Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q96ID5 (IGS21_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Immunoglobulin superfamily member 21

Short name=IgSF21
Gene names
Name:IGSF21
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length467 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted Potential.

Sequence similarities

Contains 2 Ig-like (immunoglobulin-like) domains.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainImmunoglobulin domain
Repeat
Signal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 467443Immunoglobulin superfamily member 21
PRO_0000223338

Regions

Domain25 – 132108Ig-like 1
Domain344 – 42986Ig-like 2

Amino acid modifications

Glycosylation821N-linked (GlcNAc...) Potential
Glycosylation1651N-linked (GlcNAc...) Potential
Glycosylation4071N-linked (GlcNAc...) Potential
Glycosylation4441N-linked (GlcNAc...) Potential
Disulfide bond46 ↔ 116 By similarity

Natural variations

Natural variant2451R → H.
Corresponds to variant rs2355877 [ dbSNP | Ensembl ].
VAR_056049
Natural variant3791T → M.
Corresponds to variant rs12076815 [ dbSNP | Ensembl ].
VAR_056050
Natural variant4671T → M in a colorectal cancer sample; somatic mutation. Ref.4
VAR_035518

Experimental info

Sequence conflict3691E → G in BAC11542. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q96ID5 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: F62DD2C086A3EDAC

FASTA46751,835
        10         20         30         40         50         60 
MRTAPSLRRC VCLLLAAILD LARGYLTVNI EPLPPVVAGD AVTLKCNFKT DGRMREIVWY 

        70         80         90        100        110        120 
RVTDGGTIKQ KIFTFDAMFS TNYSHMENYR KREDLVYQST VRLPEVRISD NGPYECHVGI 

       130        140        150        160        170        180 
YDRATREKVV LASGNIFLNV MAPPTSIEVV AADTPAPFSR YQAQNFTLVC IVSGGKPAPM 

       190        200        210        220        230        240 
VYFKRDGEPI DAVPLSEPPA ASSGPLQDSR PFRSLLHRDL DDTKMQKSLS LLDAENRGGR 

       250        260        270        280        290        300 
PYTERPSRGL TPDPNILLQP TTENIPETVV SREFPRWVHS AEPTYFLRHS RTPSSDGTVE 

       310        320        330        340        350        360 
VRALLTWTLN PQIDNEALFS CEVKHPALSM PMQAEVTLVA PKGPKIVMTP SRARVGDTVR 

       370        380        390        400        410        420 
ILVHGFQNEV FPEPMFTWTR VGSRLLDGSA EFDGKELVLE RVPAELNGSM YRCTAQNPLG 

       430        440        450        460 
STDTHTRLIV FENPNIPRGT EDSNGSIGPT GARLTLVLAL TVILELT 

« Hide

References

[1]"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. expand/collapse author list , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
[4]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-467.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK075316 mRNA. Translation: BAC11542.1.
AL356101 expand/collapse EMBL AC list , AL050342, AL359738, AL365209 Genomic DNA. Translation: CAH70256.1.
AL359738 expand/collapse EMBL AC list , AL050342, AL356101, AL365209 Genomic DNA. Translation: CAH71695.1.
AL365209 expand/collapse EMBL AC list , AL356101, AL050342, AL359738 Genomic DNA. Translation: CAH70900.1.
AL050342 expand/collapse EMBL AC list , AL356101, AL359738, AL365209 Genomic DNA. Translation: CAI22205.1.
BC007618 mRNA. Translation: AAH07618.1.
CCDSCCDS184.1.
RefSeqNP_116269.3. NM_032880.4.
UniGeneHs.212511.

3D structure databases

ProteinModelPortalQ96ID5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124396. 31 interactions.
IntActQ96ID5. 31 interactions.
MINTMINT-1368141.

Protein family/group databases

MEROPSI43.001.

PTM databases

PhosphoSiteQ96ID5.

Polymorphism databases

DMDM74760871.

Proteomic databases

PaxDbQ96ID5.
PRIDEQ96ID5.

Protocols and materials databases

DNASU84966.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000251296; ENSP00000251296; ENSG00000117154.
GeneID84966.
KEGGhsa:84966.
UCSCuc001bau.2. human.

Organism-specific databases

CTD84966.
GeneCardsGC01P018434.
H-InvDBHIX0019907.
HGNCHGNC:28246. IGSF21.
HPAHPA044535.
neXtProtNX_Q96ID5.
PharmGKBPA142671661.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG39561.
HOGENOMHOG000261657.
HOVERGENHBG061499.
InParanoidQ96ID5.
OMAKPAPTVY.
OrthoDBEOG77WWC4.
PhylomeDBQ96ID5.
TreeFamTF331223.

Gene expression databases

BgeeQ96ID5.
CleanExHS_IGSF21.
GenevestigatorQ96ID5.

Family and domain databases

Gene3D2.60.40.10. 4 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00409. IG. 2 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSIGSF21. human.
GenomeRNAi84966.
NextBio75492.
PROQ96ID5.

Entry information

Entry nameIGS21_HUMAN
AccessionPrimary (citable) accession number: Q96ID5
Secondary accession number(s): Q8NBR8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM