ID   ABHD8_HUMAN             Reviewed;         439 AA.
AC   Q96I13; Q9HAE9;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   27-MAR-2024, entry version 152.
DE   RecName: Full=Protein ABHD8 {ECO:0000305};
DE            EC=3.-.-.-;
DE   AltName: Full=Alpha/beta hydrolase domain-containing protein 8 {ECO:0000305};
DE            Short=Abhydrolase domain-containing protein 8 {ECO:0000312|HGNC:HGNC:23759};
GN   Name=ABHD8 {ECO:0000312|HGNC:HGNC:23759};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, Lymph, and Muscle;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q96I13; Q53EP0-3: FNDC3B; NbExp=3; IntAct=EBI-17180442, EBI-10242151;
CC       Q96I13; Q86VK4-3: ZNF410; NbExp=3; IntAct=EBI-17180442, EBI-11741890;
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. {ECO:0000305}.
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DR   EMBL; AK021805; BAB13900.1; -; mRNA.
DR   EMBL; BC007895; AAH07895.1; -; mRNA.
DR   EMBL; BC020173; AAH20173.1; -; mRNA.
DR   EMBL; BC039087; AAH39087.1; -; mRNA.
DR   CCDS; CCDS12355.1; -.
DR   RefSeq; NP_078803.4; NM_024527.4.
DR   AlphaFoldDB; Q96I13; -.
DR   SMR; Q96I13; -.
DR   BioGRID; 122722; 11.
DR   IntAct; Q96I13; 3.
DR   STRING; 9606.ENSP00000247706; -.
DR   ESTHER; human-ABHD8; ABHD8.
DR   MEROPS; S33.011; -.
DR   iPTMnet; Q96I13; -.
DR   PhosphoSitePlus; Q96I13; -.
DR   BioMuta; ABHD8; -.
DR   DMDM; 74732007; -.
DR   MassIVE; Q96I13; -.
DR   PaxDb; 9606-ENSP00000247706; -.
DR   PeptideAtlas; Q96I13; -.
DR   ProteomicsDB; 76801; -.
DR   Antibodypedia; 51446; 143 antibodies from 25 providers.
DR   DNASU; 79575; -.
DR   Ensembl; ENST00000247706.4; ENSP00000247706.2; ENSG00000127220.6.
DR   GeneID; 79575; -.
DR   KEGG; hsa:79575; -.
DR   MANE-Select; ENST00000247706.4; ENSP00000247706.2; NM_024527.5; NP_078803.4.
DR   UCSC; uc002ngb.4; human.
DR   AGR; HGNC:23759; -.
DR   CTD; 79575; -.
DR   DisGeNET; 79575; -.
DR   GeneCards; ABHD8; -.
DR   HGNC; HGNC:23759; ABHD8.
DR   HPA; ENSG00000127220; Tissue enhanced (brain).
DR   neXtProt; NX_Q96I13; -.
DR   OpenTargets; ENSG00000127220; -.
DR   PharmGKB; PA134994313; -.
DR   VEuPathDB; HostDB:ENSG00000127220; -.
DR   eggNOG; KOG2382; Eukaryota.
DR   GeneTree; ENSGT00390000007336; -.
DR   HOGENOM; CLU_057347_0_0_1; -.
DR   InParanoid; Q96I13; -.
DR   OMA; VHCQRRI; -.
DR   OrthoDB; 3044577at2759; -.
DR   PhylomeDB; Q96I13; -.
DR   TreeFam; TF331708; -.
DR   PathwayCommons; Q96I13; -.
DR   SignaLink; Q96I13; -.
DR   BioGRID-ORCS; 79575; 20 hits in 1161 CRISPR screens.
DR   ChiTaRS; ABHD8; human.
DR   GenomeRNAi; 79575; -.
DR   Pharos; Q96I13; Tdark.
DR   PRO; PR:Q96I13; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q96I13; Protein.
DR   Bgee; ENSG00000127220; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 105 other cell types or tissues.
DR   ExpressionAtlas; Q96I13; baseline and differential.
DR   GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR000639; Epox_hydrolase-like.
DR   PANTHER; PTHR42886:SF93; PROTEIN ABHD8; 1.
DR   PANTHER; PTHR42886; RE40534P-RELATED; 1.
DR   Pfam; PF00561; Abhydrolase_1; 1.
DR   PRINTS; PR00111; ABHYDROLASE.
DR   PRINTS; PR00412; EPOXHYDRLASE.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   Genevisible; Q96I13; HS.
PE   1: Evidence at protein level;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..439
FT                   /note="Protein ABHD8"
FT                   /id="PRO_0000281382"
FT   DOMAIN          177..279
FT                   /note="AB hydrolase-1"
FT                   /evidence="ECO:0000255"
FT   REGION          49..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          124..156
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        252
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        370
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        398
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        103
FT                   /note="L -> P (in Ref. 1; BAB13900)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   439 AA;  47331 MW;  5D6DBB7BDD4A87C3 CRC64;
     MLTGVTDGIF CCLLGTPPNA VGPLESVESS DGYTFVEVKP GRVLRVKHAG PAPAAAPPPP
     SSASSDAAQG DLSGLVRCQR RITVYRNGRL LVENLGRAPR ADLLHGQNGS GEPPAALEVE
     LADPAGSDGR LAPGSAGSGS GSGSGGRRRR ARRPKRTIHI DCEKRITSCK GAQADVVLFF
     IHGVGGSLAI WKEQLDFFVR LGYEVVAPDL AGHGASSAPQ VAAAYTFYAL AEDMRAIFKR
     YAKKRNVLIG HSYGVSFCTF LAHEYPDLVH KVIMINGGGP TALEPSFCSI FNMPTCVLHC
     LSPCLAWSFL KAGFARQGAK EKQLLKEGNA FNVSSFVLRA MMSGQYWPEG DEVYHAELTV
     PVLLVHGMHD KFVPVEEDQR MAEILLLAFL KLIDEGSHMV MLECPETVNT LLHEFLLWEP
     EPSPKALPEP LPAPPEDKK
//