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Protein

Transmembrane protein 141

Gene

TMEM141

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 141
Gene namesi
Name:TMEM141
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:28211. TMEM141.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei32 – 5221HelicalSequence analysisAdd
BLAST
Transmembranei58 – 7821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596262.

Polymorphism and mutation databases

BioMutaiTMEM141.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 108108Transmembrane protein 141PRO_0000279507Add
BLAST

Proteomic databases

EPDiQ96I45.
MaxQBiQ96I45.
PaxDbiQ96I45.
PeptideAtlasiQ96I45.
PRIDEiQ96I45.

Expressioni

Gene expression databases

BgeeiENSG00000244187.
CleanExiHS_TMEM141.
GenevisibleiQ96I45. HS.

Organism-specific databases

HPAiHPA014615.
HPA050244.

Interactioni

Protein-protein interaction databases

BioGridi124429. 3 interactions.

Structurei

Secondary structure

1
108
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 53Combined sources
Helixi6 – 1611Combined sources
Helixi20 – 3920Combined sources
Helixi40 – 434Combined sources
Helixi44 – 5310Combined sources
Beta strandi56 – 605Combined sources
Helixi62 – 9534Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LORNMR-A1-108[»]
ProteinModelPortaliQ96I45.
SMRiQ96I45. Positions 1-108.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM141 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0CX. Eukaryota.
ENOG4111TIE. LUCA.
GeneTreeiENSGT00390000001064.
HOGENOMiHOG000154608.
HOVERGENiHBG067289.
InParanoidiQ96I45.
OMAiCQSHAFM.
OrthoDBiEOG091G0X78.
PhylomeDBiQ96I45.
TreeFamiTF330755.

Family and domain databases

InterProiIPR026788. Tmem141.
[Graphical view]
PANTHERiPTHR21694:SF28. PTHR21694:SF28. 1 hit.
PfamiPF15110. TMEM141. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96I45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNLGLSRVD DAVAAKHPGL GEYAACQSHA FMKGVFTFVT GTGMAFGLQM
60 70 80 90 100
FIQRKFPYPL QWSLLVAVVA GSVVSYGVTR VESEKCNNLW LFLETGQLPK

DRSTDQRS
Length:108
Mass (Da):11,875
Last modified:December 1, 2001 - v1
Checksum:i948494B8AC757657
GO

Sequence cautioni

The sequence CAI12680 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355987 Genomic DNA. Translation: CAI12679.1.
AL355987 Genomic DNA. Translation: CAI12680.1. Sequence problems.
CH471090 Genomic DNA. Translation: EAW88277.1.
BC007834 mRNA. Translation: AAH07834.1.
CCDSiCCDS7007.1.
RefSeqiNP_116317.1. NM_032928.3.
UniGeneiHs.356744.

Genome annotation databases

EnsembliENST00000290079; ENSP00000290079; ENSG00000244187.
GeneIDi85014.
KEGGihsa:85014.
UCSCiuc004cje.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355987 Genomic DNA. Translation: CAI12679.1.
AL355987 Genomic DNA. Translation: CAI12680.1. Sequence problems.
CH471090 Genomic DNA. Translation: EAW88277.1.
BC007834 mRNA. Translation: AAH07834.1.
CCDSiCCDS7007.1.
RefSeqiNP_116317.1. NM_032928.3.
UniGeneiHs.356744.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LORNMR-A1-108[»]
ProteinModelPortaliQ96I45.
SMRiQ96I45. Positions 1-108.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124429. 3 interactions.

Polymorphism and mutation databases

BioMutaiTMEM141.

Proteomic databases

EPDiQ96I45.
MaxQBiQ96I45.
PaxDbiQ96I45.
PeptideAtlasiQ96I45.
PRIDEiQ96I45.

Protocols and materials databases

DNASUi85014.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290079; ENSP00000290079; ENSG00000244187.
GeneIDi85014.
KEGGihsa:85014.
UCSCiuc004cje.5. human.

Organism-specific databases

CTDi85014.
GeneCardsiTMEM141.
HGNCiHGNC:28211. TMEM141.
HPAiHPA014615.
HPA050244.
neXtProtiNX_Q96I45.
PharmGKBiPA144596262.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0CX. Eukaryota.
ENOG4111TIE. LUCA.
GeneTreeiENSGT00390000001064.
HOGENOMiHOG000154608.
HOVERGENiHBG067289.
InParanoidiQ96I45.
OMAiCQSHAFM.
OrthoDBiEOG091G0X78.
PhylomeDBiQ96I45.
TreeFamiTF330755.

Miscellaneous databases

GenomeRNAii85014.
PROiQ96I45.

Gene expression databases

BgeeiENSG00000244187.
CleanExiHS_TMEM141.
GenevisibleiQ96I45. HS.

Family and domain databases

InterProiIPR026788. Tmem141.
[Graphical view]
PANTHERiPTHR21694:SF28. PTHR21694:SF28. 1 hit.
PfamiPF15110. TMEM141. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM141_HUMAN
AccessioniPrimary (citable) accession number: Q96I45
Secondary accession number(s): A6NIZ7, Q5T5R5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.