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Protein

Putative RNA exonuclease NEF-sp

Gene

44M2.3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative RNA exonuclease NEF-sp (EC:3.1.-.-)
Gene namesi
ORF Names:44M2.3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • nucleolus Source: LIFEdb
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000005189.

Polymorphism and mutation databases

BioMutaiNA.
DMDMi74760869.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002873451 – 774Putative RNA exonuclease NEF-spAdd BLAST774

Proteomic databases

MaxQBiQ96IC2.
PaxDbiQ96IC2.
PeptideAtlasiQ96IC2.
PRIDEiQ96IC2.

PTM databases

iPTMnetiQ96IC2.
PhosphoSitePlusiQ96IC2.

Expressioni

Gene expression databases

BgeeiENSG00000005189.
ExpressionAtlasiQ96IC2. baseline and differential.
GenevisibleiQ96IC2. HS.

Organism-specific databases

HPAiHPA040755.
HPA040868.

Interactioni

Protein-protein interaction databases

BioGridi123570. 10 interactors.
IntActiQ96IC2. 2 interactors.
MINTiMINT-4720634.
STRINGi9606.ENSP00000261377.

Structurei

3D structure databases

ProteinModelPortaliQ96IC2.
SMRiQ96IC2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini228 – 376ExonucleaseAdd BLAST149
Domaini505 – 579RRM 1PROSITE-ProRule annotationAdd BLAST75
Domaini600 – 679RRM 2PROSITE-ProRule annotationAdd BLAST80

Sequence similaritiesi

Contains 1 exonuclease domain.Curated
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2248. Eukaryota.
COG0847. LUCA.
GeneTreeiENSGT00840000129821.
HOVERGENiHBG101031.
InParanoidiQ96IC2.
KOiK14570.
OMAiKMIHPYV.
OrthoDBiEOG091G0I6S.
PhylomeDBiQ96IC2.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.30.70.330. 2 hits.
InterProiIPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012677. Nucleotide-bd_a/b_plait.
IPR012337. RNaseH-like_dom.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00929. RNase_T. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00479. EXOIII. 1 hit.
SM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
SSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96IC2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPEREGTER HPRKVRESRQ APNKLVGAAE AMKAGWDLEE SQPEAKKARL
60 70 80 90 100
STILFTDNCE VTHDQLCELL KYAVLGKSNV PKPSWCQLFH QNHLNNVVVF
110 120 130 140 150
VLQGMSQLHF YRFYLEFGCL RKAFRHKFRL PPPSSDFLAD VVGLQTEQRA
160 170 180 190 200
GDLPKTMEGP LPSNAKAAIN LQDDPIIQKY GSKKVGLTRC LLTKEEMRTF
210 220 230 240 250
HFPLQGFPDC ENFLLTKCNG SIADNSPLFG LDCEMCLTSK GRELTRISLV
260 270 280 290 300
AEGGCCVMDE LVKPENKILD YLTSFSGITK KILNPVTTKL KDVQRQLKAL
310 320 330 340 350
LPPDAVLVGH SLDLDLRALK MIHPYVIDTS LLYVREQGRR FKLKFLAKVI
360 370 380 390 400
LGKDIQCPDR LGHDATEDAR TILELARYFL KHGPKKIAEL NLEALANHQE
410 420 430 440 450
IQAAGQEPKN TAEVLQHPNT SVLECLDSVG QKLLFLTRET DAGELPSSRN
460 470 480 490 500
CQTIKCLSNK EVLEQARVEI PLFPFSIVQF SFKAFSPVLT EEMNKRMRIK
510 520 530 540 550
WTEISTVYAG PFSKNCNLRA LKRLFKSFGP VQSMTFVLET RQPHLCIQYE
560 570 580 590 600
VLEAAQLAIE SLDGILVDGI CIKVQRPVTE LTLDCDTLVN ELEGDSENQG
610 620 630 640 650
SIYLSGVSET FKEQLLQEPR LFLGLEAVIL PKDLKSGKQK KYCFLKFKSF
660 670 680 690 700
GSAQQALNIL TGKDWKLKGR HALTPRHLHA WLRGLPPEST RLPGLRVVPP
710 720 730 740 750
PFEQEALQTL KLDHPKIAAW RWSRKIGKLY NSLCPGTLCL ILLPGTKSTH
760 770
GSLSGLGLMG IKEEEESAGP GLCS
Length:774
Mass (Da):86,886
Last modified:December 1, 2001 - v1
Checksum:i3860D67555EDF91F
GO
Isoform 2 (identifier: Q96IC2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     543-573: Missing.

