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Q96IC2

- REXON_HUMAN

UniProt

Q96IC2 - REXON_HUMAN

Protein

Putative RNA exonuclease NEF-sp

Gene

44M2.3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. exonuclease activity Source: UniProtKB-KW
    2. nucleotide binding Source: InterPro
    3. RNA binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Exonuclease, Hydrolase, Nuclease

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative RNA exonuclease NEF-sp (EC:3.1.-.-)
    Gene namesi
    ORF Names:44M2.3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. nucleolus Source: LIFEdb

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 774774Putative RNA exonuclease NEF-spPRO_0000287345Add
    BLAST

    Proteomic databases

    MaxQBiQ96IC2.
    PaxDbiQ96IC2.
    PRIDEiQ96IC2.

    PTM databases

    PhosphoSiteiQ96IC2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96IC2.
    BgeeiQ96IC2.
    GenevestigatoriQ96IC2.

    Organism-specific databases

    HPAiHPA040755.
    HPA040868.

    Interactioni

    Protein-protein interaction databases

    BioGridi123570. 1 interaction.
    IntActiQ96IC2. 1 interaction.
    MINTiMINT-4720634.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96IC2.
    SMRiQ96IC2. Positions 230-375, 504-675.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini228 – 376149ExonucleaseAdd
    BLAST
    Domaini505 – 57975RRM 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini600 – 67980RRM 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 exonuclease domain.Curated
    Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0847.
    HOVERGENiHBG101031.
    InParanoidiQ96IC2.
    KOiK14570.
    OMAiKMIHPYV.
    PhylomeDBiQ96IC2.

    Family and domain databases

    Gene3Di3.30.420.10. 1 hit.
    3.30.70.330. 2 hits.
    InterProiIPR006055. Exonuclease.
    IPR013520. Exonuclease_RNaseT/DNA_pol3.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR012337. RNaseH-like_dom.
    IPR000504. RRM_dom.
    [Graphical view]
    PfamiPF00929. RNase_T. 1 hit.
    PF00076. RRM_1. 1 hit.
    [Graphical view]
    SMARTiSM00479. EXOIII. 1 hit.
    SM00360. RRM. 2 hits.
    [Graphical view]
    SUPFAMiSSF53098. SSF53098. 1 hit.
    PROSITEiPS50102. RRM. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96IC2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEPEREGTER HPRKVRESRQ APNKLVGAAE AMKAGWDLEE SQPEAKKARL    50
    STILFTDNCE VTHDQLCELL KYAVLGKSNV PKPSWCQLFH QNHLNNVVVF 100
    VLQGMSQLHF YRFYLEFGCL RKAFRHKFRL PPPSSDFLAD VVGLQTEQRA 150
    GDLPKTMEGP LPSNAKAAIN LQDDPIIQKY GSKKVGLTRC LLTKEEMRTF 200
    HFPLQGFPDC ENFLLTKCNG SIADNSPLFG LDCEMCLTSK GRELTRISLV 250
    AEGGCCVMDE LVKPENKILD YLTSFSGITK KILNPVTTKL KDVQRQLKAL 300
    LPPDAVLVGH SLDLDLRALK MIHPYVIDTS LLYVREQGRR FKLKFLAKVI 350
    LGKDIQCPDR LGHDATEDAR TILELARYFL KHGPKKIAEL NLEALANHQE 400
    IQAAGQEPKN TAEVLQHPNT SVLECLDSVG QKLLFLTRET DAGELPSSRN 450
    CQTIKCLSNK EVLEQARVEI PLFPFSIVQF SFKAFSPVLT EEMNKRMRIK 500
    WTEISTVYAG PFSKNCNLRA LKRLFKSFGP VQSMTFVLET RQPHLCIQYE 550
    VLEAAQLAIE SLDGILVDGI CIKVQRPVTE LTLDCDTLVN ELEGDSENQG 600
    SIYLSGVSET FKEQLLQEPR LFLGLEAVIL PKDLKSGKQK KYCFLKFKSF 650
    GSAQQALNIL TGKDWKLKGR HALTPRHLHA WLRGLPPEST RLPGLRVVPP 700
    PFEQEALQTL KLDHPKIAAW RWSRKIGKLY NSLCPGTLCL ILLPGTKSTH 750
    GSLSGLGLMG IKEEEESAGP GLCS 774
    Length:774
    Mass (Da):86,886
    Last modified:December 1, 2001 - v1
    Checksum:i3860D67555EDF91F
    GO
    Isoform 2 (identifier: Q96IC2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         543-573: Missing.

