Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Immunoglobulin superfamily member 21

Gene

IGSF21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin superfamily member 21
Short name:
IgSF21
Gene namesi
Name:IGSF21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28246. IGSF21.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi84966.
OpenTargetsiENSG00000117154.
PharmGKBiPA142671661.

Polymorphism and mutation databases

BioMutaiIGSF21.
DMDMi74760871.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000022333825 – 467Immunoglobulin superfamily member 21Add BLAST443

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 116PROSITE-ProRule annotation
Glycosylationi82N-linked (GlcNAc...)Sequence analysis1
Glycosylationi165N-linked (GlcNAc...)Sequence analysis1
Glycosylationi407N-linked (GlcNAc...)Sequence analysis1
Glycosylationi444N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ96ID5.
MaxQBiQ96ID5.
PaxDbiQ96ID5.
PeptideAtlasiQ96ID5.
PRIDEiQ96ID5.

PTM databases

iPTMnetiQ96ID5.
PhosphoSitePlusiQ96ID5.

Expressioni

Gene expression databases

BgeeiENSG00000117154.
CleanExiHS_IGSF21.
GenevisibleiQ96ID5. HS.

Organism-specific databases

HPAiHPA044535.

Interactioni

Protein-protein interaction databases

BioGridi124396. 31 interactors.
IntActiQ96ID5. 31 interactors.
MINTiMINT-1368141.

Structurei

3D structure databases

ProteinModelPortaliQ96ID5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 132Ig-like 1Add BLAST108
Domaini344 – 429Ig-like 2Add BLAST86

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IFDU. Eukaryota.
ENOG410XPIE. LUCA.
GeneTreeiENSGT00390000002421.
HOGENOMiHOG000261657.
HOVERGENiHBG061499.
InParanoidiQ96ID5.
OMAiSTEFDGK.
OrthoDBiEOG091G096X.
PhylomeDBiQ96ID5.
TreeFamiTF331223.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96ID5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTAPSLRRC VCLLLAAILD LARGYLTVNI EPLPPVVAGD AVTLKCNFKT
60 70 80 90 100
DGRMREIVWY RVTDGGTIKQ KIFTFDAMFS TNYSHMENYR KREDLVYQST
110 120 130 140 150
VRLPEVRISD NGPYECHVGI YDRATREKVV LASGNIFLNV MAPPTSIEVV
160 170 180 190 200
AADTPAPFSR YQAQNFTLVC IVSGGKPAPM VYFKRDGEPI DAVPLSEPPA
210 220 230 240 250
ASSGPLQDSR PFRSLLHRDL DDTKMQKSLS LLDAENRGGR PYTERPSRGL
260 270 280 290 300
TPDPNILLQP TTENIPETVV SREFPRWVHS AEPTYFLRHS RTPSSDGTVE
310 320 330 340 350
VRALLTWTLN PQIDNEALFS CEVKHPALSM PMQAEVTLVA PKGPKIVMTP
360 370 380 390 400
SRARVGDTVR ILVHGFQNEV FPEPMFTWTR VGSRLLDGSA EFDGKELVLE
410 420 430 440 450
RVPAELNGSM YRCTAQNPLG STDTHTRLIV FENPNIPRGT EDSNGSIGPT
460
GARLTLVLAL TVILELT
Length:467
Mass (Da):51,835
Last modified:December 1, 2001 - v1
Checksum:iF62DD2C086A3EDAC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti369E → G in BAC11542 (PubMed:16303743).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_056049245R → H.Corresponds to variant rs2355877dbSNPEnsembl.1
Natural variantiVAR_056050379T → M.Corresponds to variant rs12076815dbSNPEnsembl.1
Natural variantiVAR_035518467T → M in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs766575681dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075316 mRNA. Translation: BAC11542.1.
AL356101
, AL050342, AL359738, AL365209 Genomic DNA. Translation: CAH70256.1.
AL359738
, AL050342, AL356101, AL365209 Genomic DNA. Translation: CAH71695.1.
AL365209
, AL356101, AL050342, AL359738 Genomic DNA. Translation: CAH70900.1.
AL050342
, AL356101, AL359738, AL365209 Genomic DNA. Translation: CAI22205.1.
BC007618 mRNA. Translation: AAH07618.1.
CCDSiCCDS184.1.
RefSeqiNP_116269.3. NM_032880.4.
UniGeneiHs.212511.

Genome annotation databases

EnsembliENST00000251296; ENSP00000251296; ENSG00000117154.
GeneIDi84966.
KEGGihsa:84966.
UCSCiuc001bau.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075316 mRNA. Translation: BAC11542.1.
AL356101
, AL050342, AL359738, AL365209 Genomic DNA. Translation: CAH70256.1.
AL359738
, AL050342, AL356101, AL365209 Genomic DNA. Translation: CAH71695.1.
AL365209
, AL356101, AL050342, AL359738 Genomic DNA. Translation: CAH70900.1.
AL050342
, AL356101, AL359738, AL365209 Genomic DNA. Translation: CAI22205.1.
BC007618 mRNA. Translation: AAH07618.1.
CCDSiCCDS184.1.
RefSeqiNP_116269.3. NM_032880.4.
UniGeneiHs.212511.

3D structure databases

ProteinModelPortaliQ96ID5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124396. 31 interactors.
IntActiQ96ID5. 31 interactors.
MINTiMINT-1368141.

PTM databases

iPTMnetiQ96ID5.
PhosphoSitePlusiQ96ID5.

Polymorphism and mutation databases

BioMutaiIGSF21.
DMDMi74760871.

Proteomic databases

EPDiQ96ID5.
MaxQBiQ96ID5.
PaxDbiQ96ID5.
PeptideAtlasiQ96ID5.
PRIDEiQ96ID5.

Protocols and materials databases

DNASUi84966.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251296; ENSP00000251296; ENSG00000117154.
GeneIDi84966.
KEGGihsa:84966.
UCSCiuc001bau.3. human.

Organism-specific databases

CTDi84966.
DisGeNETi84966.
GeneCardsiIGSF21.
H-InvDBHIX0019907.
HGNCiHGNC:28246. IGSF21.
HPAiHPA044535.
neXtProtiNX_Q96ID5.
OpenTargetsiENSG00000117154.
PharmGKBiPA142671661.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFDU. Eukaryota.
ENOG410XPIE. LUCA.
GeneTreeiENSGT00390000002421.
HOGENOMiHOG000261657.
HOVERGENiHBG061499.
InParanoidiQ96ID5.
OMAiSTEFDGK.
OrthoDBiEOG091G096X.
PhylomeDBiQ96ID5.
TreeFamiTF331223.

Miscellaneous databases

ChiTaRSiIGSF21. human.
GenomeRNAii84966.
PROiQ96ID5.

Gene expression databases

BgeeiENSG00000117154.
CleanExiHS_IGSF21.
GenevisibleiQ96ID5. HS.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIGS21_HUMAN
AccessioniPrimary (citable) accession number: Q96ID5
Secondary accession number(s): Q8NBR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.