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Protein
Submitted name:

PTPRN protein

Gene

PTPRN

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei741Phosphocysteine intermediatePROSITE-ProRule annotation1

Keywordsi

Molecular functionHydrolasePROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
PTPRN proteinImported
Gene namesi
Name:PTPRNImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei409 – 432HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34021

PTM / Processingi

Proteomic databases

PeptideAtlasiQ96IA0
PRIDEiQ96IA0

Expressioni

Gene expression databases

GenevisibleiQ96IA0 HS

Structurei

3D structure databases

ProteinModelPortaliQ96IA0
SMRiQ96IA0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini541 – 801Tyrosine-protein phosphataseInterPro annotationAdd BLAST261
Domaini720 – 792TYR_PHOSPHATASE_2InterPro annotationAdd BLAST73

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0793 Eukaryota
COG5599 LUCA
HOVERGENiHBG053762
KOiK07817

Family and domain databases

Gene3Di3.30.70.2470, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR033522 IA-2/IA-2_beta
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR021613 Receptor_IA-2_dom
IPR038112 Receptor_IA-2_ectodomain_sf
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PANTHERiPTHR19134:SF2 PTHR19134:SF2, 1 hit
PfamiView protein in Pfam
PF11548 Receptor_IA-2, 1 hit
PF00102 Y_phosphatase, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Fragment.

Q96IA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ASSSLSPLQA ELLPPLLEHL LLPPQPPHPS LSYEPALLQP YLFHQFGSRD
60 70 80 90 100
GSRVSEGSPG MVSVGPLPKA EAPALFSRTA SKGIFGDHPG HSYGDLPGPS
110 120 130 140 150
PAQLFQDSGL LYLAQELPAP SRARVPRLPE QGSSSRAEDS PEGYEKEGLG
160 170 180 190 200
DRGEKPASPA VQPDAALQRL AAVLAGYGVE LRQLTPEQLS TLLTLLQLLP
210 220 230 240 250
KGAGRNPGGV VNVGADIKKT MEGPVEGRDT AELPARTSPM PGHPTASPTS
260 270 280 290 300
SEVQQVPSPV SSEPPKAARP PVTPVLLEKK SPLGQSQPTV AGQPSARPAA
310 320 330 340 350
EEYGYIVTDQ KPLSLAAGVK LLEILAEHVH MSSGSFINIS VVGPALTFRI
360 370 380 390 400
RHNEQNLSLA DVTQQAGLVK SELEAQTGLQ ILQTGVGQRE EAAAVLPQTA
410 420 430 440 450
HSTSPMRSVL LTLVALAGVA GLLVALAVAL CVRQHARQQD KERLAALGPE
460 470 480 490 500
GAHGDTTFEY QDLCRQHMAT KSLFNRAEGP PEPSRVSSVS SQFSDAAQAS
510 520 530 540 550
PSSHSSTPSW CEEPAQANMD ISTGHMILAY MEDHLRNRDR LAKEWQALCA
560 570 580 590 600
YQAEPNTCAT AQGEGNIKKN RHPDFLPYDH ARIKLKVESS PSRSDYINAS
610 620 630 640 650
PIIEHDPRMP AYIATQGPLS HTIADFWQMV WESGCTVIVM LTPLVEDGVK
660 670 680 690 700
QCDRYWPDEG ASLYHVYEVN LVSEHIWCED FLVRSFYLKN VQTQETRTLT
710 720 730 740 750
QFHFLSWPAE GTPASTRPLL DFRRKVNKCY RGRSCPIIVH CSDGAGRTGT
760 770 780 790 800
YILIDMVLNR MAKGVKEIDI AATLEHVRDQ RPGLVRSKDQ FEFALTAVAE
810
EVNAILKALP Q
Length:811
Mass (Da):87,841
Last modified:July 5, 2004 - v2
Checksum:i1CC9B2B4F9D2F5B3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007713 mRNA Translation: AAH07713.2
RefSeqiNP_002837.1, NM_002846.3
UniGeneiHs.89655

Genome annotation databases

GeneIDi5798
KEGGihsa:5798

Similar proteinsi

Entry informationi

Entry nameiQ96IA0_HUMAN
AccessioniPrimary (citable) accession number: Q96IA0
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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