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Protein

MORF4 family-associated protein 1-like 1

Gene

MRFAP1L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • identical protein binding Source: IntAct
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
MORF4 family-associated protein 1-like 1
Gene namesi
ORF Names:PP784
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:28796. MRFAP1L1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671333.

Polymorphism and mutation databases

BioMutaiMRFAP1L1.
DMDMi74731978.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 127127MORF4 family-associated protein 1-like 1PRO_0000318718Add
BLAST

Proteomic databases

EPDiQ96HT8.
MaxQBiQ96HT8.
PaxDbiQ96HT8.
PRIDEiQ96HT8.

PTM databases

iPTMnetiQ96HT8.
PhosphoSiteiQ96HT8.

Expressioni

Gene expression databases

BgeeiQ96HT8.
CleanExiHS_MRFAP1L1.
ExpressionAtlasiQ96HT8. baseline and differential.
GenevisibleiQ96HT8. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-748896,EBI-748896
ABI2Q9NYB95EBI-748896,EBI-743598
ABI3Q9P2A43EBI-748896,EBI-742038
BYSLQ138956EBI-748896,EBI-358049
C3orf62Q6ZUJ43EBI-748896,EBI-2837036
CAGE1Q8TC203EBI-748896,EBI-10196469
CCDC36Q8IYA83EBI-748896,EBI-8638439
CDK2AP1O145194EBI-748896,EBI-1052532
CENPKQ9BS163EBI-748896,EBI-6871750
CEP44Q9C0F13EBI-748896,EBI-744115
CSPP1Q1MSJ5-23EBI-748896,EBI-10239155
DOC-1RQ6IAV43EBI-748896,EBI-724649
EIF2B2Q53XC23EBI-748896,EBI-10288660
EIF2B2Q9BPX43EBI-748896,EBI-10288788
HGSO149643EBI-748896,EBI-740220
HTTP428583EBI-748896,EBI-466029
LMO2P257913EBI-748896,EBI-739696
LNX1Q8TBB13EBI-748896,EBI-739832
MEOX2A4D1273EBI-748896,EBI-10172134
MORF4L1Q9UBU88EBI-748896,EBI-399246
MORF4L1Q9UBU8-25EBI-748896,EBI-10288852
MORF4L2Q150145EBI-748896,EBI-399257
MRFAP1Q9Y6053EBI-748896,EBI-995714
PIH1D2Q8WWB53EBI-748896,EBI-10232538
PIK3R2O004594EBI-748896,EBI-346930
PRKCDBPQ969G53EBI-748896,EBI-3893101
PSMA1P257864EBI-748896,EBI-359352
RADILQ96JH83EBI-748896,EBI-744267
RDM1Q8NG503EBI-748896,EBI-10288724
SDCBPO005605EBI-748896,EBI-727004
SFR1Q86XK33EBI-748896,EBI-1104535
SMARCE1Q969G33EBI-748896,EBI-455078
SMU1Q2TAY74EBI-748896,EBI-298027
SYCE1Q8N0S23EBI-748896,EBI-6872807
TCF4P158843EBI-748896,EBI-533224
TMEM126BQ8IUX13EBI-748896,EBI-2800657
TXN2Q997573EBI-748896,EBI-2932492
UBTD1Q9HAC83EBI-748896,EBI-745871

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi125400. 38 interactions.
DIPiDIP-29019N.
IntActiQ96HT8. 40 interactions.
MINTiMINT-1472696.
STRINGi9606.ENSP00000318154.

Structurei

3D structure databases

ProteinModelPortaliQ96HT8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili87 – 11832Sequence analysisAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410JCRB. Eukaryota.
ENOG41114ZF. LUCA.
GeneTreeiENSGT00510000048749.
HOGENOMiHOG000070216.
HOVERGENiHBG104090.
InParanoidiQ96HT8.
OMAiVWRIEKS.
OrthoDBiEOG7K6PXM.
PhylomeDBiQ96HT8.
TreeFamiTF338232.

