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Q96I34

- PP16A_HUMAN

UniProt

Q96I34 - PP16A_HUMAN

Protein

Protein phosphatase 1 regulatory subunit 16A

Gene

PPP1R16A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 1 regulatory subunit 16A
    Alternative name(s):
    Myosin phosphatase-targeting subunit 3
    Gene namesi
    Name:PPP1R16A
    Synonyms:MYPT3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:14941. PPP1R16A.

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchor By similarity

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33634.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 525525Protein phosphatase 1 regulatory subunit 16APRO_0000067040Add
    BLAST
    Propeptidei526 – 5283Removed in mature formSequence AnalysisPRO_0000396707

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi524 – 5241S-palmitoyl cysteineSequence Analysis
    Modified residuei525 – 5251Cysteine methyl esterSequence Analysis
    Lipidationi525 – 5251S-farnesyl cysteineSequence Analysis

    Keywords - PTMi

    Lipoprotein, Methylation, Palmitate, Prenylation

    Proteomic databases

    MaxQBiQ96I34.
    PaxDbiQ96I34.
    PRIDEiQ96I34.

    PTM databases

    PhosphoSiteiQ96I34.

    Expressioni

    Gene expression databases

    BgeeiQ96I34.
    CleanExiHS_PPP1R16A.
    GenevestigatoriQ96I34.

    Organism-specific databases

    HPAiHPA023755.

    Interactioni

    Subunit structurei

    Binds PP1.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PUF60Q9UHX12EBI-710402,EBI-1053259
    TRIP6Q156543EBI-710402,EBI-742327

    Protein-protein interaction databases

    BioGridi124414. 14 interactions.
    IntActiQ96I34. 17 interactions.
    MINTiMINT-1368047.
    STRINGi9606.ENSP00000292539.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96I34.
    SMRiQ96I34. Positions 22-343.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati70 – 9930ANK 1Add
    BLAST
    Repeati103 – 13230ANK 2Add
    BLAST
    Repeati136 – 16530ANK 3Add
    BLAST
    Repeati231 – 26030ANK 4Add
    BLAST
    Repeati264 – 29330ANK 5Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili18 – 4528Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 5 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiCOG0666.
    HOGENOMiHOG000236276.
    HOVERGENiHBG053644.
    InParanoidiQ96I34.
    KOiK17458.
    OMAiNARDSEC.
    OrthoDBiEOG7P5T0H.
    PhylomeDBiQ96I34.
    TreeFamiTF316803.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR017417. Pase-1_reg_su_16AB_euk.
    [Graphical view]
    PfamiPF12796. Ank_2. 2 hits.
    [Graphical view]
    PIRSFiPIRSF038159. PP1_16AB_vert. 1 hit.
    PRINTSiPR01415. ANKYRIN.
    SMARTiSM00248. ANK. 4 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q96I34-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEHLELLAE MPMVGRMSTQ ERLKHAQKRR AQQVKMWAQA EKEAQGKKGP    50
    GERPRKEAAS QGLLKQVLFP PSVVLLEAAA RNDLEEVRQF LGSGVSPDLA 100
    NEDGLTALHQ CCIDDFREMV QQLLEAGANI NACDSECWTP LHAAATCGHL 150
    HLVELLIASG ANLLAVNTDG NMPYDLCDDE QTLDCLETAM ADRGITQDSI 200
    EAARAVPELR MLDDIRSRLQ AGADLHAPLD HGATLLHVAA ANGFSEAAAL 250
    LLEHRASLSA KDQDGWEPLH AAAYWGQVPL VELLVAHGAD LNAKSLMDET 300
    PLDVCGDEEV RAKLLELKHK HDALLRAQSR QRSLLRRRTS SAGSRGKVVR 350
    RVSLTQRTDL YRKQHAQEAI VWQQPPPTSP EPPEDNDDRQ TGAELRPPPP 400
    EEDNPEVVRP HNGRVGGSPV RHLYSKRLDR SVSYQLSPLD STTPHTLVHD 450
    KAHHTLADLK RQRAAAKLQR PPPEGPESPE TAEPGLPGDT VTPQPDCGFR 500
    AGGDPPLLKL TAPAVEAPVE RRPCCLLM 528
    Length:528
    Mass (Da):57,811
    Last modified:December 1, 2001 - v1
    Checksum:iA5A2D5E1A16A438C
    GO