    Show »
    Length:743
    Mass (Da):83,536
    Checksum:iB8DB32F3E54A1E3B
    GO

    Sequence cautioni

    The sequence AAC31668.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti18 – 181S → G in AAK17192. 1 PublicationCurated
    Sequence conflicti213 – 2131F → S in AK057254. (PubMed:14702039)Curated
    Sequence conflicti748 – 7481S → R in AAC31668. (PubMed:10493829)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei543 – 57331Missing in isoform 2. 1 PublicationVSP_025443Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF332193 mRNA. Translation: AAK17192.1.
    AL136763 mRNA. Translation: CAB66697.1.
    AK057254 mRNA. No translation available.
    AK314458 mRNA. Translation: BAG37066.1.
    AC004381 Genomic DNA. Translation: AAC31668.1. Sequence problems.
    CH471228 Genomic DNA. Translation: EAW66838.1.
    BC007646 mRNA. Translation: AAH07646.1.
    BC068503 mRNA. Translation: AAH68503.1.
    AL162035 mRNA. Translation: CAB82386.1.
    CCDSiCCDS10591.1. [Q96IC2-1]
    CCDS45437.1. [Q96IC2-2]
    PIRiT47187.
    RefSeqiNP_001138396.1. NM_001144924.1. [Q96IC2-2]
    NP_001185982.1. NM_001199053.1. [Q96IC2-1]
    NP_112203.2. NM_030941.2. [Q96IC2-1]
    XP_005255661.1. XM_005255604.1. [Q96IC2-1]
    XP_005255663.1. XM_005255606.2. [Q96IC2-2]
    UniGeneiHs.177926.

    Genome annotation databases

    GeneIDi81691.
    KEGGihsa:81691.
    UCSCiuc002dhv.3. human. [Q96IC2-1]
    uc002dhx.3. human. [Q96IC2-2]

    Polymorphism databases

    DMDMi74760869.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF332193 mRNA. Translation: AAK17192.1 .
    AL136763 mRNA. Translation: CAB66697.1 .
    AK057254 mRNA. No translation available.
    AK314458 mRNA. Translation: BAG37066.1 .
    AC004381 Genomic DNA. Translation: AAC31668.1 . Sequence problems.
    CH471228 Genomic DNA. Translation: EAW66838.1 .
    BC007646 mRNA. Translation: AAH07646.1 .
    BC068503 mRNA. Translation: AAH68503.1 .
    AL162035 mRNA. Translation: CAB82386.1 .
    CCDSi CCDS10591.1. [Q96IC2-1 ]
    CCDS45437.1. [Q96IC2-2 ]
    PIRi T47187.
    RefSeqi NP_001138396.1. NM_001144924.1. [Q96IC2-2 ]
    NP_001185982.1. NM_001199053.1. [Q96IC2-1 ]
    NP_112203.2. NM_030941.2. [Q96IC2-1 ]
    XP_005255661.1. XM_005255604.1. [Q96IC2-1 ]
    XP_005255663.1. XM_005255606.2. [Q96IC2-2 ]
    UniGenei Hs.177926.

    3D structure databases

    ProteinModelPortali Q96IC2.
    SMRi Q96IC2. Positions 230-375, 504-675.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123570. 1 interaction.
    IntActi Q96IC2. 1 interaction.
    MINTi MINT-4720634.

    PTM databases

    PhosphoSitei Q96IC2.

    Polymorphism databases

    DMDMi 74760869.

    Proteomic databases

    MaxQBi Q96IC2.
    PaxDbi Q96IC2.
    PRIDEi Q96IC2.

    Protocols and materials databases

    DNASUi 81691.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 81691.
    KEGGi hsa:81691.
    UCSCi uc002dhv.3. human. [Q96IC2-1 ]
    uc002dhx.3. human. [Q96IC2-2 ]

    Organism-specific databases

    GeneCardsi GC16P020817.
    HPAi HPA040755.
    HPA040868.
    neXtProti NX_Q96IC2.

    Phylogenomic databases

    eggNOGi COG0847.
    HOVERGENi HBG101031.
    InParanoidi Q96IC2.
    KOi K14570.
    OMAi KMIHPYV.
    PhylomeDBi Q96IC2.

    Miscellaneous databases

    GeneWikii LOC81691.
    GenomeRNAii 81691.
    NextBioi 72040.

    Gene expression databases

    ArrayExpressi Q96IC2.
    Bgeei Q96IC2.
    Genevestigatori Q96IC2.

    Family and domain databases

    Gene3Di 3.30.420.10. 1 hit.
    3.30.70.330. 2 hits.
    InterProi IPR006055. Exonuclease.
    IPR013520. Exonuclease_RNaseT/DNA_pol3.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR012337. RNaseH-like_dom.
    IPR000504. RRM_dom.
    [Graphical view ]
    Pfami PF00929. RNase_T. 1 hit.
    PF00076. RRM_1. 1 hit.
    [Graphical view ]
    SMARTi SM00479. EXOIII. 1 hit.
    SM00360. RRM. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53098. SSF53098. 1 hit.
    PROSITEi PS50102. RRM. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a novel exonuclease factor gene related to testis development in humans."
      Li J.M., Sha J.H., Zhou Z.M.
      Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung and Testis.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 416-774 (ISOFORM 1).
      Tissue: Testis.

    Entry informationi

    Entry nameiREXON_HUMAN
    AccessioniPrimary (citable) accession number: Q96IC2
    Secondary accession number(s): B2RB19
    , O60364, Q96MB1, Q9BXH9, Q9H0K2, Q9NSM2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3