Q96I13 (ABHD8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Abhydrolase domain-containing protein 8
EC=3.-.-.-

Gene names

Name:

ABHD8

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	439 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the AB hydrolase superfamily.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	metabolic process Inferred from electronic annotation. Source: GOC
Molecular_function	hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 439	439	Abhydrolase domain-containing protein 8		PRO_0000281382
Sites
	Active site	252	1	Charge relay system By similarity
	Active site	370	1	Charge relay system By similarity
	Active site	398	1	Charge relay system By similarity
Experimental info
	Sequence conflict	103	1	L → P in BAB13900. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q96I13 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 5D6DBB7BDD4A87C3	FASTA	439	47,331
	10 20 30 40 50 60 MLTGVTDGIF CCLLGTPPNA VGPLESVESS DGYTFVEVKP GRVLRVKHAG PAPAAAPPPP 70 80 90 100 110 120 SSASSDAAQG DLSGLVRCQR RITVYRNGRL LVENLGRAPR ADLLHGQNGS GEPPAALEVE 130 140 150 160 170 180 LADPAGSDGR LAPGSAGSGS GSGSGGRRRR ARRPKRTIHI DCEKRITSCK GAQADVVLFF 190 200 210 220 230 240 IHGVGGSLAI WKEQLDFFVR LGYEVVAPDL AGHGASSAPQ VAAAYTFYAL AEDMRAIFKR 250 260 270 280 290 300 YAKKRNVLIG HSYGVSFCTF LAHEYPDLVH KVIMINGGGP TALEPSFCSI FNMPTCVLHC 310 320 330 340 350 360 LSPCLAWSFL KAGFARQGAK EKQLLKEGNA FNVSSFVLRA MMSGQYWPEG DEVYHAELTV 370 380 390 400 410 420 PVLLVHGMHD KFVPVEEDQR MAEILLLAFL KLIDEGSHMV MLECPETVNT LLHEFLLWEP 430 EPSPKALPEP LPAPPEDKK

References

[1]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain, Lymph and Muscle.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK021805 mRNA. Translation: BAB13900.1. BC007895 mRNA. Translation: AAH07895.1. BC020173 mRNA. Translation: AAH20173.1. BC039087 mRNA. Translation: AAH39087.1.
IPI	IPI00101651.
RefSeq	NP_078803.4. NM_024527.4.
UniGene	Hs.515664.
3D structure databases
ProteinModelPortal	Q96I13.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000247706.
Protein family/group databases
MEROPS	S33.011.
PTM databases
PhosphoSite	Q96I13.
Polymorphism databases
DMDM	74732007.
Proteomic databases
PaxDb	Q96I13.
PRIDE	Q96I13.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000247706; ENSP00000247706; ENSG00000127220.
GeneID	79575.
KEGG	hsa:79575.
UCSC	uc002ngb.4. human.
Organism-specific databases
CTD	79575.
GeneCards	GC19M017402.
HGNC	HGNC:23759. ABHD8.
HPA	HPA037658.
neXtProt	NX_Q96I13.
PharmGKB	PA134994313.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0596.
HOGENOM	HOG000261674.
HOVERGEN	HBG080814.
InParanoid	Q96I13.
KO	K13701.
OMA	SICSIFN.
OrthoDB	EOG4X0MSH.
PhylomeDB	Q96I13.
Gene expression databases
ArrayExpress	Q96I13.
Bgee	Q96I13.
CleanEx	HS_ABHD8.
Genevestigator	Q96I13.
Family and domain databases
InterPro	IPR000073. AB_hydrolase_1. IPR000639. Epox_hydrolase-like. [Graphical view]
PRINTS	PR00111. ABHYDROLASE. PR00412. EPOXHYDRLASE.
ProtoNet	Search...
Other
GenomeRNAi	79575.
NextBio	68554.

Entry information

Entry name

ABHD8_HUMAN

Accession

Primary (citable) accession number: Q96I13
Secondary accession number(s): Q9HAE9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.