Show »
Length:743
Mass (Da):83,536
Checksum:iB8DB32F3E54A1E3B
GO

Sequence cautioni

The sequence AAC31668 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18S → G in AAK17192 (Ref. 1) Curated1
Sequence conflicti213F → S in AK057254 (PubMed:14702039).Curated1
Sequence conflicti748S → R in AAC31668 (PubMed:10493829).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025443543 – 573Missing in isoform 2. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332193 mRNA. Translation: AAK17192.1.
AL136763 mRNA. Translation: CAB66697.1.
AK057254 mRNA. No translation available.
AK314458 mRNA. Translation: BAG37066.1.
AC004381 Genomic DNA. Translation: AAC31668.1. Sequence problems.
CH471228 Genomic DNA. Translation: EAW66838.1.
BC007646 mRNA. Translation: AAH07646.1.
BC068503 mRNA. Translation: AAH68503.1.
AL162035 mRNA. Translation: CAB82386.1.
CCDSiCCDS10591.1. [Q96IC2-1]
CCDS45437.1. [Q96IC2-2]
PIRiT47187.
RefSeqiNP_001138396.1. NM_001144924.1. [Q96IC2-2]
NP_001185982.1. NM_001199053.1. [Q96IC2-1]
NP_112203.2. NM_030941.2. [Q96IC2-1]
XP_005255661.1. XM_005255604.1. [Q96IC2-1]
XP_011544265.1. XM_011545963.1. [Q96IC2-1]
XP_016879228.1. XM_017023739.1. [Q96IC2-2]
UniGeneiHs.177926.

Genome annotation databases

GeneIDi81691.
KEGGihsa:81691.
UCSCiuc002dhv.4. human. [Q96IC2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332193 mRNA. Translation: AAK17192.1.
AL136763 mRNA. Translation: CAB66697.1.
AK057254 mRNA. No translation available.
AK314458 mRNA. Translation: BAG37066.1.
AC004381 Genomic DNA. Translation: AAC31668.1. Sequence problems.
CH471228 Genomic DNA. Translation: EAW66838.1.
BC007646 mRNA. Translation: AAH07646.1.
BC068503 mRNA. Translation: AAH68503.1.
AL162035 mRNA. Translation: CAB82386.1.
CCDSiCCDS10591.1. [Q96IC2-1]
CCDS45437.1. [Q96IC2-2]
PIRiT47187.
RefSeqiNP_001138396.1. NM_001144924.1. [Q96IC2-2]
NP_001185982.1. NM_001199053.1. [Q96IC2-1]
NP_112203.2. NM_030941.2. [Q96IC2-1]
XP_005255661.1. XM_005255604.1. [Q96IC2-1]
XP_011544265.1. XM_011545963.1. [Q96IC2-1]
XP_016879228.1. XM_017023739.1. [Q96IC2-2]
UniGeneiHs.177926.

3D structure databases

ProteinModelPortaliQ96IC2.
SMRiQ96IC2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123570. 10 interactors.
IntActiQ96IC2. 2 interactors.
MINTiMINT-4720634.
STRINGi9606.ENSP00000261377.

PTM databases

iPTMnetiQ96IC2.
PhosphoSitePlusiQ96IC2.

Polymorphism and mutation databases

BioMutaiNA.
DMDMi74760869.

Proteomic databases

MaxQBiQ96IC2.
PaxDbiQ96IC2.
PeptideAtlasiQ96IC2.
PRIDEiQ96IC2.

Protocols and materials databases

DNASUi81691.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi81691.
KEGGihsa:81691.
UCSCiuc002dhv.4. human. [Q96IC2-1]

Organism-specific databases

GeneCardsiLOC81691.
HPAiHPA040755.
HPA040868.
neXtProtiNX_Q96IC2.
OpenTargetsiENSG00000005189.

Phylogenomic databases

eggNOGiKOG2248. Eukaryota.
COG0847. LUCA.
GeneTreeiENSGT00840000129821.
HOVERGENiHBG101031.
InParanoidiQ96IC2.
KOiK14570.
OMAiKMIHPYV.
OrthoDBiEOG091G0I6S.
PhylomeDBiQ96IC2.

Miscellaneous databases

GeneWikiiLOC81691.
GenomeRNAii81691.
PROiQ96IC2.

Gene expression databases

BgeeiENSG00000005189.
ExpressionAtlasiQ96IC2. baseline and differential.
GenevisibleiQ96IC2. HS.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.30.70.330. 2 hits.
InterProiIPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012677. Nucleotide-bd_a/b_plait.
IPR012337. RNaseH-like_dom.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00929. RNase_T. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00479. EXOIII. 1 hit.
SM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
SSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiREXON_HUMAN
AccessioniPrimary (citable) accession number: Q96IC2
Secondary accession number(s): B2RB19
, O60364, Q96MB1, Q9BXH9, Q9H0K2, Q9NSM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.