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Protein

GTP-binding protein Di-Ras2

Gene

DIRAS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Displays low GTPase activity and exists predominantly in the GTP-bound form.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 21GTPCombined sources1 Publication8
Nucleotide bindingi33 – 39GTPCombined sources1 Publication7
Nucleotide bindingi61 – 65GTPCombined sources1 Publication5
Nucleotide bindingi121 – 124GTPCombined sources1 Publication4
Nucleotide bindingi152 – 153GTPCombined sources1 Publication2

GO - Molecular functioni

  • GTP binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000165023-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein Di-Ras2
Alternative name(s):
Distinct subgroup of the Ras family member 2
Gene namesi
Name:DIRAS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:19323. DIRAS2.

Subcellular locationi

GO - Cellular componenti

  • intracellular Source: GOC
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi54769.
OpenTargetsiENSG00000165023.
PharmGKBiPA134958969.

Polymorphism and mutation databases

BioMutaiDIRAS2.
DMDMi62286631.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001916501 – 196GTP-binding protein Di-Ras2Add BLAST196
PropeptideiPRO_0000370777197 – 199Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35PhosphoserineBy similarity1
Modified residuei126PhosphoserineBy similarity1
Modified residuei196Cysteine methyl esterSequence analysis1
Lipidationi196S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ96HU8.
MaxQBiQ96HU8.
PaxDbiQ96HU8.
PeptideAtlasiQ96HU8.
PRIDEiQ96HU8.

PTM databases

iPTMnetiQ96HU8.
PhosphoSitePlusiQ96HU8.

Expressioni

Tissue specificityi

Highly expressed in brain.1 Publication

Gene expression databases

BgeeiENSG00000165023.
CleanExiHS_DIRAS2.
GenevisibleiQ96HU8. HS.

Organism-specific databases

HPAiHPA043758.

Interactioni

Protein-protein interaction databases

BioGridi120143. 6 interactors.
IntActiQ96HU8. 5 interactors.
STRINGi9606.ENSP00000364919.

Structurei

Secondary structure

1199
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 13Combined sources7
Helixi20 – 28Combined sources9
Beta strandi42 – 50Combined sources9
Beta strandi53 – 61Combined sources9
Helixi69 – 78Combined sources10
Beta strandi80 – 87Combined sources8
Helixi91 – 95Combined sources5
Helixi98 – 108Combined sources11
Beta strandi116 – 121Combined sources6
Helixi123 – 128Combined sources6
Helixi133 – 143Combined sources11
Beta strandi146 – 149Combined sources4
Turni152 – 155Combined sources4
Helixi158 – 167Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ERXX-ray1.65A/B5-176[»]
ProteinModelPortaliQ96HU8.
SMRiQ96HU8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96HU8.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi36 – 44Effector regionSequence analysis9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Di-Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133678.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ96HU8.
KOiK07841.
OMAiWGVSFME.
OrthoDBiEOG091G0SBH.
PhylomeDBiQ96HU8.
TreeFamiTF313014.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96HU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEQSNDYRV AVFGAGGVGK SSLVLRFVKG TFRESYIPTV EDTYRQVISC
60 70 80 90 100
DKSICTLQIT DTTGSHQFPA MQRLSISKGH AFILVYSITS RQSLEELKPI
110 120 130 140 150
YEQICEIKGD VESIPIMLVG NKCDESPSRE VQSSEAEALA RTWKCAFMET
160 170 180 190
SAKLNHNVKE LFQELLNLEK RRTVSLQIDG KKSKQQKRKE KLKGKCVIM
Length:199
Mass (Da):22,485
Last modified:December 1, 2001 - v1
Checksum:i429D17026CC3EADC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076889 mRNA. Translation: BAC01116.1.
AK122986 mRNA. Translation: BAG53834.1.
AL353619 Genomic DNA. Translation: CAI15748.1.
CH471089 Genomic DNA. Translation: EAW62780.1.
BC008065 mRNA. Translation: AAH08065.1.
CCDSiCCDS6687.1.
RefSeqiNP_060064.2. NM_017594.4.
UniGeneiHs.165636.

Genome annotation databases

EnsembliENST00000375765; ENSP00000364919; ENSG00000165023.
GeneIDi54769.
KEGGihsa:54769.
UCSCiuc004aqx.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076889 mRNA. Translation: BAC01116.1.
AK122986 mRNA. Translation: BAG53834.1.
AL353619 Genomic DNA. Translation: CAI15748.1.
CH471089 Genomic DNA. Translation: EAW62780.1.
BC008065 mRNA. Translation: AAH08065.1.
CCDSiCCDS6687.1.
RefSeqiNP_060064.2. NM_017594.4.
UniGeneiHs.165636.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ERXX-ray1.65A/B5-176[»]
ProteinModelPortaliQ96HU8.
SMRiQ96HU8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120143. 6 interactors.
IntActiQ96HU8. 5 interactors.
STRINGi9606.ENSP00000364919.

PTM databases

iPTMnetiQ96HU8.
PhosphoSitePlusiQ96HU8.

Polymorphism and mutation databases

BioMutaiDIRAS2.
DMDMi62286631.

Proteomic databases

EPDiQ96HU8.
MaxQBiQ96HU8.
PaxDbiQ96HU8.
PeptideAtlasiQ96HU8.
PRIDEiQ96HU8.

Protocols and materials databases

DNASUi54769.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375765; ENSP00000364919; ENSG00000165023.
GeneIDi54769.
KEGGihsa:54769.
UCSCiuc004aqx.2. human.

Organism-specific databases

CTDi54769.
DisGeNETi54769.
GeneCardsiDIRAS2.
HGNCiHGNC:19323. DIRAS2.
HPAiHPA043758.
MIMi607863. gene.
neXtProtiNX_Q96HU8.
OpenTargetsiENSG00000165023.
PharmGKBiPA134958969.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133678.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ96HU8.
KOiK07841.
OMAiWGVSFME.
OrthoDBiEOG091G0SBH.
PhylomeDBiQ96HU8.
TreeFamiTF313014.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000165023-MONOMER.

Miscellaneous databases

ChiTaRSiDIRAS2. human.
EvolutionaryTraceiQ96HU8.
GenomeRNAii54769.
PROiQ96HU8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165023.
CleanExiHS_DIRAS2.
GenevisibleiQ96HU8. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDIRA2_HUMAN
AccessioniPrimary (citable) accession number: Q96HU8
Secondary accession number(s): B3KVM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.