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Q96I13 (ABHD8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Abhydrolase domain-containing protein 8

EC=3.-.-.-
Gene names
Name:ABHD8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length439 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the AB hydrolase superfamily.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionhydrolase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 439439Abhydrolase domain-containing protein 8
PRO_0000281382

Sites

Active site2521Charge relay system By similarity
Active site3701Charge relay system By similarity
Active site3981Charge relay system By similarity

Experimental info

Sequence conflict1031L → P in BAB13900. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q96I13 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 5D6DBB7BDD4A87C3

FASTA43947,331
        10         20         30         40         50         60 
MLTGVTDGIF CCLLGTPPNA VGPLESVESS DGYTFVEVKP GRVLRVKHAG PAPAAAPPPP 

        70         80         90        100        110        120 
SSASSDAAQG DLSGLVRCQR RITVYRNGRL LVENLGRAPR ADLLHGQNGS GEPPAALEVE 

       130        140        150        160        170        180 
LADPAGSDGR LAPGSAGSGS GSGSGGRRRR ARRPKRTIHI DCEKRITSCK GAQADVVLFF 

       190        200        210        220        230        240 
IHGVGGSLAI WKEQLDFFVR LGYEVVAPDL AGHGASSAPQ VAAAYTFYAL AEDMRAIFKR 

       250        260        270        280        290        300 
YAKKRNVLIG HSYGVSFCTF LAHEYPDLVH KVIMINGGGP TALEPSFCSI FNMPTCVLHC 

       310        320        330        340        350        360 
LSPCLAWSFL KAGFARQGAK EKQLLKEGNA FNVSSFVLRA MMSGQYWPEG DEVYHAELTV 

       370        380        390        400        410        420 
PVLLVHGMHD KFVPVEEDQR MAEILLLAFL KLIDEGSHMV MLECPETVNT LLHEFLLWEP 

       430 
EPSPKALPEP LPAPPEDKK 

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain, Lymph and Muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK021805 mRNA. Translation: BAB13900.1.
BC007895 mRNA. Translation: AAH07895.1.
BC020173 mRNA. Translation: AAH20173.1.
BC039087 mRNA. Translation: AAH39087.1.
CCDSCCDS12355.1.
RefSeqNP_078803.4. NM_024527.4.
UniGeneHs.515664.

3D structure databases

ProteinModelPortalQ96I13.
SMRQ96I13. Positions 177-416.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000247706.

Protein family/group databases

MEROPSS33.011.

PTM databases

PhosphoSiteQ96I13.

Polymorphism databases

DMDM74732007.

Proteomic databases

PaxDbQ96I13.
PRIDEQ96I13.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000247706; ENSP00000247706; ENSG00000127220.
GeneID79575.
KEGGhsa:79575.
UCSCuc002ngb.4. human.

Organism-specific databases

CTD79575.
GeneCardsGC19M017402.
HGNCHGNC:23759. ABHD8.
HPAHPA037658.
neXtProtNX_Q96I13.
PharmGKBPA134994313.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0596.
HOGENOMHOG000261674.
HOVERGENHBG080814.
InParanoidQ96I13.
KOK13701.
OMASICSIFN.
OrthoDBEOG7R2BJM.
PhylomeDBQ96I13.
TreeFamTF331708.

Gene expression databases

ArrayExpressQ96I13.
BgeeQ96I13.
CleanExHS_ABHD8.
GenevestigatorQ96I13.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
[Graphical view]
PRINTSPR00111. ABHYDROLASE.
PR00412. EPOXHYDRLASE.
SUPFAMSSF53474. SSF53474. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi79575.
NextBio68554.
PROQ96I13.

Entry information

Entry nameABHD8_HUMAN
AccessionPrimary (citable) accession number: Q96I13
Secondary accession number(s): Q9HAE9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM