiHBG051586.
InParanoidiQ96IG2.
KOiK10268.
OrthoDBiEOG7CVPXM.
PhylomeDBiQ96IG2.
TreeFamiTF313434.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF13516. LRR_6. 4 hits.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00367. LRR_CC. 12 hits.
[Graphical view]
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96IG2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRDVNGVTK SRFEMFSNSD EAVINKKLPK ELLLRIFSFL DVVTLCRCAQ
60 70 80 90 100
VSRAWNVLAL DGSNWQRIDL FDFQRDIEGR VVENISKRCG GFLRKLSLRG
110 120 130 140 150
CLGVGDNALR TFAQNCRNIE VLNLNGCTKT TDATCTSLSK FCSKLRHLDL
160 170 180 190 200
ASCTSITNMS LKALSEGCPL LEQLNISWCD QVTKDGIQAL VRGCGGLKAL
210 220 230 240 250
FLKGCTQLED EALKYIGAHC PELVTLNLQT CLQITDEGLI TICRGCHKLQ
260 270 280 290 300
SLCASGCSNI TDAILNALGQ NCPRLRILEV ARCSQLTDVG FTTLARNCHE
310 320 330 340 350
LEKMDLEECV QITDSTLIQL SIHCPRLQVL SLSHCELITD DGIRHLGNGA
360 370 380 390 400
CAHDQLEVIE LDNCPLITDA SLEHLKSCHS LERIELYDCQ QITRAGIKRL
410 420 430
RTHLPNIKVH AYFAPVTPPP SVGGSRQRFC RCCIIL
Length:436
Mass (Da):48,423
Last modified:June 1, 2003 - v2
Checksum:i39CD04A505C8CE3E
GO
Isoform 2 (identifier: Q96IG2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-165: Missing.

Show »
Length:404
Mass (Da):44,980
Checksum:iABE96E243C2F3A6D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171S → P in BAF84533 (Ref. 1) Curated
Sequence conflicti375 – 3751L → F in BAF84533 (Ref. 1) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei134 – 16532Missing in isoform 2. 1 PublicationVSP_030769Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ223959 mRNA. Translation: ABB03906.1.
AK291844 mRNA. Translation: BAF84533.1.
BC007557 mRNA. Translation: AAH07557.2.
CCDSiCCDS32640.1. [Q96IG2-1]
CCDS54116.1. [Q96IG2-2]
RefSeqiNP_001171835.1. NM_001184906.1. [Q96IG2-2]
NP_116264.2. NM_032875.2. [Q96IG2-1]
UniGeneiHs.462946.

Genome annotation databases

EnsembliENST00000264658; ENSP00000264658; ENSG00000108306. [Q96IG2-1]
ENST00000394294; ENSP00000377832; ENSG00000108306. [Q96IG2-2]
ENST00000583610; ENSP00000462271; ENSG00000108306. [Q96IG2-1]
GeneIDi84961.
KEGGihsa:84961.
UCSCiuc002hrt.4. human. [Q96IG2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ223959 mRNA. Translation: ABB03906.1.
AK291844 mRNA. Translation: BAF84533.1.
BC007557 mRNA. Translation: AAH07557.2.
CCDSiCCDS32640.1. [Q96IG2-1]
CCDS54116.1. [Q96IG2-2]
RefSeqiNP_001171835.1. NM_001184906.1. [Q96IG2-2]
NP_116264.2. NM_032875.2. [Q96IG2-1]
UniGeneiHs.462946.

3D structure databases

ProteinModelPortaliQ96IG2.
SMRiQ96IG2. Positions 28-389.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124392. 6 interactions.
STRINGi9606.ENSP00000264658.

PTM databases

iPTMnetiQ96IG2.
PhosphoSiteiQ96IG2.
SwissPalmiQ96IG2.

Polymorphism and mutation databases

BioMutaiFBXL20.
DMDMi38503141.

Proteomic databases

EPDiQ96IG2.
MaxQBiQ96IG2.
PaxDbiQ96IG2.
PRIDEiQ96IG2.

Protocols and materials databases

DNASUi84961.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264658; ENSP00000264658; ENSG00000108306. [Q96IG2-1]
ENST00000394294; ENSP00000377832; ENSG00000108306. [Q96IG2-2]
ENST00000583610; ENSP00000462271; ENSG00000108306. [Q96IG2-1]
GeneIDi84961.
KEGGihsa:84961.
UCSCiuc002hrt.4. human. [Q96IG2-1]

Organism-specific databases

CTDi84961.
GeneCardsiFBXL20.
HGNCiHGNC:24679. FBXL20.
HPAiHPA044748.
HPA050397.
MIMi609086. gene.
neXtProtiNX_Q96IG2.
PharmGKBiPA134976410.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4341. Eukaryota.
ENOG410XQ54. LUCA.
GeneTreeiENSGT00760000119059.
HOGENOMiHOG000230659.
HOVERGENiHBG051586.
InParanoidiQ96IG2.
KOiK10268.
OrthoDBiEOG7CVPXM.
PhylomeDBiQ96IG2.
TreeFamiTF313434.

Miscellaneous databases

ChiTaRSiFBXL20. human.
GenomeRNAii84961.
PROiQ96IG2.
SOURCEiSearch...

Gene expression databases

BgeeiQ96IG2.
CleanExiHS_FBXL20.
ExpressionAtlasiQ96IG2. baseline and differential.
GenevisibleiQ96IG2. HS.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF13516. LRR_6. 4 hits.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00367. LRR_CC. 12 hits.
[Graphical view]
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel FBXL20 splice variant."
    Stavropoulou A.V., Alao J.P., Lam E.W.F., Coombes R.C., Vigushin D.M.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-417, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-417, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-417, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiFXL20_HUMAN
AccessioniPrimary (citable) accession number: Q96IG2
Secondary accession number(s): A8K729, Q38J52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.