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Protein

Protein ABHD8

Gene

ABHD8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei252Charge relay systemBy similarity1
Active sitei370Charge relay systemBy similarity1
Active sitei398Charge relay systemBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciZFISH:ENSG00000127220-MONOMER.

Protein family/group databases

ESTHERihuman-ABHD8. Epoxide_hydrolase.
MEROPSiS33.011.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ABHD8Curated (EC:3.-.-.-)
Alternative name(s):
Alpha/beta hydrolase domain-containing protein 8Curated
Short name:
Abhydrolase domain-containing protein 8Imported
Gene namesi
Name:ABHD8Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:23759. ABHD8.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000127220.
PharmGKBiPA134994313.

Polymorphism and mutation databases

BioMutaiABHD8.
DMDMi74732007.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002813821 – 439Protein ABHD8Add BLAST439

Proteomic databases

EPDiQ96I13.
PaxDbiQ96I13.
PRIDEiQ96I13.

PTM databases

iPTMnetiQ96I13.
PhosphoSitePlusiQ96I13.

Expressioni

Gene expression databases

BgeeiENSG00000127220.
CleanExiHS_ABHD8.
ExpressionAtlasiQ96I13. baseline and differential.
GenevisibleiQ96I13. HS.

Organism-specific databases

HPAiHPA037658.
HPA058209.

Interactioni

Protein-protein interaction databases

BioGridi122722. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ96I13.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini177 – 279AB hydrolase-1Sequence analysisAdd BLAST103

Sequence similaritiesi

Belongs to the AB hydrolase superfamily.Curated

Phylogenomic databases

eggNOGiENOG410IR1S. Eukaryota.
ENOG41120U2. LUCA.
GeneTreeiENSGT00390000007336.
HOGENOMiHOG000261674.
HOVERGENiHBG080814.
InParanoidiQ96I13.
KOiK13701.
OMAiFFCCLLG.
OrthoDBiEOG091G09BH.
PhylomeDBiQ96I13.
TreeFamiTF331708.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
PR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96I13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTGVTDGIF CCLLGTPPNA VGPLESVESS DGYTFVEVKP GRVLRVKHAG
60 70 80 90 100
PAPAAAPPPP SSASSDAAQG DLSGLVRCQR RITVYRNGRL LVENLGRAPR
110 120 130 140 150
ADLLHGQNGS GEPPAALEVE LADPAGSDGR LAPGSAGSGS GSGSGGRRRR
160 170 180 190 200
ARRPKRTIHI DCEKRITSCK GAQADVVLFF IHGVGGSLAI WKEQLDFFVR
210 220 230 240 250
LGYEVVAPDL AGHGASSAPQ VAAAYTFYAL AEDMRAIFKR YAKKRNVLIG
260 270 280 290 300
HSYGVSFCTF LAHEYPDLVH KVIMINGGGP TALEPSFCSI FNMPTCVLHC
310 320 330 340 350
LSPCLAWSFL KAGFARQGAK EKQLLKEGNA FNVSSFVLRA MMSGQYWPEG
360 370 380 390 400
DEVYHAELTV PVLLVHGMHD KFVPVEEDQR MAEILLLAFL KLIDEGSHMV
410 420 430
MLECPETVNT LLHEFLLWEP EPSPKALPEP LPAPPEDKK
Length:439
Mass (Da):47,331
Last modified:December 1, 2001 - v1
Checksum:i5D6DBB7BDD4A87C3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103L → P in BAB13900 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021805 mRNA. Translation: BAB13900.1.
BC007895 mRNA. Translation: AAH07895.1.
BC020173 mRNA. Translation: AAH20173.1.
BC039087 mRNA. Translation: AAH39087.1.
CCDSiCCDS12355.1.
RefSeqiNP_078803.4. NM_024527.4.
UniGeneiHs.515664.

Genome annotation databases

EnsembliENST00000247706; ENSP00000247706; ENSG00000127220.
GeneIDi79575.
KEGGihsa:79575.
UCSCiuc002ngb.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021805 mRNA. Translation: BAB13900.1.
BC007895 mRNA. Translation: AAH07895.1.
BC020173 mRNA. Translation: AAH20173.1.
BC039087 mRNA. Translation: AAH39087.1.
CCDSiCCDS12355.1.
RefSeqiNP_078803.4. NM_024527.4.
UniGeneiHs.515664.

3D structure databases

ProteinModelPortaliQ96I13.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122722. 1 interactor.

Protein family/group databases

ESTHERihuman-ABHD8. Epoxide_hydrolase.
MEROPSiS33.011.

PTM databases

iPTMnetiQ96I13.
PhosphoSitePlusiQ96I13.

Polymorphism and mutation databases

BioMutaiABHD8.
DMDMi74732007.

Proteomic databases

EPDiQ96I13.
PaxDbiQ96I13.
PRIDEiQ96I13.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000247706; ENSP00000247706; ENSG00000127220.
GeneIDi79575.
KEGGihsa:79575.
UCSCiuc002ngb.4. human.

Organism-specific databases

CTDi79575.
GeneCardsiABHD8.
HGNCiHGNC:23759. ABHD8.
HPAiHPA037658.
HPA058209.
neXtProtiNX_Q96I13.
OpenTargetsiENSG00000127220.
PharmGKBiPA134994313.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IR1S. Eukaryota.
ENOG41120U2. LUCA.
GeneTreeiENSGT00390000007336.
HOGENOMiHOG000261674.
HOVERGENiHBG080814.
InParanoidiQ96I13.
KOiK13701.
OMAiFFCCLLG.
OrthoDBiEOG091G09BH.
PhylomeDBiQ96I13.
TreeFamiTF331708.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000127220-MONOMER.

Miscellaneous databases

GenomeRNAii79575.
PROiQ96I13.

Gene expression databases

BgeeiENSG00000127220.
CleanExiHS_ABHD8.
ExpressionAtlasiQ96I13. baseline and differential.
GenevisibleiQ96I13. HS.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
PR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiABHD8_HUMAN
AccessioniPrimary (citable) accession number: Q96I13
Secondary accession number(s): Q9HAE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.