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Q96IC2

- REXON_HUMAN

UniProt

Q96IC2 - REXON_HUMAN

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Protein

Putative RNA exonuclease NEF-sp

Gene

44M2.3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. exonuclease activity Source: UniProtKB-KW
  2. nucleotide binding Source: InterPro
  3. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative RNA exonuclease NEF-sp (EC:3.1.-.-)
Gene namesi
ORF Names:44M2.3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. nucleolus Source: LIFEdb
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 774774Putative RNA exonuclease NEF-spPRO_0000287345Add
BLAST

Proteomic databases

MaxQBiQ96IC2.
PaxDbiQ96IC2.
PRIDEiQ96IC2.

PTM databases

PhosphoSiteiQ96IC2.

Expressioni

Gene expression databases

BgeeiQ96IC2.
ExpressionAtlasiQ96IC2. baseline and differential.
GenevestigatoriQ96IC2.

Organism-specific databases

HPAiHPA040755.
HPA040868.

Interactioni

Protein-protein interaction databases

BioGridi123570. 2 interactions.
IntActiQ96IC2. 1 interaction.
MINTiMINT-4720634.

Structurei

3D structure databases

ProteinModelPortaliQ96IC2.
SMRiQ96IC2. Positions 230-375, 504-675.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini228 – 376149ExonucleaseAdd
BLAST
Domaini505 – 57975RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini600 – 67980RRM 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 exonuclease domain.Curated
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0847.
GeneTreeiENSGT00770000120662.
HOVERGENiHBG101031.
InParanoidiQ96IC2.
KOiK14570.
OMAiKMIHPYV.
PhylomeDBiQ96IC2.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.30.70.330. 2 hits.
InterProiIPR006055. Exonuclease.
IPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012677. Nucleotide-bd_a/b_plait.
IPR012337. RNaseH-like_dom.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00929. RNase_T. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00479. EXOIII. 1 hit.
SM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96IC2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPEREGTER HPRKVRESRQ APNKLVGAAE AMKAGWDLEE SQPEAKKARL
60 70 80 90 100
STILFTDNCE VTHDQLCELL KYAVLGKSNV PKPSWCQLFH QNHLNNVVVF
110 120 130 140 150
VLQGMSQLHF YRFYLEFGCL RKAFRHKFRL PPPSSDFLAD VVGLQTEQRA
160 170 180 190 200
GDLPKTMEGP LPSNAKAAIN LQDDPIIQKY GSKKVGLTRC LLTKEEMRTF
210 220 230 240 250
HFPLQGFPDC ENFLLTKCNG SIADNSPLFG LDCEMCLTSK GRELTRISLV
260 270 280 290 300
AEGGCCVMDE LVKPENKILD YLTSFSGITK KILNPVTTKL KDVQRQLKAL
310 320 330 340 350
LPPDAVLVGH SLDLDLRALK MIHPYVIDTS LLYVREQGRR FKLKFLAKVI
360 370 380 390 400
LGKDIQCPDR LGHDATEDAR TILELARYFL KHGPKKIAEL NLEALANHQE
410 420 430 440 450
IQAAGQEPKN TAEVLQHPNT SVLECLDSVG QKLLFLTRET DAGELPSSRN
460 470 480 490 500
CQTIKCLSNK EVLEQARVEI PLFPFSIVQF SFKAFSPVLT EEMNKRMRIK
510 520 530 540 550
WTEISTVYAG PFSKNCNLRA LKRLFKSFGP VQSMTFVLET RQPHLCIQYE
560 570 580 590 600
VLEAAQLAIE SLDGILVDGI CIKVQRPVTE LTLDCDTLVN ELEGDSENQG
610 620 630 640 650
SIYLSGVSET FKEQLLQEPR LFLGLEAVIL PKDLKSGKQK KYCFLKFKSF
660 670 680 690 700
GSAQQALNIL TGKDWKLKGR HALTPRHLHA WLRGLPPEST RLPGLRVVPP
710 720 730 740 750
PFEQEALQTL KLDHPKIAAW RWSRKIGKLY NSLCPGTLCL ILLPGTKSTH
760 770
GSLSGLGLMG IKEEEESAGP GLCS
Length:774
Mass (Da):86,886
Last modified:December 1, 2001 - v1
Checksum:i3860D67555EDF91F
GO
Isoform 2 (identifier: Q96IC2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     543-573: Missing.

