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Protein
Submitted name:

EIF4G1 protein

Gene

EIF4G1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Initiation factorImported

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Submitted name:
EIF4G1 proteinImported
Submitted name:
Eukaryotic translation initiation factor 4 gamma, 1Imported
Gene namesi
Name:EIF4G1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PeptideAtlasiQ96I65.

Interactioni

Protein-protein interaction databases

MINTiMINT-1382239.
STRINGi9606.ENSP00000338020.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini287 – 409123MIInterPro annotationAdd
BLAST
Domaini479 – 645167W2InterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG0401. Eukaryota.
ENOG410XS4P. LUCA.
HOGENOMiHOG000231658.
HOVERGENiHBG052083.

Family and domain databases

Gene3Di1.25.40.180. 3 hits.
InterProiIPR016024. ARM-type_fold.
IPR003891. Initiation_fac_eIF4g_MI.
IPR016021. MIF4-like.
IPR003890. MIF4G-like_typ-3.
IPR003307. W2_domain.
[Graphical view]
PfamiPF02847. MA3. 1 hit.
PF02854. MIF4G. 1 hit.
PF02020. W2. 1 hit.
[Graphical view]
SMARTiSM00515. eIF5C. 1 hit.
SM00544. MA3. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
PROSITEiPS51366. MI. 1 hit.
PS51363. W2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96I65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQYFNQMEK IIKEKKTSSR IRFMLQDVLD LRGSNWVPRR GDQGPKTIDQ
60 70 80 90 100
IHKEAEMEEH REHIKVQQLM AKGSDKRRGG PPGPPISRGL PLVDDGGWNT
110 120 130 140 150
VPISKGSRPI DTSRLTKITK PGSIDSNNQL FAPGGRLSWG KGSSGGSGAK
160 170 180 190 200
PSDAASEAAR PATSTLNRFS ALQQAVPTES TDNRRVVQRS SLSRERGEKA
210 220 230 240 250
GDRGDRLERS ERGGDRGDRL DRARTPATKR SFSKEVEERS RERPSQPEGL
260 270 280 290 300
RKAASLTEDR DRGRDAVKRE AALPPVSPLK AALSEEELEK KSKAIIEEYL
310 320 330 340 350
HLNDMKEAVQ CVQELASPSL LFIFVRHGVE STLERSAIAR EHMGQLLHQL
360 370 380 390 400
LCAGHLSTAQ YYQGLYEILE LAEDMEIDIP HVWLYLAELV TPILQEGGVP
410 420 430 440 450
MGELFREITK PLRPLGKAAS LLLEILGLLC KSMGPKKVGT LWREAGLSWK
460 470 480 490 500
EFLPEGQDIG AFVAEQKVEY TLGEESEAPG QRALPSEELN RQLEKLLKEG
510 520 530 540 550
SSNQRVFDWI EANLSEQQIV SNTLVRALMT AVCYSAIIFE TPLRVDVAVL
560 570 580 590 600
KARAKLLQKY LCDEQKELQA LYALQALVVT LEQPPNLLRM FFDALYDEDV
610 620 630 640
VKEDAFYSWE SSKDPAEQQG KGVALKSVTA FFKWLREAEE ESDHN
Length:645
Mass (Da):72,201
Last modified:December 1, 2001 - v1
Checksum:iDD257232574A45B8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007788 mRNA. Translation: AAH07788.1.
BT007282 mRNA. Translation: AAP35946.1.
RefSeqiNP_937884.1. NM_198241.2.
NP_937887.1. NM_198244.2.
UniGeneiHs.433750.

Genome annotation databases

GeneIDi1981.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007788 mRNA. Translation: AAH07788.1.
BT007282 mRNA. Translation: AAP35946.1.
RefSeqiNP_937884.1. NM_198241.2.
NP_937887.1. NM_198244.2.
UniGeneiHs.433750.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1382239.
STRINGi9606.ENSP00000338020.

Proteomic databases

PeptideAtlasiQ96I65.

Protocols and materials databases

DNASUi1981.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1981.

Organism-specific databases

CTDi1981.

Phylogenomic databases

eggNOGiKOG0401. Eukaryota.
ENOG410XS4P. LUCA.
HOGENOMiHOG000231658.
HOVERGENiHBG052083.

Miscellaneous databases

ChiTaRSiEIF4G1. human.
GenomeRNAii1981.

Family and domain databases

Gene3Di1.25.40.180. 3 hits.
InterProiIPR016024. ARM-type_fold.
IPR003891. Initiation_fac_eIF4g_MI.
IPR016021. MIF4-like.
IPR003890. MIF4G-like_typ-3.
IPR003307. W2_domain.
[Graphical view]
PfamiPF02847. MA3. 1 hit.
PF02854. MIF4G. 1 hit.
PF02020. W2. 1 hit.
[Graphical view]
SMARTiSM00515. eIF5C. 1 hit.
SM00544. MA3. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
PROSITEiPS51366. MI. 1 hit.
PS51363. W2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of human full-length CDSs in BD Creator(TM) System Donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PancreasImported.

Entry informationi

Entry nameiQ96I65_HUMAN
AccessioniPrimary (citable) accession number: Q96I65
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.