Family and domain databases

InterProiIPR029254. MRFAP1.
[Graphical view]
PfamiPF15155. MRFAP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96HT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPLDIDEVE APEEVEVLEP EEDFEQFLLP VINEMREDIA SLIREHGRAY
60 70 80 90 100
LRTRSKLWEM DNMLIQIKTQ VEASEESALN HVQHPSGEAD ERVSELCEKA
110 120
EEKAKEIAKM AEMLVELVWR IERSESS
Length:127
Mass (Da):14,808
Last modified:December 1, 2001 - v1
Checksum:i6C914B0B4BEECAE5
GO

Sequence cautioni

The sequence AAF67011.1 differs from that shown. Reason: Frameshift at position 89. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331N → H in AAH66897 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155654 mRNA. Translation: AAF67011.1. Frameshift.
AF258591 mRNA. Translation: AAG23794.1.
AK312676 mRNA. Translation: BAG35557.1.
CH471131 Genomic DNA. Translation: EAW82383.1.
BC008087 mRNA. Translation: AAH08087.1.
BC066897 mRNA. Translation: AAH66897.1.
CCDSiCCDS3392.1.
RefSeqiNP_982287.1. NM_203462.2.
XP_005247989.1. XM_005247932.1.
UniGeneiHs.593159.

Genome annotation databases

EnsembliENST00000320848; ENSP00000318154; ENSG00000178988.
GeneIDi114932.
KEGGihsa:114932.
UCSCiuc003gjo.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155654 mRNA. Translation: AAF67011.1. Frameshift.
AF258591 mRNA. Translation: AAG23794.1.
AK312676 mRNA. Translation: BAG35557.1.
CH471131 Genomic DNA. Translation: EAW82383.1.
BC008087 mRNA. Translation: AAH08087.1.
BC066897 mRNA. Translation: AAH66897.1.
CCDSiCCDS3392.1.
RefSeqiNP_982287.1. NM_203462.2.
XP_005247989.1. XM_005247932.1.
UniGeneiHs.593159.

3D structure databases

ProteinModelPortaliQ96HT8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125400. 38 interactions.
DIPiDIP-29019N.
IntActiQ96HT8. 40 interactions.
MINTiMINT-1472696.
STRINGi9606.ENSP00000318154.

PTM databases

iPTMnetiQ96HT8.
PhosphoSiteiQ96HT8.

Polymorphism and mutation databases

BioMutaiMRFAP1L1.
DMDMi74731978.

Proteomic databases

EPDiQ96HT8.
MaxQBiQ96HT8.
PaxDbiQ96HT8.
PRIDEiQ96HT8.

Protocols and materials databases

DNASUi114932.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320848; ENSP00000318154; ENSG00000178988.
GeneIDi114932.
KEGGihsa:114932.
UCSCiuc003gjo.5. human.

Organism-specific databases

CTDi114932.
GeneCardsiMRFAP1L1.
H-InvDBHIX0004066.
HGNCiHGNC:28796. MRFAP1L1.
neXtProtiNX_Q96HT8.
PharmGKBiPA142671333.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JCRB. Eukaryota.
ENOG41114ZF. LUCA.
GeneTreeiENSGT00510000048749.
HOGENOMiHOG000070216.
HOVERGENiHBG104090.
InParanoidiQ96HT8.
OMAiVWRIEKS.
OrthoDBiEOG7K6PXM.
PhylomeDBiQ96HT8.
TreeFamiTF338232.

Miscellaneous databases

GenomeRNAii114932.
NextBioi79454.
PROiQ96HT8.

Gene expression databases

BgeeiQ96HT8.
CleanExiHS_MRFAP1L1.
ExpressionAtlasiQ96HT8. baseline and differential.
GenevisibleiQ96HT8. HS.

Family and domain databases

InterProiIPR029254. MRFAP1.
[Graphical view]
PfamiPF15155. MRFAP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Adrenal gland.
  2. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hippocampus and Placenta.

Entry informationi

Entry nameiMR1L1_HUMAN
AccessioniPrimary (citable) accession number: Q96HT8
Secondary accession number(s): B2R6R0, Q6NXT8, Q9P0J5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.