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Q96IC2

- REXON_HUMAN

UniProt

Q96IC2 - REXON_HUMAN

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Protein
Putative RNA exonuclease NEF-sp
Gene
44M2.3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
  2. exonuclease activity Source: UniProtKB-KW
  3. nucleotide binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative RNA exonuclease NEF-sp (EC:3.1.-.-)
Gene namesi
ORF Names:44M2.3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. nucleolus Source: LIFEdb
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 774774Putative RNA exonuclease NEF-sp
PRO_0000287345Add
BLAST

Proteomic databases

MaxQBiQ96IC2.
PaxDbiQ96IC2.
PRIDEiQ96IC2.

PTM databases

PhosphoSiteiQ96IC2.

Expressioni

Gene expression databases

ArrayExpressiQ96IC2.
BgeeiQ96IC2.
GenevestigatoriQ96IC2.

Organism-specific databases

HPAiHPA040755.
HPA040868.

Interactioni

Protein-protein interaction databases

BioGridi123570. 1 interaction.
IntActiQ96IC2. 1 interaction.
MINTiMINT-4720634.

Structurei

3D structure databases

ProteinModelPortaliQ96IC2.
SMRiQ96IC2. Positions 230-375, 504-675.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini228 – 376149Exonuclease
Add
BLAST
Domaini505 – 57975RRM 1
Add
BLAST
Domaini600 – 67980RRM 2
Add
BLAST

Sequence similaritiesi

Contains 1 exonuclease domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0847.
HOVERGENiHBG101031.
InParanoidiQ96IC2.
KOiK14570.
OMAiKMIHPYV.
PhylomeDBiQ96IC2.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.30.70.330. 2 hits.
InterProiIPR006055. Exonuclease.
IPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012677. Nucleotide-bd_a/b_plait.
IPR012337. RNaseH-like_dom.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00929. RNase_T. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00479. EXOIII. 1 hit.
SM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96IC2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEPEREGTER HPRKVRESRQ APNKLVGAAE AMKAGWDLEE SQPEAKKARL    50
STILFTDNCE VTHDQLCELL KYAVLGKSNV PKPSWCQLFH QNHLNNVVVF 100
VLQGMSQLHF YRFYLEFGCL RKAFRHKFRL PPPSSDFLAD VVGLQTEQRA 150
GDLPKTMEGP LPSNAKAAIN LQDDPIIQKY GSKKVGLTRC LLTKEEMRTF 200
HFPLQGFPDC ENFLLTKCNG SIADNSPLFG LDCEMCLTSK GRELTRISLV 250
AEGGCCVMDE LVKPENKILD YLTSFSGITK KILNPVTTKL KDVQRQLKAL 300
LPPDAVLVGH SLDLDLRALK MIHPYVIDTS LLYVREQGRR FKLKFLAKVI 350
LGKDIQCPDR LGHDATEDAR TILELARYFL KHGPKKIAEL NLEALANHQE 400
IQAAGQEPKN TAEVLQHPNT SVLECLDSVG QKLLFLTRET DAGELPSSRN 450
CQTIKCLSNK EVLEQARVEI PLFPFSIVQF SFKAFSPVLT EEMNKRMRIK 500
WTEISTVYAG PFSKNCNLRA LKRLFKSFGP VQSMTFVLET RQPHLCIQYE 550
VLEAAQLAIE SLDGILVDGI CIKVQRPVTE LTLDCDTLVN ELEGDSENQG 600
SIYLSGVSET FKEQLLQEPR LFLGLEAVIL PKDLKSGKQK KYCFLKFKSF 650
GSAQQALNIL TGKDWKLKGR HALTPRHLHA WLRGLPPEST RLPGLRVVPP 700
PFEQEALQTL KLDHPKIAAW RWSRKIGKLY NSLCPGTLCL ILLPGTKSTH 750
GSLSGLGLMG IKEEEESAGP GLCS 774
Length:774
Mass (Da):86,886
Last modified:December 1, 2001 - v1
Checksum:i3860D67555EDF91F
GO
Isoform 2 (identifier: Q96IC2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     543-573: Missing.

