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Protein
Submitted name:

PTPRN protein

Gene

PTPRN

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
PTPRN proteinImported
Gene namesi
Name:PTPRNImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei409 – 43224HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34021.

PTM / Processingi

Proteomic databases

PaxDbiQ96IA0.
PeptideAtlasiQ96IA0.

Expressioni

Gene expression databases

BgeeiENSG00000054356.
GenevisibleiQ96IA0. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000295718.

Structurei

3D structure databases

ProteinModelPortaliQ96IA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini541 – 801261Tyrosine-protein phosphataseInterPro annotationAdd
BLAST
Domaini720 – 79273TYR_PHOSPHATASE_2InterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0793. Eukaryota.
COG5599. LUCA.
HOVERGENiHBG053762.
KOiK07817.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR033522. PTPRN.
IPR021613. Receptor_IA-2_dom.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PANTHERiPTHR19134:SF2. PTHR19134:SF2. 1 hit.
PfamiPF11548. Receptor_IA-2. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q96IA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ASSSLSPLQA ELLPPLLEHL LLPPQPPHPS LSYEPALLQP YLFHQFGSRD
60 70 80 90 100
GSRVSEGSPG MVSVGPLPKA EAPALFSRTA SKGIFGDHPG HSYGDLPGPS
110 120 130 140 150
PAQLFQDSGL LYLAQELPAP SRARVPRLPE QGSSSRAEDS PEGYEKEGLG
160 170 180 190 200
DRGEKPASPA VQPDAALQRL AAVLAGYGVE LRQLTPEQLS TLLTLLQLLP
210 220 230 240 250
KGAGRNPGGV VNVGADIKKT MEGPVEGRDT AELPARTSPM PGHPTASPTS
260 270 280 290 300
SEVQQVPSPV SSEPPKAARP PVTPVLLEKK SPLGQSQPTV AGQPSARPAA
310 320 330 340 350
EEYGYIVTDQ KPLSLAAGVK LLEILAEHVH MSSGSFINIS VVGPALTFRI
360 370 380 390 400
RHNEQNLSLA DVTQQAGLVK SELEAQTGLQ ILQTGVGQRE EAAAVLPQTA
410 420 430 440 450
HSTSPMRSVL LTLVALAGVA GLLVALAVAL CVRQHARQQD KERLAALGPE
460 470 480 490 500
GAHGDTTFEY QDLCRQHMAT KSLFNRAEGP PEPSRVSSVS SQFSDAAQAS
510 520 530 540 550
PSSHSSTPSW CEEPAQANMD ISTGHMILAY MEDHLRNRDR LAKEWQALCA
560 570 580 590 600
YQAEPNTCAT AQGEGNIKKN RHPDFLPYDH ARIKLKVESS PSRSDYINAS
610 620 630 640 650
PIIEHDPRMP AYIATQGPLS HTIADFWQMV WESGCTVIVM LTPLVEDGVK
660 670 680 690 700
QCDRYWPDEG ASLYHVYEVN LVSEHIWCED FLVRSFYLKN VQTQETRTLT
710 720 730 740 750
QFHFLSWPAE GTPASTRPLL DFRRKVNKCY RGRSCPIIVH CSDGAGRTGT
760 770 780 790 800
YILIDMVLNR MAKGVKEIDI AATLEHVRDQ RPGLVRSKDQ FEFALTAVAE
810
EVNAILKALP Q
Length:811
Mass (Da):87,841
Last modified:July 5, 2004 - v2
Checksum:i1CC9B2B4F9D2F5B3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007713 mRNA. Translation: AAH07713.2.
RefSeqiNP_002837.1. NM_002846.3.
UniGeneiHs.89655.

Genome annotation databases

GeneIDi5798.
KEGGihsa:5798.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007713 mRNA. Translation: AAH07713.2.
RefSeqiNP_002837.1. NM_002846.3.
UniGeneiHs.89655.

3D structure databases

ProteinModelPortaliQ96IA0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000295718.

Proteomic databases

PaxDbiQ96IA0.
PeptideAtlasiQ96IA0.

Protocols and materials databases

DNASUi5798.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5798.
KEGGihsa:5798.

Organism-specific databases

CTDi5798.
PharmGKBiPA34021.

Phylogenomic databases

eggNOGiKOG0793. Eukaryota.
COG5599. LUCA.
HOVERGENiHBG053762.
KOiK07817.

Miscellaneous databases

ChiTaRSiPTPRN. human.
GenomeRNAii5798.

Gene expression databases

BgeeiENSG00000054356.
GenevisibleiQ96IA0. HS.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR033522. PTPRN.
IPR021613. Receptor_IA-2_dom.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PANTHERiPTHR19134:SF2. PTHR19134:SF2. 1 hit.
PfamiPF11548. Receptor_IA-2. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ96IA0_HUMAN
AccessioniPrimary (citable) accession number: Q96IA0
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.