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Q96I13

- ABHD8_HUMAN

UniProt

Q96I13 - ABHD8_HUMAN

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Protein
Abhydrolase domain-containing protein 8
Gene
ABHD8
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei252 – 2521Charge relay system By similarity
Active sitei370 – 3701Charge relay system By similarity
Active sitei398 – 3981Charge relay system By similarity

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Protein family/group databases

MEROPSiS33.011.

Names & Taxonomyi

Protein namesi
Recommended name:
Abhydrolase domain-containing protein 8 (EC:3.-.-.-)
Gene namesi
Name:ABHD8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:23759. ABHD8.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134994313.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 439439Abhydrolase domain-containing protein 8
PRO_0000281382Add
BLAST

Proteomic databases

PaxDbiQ96I13.
PRIDEiQ96I13.

PTM databases

PhosphoSiteiQ96I13.

Expressioni

Gene expression databases

ArrayExpressiQ96I13.
BgeeiQ96I13.
CleanExiHS_ABHD8.
GenevestigatoriQ96I13.

Organism-specific databases

HPAiHPA037658.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000247706.

Structurei

3D structure databases

ProteinModelPortaliQ96I13.
SMRiQ96I13. Positions 177-416.

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily.

Phylogenomic databases

eggNOGiCOG0596.
HOGENOMiHOG000261674.
HOVERGENiHBG080814.
InParanoidiQ96I13.
KOiK13701.
OMAiSICSIFN.
OrthoDBiEOG7R2BJM.
PhylomeDBiQ96I13.
TreeFamiTF331708.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
PR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96I13-1 [UniParc]FASTAAdd to Basket

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MLTGVTDGIF CCLLGTPPNA VGPLESVESS DGYTFVEVKP GRVLRVKHAG    50
PAPAAAPPPP SSASSDAAQG DLSGLVRCQR RITVYRNGRL LVENLGRAPR 100
ADLLHGQNGS GEPPAALEVE LADPAGSDGR LAPGSAGSGS GSGSGGRRRR 150
ARRPKRTIHI DCEKRITSCK GAQADVVLFF IHGVGGSLAI WKEQLDFFVR 200
LGYEVVAPDL AGHGASSAPQ VAAAYTFYAL AEDMRAIFKR YAKKRNVLIG 250
HSYGVSFCTF LAHEYPDLVH KVIMINGGGP TALEPSFCSI FNMPTCVLHC 300
LSPCLAWSFL KAGFARQGAK EKQLLKEGNA FNVSSFVLRA MMSGQYWPEG 350
DEVYHAELTV PVLLVHGMHD KFVPVEEDQR MAEILLLAFL KLIDEGSHMV 400
MLECPETVNT LLHEFLLWEP EPSPKALPEP LPAPPEDKK 439
Length:439
Mass (Da):47,331
Last modified:December 1, 2001 - v1
Checksum:i5D6DBB7BDD4A87C3
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti103 – 1031L → P in BAB13900. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK021805 mRNA. Translation: BAB13900.1.
BC007895 mRNA. Translation: AAH07895.1.
BC020173 mRNA. Translation: AAH20173.1.
BC039087 mRNA. Translation: AAH39087.1.
CCDSiCCDS12355.1.
RefSeqiNP_078803.4. NM_024527.4.
UniGeneiHs.515664.

Genome annotation databases

EnsembliENST00000247706; ENSP00000247706; ENSG00000127220.
GeneIDi79575.
KEGGihsa:79575.
UCSCiuc002ngb.4. human.

Polymorphism databases

DMDMi74732007.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK021805 mRNA. Translation: BAB13900.1 .
BC007895 mRNA. Translation: AAH07895.1 .
BC020173 mRNA. Translation: AAH20173.1 .
BC039087 mRNA. Translation: AAH39087.1 .
CCDSi CCDS12355.1.
RefSeqi NP_078803.4. NM_024527.4.
UniGenei Hs.515664.

3D structure databases

ProteinModelPortali Q96I13.
SMRi Q96I13. Positions 177-416.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000247706.

Protein family/group databases

MEROPSi S33.011.

PTM databases

PhosphoSitei Q96I13.

Polymorphism databases

DMDMi 74732007.

Proteomic databases

PaxDbi Q96I13.
PRIDEi Q96I13.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000247706 ; ENSP00000247706 ; ENSG00000127220 .
GeneIDi 79575.
KEGGi hsa:79575.
UCSCi uc002ngb.4. human.

Organism-specific databases

CTDi 79575.
GeneCardsi GC19M017402.
HGNCi HGNC:23759. ABHD8.
HPAi HPA037658.
neXtProti NX_Q96I13.
PharmGKBi PA134994313.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0596.
HOGENOMi HOG000261674.
HOVERGENi HBG080814.
InParanoidi Q96I13.
KOi K13701.
OMAi SICSIFN.
OrthoDBi EOG7R2BJM.
PhylomeDBi Q96I13.
TreeFami TF331708.

Miscellaneous databases

GenomeRNAii 79575.
NextBioi 68554.
PROi Q96I13.

Gene expression databases

ArrayExpressi Q96I13.
Bgeei Q96I13.
CleanExi HS_ABHD8.
Genevestigatori Q96I13.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
[Graphical view ]
PRINTSi PR00111. ABHYDROLASE.
PR00412. EPOXHYDRLASE.
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Lymph and Muscle.

Entry informationi

Entry nameiABHD8_HUMAN
AccessioniPrimary (citable) accession number: Q96I13
Secondary accession number(s): Q9HAE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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