    Sequence cautioni

    The sequence BAC03452.1 differs from that shown. Reason: Cloning artifact.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti34 – 7138Missing in BAC03452. 1 PublicationCuratedAdd
    BLAST
    Sequence conflicti249 – 2491A → P in BAC03452. 1 PublicationCurated
    Sequence conflicti272 – 2721A → P in BAC03452. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK090471 mRNA. Translation: BAC03452.1. Sequence problems.
    BT006845 mRNA. Translation: AAP35491.1.
    CH471162 Genomic DNA. Translation: EAW82080.1.
    CH471162 Genomic DNA. Translation: EAW82081.1.
    CH471162 Genomic DNA. Translation: EAW82082.1.
    BC007854 mRNA. Translation: AAH07854.1.
    BC049841 mRNA. Translation: AAH49841.1.
    BC053506 mRNA. Translation: AAH53506.1.
    CCDSiCCDS6429.1.
    RefSeqiNP_116291.1. NM_032902.5.
    XP_005272407.1. XM_005272350.1.
    XP_006716737.1. XM_006716674.1.
    XP_006716738.1. XM_006716675.1.
    UniGeneiHs.521937.

    Genome annotation databases

    EnsembliENST00000292539; ENSP00000292539; ENSG00000160972.
    ENST00000435887; ENSP00000391126; ENSG00000160972.
    GeneIDi84988.
    KEGGihsa:84988.
    UCSCiuc003zdd.3. human.

    Polymorphism databases

    DMDMi22256976.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK090471 mRNA. Translation: BAC03452.1 . Sequence problems.
    BT006845 mRNA. Translation: AAP35491.1 .
    CH471162 Genomic DNA. Translation: EAW82080.1 .
    CH471162 Genomic DNA. Translation: EAW82081.1 .
    CH471162 Genomic DNA. Translation: EAW82082.1 .
    BC007854 mRNA. Translation: AAH07854.1 .
    BC049841 mRNA. Translation: AAH49841.1 .
    BC053506 mRNA. Translation: AAH53506.1 .
    CCDSi CCDS6429.1.
    RefSeqi NP_116291.1. NM_032902.5.
    XP_005272407.1. XM_005272350.1.
    XP_006716737.1. XM_006716674.1.
    XP_006716738.1. XM_006716675.1.
    UniGenei Hs.521937.

    3D structure databases

    ProteinModelPortali Q96I34.
    SMRi Q96I34. Positions 22-343.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124414. 14 interactions.
    IntActi Q96I34. 17 interactions.
    MINTi MINT-1368047.
    STRINGi 9606.ENSP00000292539.

    PTM databases

    PhosphoSitei Q96I34.

    Polymorphism databases

    DMDMi 22256976.

    Proteomic databases

    MaxQBi Q96I34.
    PaxDbi Q96I34.
    PRIDEi Q96I34.

    Protocols and materials databases

    DNASUi 84988.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000292539 ; ENSP00000292539 ; ENSG00000160972 .
    ENST00000435887 ; ENSP00000391126 ; ENSG00000160972 .
    GeneIDi 84988.
    KEGGi hsa:84988.
    UCSCi uc003zdd.3. human.

    Organism-specific databases

    CTDi 84988.
    GeneCardsi GC08P145703.
    HGNCi HGNC:14941. PPP1R16A.
    HPAi HPA023755.
    MIMi 609172. gene.
    neXtProti NX_Q96I34.
    PharmGKBi PA33634.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0666.
    HOGENOMi HOG000236276.
    HOVERGENi HBG053644.
    InParanoidi Q96I34.
    KOi K17458.
    OMAi NARDSEC.
    OrthoDBi EOG7P5T0H.
    PhylomeDBi Q96I34.
    TreeFami TF316803.

    Miscellaneous databases

    GenomeRNAii 84988.
    NextBioi 75568.
    PROi Q96I34.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96I34.
    CleanExi HS_PPP1R16A.
    Genevestigatori Q96I34.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR017417. Pase-1_reg_su_16AB_euk.
    [Graphical view ]
    Pfami PF12796. Ank_2. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF038159. PP1_16AB_vert. 1 hit.
    PRINTSi PR01415. ANKYRIN.
    SMARTi SM00248. ANK. 4 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
      Jikuya H., Takano J., Kikuno R., Nagase T., Ohara O.
      Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Spleen.
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung, Placenta and Uterus.

    Entry informationi

    Entry nameiPP16A_HUMAN
    AccessioniPrimary (citable) accession number: Q96I34
    Secondary accession number(s): D3DWM5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3