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Q96ID5

- IGS21_HUMAN

UniProt

Q96ID5 - IGS21_HUMAN

Protein

Immunoglobulin superfamily member 21

Gene

IGSF21

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Protein family/group databases

    MEROPSiI43.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Immunoglobulin superfamily member 21
    Short name:
    IgSF21
    Gene namesi
    Name:IGSF21
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:28246. IGSF21.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671661.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 467443Immunoglobulin superfamily member 21PRO_0000223338Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi46 ↔ 116PROSITE-ProRule annotation
    Glycosylationi82 – 821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi165 – 1651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi407 – 4071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi444 – 4441N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ96ID5.
    PRIDEiQ96ID5.

    PTM databases

    PhosphoSiteiQ96ID5.

    Expressioni

    Gene expression databases

    BgeeiQ96ID5.
    CleanExiHS_IGSF21.
    GenevestigatoriQ96ID5.

    Organism-specific databases

    HPAiHPA044535.

    Interactioni

    Protein-protein interaction databases

    BioGridi124396. 31 interactions.
    IntActiQ96ID5. 31 interactions.
    MINTiMINT-1368141.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96ID5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 132108Ig-like 1Add
    BLAST
    Domaini344 – 42986Ig-like 2Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG39561.
    HOGENOMiHOG000261657.
    HOVERGENiHBG061499.
    InParanoidiQ96ID5.
    OMAiKPAPTVY.
    OrthoDBiEOG77WWC4.
    PhylomeDBiQ96ID5.
    TreeFamiTF331223.

    Family and domain databases

    Gene3Di2.60.40.10. 4 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 2 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q96ID5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRTAPSLRRC VCLLLAAILD LARGYLTVNI EPLPPVVAGD AVTLKCNFKT    50
    DGRMREIVWY RVTDGGTIKQ KIFTFDAMFS TNYSHMENYR KREDLVYQST 100
    VRLPEVRISD NGPYECHVGI YDRATREKVV LASGNIFLNV MAPPTSIEVV 150
    AADTPAPFSR YQAQNFTLVC IVSGGKPAPM VYFKRDGEPI DAVPLSEPPA 200
    ASSGPLQDSR PFRSLLHRDL DDTKMQKSLS LLDAENRGGR PYTERPSRGL 250
    TPDPNILLQP TTENIPETVV SREFPRWVHS AEPTYFLRHS RTPSSDGTVE 300
    VRALLTWTLN PQIDNEALFS CEVKHPALSM PMQAEVTLVA PKGPKIVMTP 350
    SRARVGDTVR ILVHGFQNEV FPEPMFTWTR VGSRLLDGSA EFDGKELVLE 400
    RVPAELNGSM YRCTAQNPLG STDTHTRLIV FENPNIPRGT EDSNGSIGPT 450
    GARLTLVLAL TVILELT 467
    Length:467
    Mass (Da):51,835
    Last modified:December 1, 2001 - v1
    Checksum:iF62DD2C086A3EDAC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti369 – 3691E → G in BAC11542. (PubMed:16303743)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti245 – 2451R → H.
    Corresponds to variant rs2355877 [ dbSNP | Ensembl ].
    VAR_056049
    Natural varianti379 – 3791T → M.
    Corresponds to variant rs12076815 [ dbSNP | Ensembl ].
    VAR_056050
    Natural varianti467 – 4671T → M in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035518

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK075316 mRNA. Translation: BAC11542.1.
    AL356101
    , AL050342, AL359738, AL365209 Genomic DNA. Translation: CAH70256.1.
    AL359738
    , AL050342, AL356101, AL365209 Genomic DNA. Translation: CAH71695.1.
    AL365209
    , AL356101, AL050342, AL359738 Genomic DNA. Translation: CAH70900.1.
    AL050342
    , AL356101, AL359738, AL365209 Genomic DNA. Translation: CAI22205.1.
    BC007618 mRNA. Translation: AAH07618.1.
    CCDSiCCDS184.1.
    RefSeqiNP_116269.3. NM_032880.4.
    UniGeneiHs.212511.

    Genome annotation databases

    EnsembliENST00000251296; ENSP00000251296; ENSG00000117154.
    GeneIDi84966.
    KEGGihsa:84966.
    UCSCiuc001bau.2. human.

    Polymorphism databases

    DMDMi74760871.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK075316 mRNA. Translation: BAC11542.1 .
    AL356101
    , AL050342 , AL359738 , AL365209 Genomic DNA. Translation: CAH70256.1 .
    AL359738
    , AL050342 , AL356101 , AL365209 Genomic DNA. Translation: CAH71695.1 .
    AL365209
    , AL356101 , AL050342 , AL359738 Genomic DNA. Translation: CAH70900.1 .
    AL050342
    , AL356101 , AL359738 , AL365209 Genomic DNA. Translation: CAI22205.1 .
    BC007618 mRNA. Translation: AAH07618.1 .
    CCDSi CCDS184.1.
    RefSeqi NP_116269.3. NM_032880.4.
    UniGenei Hs.212511.

    3D structure databases

    ProteinModelPortali Q96ID5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124396. 31 interactions.
    IntActi Q96ID5. 31 interactions.
    MINTi MINT-1368141.

    Protein family/group databases

    MEROPSi I43.001.

    PTM databases

    PhosphoSitei Q96ID5.

    Polymorphism databases

    DMDMi 74760871.

    Proteomic databases

    PaxDbi Q96ID5.
    PRIDEi Q96ID5.

    Protocols and materials databases

    DNASUi 84966.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000251296 ; ENSP00000251296 ; ENSG00000117154 .
    GeneIDi 84966.
    KEGGi hsa:84966.
    UCSCi uc001bau.2. human.

    Organism-specific databases

    CTDi 84966.
    GeneCardsi GC01P018434.
    H-InvDB HIX0019907.
    HGNCi HGNC:28246. IGSF21.
    HPAi HPA044535.
    neXtProti NX_Q96ID5.
    PharmGKBi PA142671661.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39561.
    HOGENOMi HOG000261657.
    HOVERGENi HBG061499.
    InParanoidi Q96ID5.
    OMAi KPAPTVY.
    OrthoDBi EOG77WWC4.
    PhylomeDBi Q96ID5.
    TreeFami TF331223.

    Miscellaneous databases

    ChiTaRSi IGSF21. human.
    GenomeRNAii 84966.
    NextBioi 75492.
    PROi Q96ID5.

    Gene expression databases

    Bgeei Q96ID5.
    CleanExi HS_IGSF21.
    Genevestigatori Q96ID5.

    Family and domain databases

    Gene3Di 2.60.40.10. 4 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 2 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    4. Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-467.

    Entry informationi

    Entry nameiIGS21_HUMAN
    AccessioniPrimary (citable) accession number: Q96ID5
    Secondary accession number(s): Q8NBR8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3