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Protein

Protein preY, mitochondrial

Gene

PYURF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • GPI anchor biosynthetic process Source: HGNC
  • positive regulation of metabolic process Source: HGNC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein preY, mitochondrial
Alternative name(s):
PIGY upstream reading frame protein
Gene namesi
Name:PYURF
Synonyms:PREY
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:44317. PYURF.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: HGNC
  • glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex Source: HGNC
  • mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485576.

Polymorphism and mutation databases

DMDMi74732012.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3535MitochondrionSequence analysisAdd
BLAST
Chaini36 – 11479Protein preY, mitochondrialPRO_0000246315Add
BLAST

Proteomic databases

EPDiQ96I23.
MaxQBiQ96I23.
PaxDbiQ96I23.
PeptideAtlasiQ96I23.
PRIDEiQ96I23.
TopDownProteomicsiQ96I23.

Expressioni

Gene expression databases

BgeeiQ96I23.
GenevisibleiQ96I23. HS.

Organism-specific databases

HPAiHPA036455.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000273968.

Structurei

3D structure databases

ProteinModelPortaliQ96I23.
SMRiQ96I23. Positions 50-95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 9747TRM112Add
BLAST

Sequence similaritiesi

Belongs to the PREY family.Curated
Contains 1 TRM112 domain.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IZ7U. Eukaryota.
ENOG41124MY. LUCA.
GeneTreeiENSGT00390000015889.
HOGENOMiHOG000227338.
HOVERGENiHBG082168.
InParanoidiQ96I23.
OMAiRRCLHAS.
OrthoDBiEOG7JX36B.
PhylomeDBiQ96I23.

Family and domain databases

InterProiIPR005651. UPF0434/Trm112.
[Graphical view]
PfamiPF03966. Trm112p. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96I23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSGARCRLA SALRGTRAPP SAVARRCLHA SGSRPLADRG KKTEEPPRDF
60 70 80 90 100
DPALLEFLVC PLSKKPLRYE ASTNELINEE LGIAYPIIDG IPNMIPQAAR
110
MTRQSKKQEE VEQR
Length:114
Mass (Da):12,655
Last modified:December 1, 2001 - v1
Checksum:iB7A33E980FC61A3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312082 mRNA. Translation: BAG35018.1.
AB206972 mRNA. No translation available.
BC007876 mRNA. No translation available.
CCDSiCCDS3631.1.
RefSeqiNP_116295.1. NM_032906.4.
UniGeneiHs.26136.
Hs.743393.

Genome annotation databases

EnsembliENST00000273968; ENSP00000273968; ENSG00000145337.
GeneIDi100996939.
KEGGihsa:100996939.
UCSCiuc003hru.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312082 mRNA. Translation: BAG35018.1.
AB206972 mRNA. No translation available.
BC007876 mRNA. No translation available.
CCDSiCCDS3631.1.
RefSeqiNP_116295.1. NM_032906.4.
UniGeneiHs.26136.
Hs.743393.

3D structure databases

ProteinModelPortaliQ96I23.
SMRiQ96I23. Positions 50-95.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000273968.

Polymorphism and mutation databases

DMDMi74732012.

Proteomic databases

EPDiQ96I23.
MaxQBiQ96I23.
PaxDbiQ96I23.
PeptideAtlasiQ96I23.
PRIDEiQ96I23.
TopDownProteomicsiQ96I23.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273968; ENSP00000273968; ENSG00000145337.
GeneIDi100996939.
KEGGihsa:100996939.
UCSCiuc003hru.3. human.

Organism-specific databases

CTDi100996939.
GeneCardsiPYURF.
H-InvDBHIX0004366.
HGNCiHGNC:44317. PYURF.
HPAiHPA036455.
neXtProtiNX_Q96I23.
PharmGKBiPA143485576.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZ7U. Eukaryota.
ENOG41124MY. LUCA.
GeneTreeiENSGT00390000015889.
HOGENOMiHOG000227338.
HOVERGENiHBG082168.
InParanoidiQ96I23.
OMAiRRCLHAS.
OrthoDBiEOG7JX36B.
PhylomeDBiQ96I23.

Miscellaneous databases

GenomeRNAii100996939.
NextBioi75581.
PROiQ96I23.

Gene expression databases

BgeeiQ96I23.
GenevisibleiQ96I23. HS.

Family and domain databases

InterProiIPR005651. UPF0434/Trm112.
[Graphical view]
PfamiPF03966. Trm112p. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  2. "The initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component."
    Murakami Y., Siripanyaphinyo U., Hong Y., Tashima Y., Maeda Y., Kinoshita T.
    Mol. Biol. Cell 16:5236-5246(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  4. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiPREY_HUMAN
AccessioniPrimary (citable) accession number: Q96I23
Secondary accession number(s): B2R571
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: December 1, 2001
Last modified: March 16, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

PREY and PIGY, 2 apparently unrelated proteins, are respectively the product of an upstream and a downstream ORF contained in a single bicistronic transcript.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.