Show »
Length:743
Mass (Da):83,536
Checksum:iB8DB32F3E54A1E3B
GO

Sequence cautioni

The sequence AAC31668.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 181S → G in AAK17192. 1 PublicationCurated
Sequence conflicti213 – 2131F → S in AK057254. (PubMed:14702039)Curated
Sequence conflicti748 – 7481S → R in AAC31668. (PubMed:10493829)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei543 – 57331Missing in isoform 2. 1 PublicationVSP_025443Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332193 mRNA. Translation: AAK17192.1.
AL136763 mRNA. Translation: CAB66697.1.
AK057254 mRNA. No translation available.
AK314458 mRNA. Translation: BAG37066.1.
AC004381 Genomic DNA. Translation: AAC31668.1. Sequence problems.
CH471228 Genomic DNA. Translation: EAW66838.1.
BC007646 mRNA. Translation: AAH07646.1.
BC068503 mRNA. Translation: AAH68503.1.
AL162035 mRNA. Translation: CAB82386.1.
CCDSiCCDS10591.1. [Q96IC2-1]
CCDS45437.1. [Q96IC2-2]
PIRiT47187.
RefSeqiNP_001138396.1. NM_001144924.1. [Q96IC2-2]
NP_001185982.1. NM_001199053.1. [Q96IC2-1]
NP_112203.2. NM_030941.2. [Q96IC2-1]
XP_005255661.1. XM_005255604.1. [Q96IC2-1]
XP_005255663.1. XM_005255606.2. [Q96IC2-2]
UniGeneiHs.177926.

Genome annotation databases

GeneIDi81691.
KEGGihsa:81691.
UCSCiuc002dhv.3. human. [Q96IC2-1]
uc002dhx.3. human. [Q96IC2-2]

Polymorphism databases

DMDMi74760869.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332193 mRNA. Translation: AAK17192.1 .
AL136763 mRNA. Translation: CAB66697.1 .
AK057254 mRNA. No translation available.
AK314458 mRNA. Translation: BAG37066.1 .
AC004381 Genomic DNA. Translation: AAC31668.1 . Sequence problems.
CH471228 Genomic DNA. Translation: EAW66838.1 .
BC007646 mRNA. Translation: AAH07646.1 .
BC068503 mRNA. Translation: AAH68503.1 .
AL162035 mRNA. Translation: CAB82386.1 .
CCDSi CCDS10591.1. [Q96IC2-1 ]
CCDS45437.1. [Q96IC2-2 ]
PIRi T47187.
RefSeqi NP_001138396.1. NM_001144924.1. [Q96IC2-2 ]
NP_001185982.1. NM_001199053.1. [Q96IC2-1 ]
NP_112203.2. NM_030941.2. [Q96IC2-1 ]
XP_005255661.1. XM_005255604.1. [Q96IC2-1 ]
XP_005255663.1. XM_005255606.2. [Q96IC2-2 ]
UniGenei Hs.177926.

3D structure databases

ProteinModelPortali Q96IC2.
SMRi Q96IC2. Positions 230-375, 504-675.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123570. 2 interactions.
IntActi Q96IC2. 1 interaction.
MINTi MINT-4720634.

PTM databases

PhosphoSitei Q96IC2.

Polymorphism databases

DMDMi 74760869.

Proteomic databases

MaxQBi Q96IC2.
PaxDbi Q96IC2.
PRIDEi Q96IC2.

Protocols and materials databases

DNASUi 81691.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 81691.
KEGGi hsa:81691.
UCSCi uc002dhv.3. human. [Q96IC2-1 ]
uc002dhx.3. human. [Q96IC2-2 ]

Organism-specific databases

GeneCardsi GC16P020817.
HPAi HPA040755.
HPA040868.
neXtProti NX_Q96IC2.

Phylogenomic databases

eggNOGi COG0847.
GeneTreei ENSGT00770000120662.
HOVERGENi HBG101031.
InParanoidi Q96IC2.
KOi K14570.
OMAi KMIHPYV.
PhylomeDBi Q96IC2.

Miscellaneous databases

GeneWikii LOC81691.
GenomeRNAii 81691.
NextBioi 72040.

Gene expression databases

Bgeei Q96IC2.
ExpressionAtlasi Q96IC2. baseline and differential.
Genevestigatori Q96IC2.

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
3.30.70.330. 2 hits.
InterProi IPR006055. Exonuclease.
IPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012677. Nucleotide-bd_a/b_plait.
IPR012337. RNaseH-like_dom.
IPR000504. RRM_dom.
[Graphical view ]
Pfami PF00929. RNase_T. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view ]
SMARTi SM00479. EXOIII. 1 hit.
SM00360. RRM. 2 hits.
[Graphical view ]
SUPFAMi SSF53098. SSF53098. 1 hit.
PROSITEi PS50102. RRM. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a novel exonuclease factor gene related to testis development in humans."
    Li J.M., Sha J.H., Zhou Z.M.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung and Testis.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 416-774 (ISOFORM 1).
    Tissue: Testis.

Entry informationi

Entry nameiREXON_HUMAN
AccessioniPrimary (citable) accession number: Q96IC2
Secondary accession number(s): B2RB19
, O60364, Q96MB1, Q9BXH9, Q9H0K2, Q9NSM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: December 1, 2001
Last modified: November 26, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3