Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q96I13

- ABHD8_HUMAN

UniProt

Q96I13 - ABHD8_HUMAN

Protein

Abhydrolase domain-containing protein 8

Gene

ABHD8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei252 – 2521Charge relay systemBy similarity
    Active sitei370 – 3701Charge relay systemBy similarity
    Active sitei398 – 3981Charge relay systemBy similarity

    GO - Molecular functioni

    1. hydrolase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Protein family/group databases

    MEROPSiS33.011.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Abhydrolase domain-containing protein 8 (EC:3.-.-.-)
    Gene namesi
    Name:ABHD8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:23759. ABHD8.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134994313.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 439439Abhydrolase domain-containing protein 8PRO_0000281382Add
    BLAST

    Proteomic databases

    PaxDbiQ96I13.
    PRIDEiQ96I13.

    PTM databases

    PhosphoSiteiQ96I13.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96I13.
    BgeeiQ96I13.
    CleanExiHS_ABHD8.
    GenevestigatoriQ96I13.

    Organism-specific databases

    HPAiHPA037658.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000247706.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96I13.
    SMRiQ96I13. Positions 177-416.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AB hydrolase superfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0596.
    HOGENOMiHOG000261674.
    HOVERGENiHBG080814.
    InParanoidiQ96I13.
    KOiK13701.
    OMAiSICSIFN.
    OrthoDBiEOG7R2BJM.
    PhylomeDBiQ96I13.
    TreeFamiTF331708.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR000073. AB_hydrolase_1.
    IPR000639. Epox_hydrolase-like.
    [Graphical view]
    PRINTSiPR00111. ABHYDROLASE.
    PR00412. EPOXHYDRLASE.
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q96I13-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLTGVTDGIF CCLLGTPPNA VGPLESVESS DGYTFVEVKP GRVLRVKHAG    50
    PAPAAAPPPP SSASSDAAQG DLSGLVRCQR RITVYRNGRL LVENLGRAPR 100
    ADLLHGQNGS GEPPAALEVE LADPAGSDGR LAPGSAGSGS GSGSGGRRRR 150
    ARRPKRTIHI DCEKRITSCK GAQADVVLFF IHGVGGSLAI WKEQLDFFVR 200
    LGYEVVAPDL AGHGASSAPQ VAAAYTFYAL AEDMRAIFKR YAKKRNVLIG 250
    HSYGVSFCTF LAHEYPDLVH KVIMINGGGP TALEPSFCSI FNMPTCVLHC 300
    LSPCLAWSFL KAGFARQGAK EKQLLKEGNA FNVSSFVLRA MMSGQYWPEG 350
    DEVYHAELTV PVLLVHGMHD KFVPVEEDQR MAEILLLAFL KLIDEGSHMV 400
    MLECPETVNT LLHEFLLWEP EPSPKALPEP LPAPPEDKK 439
    Length:439
    Mass (Da):47,331
    Last modified:December 1, 2001 - v1
    Checksum:i5D6DBB7BDD4A87C3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti103 – 1031L → P in BAB13900. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK021805 mRNA. Translation: BAB13900.1.
    BC007895 mRNA. Translation: AAH07895.1.
    BC020173 mRNA. Translation: AAH20173.1.
    BC039087 mRNA. Translation: AAH39087.1.
    CCDSiCCDS12355.1.
    RefSeqiNP_078803.4. NM_024527.4.
    UniGeneiHs.515664.

    Genome annotation databases

    EnsembliENST00000247706; ENSP00000247706; ENSG00000127220.
    GeneIDi79575.
    KEGGihsa:79575.
    UCSCiuc002ngb.4. human.

    Polymorphism databases

    DMDMi74732007.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK021805 mRNA. Translation: BAB13900.1 .
    BC007895 mRNA. Translation: AAH07895.1 .
    BC020173 mRNA. Translation: AAH20173.1 .
    BC039087 mRNA. Translation: AAH39087.1 .
    CCDSi CCDS12355.1.
    RefSeqi NP_078803.4. NM_024527.4.
    UniGenei Hs.515664.

    3D structure databases

    ProteinModelPortali Q96I13.
    SMRi Q96I13. Positions 177-416.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000247706.

    Protein family/group databases

    MEROPSi S33.011.

    PTM databases

    PhosphoSitei Q96I13.

    Polymorphism databases

    DMDMi 74732007.

    Proteomic databases

    PaxDbi Q96I13.
    PRIDEi Q96I13.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000247706 ; ENSP00000247706 ; ENSG00000127220 .
    GeneIDi 79575.
    KEGGi hsa:79575.
    UCSCi uc002ngb.4. human.

    Organism-specific databases

    CTDi 79575.
    GeneCardsi GC19M017402.
    HGNCi HGNC:23759. ABHD8.
    HPAi HPA037658.
    neXtProti NX_Q96I13.
    PharmGKBi PA134994313.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0596.
    HOGENOMi HOG000261674.
    HOVERGENi HBG080814.
    InParanoidi Q96I13.
    KOi K13701.
    OMAi SICSIFN.
    OrthoDBi EOG7R2BJM.
    PhylomeDBi Q96I13.
    TreeFami TF331708.

    Miscellaneous databases

    GenomeRNAii 79575.
    NextBioi 68554.
    PROi Q96I13.

    Gene expression databases

    ArrayExpressi Q96I13.
    Bgeei Q96I13.
    CleanExi HS_ABHD8.
    Genevestigatori Q96I13.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR000073. AB_hydrolase_1.
    IPR000639. Epox_hydrolase-like.
    [Graphical view ]
    PRINTSi PR00111. ABHYDROLASE.
    PR00412. EPOXHYDRLASE.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain, Lymph and Muscle.

    Entry informationi

    Entry nameiABHD8_HUMAN
    AccessioniPrimary (citable) accession number: Q96I13
    Secondary accession number(s): Q9HAE9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3