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Protein

Abhydrolase domain-containing protein 8

Gene

ABHD8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei252 – 2521Charge relay systemBy similarity
Active sitei370 – 3701Charge relay systemBy similarity
Active sitei398 – 3981Charge relay systemBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Protein family/group databases

ESTHERihuman-ABHD8. Epoxide_hydrolase.
MEROPSiS33.011.

Names & Taxonomyi

Protein namesi
Recommended name:
Abhydrolase domain-containing protein 8 (EC:3.-.-.-)
Gene namesi
Name:ABHD8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:23759. ABHD8.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134994313.

Polymorphism and mutation databases

BioMutaiABHD8.
DMDMi74732007.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 439439Abhydrolase domain-containing protein 8PRO_0000281382Add
BLAST

Proteomic databases

PaxDbiQ96I13.
PRIDEiQ96I13.

PTM databases

PhosphoSiteiQ96I13.

Expressioni

Gene expression databases

BgeeiQ96I13.
CleanExiHS_ABHD8.
ExpressionAtlasiQ96I13. baseline.
GenevisibleiQ96I13. HS.

Organism-specific databases

HPAiHPA037658.
HPA058209.

Structurei

3D structure databases

ProteinModelPortaliQ96I13.
SMRiQ96I13. Positions 177-416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily.Curated

Phylogenomic databases

eggNOGiCOG0596.
GeneTreeiENSGT00390000007336.
HOGENOMiHOG000261674.
HOVERGENiHBG080814.
InParanoidiQ96I13.
KOiK13701.
OMAiSICSIFN.
OrthoDBiEOG7R2BJM.
PhylomeDBiQ96I13.
TreeFamiTF331708.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
[Graphical view]
PfamiPF12697. Abhydrolase_6. 1 hit.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
PR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96I13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTGVTDGIF CCLLGTPPNA VGPLESVESS DGYTFVEVKP GRVLRVKHAG
60 70 80 90 100
PAPAAAPPPP SSASSDAAQG DLSGLVRCQR RITVYRNGRL LVENLGRAPR
110 120 130 140 150
ADLLHGQNGS GEPPAALEVE LADPAGSDGR LAPGSAGSGS GSGSGGRRRR
160 170 180 190 200
ARRPKRTIHI DCEKRITSCK GAQADVVLFF IHGVGGSLAI WKEQLDFFVR
210 220 230 240 250
LGYEVVAPDL AGHGASSAPQ VAAAYTFYAL AEDMRAIFKR YAKKRNVLIG
260 270 280 290 300
HSYGVSFCTF LAHEYPDLVH KVIMINGGGP TALEPSFCSI FNMPTCVLHC
310 320 330 340 350
LSPCLAWSFL KAGFARQGAK EKQLLKEGNA FNVSSFVLRA MMSGQYWPEG
360 370 380 390 400
DEVYHAELTV PVLLVHGMHD KFVPVEEDQR MAEILLLAFL KLIDEGSHMV
410 420 430
MLECPETVNT LLHEFLLWEP EPSPKALPEP LPAPPEDKK
Length:439
Mass (Da):47,331
Last modified:December 1, 2001 - v1
Checksum:i5D6DBB7BDD4A87C3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti103 – 1031L → P in BAB13900 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021805 mRNA. Translation: BAB13900.1.
BC007895 mRNA. Translation: AAH07895.1.
BC020173 mRNA. Translation: AAH20173.1.
BC039087 mRNA. Translation: AAH39087.1.
CCDSiCCDS12355.1.
RefSeqiNP_078803.4. NM_024527.4.
UniGeneiHs.515664.

Genome annotation databases

EnsembliENST00000247706; ENSP00000247706; ENSG00000127220.
GeneIDi79575.
KEGGihsa:79575.
UCSCiuc002ngb.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021805 mRNA. Translation: BAB13900.1.
BC007895 mRNA. Translation: AAH07895.1.
BC020173 mRNA. Translation: AAH20173.1.
BC039087 mRNA. Translation: AAH39087.1.
CCDSiCCDS12355.1.
RefSeqiNP_078803.4. NM_024527.4.
UniGeneiHs.515664.

3D structure databases

ProteinModelPortaliQ96I13.
SMRiQ96I13. Positions 177-416.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERihuman-ABHD8. Epoxide_hydrolase.
MEROPSiS33.011.

PTM databases

PhosphoSiteiQ96I13.

Polymorphism and mutation databases

BioMutaiABHD8.
DMDMi74732007.

Proteomic databases

PaxDbiQ96I13.
PRIDEiQ96I13.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000247706; ENSP00000247706; ENSG00000127220.
GeneIDi79575.
KEGGihsa:79575.
UCSCiuc002ngb.4. human.

Organism-specific databases

CTDi79575.
GeneCardsiGC19M017402.
HGNCiHGNC:23759. ABHD8.
HPAiHPA037658.
HPA058209.
neXtProtiNX_Q96I13.
PharmGKBiPA134994313.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0596.
GeneTreeiENSGT00390000007336.
HOGENOMiHOG000261674.
HOVERGENiHBG080814.
InParanoidiQ96I13.
KOiK13701.
OMAiSICSIFN.
OrthoDBiEOG7R2BJM.
PhylomeDBiQ96I13.
TreeFamiTF331708.

Miscellaneous databases

GenomeRNAii79575.
NextBioi68554.
PROiQ96I13.

Gene expression databases

BgeeiQ96I13.
CleanExiHS_ABHD8.
ExpressionAtlasiQ96I13. baseline.
GenevisibleiQ96I13. HS.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
[Graphical view]
PfamiPF12697. Abhydrolase_6. 1 hit.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
PR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Lymph and Muscle.

Entry informationi

Entry nameiABHD8_HUMAN
AccessioniPrimary (citable) accession number: Q96I13
Secondary accession number(s): Q9HAE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: December 1, 2001
Last modified: June 24, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.