Q96ID5 (IGS21_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Immunoglobulin superfamily member 21
Short name=IgSF21

Gene names

Name:

IGSF21

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	467 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted Potential.
Sequence similarities	Contains 2 Ig-like (immunoglobulin-like) domains.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Repeat Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 467	443	Immunoglobulin superfamily member 21		PRO_0000223338
Regions
	Domain	25 – 132	108	Ig-like 1
	Domain	344 – 429	86	Ig-like 2
Amino acid modifications
	Glycosylation	82	1	N-linked (GlcNAc...) Potential
	Glycosylation	165	1	N-linked (GlcNAc...) Potential
	Glycosylation	407	1	N-linked (GlcNAc...) Potential
	Glycosylation	444	1	N-linked (GlcNAc...) Potential
	Disulfide bond	46 ↔ 116		By similarity
Natural variations
	Natural variant	245	1	R → H. Corresponds to variant rs2355877 [ dbSNP | Ensembl ].		VAR_056049
	Natural variant	379	1	T → M. Corresponds to variant rs12076815 [ dbSNP | Ensembl ].		VAR_056050
	Natural variant	467	1	T → M in a colorectal cancer sample; somatic mutation. Ref.4		VAR_035518
Experimental info
	Sequence conflict	369	1	E → G in BAC11542. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q96ID5 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: F62DD2C086A3EDAC	FASTA	467	51,835
	10 20 30 40 50 60 MRTAPSLRRC VCLLLAAILD LARGYLTVNI EPLPPVVAGD AVTLKCNFKT DGRMREIVWY 70 80 90 100 110 120 RVTDGGTIKQ KIFTFDAMFS TNYSHMENYR KREDLVYQST VRLPEVRISD NGPYECHVGI 130 140 150 160 170 180 YDRATREKVV LASGNIFLNV MAPPTSIEVV AADTPAPFSR YQAQNFTLVC IVSGGKPAPM 190 200 210 220 230 240 VYFKRDGEPI DAVPLSEPPA ASSGPLQDSR PFRSLLHRDL DDTKMQKSLS LLDAENRGGR 250 260 270 280 290 300 PYTERPSRGL TPDPNILLQP TTENIPETVV SREFPRWVHS AEPTYFLRHS RTPSSDGTVE 310 320 330 340 350 360 VRALLTWTLN PQIDNEALFS CEVKHPALSM PMQAEVTLVA PKGPKIVMTP SRARVGDTVR 370 380 390 400 410 420 ILVHGFQNEV FPEPMFTWTR VGSRLLDGSA EFDGKELVLE RVPAELNGSM YRCTAQNPLG 430 440 450 460 STDTHTRLIV FENPNIPRGT EDSNGSIGPT GARLTLVLAL TVILELT

References

[1]	"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T. DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
[4]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-467.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK075316 mRNA. Translation: BAC11542.1. AL356101 , AL050342, AL359738, AL365209 Genomic DNA. Translation: CAH70256.1. AL359738 , AL050342, AL356101, AL365209 Genomic DNA. Translation: CAH71695.1. AL365209 , AL356101, AL050342, AL359738 Genomic DNA. Translation: CAH70900.1. AL050342 , AL356101, AL359738, AL365209 Genomic DNA. Translation: CAI22205.1. BC007618 mRNA. Translation: AAH07618.1.
IPI	IPI00301255.
RefSeq	NP_116269.3. NM_032880.4.
UniGene	Hs.212511.
3D structure databases
ProteinModelPortal	Q96ID5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96ID5. 28 interactions.
MINT	MINT-1368141.
Protein family/group databases
MEROPS	I43.001.
PTM databases
PhosphoSite	Q96ID5.
Polymorphism databases
DMDM	74760871.
Proteomic databases
PaxDb	Q96ID5.
PRIDE	Q96ID5.
Protocols and materials databases
DNASU	84966.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000251296; ENSP00000251296; ENSG00000117154.
GeneID	84966.
KEGG	hsa:84966.
UCSC	uc001bau.2. human.
Organism-specific databases
CTD	84966.
GeneCards	GC01P018434.
H-InvDB	HIX0019907.
HGNC	HGNC:28246. IGSF21.
HPA	HPA044535.
neXtProt	NX_Q96ID5.
PharmGKB	PA142671661.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG39561.
HOGENOM	HOG000261657.
HOVERGEN	HBG061499.
InParanoid	Q96ID5.
OMA	KPAPTVY.
OrthoDB	EOG4XGZZZ.
PhylomeDB	Q96ID5.
Gene expression databases
Bgee	Q96ID5.
CleanEx	HS_IGSF21.
Genevestigator	Q96ID5.
GermOnline	ENSG00000117154. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 4 hits.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR013106. Ig_V-set. [Graphical view]
Pfam	PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00409. IG. 2 hits. [Graphical view]
PROSITE	PS50835. IG_LIKE. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	IGSF21. human.
GenomeRNAi	84966.
NextBio	75492.

Entry information

Entry name

IGS21_HUMAN

Accession

Primary (citable) accession number: Q96ID5
Secondary accession number(s): Q8NBR8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2006
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.