Q96I59 (SYNM_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 98.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Probable asparagine--tRNA ligase, mitochondrial EC=6.1.1.22 Alternative name(s): Asparaginyl-tRNA synthetase Short name=AsnRS | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Reference proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo![]() |
Protein attributes
| Sequence length | 477 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Catalytic activity | ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn). |
| Subcellular location | Mitochondrion matrix By similarity. |
| Sequence similarities | Belongs to the class-II aminoacyl-tRNA synthetase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Protein biosynthesis |
| Cellular component | Mitochondrion |
| Coding sequence diversity | Polymorphism |
| Domain | Transit peptide |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Aminoacyl-tRNA synthetase Ligase |
| PTM | Acetylation |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | asparaginyl-tRNA aminoacylation Inferred from sequence or structural similarity. Source: UniProtKB |
| Cellular_component | mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrionInferred from sequence or structural similarity. Source: UniProtKB |
| Molecular_function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW asparagine-tRNA ligase activityInferred from sequence or structural similarity. Source: UniProtKB nucleic acid bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 14 | 14 | Mitochondrion Potential | ||||||
| Chain | 15 – 477 | 463 | Probable asparagine--tRNA ligase, mitochondrial | PRO_0000250722 | |||||
Amino acid modifications | |||||||||
| Modified residue | 353 | 1 | N6-acetyllysine Ref.4 | ||||||
Natural variations | |||||||||
| Natural variant | 87 | 1 | N → T. Ref.2 Corresponds to variant rs10501429 [ dbSNP | Ensembl ]. | VAR_052636 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. Sakaki Y.Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-87. Tissue: Brain. |
| [3] | "Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS." Bonnefond L., Fender A., Rudinger-Thirion J., Giege R., Florentz C., Sissler M. Biochemistry 44:4805-4816(2005) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION. |
| [4] | "Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-353, MASS SPECTROMETRY. |
| [5] | "Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AP003086 Genomic DNA. No translation available. AP003110 Genomic DNA. No translation available. BC007800 mRNA. Translation: AAH07800.2. |
| IPI | IPI00101664. |
| RefSeq | NP_078954.4. NM_024678.5. |
| UniGene | Hs.503389. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1X56 based on UniProtKB O57980. |
| ProteinModelPortal | Q96I59. |
| SMR | Q96I59. Positions 41-472. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q96I59. 1 interaction. |
| STRING | 9606.ENSP00000281038. |
PTM databases | |
| PhosphoSite | Q96I59. |
Polymorphism databases | |
| DMDM | 296452944. |
Proteomic databases | |
| PaxDb | Q96I59. |
| PRIDE | Q96I59. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000281038; ENSP00000281038; ENSG00000137513. |
| GeneID | 79731. |
| KEGG | hsa:79731. |
| UCSC | uc001ozi.3. human. |
Organism-specific databases | |
| CTD | 79731. |
| GeneCards | GC11M078147. |
| HGNC | HGNC:26274. NARS2. |
| HPA | HPA026793. |
| MIM | 612803. gene. |
| neXtProt | NX_Q96I59. |
| PharmGKB | PA143485554. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | COG0017. |
| HOGENOM | HOG000226033. |
| HOVERGEN | HBG067799. |
| InParanoid | Q96I59. |
| KO | K01893. |
| OMA | DLWWYLD. |
| OrthoDB | EOG4DJJWB. |
| PhylomeDB | Q96I59. |
Enzyme and pathway databases | |
| Reactome | REACT_71. Gene Expression. |
Gene expression databases | |
| ArrayExpress | Q96I59. |
| Bgee | Q96I59. |
| CleanEx | HS_NARS2. |
| Genevestigator | Q96I59. |
| GermOnline | ENSG00000137513. Homo sapiens. |
Family and domain databases | |
| Gene3D | 2.40.50.140. 1 hit. |
| InterPro | IPR004364. aa-tRNA-synt_II. IPR018150. aa-tRNA-synt_II-like. IPR006195. aa-tRNA-synth_II. IPR004522. Asn-tRNA-ligase_IIb. IPR002312. Asp/Asn-tRNA-synth_IIb. IPR012340. NA-bd_OB-fold. IPR004365. NA-bd_OB_tRNA-helicase. [Graphical view] |
| PANTHER | PTHR22594. PTHR22594. 1 hit. PTHR22594:SF6. PTHR22594:SF6. 1 hit. |
| Pfam | PF00152. tRNA-synt_2. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view] |
| PRINTS | PR01042. TRNASYNTHASP. |
| SUPFAM | SSF50249. Nucleic_acid_OB. 1 hit. |
| TIGRFAMs | TIGR00457. asnS. 1 hit. |
| PROSITE | PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| ChiTaRS | NARS2. human. |
| DrugBank | DB00174. L-Asparagine. |
| GenomeRNAi | 79731. |
| NextBio | 69114. |
| SOURCE | Search... |
Entry information
| Entry name | SYNM_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q96I59 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Aminoacyl-tRNA synthetases List of aminoacyl-tRNA synthetase entries |
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with