Show »
Length:743
Mass (Da):83,536
Checksum:iB8DB32F3E54A1E3B
GO

Sequence cautioni

The sequence AAC31668.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei543 – 57331Missing in isoform 2.
VSP_025443Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 181S → G in AAK17192. 1 Publication
Sequence conflicti213 – 2131F → S in AK057254. 1 Publication
Sequence conflicti748 – 7481S → R in AAC31668. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF332193 mRNA. Translation: AAK17192.1.
AL136763 mRNA. Translation: CAB66697.1.
AK057254 mRNA. No translation available.
AK314458 mRNA. Translation: BAG37066.1.
AC004381 Genomic DNA. Translation: AAC31668.1. Sequence problems.
CH471228 Genomic DNA. Translation: EAW66838.1.
BC007646 mRNA. Translation: AAH07646.1.
BC068503 mRNA. Translation: AAH68503.1.
AL162035 mRNA. Translation: CAB82386.1.
CCDSiCCDS10591.1. [Q96IC2-1]
CCDS45437.1. [Q96IC2-2]
PIRiT47187.
RefSeqiNP_001138396.1. NM_001144924.1. [Q96IC2-2]
NP_001185982.1. NM_001199053.1. [Q96IC2-1]
NP_112203.2. NM_030941.2. [Q96IC2-1]
XP_005255661.1. XM_005255604.1. [Q96IC2-1]
XP_005255663.1. XM_005255606.2. [Q96IC2-2]
UniGeneiHs.177926.

Genome annotation databases

GeneIDi81691.
KEGGihsa:81691.
UCSCiuc002dhv.3. human. [Q96IC2-1]
uc002dhx.3. human. [Q96IC2-2]

Polymorphism databases

DMDMi74760869.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF332193 mRNA. Translation: AAK17192.1 .
AL136763 mRNA. Translation: CAB66697.1 .
AK057254 mRNA. No translation available.
AK314458 mRNA. Translation: BAG37066.1 .
AC004381 Genomic DNA. Translation: AAC31668.1 . Sequence problems.
CH471228 Genomic DNA. Translation: EAW66838.1 .
BC007646 mRNA. Translation: AAH07646.1 .
BC068503 mRNA. Translation: AAH68503.1 .
AL162035 mRNA. Translation: CAB82386.1 .
CCDSi CCDS10591.1. [Q96IC2-1 ]
CCDS45437.1. [Q96IC2-2 ]
PIRi T47187.
RefSeqi NP_001138396.1. NM_001144924.1. [Q96IC2-2 ]
NP_001185982.1. NM_001199053.1. [Q96IC2-1 ]
NP_112203.2. NM_030941.2. [Q96IC2-1 ]
XP_005255661.1. XM_005255604.1. [Q96IC2-1 ]
XP_005255663.1. XM_005255606.2. [Q96IC2-2 ]
UniGenei Hs.177926.

3D structure databases

ProteinModelPortali Q96IC2.
SMRi Q96IC2. Positions 230-375, 504-675.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123570. 1 interaction.
IntActi Q96IC2. 1 interaction.
MINTi MINT-4720634.

PTM databases

PhosphoSitei Q96IC2.

Polymorphism databases

DMDMi 74760869.

Proteomic databases

MaxQBi Q96IC2.
PaxDbi Q96IC2.
PRIDEi Q96IC2.

Protocols and materials databases

DNASUi 81691.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 81691.
KEGGi hsa:81691.
UCSCi uc002dhv.3. human. [Q96IC2-1 ]
uc002dhx.3. human. [Q96IC2-2 ]

Organism-specific databases

GeneCardsi GC16P020817.
HPAi HPA040755.
HPA040868.
neXtProti NX_Q96IC2.

Phylogenomic databases

eggNOGi COG0847.
HOVERGENi HBG101031.
InParanoidi Q96IC2.
KOi K14570.
OMAi KMIHPYV.
PhylomeDBi Q96IC2.

Miscellaneous databases

GeneWikii LOC81691.
GenomeRNAii 81691.
NextBioi 72040.

Gene expression databases

ArrayExpressi Q96IC2.
Bgeei Q96IC2.
Genevestigatori Q96IC2.

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
3.30.70.330. 2 hits.
InterProi IPR006055. Exonuclease.
IPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012677. Nucleotide-bd_a/b_plait.
IPR012337. RNaseH-like_dom.
IPR000504. RRM_dom.
[Graphical view ]
Pfami PF00929. RNase_T. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view ]
SMARTi SM00479. EXOIII. 1 hit.
SM00360. RRM. 2 hits.
[Graphical view ]
SUPFAMi SSF53098. SSF53098. 1 hit.
PROSITEi PS50102. RRM. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a novel exonuclease factor gene related to testis development in humans."
    Li J.M., Sha J.H., Zhou Z.M.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung and Testis.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 416-774 (ISOFORM 1).
    Tissue: Testis.

Entry informationi

Entry nameiREXON_HUMAN
AccessioniPrimary (citable) accession number: Q96IC2
Secondary accession number(s): B2RB19
, O60364, Q96MB1, Q9BXH9, Q9H0K2, Q9NSM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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