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Q96ID5

- IGS21_HUMAN

UniProt

Q96ID5 - IGS21_HUMAN

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Protein

Immunoglobulin superfamily member 21

Gene
IGSF21
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin superfamily member 21
Short name:
IgSF21
Gene namesi
Name:IGSF21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:28246. IGSF21.

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671661.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed predictionAdd
BLAST
Chaini25 – 467443Immunoglobulin superfamily member 21PRO_0000223338Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi46 ↔ 116 By similarity
Glycosylationi82 – 821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi165 – 1651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi407 – 4071N-linked (GlcNAc...) Reviewed prediction
Glycosylationi444 – 4441N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96ID5.
PRIDEiQ96ID5.

PTM databases

PhosphoSiteiQ96ID5.

Expressioni

Gene expression databases

BgeeiQ96ID5.
CleanExiHS_IGSF21.
GenevestigatoriQ96ID5.

Organism-specific databases

HPAiHPA044535.

Interactioni

Protein-protein interaction databases

BioGridi124396. 31 interactions.
IntActiQ96ID5. 31 interactions.
MINTiMINT-1368141.

Structurei

3D structure databases

ProteinModelPortaliQ96ID5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 132108Ig-like 1Add
BLAST
Domaini344 – 42986Ig-like 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG39561.
HOGENOMiHOG000261657.
HOVERGENiHBG061499.
InParanoidiQ96ID5.
OMAiKPAPTVY.
OrthoDBiEOG77WWC4.
PhylomeDBiQ96ID5.
TreeFamiTF331223.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96ID5-1 [UniParc]FASTAAdd to Basket

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MRTAPSLRRC VCLLLAAILD LARGYLTVNI EPLPPVVAGD AVTLKCNFKT    50
DGRMREIVWY RVTDGGTIKQ KIFTFDAMFS TNYSHMENYR KREDLVYQST 100
VRLPEVRISD NGPYECHVGI YDRATREKVV LASGNIFLNV MAPPTSIEVV 150
AADTPAPFSR YQAQNFTLVC IVSGGKPAPM VYFKRDGEPI DAVPLSEPPA 200
ASSGPLQDSR PFRSLLHRDL DDTKMQKSLS LLDAENRGGR PYTERPSRGL 250
TPDPNILLQP TTENIPETVV SREFPRWVHS AEPTYFLRHS RTPSSDGTVE 300
VRALLTWTLN PQIDNEALFS CEVKHPALSM PMQAEVTLVA PKGPKIVMTP 350
SRARVGDTVR ILVHGFQNEV FPEPMFTWTR VGSRLLDGSA EFDGKELVLE 400
RVPAELNGSM YRCTAQNPLG STDTHTRLIV FENPNIPRGT EDSNGSIGPT 450
GARLTLVLAL TVILELT 467
Length:467
Mass (Da):51,835
Last modified:December 1, 2001 - v1
Checksum:iF62DD2C086A3EDAC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti245 – 2451R → H.
Corresponds to variant rs2355877 [ dbSNP | Ensembl ].
VAR_056049
Natural varianti379 – 3791T → M.
Corresponds to variant rs12076815 [ dbSNP | Ensembl ].
VAR_056050
Natural varianti467 – 4671T → M in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035518

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti369 – 3691E → G in BAC11542. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK075316 mRNA. Translation: BAC11542.1.
AL356101
, AL050342, AL359738, AL365209 Genomic DNA. Translation: CAH70256.1.
AL359738
, AL050342, AL356101, AL365209 Genomic DNA. Translation: CAH71695.1.
AL365209
, AL356101, AL050342, AL359738 Genomic DNA. Translation: CAH70900.1.
AL050342
, AL356101, AL359738, AL365209 Genomic DNA. Translation: CAI22205.1.
BC007618 mRNA. Translation: AAH07618.1.
CCDSiCCDS184.1.
RefSeqiNP_116269.3. NM_032880.4.
UniGeneiHs.212511.

Genome annotation databases

EnsembliENST00000251296; ENSP00000251296; ENSG00000117154.
GeneIDi84966.
KEGGihsa:84966.
UCSCiuc001bau.2. human.

Polymorphism databases

DMDMi74760871.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK075316 mRNA. Translation: BAC11542.1 .
AL356101
, AL050342 , AL359738 , AL365209 Genomic DNA. Translation: CAH70256.1 .
AL359738
, AL050342 , AL356101 , AL365209 Genomic DNA. Translation: CAH71695.1 .
AL365209
, AL356101 , AL050342 , AL359738 Genomic DNA. Translation: CAH70900.1 .
AL050342
, AL356101 , AL359738 , AL365209 Genomic DNA. Translation: CAI22205.1 .
BC007618 mRNA. Translation: AAH07618.1 .
CCDSi CCDS184.1.
RefSeqi NP_116269.3. NM_032880.4.
UniGenei Hs.212511.

3D structure databases

ProteinModelPortali Q96ID5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124396. 31 interactions.
IntActi Q96ID5. 31 interactions.
MINTi MINT-1368141.

Protein family/group databases

MEROPSi I43.001.

PTM databases

PhosphoSitei Q96ID5.

Polymorphism databases

DMDMi 74760871.

Proteomic databases

PaxDbi Q96ID5.
PRIDEi Q96ID5.

Protocols and materials databases

DNASUi 84966.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000251296 ; ENSP00000251296 ; ENSG00000117154 .
GeneIDi 84966.
KEGGi hsa:84966.
UCSCi uc001bau.2. human.

Organism-specific databases

CTDi 84966.
GeneCardsi GC01P018434.
H-InvDB HIX0019907.
HGNCi HGNC:28246. IGSF21.
HPAi HPA044535.
neXtProti NX_Q96ID5.
PharmGKBi PA142671661.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG39561.
HOGENOMi HOG000261657.
HOVERGENi HBG061499.
InParanoidi Q96ID5.
OMAi KPAPTVY.
OrthoDBi EOG77WWC4.
PhylomeDBi Q96ID5.
TreeFami TF331223.

Miscellaneous databases

ChiTaRSi IGSF21. human.
GenomeRNAii 84966.
NextBioi 75492.
PROi Q96ID5.

Gene expression databases

Bgeei Q96ID5.
CleanExi HS_IGSF21.
Genevestigatori Q96ID5.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 2 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  4. Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-467.

Entry informationi

Entry nameiIGS21_HUMAN
AccessioniPrimary (citable) accession number: Q96ID5
Secondary accession number(s): Q8NBR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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